Mathematical modeling of bacterial cell cycle: The problem of coordinating genome replication with cell growth

2014 ◽  
Vol 12 (03) ◽  
pp. 1450009 ◽  
Author(s):  
Vitaly A. Likhoshvai ◽  
Tamara M. Khlebodarova
Keyword(s):  
Cell Cycle ◽  
Dna Replication ◽  
Cell Growth ◽  
Growth Rates ◽  
Bacterial Cell ◽  
Genome Replication ◽  
Linear Type ◽  
A Cell ◽  
Growth Laws ◽  
Bacterial Cell Cycle

In this paper, we perform an analysis of bacterial cell-cycle models implementing different strategies to coordinately regulate genome replication and cell growth dynamics. It has been shown that the problem of coupling these processes does not depend directly on the dynamics of cell volume expansion, but does depend on the type of cell growth law. Our analysis has distinguished two types of cell growth laws, "exponential" and "linear", each of which may include both exponential and linear patterns of cell growth. If a cell grows following a law of the "exponential" type, including the exponential V(t) = V0exp (kt) and linear V(t) = V0(1 + kt) dynamic patterns, then the cell encounters the problem of coupling growth rates and replication. It has been demonstrated that to solve the problem, it is sufficient for a cell to have a repressor mechanism to regulate DNA replication initiation. For a cell expanding its volume by a law of the "linear" type, including exponential V(t) = V0+ V1exp (kt) and linear V(t) = V0+ kt dynamic patterns, the problem of coupling growth rates and replication does not exist. In other words, in the context of the coupling problem, a repressor mechanism to regulate DNA replication, and cell growth laws of the "linear" type displays the attributes of universality. The repressor-type mechanism allows a cell to follow any growth dynamic pattern, while the "linear" type growth law allows a cell to use any mechanism to regulate DNA replication.

DNA replication, the bacterial cell cycle, and cell growth

Cell ◽  
1992 ◽  
Vol 69 (1) ◽  
pp. 5-8 ◽  
Author(s):  
Judith W. Zyskind ◽  
Douglas W. Smith
Keyword(s):  
Cell Cycle ◽  
Dna Replication ◽  
Cell Growth ◽  
Bacterial Cell ◽  
Bacterial Cell Cycle

scholarly journals Successive Paradigm Shifts in the Bacterial Cell Cycle and Related Subjects

Life ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 27
Author(s):  
Vic Norris
Keyword(s):  
Cell Cycle ◽  
Steady State ◽  
Growth Rates ◽  
Bacterial Cell ◽  
Paradigm Shift ◽  
Eukaryotic Cell ◽  
Origins Of Life ◽  
Paradigm Shifts ◽  
Bacterial Physiology ◽  
Bacterial Cell Cycle

A paradigm shift in one field can trigger paradigm shifts in other fields. This is illustrated by the paradigm shifts that have occurred in bacterial physiology following the discoveries that bacteria are not unstructured, that the bacterial cell cycle is not controlled by the dynamics of peptidoglycan, and that the growth rates of bacteria in the same steady-state population are not at all the same. These paradigm shifts are having an effect on longstanding hypotheses about the regulation of the bacterial cell cycle, which appear increasingly to be inadequate. I argue that, just as one earthquake can trigger others, an imminent paradigm shift in the regulation of the bacterial cell cycle will have repercussions or “paradigm quakes” on hypotheses about the origins of life and about the regulation of the eukaryotic cell cycle.

scholarly journals Metabolism, cell growth and the bacterial cell cycle

2009 ◽  
Vol 7 (11) ◽  
pp. 822-827 ◽  
Author(s):  
Jue D. Wang ◽  
Petra A. Levin
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Bacterial Cell ◽  
Bacterial Cell Cycle

scholarly journals The bacterial cell cycle, chromosome inheritance and cell growth

2019 ◽  
Vol 17 (8) ◽  
pp. 467-478 ◽  
Author(s):  
Rodrigo Reyes-Lamothe ◽  
David J. Sherratt
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Bacterial Cell ◽  
Bacterial Cell Cycle

scholarly journals Bacterial cell proliferation: from molecules to cells

2020 ◽  
Author(s):  
Alix Meunier ◽  
François Cornet ◽  
Manuel Campos
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Cell Division ◽  
Dna Replication ◽  
Cell Growth ◽  
Bacterial Cell ◽  
Cell Biology ◽  
Molecular Mechanisms ◽  
Cell Physiology ◽  
Precise Knowledge

ABSTRACT Bacterial cell proliferation is highly efficient, both because bacteria grow fast and multiply with a low failure rate. This efficiency is underpinned by the robustness of the cell cycle and its synchronization with cell growth and cytokinesis. Recent advances in bacterial cell biology brought about by single-cell physiology in microfluidic chambers suggest a series of simple phenomenological models at the cellular scale, coupling cell size and growth with the cell cycle. We contrast the apparent simplicity of these mechanisms based on the addition of a constant size between cell cycle events (e.g. two consecutive initiation of DNA replication or cell division) with the complexity of the underlying regulatory networks. Beyond the paradigm of cell cycle checkpoints, the coordination between the DNA and division cycles and cell growth is largely mediated by a wealth of other mechanisms. We propose our perspective on these mechanisms, through the prism of the known crosstalk between DNA replication and segregation, cell division and cell growth or size. We argue that the precise knowledge of these molecular mechanisms is critical to integrate the diverse layers of controls at different time and space scales into synthetic and verifiable models.

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