The Role of Actin-Binding Protein Filamin A in Cellular Stiffness and Morphology Studied by Wide-Range Scanning Probe Microscopy

2006 ◽  
Vol 45 (3B) ◽  
pp. 2328-2332 ◽  
Author(s):  
Kosaku Kato ◽  
Yukiko Ohmori ◽  
Takeomi Mizutani ◽  
Hisashi Haga ◽  
Kazuyo Ohashi ◽  
...  
Keyword(s):  
Scanning Probe Microscopy ◽  
Binding Protein ◽  
Scanning Probe ◽  
Actin Binding ◽  
Filamin A ◽  
Probe Microscopy ◽  
Actin Binding Protein ◽  
Wide Range ◽  
Range Scanning

Wide-Range Scanning Probe Microscopy for Visualizing Biomaterials in the Submillimeter Range

2004 ◽  
Vol 43 (7B) ◽  
pp. 4525-4528 ◽  
Author(s):  
Takeomi Mizutani ◽  
Hisashi Haga ◽  
Koji Nemoto ◽  
Kazushige Kawabata
Keyword(s):  
Scanning Probe Microscopy ◽  
Scanning Probe ◽  
Submillimeter Range ◽  
Probe Microscopy ◽  
Wide Range ◽  
Range Scanning

scholarly journals Wide range scanning probe microscopy for probing mechanical effects on cellular function

2009 ◽  
Vol 72 (4/5) ◽  
pp. 235-243
Author(s):  
Takeomi Mizutani ◽  
Hisashi Haga ◽  
Kosaku Kato ◽  
Kazushige Kawabata
Keyword(s):  
Scanning Probe Microscopy ◽  
Cellular Function ◽  
Scanning Probe ◽  
Probe Microscopy ◽  
Mechanical Effects ◽  
Wide Range ◽  
Range Scanning

Observation of Stiff Domain Structure on Collagen Gels by Wide-Range Scanning Probe Microscopy

2006 ◽  
Vol 45 (3B) ◽  
pp. 2353-2356 ◽  
Author(s):  
Takeomi Mizutani ◽  
Hisashi Haga ◽  
Kosaku Kato ◽  
Kenta Matsuda ◽  
Kazushige Kawabata
Keyword(s):  
Domain Structure ◽  
Scanning Probe Microscopy ◽  
Scanning Probe ◽  
Collagen Gels ◽  
Probe Microscopy ◽  
Wide Range ◽  
Range Scanning

The Role of Scanning Probe Microscopy in Drug Delivery Research

1996 ◽  
Vol 13 (3-4) ◽  
pp. 225-256 ◽  
Author(s):  
Kevin M. Shakesheff ◽  
Martyn C. Davies ◽  
Clive J. Roberts ◽  
Saul J. B. Tendler ◽  
Philip M. Williams
Keyword(s):  
Drug Delivery ◽  
Scanning Probe Microscopy ◽  
Scanning Probe ◽  
Probe Microscopy

scholarly journals Mapping intrinsic electromechanical responses at the nanoscale via sequential excitation scanning probe microscopy empowered by deep data

2018 ◽  
Vol 6 (1) ◽  
pp. 55-63 ◽  
Author(s):  
Boyuan Huang ◽  
Ehsan Nasr Esfahani ◽  
Jiangyu Li
Keyword(s):  
Scanning Probe Microscopy ◽  
Data Analytics ◽  
Electromechanical Coupling ◽  
Principal Component ◽  
Scientific Data ◽  
Scanning Probe ◽  
Physical Analysis ◽  
Brute Force ◽  
Probe Microscopy ◽  
Wide Range

Abstract Ever-increasing hardware capabilities and computation powers have enabled acquisition and analysis of big scientific data at the nanoscale routine, though much of the data acquired often turn out to be redundant, noisy and/or irrelevant to the problems of interest, and it remains nontrivial to draw clear mechanistic insights from pure data analytics. In this work, we use scanning probe microscopy (SPM) as an example to demonstrate deep data methodology for nanosciences, transitioning from brute-force analytics such as data mining, correlation analysis and unsupervised classification to informed and/or targeted causative data analytics built on sound physical understanding. Three key ingredients of such deep data analytics are presented. A sequential excitation scanning probe microscopy (SE-SPM) technique is first developed to acquire high-quality, efficient and physically relevant data, which can be easily implemented on any standard atomic force microscope (AFM). Brute-force physical analysis is then carried out using a simple harmonic oscillator (SHO) model, enabling us to derive intrinsic electromechanical coupling of interest. Finally, principal component analysis (PCA) is carried out, which not only speeds up the analysis by four orders of magnitude, but also allows a clear physical interpretation of its modes in combination with SHO analysis. A rough piezoelectric material has been probed using such a strategy, enabling us to map its intrinsic electromechanical properties at the nanoscale with high fidelity, where conventional methods fail. The SE in combination with deep data methodology can be easily adapted for other SPM techniques to probe a wide range of functional phenomena at the nanoscale.

The role of ambient ice-like water adlayers formed at the interfaces of graphene on hydrophobic and hydrophilic substrates probed using scanning probe microscopy

2015 ◽  
Vol 17 (21) ◽  
pp. 13964-13972 ◽  
Author(s):  
Thavasiappan Gowthami ◽  
Gopal Tamilselvi ◽  
George Jacob ◽  
Gargi Raina
Keyword(s):  
Scanning Probe Microscopy ◽  
Scanning Probe ◽  
Ambient Conditions ◽  
Probe Microscopy

Ice-like water adlayer growth under ambient conditions for graphene on hydrophobic and hydrophilic substrates.

scholarly journals The Role of Protein Kinase C in the Transient Association of p57, a Coronin Family Actin-Binding Protein, with Phagosomes

2002 ◽  
Vol 25 (7) ◽  
pp. 837-844 ◽  
Author(s):  
Saotomo Itoh ◽  
Kensuke Suzuki ◽  
Jun Nishihata ◽  
Mitsusada Iwasa ◽  
Teruaki Oku ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Binding Protein ◽  
Actin Binding ◽  
Actin Binding Protein ◽  
Kinase C
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