Design for an in silico Platform of Precision Medicine on Cancer Therapy

Background: Cancer is characterized by overexpression of p53 associated proteins, which down-regulate P53 signaling pathway. In cancer therapy, p53 activity can be restored by inhibiting the interaction of MDMX (2N0W) and MDM2 (4JGR) proteins with P53 protein. Objective: In the current, study in silico approaches were adapted to use a natural product as a source of cancer therapy. Methods: In the current study in silico approaches were adapted to use a natural product as a source of cancer therapy. For in silico studies, Chemdraw and Molecular Operating Environment were used for structure drawing and molecular docking, respectively. Flavonoids isolated from D. carota were docked with cancerous proteins. Result: Based on the docking score analysis, we found that compound 7 was the potent inhibitor of both cancerous proteins and can be used as a potent molecule for inhibition of 2N0W and 4JGR interaction with p53. Conclusion: Thus the compound 7 can be used for the revival of p53 signaling pathway function however, intensive in vitro and in vivo experiments are required to prove the in silico analysis.

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Intuitive repositioning of an anti-depressant drug in combination with tivozanib: precision medicine for breast cancer therapy

Molecular and Cellular Biochemistry ◽

10.1007/s11010-021-04230-1 ◽

2021 ◽

Author(s):

Naveen Kumar ◽

Masoom Raza ◽

Seema Sehrawat

Keyword(s):

Breast Cancer ◽

Cancer Therapy ◽

Precision Medicine ◽

Breast Cancer Therapy ◽

Depressant Drug

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Personalized Medicine: Recent Progress in Cancer Therapy

Cancers ◽

10.3390/cancers13020242 ◽

2021 ◽

Vol 13 (2) ◽

pp. 242

Author(s):

Ann Hoeben ◽

Elbert A. J. Joosten ◽

Marieke H. J. van den Beuken-van Everdingen

Keyword(s):

Cancer Therapy ◽

Personalized Medicine ◽

Precision Medicine ◽

Recent Progress ◽

Tumor Treatment ◽

Treatment And Prevention

Personalized medicine (PM) or precision medicine in oncology is an emerging approach for tumor treatment and prevention that takes into account inter- and intra-tumor variability in genes, tumor (immune) environment, and lifestyle and morbidities of each person diagnosed with cancer [...]

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An in Silico Investigation of Binding Modes and Pathway of APTO-253 on c-KIT G-Quadruplex DNA

Physical Chemistry Chemical Physics ◽

10.1039/d0cp05210h ◽

2020 ◽

Author(s):

Saikat Pal ◽

Sandip Paul

Keyword(s):

Cancer Therapy ◽

In Silico ◽

Binding Modes ◽

Quadruplex Dna ◽

G Quadruplex ◽

The Stability

The stability of c-KIT G-quadruplex DNA by ligands has been a significant concern in the growing field of cancer therapy. Thus, it is very important to understand the mechanism behind...

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