scholarly journals Retrospective Observational Study of Brain MRI Findings in Patients with Acute SARS-CoV-2 Infection and Neurologic Manifestations

Radiology ◽  
2020 ◽  
Vol 297 (3) ◽  
pp. E313-E323 ◽  
Author(s):  
Lydia Chougar ◽  
Natalia Shor ◽  
Nicolas Weiss ◽  
Damien Galanaud ◽  
Delphine Leclercq ◽  
...  
Keyword(s):  
Observational Study ◽  
Brain Mri ◽  
Retrospective Observational Study ◽  
Neurologic Manifestations ◽  
Mri Findings

scholarly journals Brain MRI Findings in Severe COVID-19: A Retrospective Observational Study

Radiology ◽  
2020 ◽  
Vol 297 (2) ◽  
pp. E242-E251 ◽  
Author(s):  
Stéphane Kremer ◽  
François Lersy ◽  
Jérome de Sèze ◽  
Jean-Christophe Ferré ◽  
Adel Maamar ◽  
...  
Keyword(s):  
Observational Study ◽  
Brain Mri ◽  
Retrospective Observational Study ◽  
Mri Findings

scholarly journals Two neurologic facets of CTLA4-related haploinsufficiency

2020 ◽  
Vol 7 (4) ◽  
pp. e751
Author(s):  
Xavier Ayrignac ◽  
Radjiv Goulabchand ◽  
Eric Jeziorski ◽  
Patricia Rullier ◽  
Clarissa Carra-Dallière ◽  
...  
Keyword(s):  
Cerebellar Ataxia ◽  
Cytotoxic T Lymphocyte ◽  
Wide Spectrum ◽  
Brain Mri ◽  
White Matter Hyperintensity ◽  
Motor Deficit ◽  
Neurologic Manifestations ◽  
Combined Immunodeficiency ◽  
Mri Findings ◽  
Previous Diagnosis

ObjectiveTo describe the clinical and radiologic neurologic characteristics of patients with cytotoxic T-lymphocyte antigen-4 (CTLA4) haploinsufficiency.MethodsThree patients from 2 families had neurologic manifestations in the context of CTLA4 haploinsufficiency. Their clinical and MRI findings are presented.ResultsA 16-year-old boy with a previous diagnosis of combined immunodeficiency presented with severe recurrent episodes of headaches, motor deficit, and seizures associated with waxing and waning gadolinium-enhancing FLAIR cortical/juxtacortical hyperintensities. His sister, who also had combined immunodeficiency, had a brain MRI when she was aged 13 years due to recent headaches and transient right hemianopsia. It revealed a gadolinium-enhancing left occipital white matter hyperintensity. Another 49-year-old woman had progressive visual loss and cerebellar ataxia in the context of recurrent pulmonary infections. All 3 patients were found to have inherited CTLA4 haploinsufficiency. Patient 1's general condition and neurologic manifestations were completely controlled with abatacept (CTLA4-Ig).ConclusionsThese cases suggest that in addition to the variable clinical penetrance and wide spectrum of CTLA4 haploinsufficiency, its neurologic spectrum is broad, ranging from recurrent tumefactive lesions to progressive deficits including cerebellar ataxia and optic atrophy with leukoencephalopathy. These phenotypes must be recognized, and should lead to a complete immunologic workup, because potentially effective targeted immunotherapy exists.

scholarly journals Cerebrospinal fluid features in COVID-19 patients with neurologic manifestations: correlation with brain MRI findings in 58 patients

2020 ◽  
Author(s):  
François Lersy ◽  
Ilies Benotmane ◽  
Julie Helms ◽  
Olivier Collange ◽  
Maleka Schenck ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Clinical Laboratory ◽  
Brain Mri ◽  
Oligoclonal Bands ◽  
Neurologic Manifestations ◽  
Neurological Manifestations ◽  
Rt Pcr ◽  
Mri Findings ◽  
Leptomeningeal Enhancement ◽  
Csf Analysis

Abstract Background Neurological manifestations are common in patients with COVID-19, but little is known about pathophysiological mechanisms. In this single-center study, we describe neurological manifestations of 58 patients, regarding cerebrospinal fluid (CSF) analysis and neuroimaging findings. Methods 58 COVID-19 patients with neurologic manifestations and SARS-CoV-2 RT-PCR screening on CSF analysis were included. Clinical, laboratory, and brain MRI data were retrospectively collected and analyzed. Results Patients were mostly men (66%) with a median age of 62 years. Encephalopathy was frequent (81%), followed by a pyramidal dysfunction (16%), seizures (10%), and headaches (5%). Protein and albumin levels in CSF were increased in 38% and 23%, respectively. A total of 40% of patients displayed an elevated albumin quotient suggesting impaired blood-brain barrier integrity. CSF-specific IgG oligoclonal band was found in five (11%) cases, suggesting an intrathecal synthesis of IgG, and 26 (55%) patients presented identical oligoclonal bands in serum and CSF. Four (7%) patients harbored a positive SARS-CoV-2 RT-PCR in CSF. Regarding brain MRI, 20 (38%) patients presented leptomeningeal enhancement. Conclusions Brain MRI abnormalities, especially leptomeningeal enhancement, and increased inflammatory markers in CSF are frequent in patients with neurological manifestations related to COVID-19, whereas SARS-CoV 2 detection in CSF remained scanty.

Hemmkörperentwicklung bei Hämophilie-Patienten nach Präparate wechsel

2012 ◽  
Vol 32 (S 01) ◽  
pp. S39-S42 ◽  
Author(s):  
S. Kocher ◽  
G. Asmelash ◽  
V. Makki ◽  
S. Müller ◽  
S. Krekeler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Observational Study ◽  
Retrospective Observational Study ◽  
Frequent Change ◽  
Patient Age ◽  
Treatment Regimens ◽  
Patient Âgé ◽  
The Relationship ◽  
Observation Period

SummaryThe retrospective observational study surveys the relationship between development of inhibitors in the treatment of haemophilia patients and risk factors such as changing FVIII products. A total of 119 patients were included in this study, 198 changes of FVIII products were evaluated. Results: During the observation period of 12 months none of the patients developed an inhibitor, which was temporally associated with a change of FVIII products. A frequent change of FVIII products didn’t lead to an increase in inhibitor risk. The change between plasmatic and recombinant preparations could not be confirmed as a risk factor. Furthermore, no correlation between treatment regimens, severity, patient age and comorbidities of the patients could be found.

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