Primary and Recurrent Early Stage Laryngeal Cancer: Preliminary Results of 2-[Fluorine 18]fluoro-2-deoxy-d-glucose PET Imaging

AbstractBackground:Over the last decade, we have observed an escalating trend in the number of laryngeal biopsies performed, despite the incidence of laryngeal cancer remaining constant. This study aimed to quantify the rate of laryngeal biopsies and record the indications.Method:A retrospective analysis of laryngeal biopsies performed in North Glasgow, Scotland, UK, between 2001 and 2010, was conducted.Results:From 2001 to 2010, 3902 laryngeal biopsies were carried out in North Glasgow. Histopathological results indicated the following diagnoses: squamous cell carcinoma, in 889 cases (23 per cent); dysplasia, in 986 cases (25 per cent); ‘no tumour’, in 913 cases (23 per cent); and benign pathology, in the remaining 1084 cases (28 per cent). There has been a significant increase in the number of biopsies performed after 2004, with the incidence of squamous cell carcinoma and benign disease remaining relatively static.Conclusion:It is hypothesised that organ preservation strategies, endoscopic resection in early stage laryngeal cancer and chemoradiotherapy in advanced head and neck cancer are responsible for the increase in laryngeal biopsies.

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Preliminary Results of a Phase 1 Dose-Escalation Trial for Early-Stage Breast Cancer Using 5-Fraction Stereotactic Body Radiation Therapy for Partial-Breast Irradiation

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2017.01.020 ◽

2017 ◽

Vol 98 (1) ◽

pp. 196-205.e2 ◽

Cited By ~ 15

Author(s):

Asal Rahimi ◽

Kimberly Thomas ◽

Ann Spangler ◽

Roshni Rao ◽

Marilyn Leitch ◽

...

Keyword(s):

Breast Cancer ◽

Radiation Therapy ◽

Dose Escalation ◽

Stereotactic Body Radiation Therapy ◽

Early Stage ◽

Phase 1 ◽

Early Stage Breast Cancer ◽

Partial Breast Irradiation ◽

Breast Irradiation ◽

Preliminary Results

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Abstract P1-13-11: Adjuvant treatment of early-stage breast cancer with eribulin mesylate following dose-dense doxorubicin and cyclophosphamide: preliminary results from a phase 2, single-arm feasibility study

10.1158/0008-5472.sabcs12-p1-13-11 ◽

2012 ◽

Author(s):

TA Traina ◽

C Hudis ◽

M Fornier ◽

D Lake ◽

R Lehman ◽

...

Keyword(s):

Breast Cancer ◽

Feasibility Study ◽

Adjuvant Treatment ◽

Early Stage ◽

Early Stage Breast Cancer ◽

Phase 2 ◽

Eribulin Mesylate ◽

Preliminary Results ◽

Dose Dense

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Radiosynthesis of [18F]-Labelled Pro-Nucleotides (ProTides)

Molecules ◽

10.3390/molecules25030704 ◽

2020 ◽

Vol 25 (3) ◽

pp. 704

Author(s):

Alessandra Cavaliere ◽

Katrin C. Probst ◽

Stephen J. Paisey ◽

Christopher Marshall ◽

Abdul K. H. Dheere ◽

...

Keyword(s):

Total Synthesis ◽

Pet Imaging ◽

Early Stage ◽

Proof Of Concept ◽

Synthesis Time ◽

Positron Emission ◽

Anti Cancer ◽

Radiochemical Yields ◽

Radiochemical Synthesis

Phosphoramidate pro-nucleotides (ProTides) have revolutionized the field of anti-viral and anti-cancer nucleoside therapy, overcoming the major limitations of nucleoside therapies and achieving clinical and commercial success. Despite the translation of ProTide technology into the clinic, there remain unresolved in vivo pharmacokinetic and pharmacodynamic questions. Positron Emission Tomography (PET) imaging using [18F]-labelled model ProTides could directly address key mechanistic questions and predict response to ProTide therapy. Here we report the first radiochemical synthesis of [18F]ProTides as novel probes for PET imaging. As a proof of concept, two chemically distinct radiolabelled ProTides have been synthesized as models of 3′- and 2′-fluorinated ProTides following different radiosynthetic approaches. The 3′-[18F]FLT ProTide was obtained via a late stage [18F]fluorination in radiochemical yields (RCY) of 15–30% (n = 5, decay-corrected from end of bombardment (EoB)), with high radiochemical purities (97%) and molar activities of 56 GBq/μmol (total synthesis time of 130 min.). The 2′-[18F]FIAU ProTide was obtained via an early stage [18F]fluorination approach with an RCY of 1–5% (n = 7, decay-corrected from EoB), with high radiochemical purities (98%) and molar activities of 53 GBq/μmol (total synthesis time of 240 min).

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