scholarly journals Hepatosplanchnic clearance of interleukin-6 in humans during exercise

2003 ◽  
Vol 285 (2) ◽  
pp. E397-E402 ◽  
Author(s):  
Mark A. Febbraio ◽  
Peter Ott ◽  
Henning Bay Nielsen ◽  
Adam Steensberg ◽  
Charlotte Keller ◽  
...  
Keyword(s):  
Blood Flow ◽  
Indocyanine Green ◽  
Brachial Artery ◽  
Interleukin 6 ◽  
Healthy Male ◽  
Blood Samples ◽  
Arterial Plasma ◽  
Metabolic Action ◽  
Infusion Technique ◽  
Male Subjects

The cytokine interleukin (IL)-6 can increase markedly in the circulation during exercise, but whether the liver is a source of this increase is unknown. The aim of this study was to measure IL-6 flux across the hepatosplanchnic tissues in humans. To elevate systemic concentrations of IL-6, six healthy male subjects performed 120 min of semirecumbent cycling, and blood samples were simultaneously obtained from a brachial artery and the hepatic vein before and during exercise for the analysis of IL-6. Hepatosplanchnic blood flow (HBF) was measured using the indocyanine green infusion technique. Net hepatosplanchnic IL-6 balance was calculated from these measures. HBF was 1.3 ± 0.1 l/min at rest and was not reduced throughout exercise, averaging 1.1 ± 0.2 l/min. Arterial plasma IL-6 markedly increased ( P < 0.05) from 1.8 ± 0.6 ng/l at rest to 14.3 ± 3.2 ng/l after 120 min of exercise. The hepatosplanchnic viscera did not contribute to this increase, since there was a net hepatosplanchnic IL-6 uptake (0.8 ± 0.3 vs. 5.5 ± 1.9 ng/min, rest vs. 120 min; P < 0.05). These data demonstrate that the hepatosplanchnic viscera remove IL-6 from the circulation in humans. This removal may constitute a mechanism limiting the negative chronic metabolic action of chronically elevated circulating IL-6.

scholarly journals Local cooling during hot water immersion improves perceptions without inhibiting the acute interleukin-6 response

2021 ◽  
Author(s):  
R. G. Mansfield ◽  
S. P. Hoekstra ◽  
J. J. Bill ◽  
Christof A. Leicht
Keyword(s):  
Thermal Comfort ◽  
Interleukin 6 ◽  
Water Immersion ◽  
Hot Water ◽  
Upper Body ◽  
Healthy Male ◽  
Local Cooling ◽  
Blood Samples ◽  
Body Cooling ◽  
Hot Water Immersion

Abstract Purpose Passive elevation of body temperature can induce an acute inflammatory response that has been proposed to be beneficial; however, it can be perceived as uncomfortable. Here, we investigate whether local cooling of the upper body during hot water immersion can improve perception without inhibiting the interleukin-6 (IL-6) response. Methods Nine healthy male participants (age: 22 ± 1 years, body mass: 83.4 ± 9.4 kg) were immersed up to the waist for three 60-min water immersion conditions: 42 °C hot water immersion (HWI), 42 °C HWI with simultaneous upper-body cooling using a fan (FAN), and 36 °C thermoneutral water immersion (CON). Blood samples to determine IL-6 plasma concentration were collected pre- and post-water immersion; basic affect and thermal comfort were assessed throughout the intervention. Results Plasma IL-6 concentration was higher for HWI and FAN when compared with CON (P < 0.01) and did not differ between HWI and FAN (P = 0.22; pre to post, HWI: 1.0 ± 0.6 to 1.5 ± 0.7 pg·ml−1, FAN: 0.7 ± 0.5 to 1.1 ± 0.5 pg·ml−1, CON: 0.5 ± 0.2 to 0.5 ± 0.2 pg·ml−1). At the end of immersion, basic affect was lowest for HWI (HWI: − 1.8 ± 2.0, FAN: 0.2 ± 1.6, CON 1.0 ± 2.1, P < 0.02); thermal comfort for HWI was in the uncomfortable range (3.0 ± 1.0, P < 0.01 when compared with FAN and CON), whereas FAN (0.7 ± 0.7) and CON (-0.2 ± 0.7) were in the comfortable range. Conclusion Local cooling of the upper body during hot water immersion improves basic affect and thermal comfort without inhibiting the acute IL-6 response.

scholarly journals Relationship between Autistic Spectrum Trait and Regional Cerebral Blood Flow in Healthy Male Subjects

2018 ◽  
Vol 15 (10) ◽  
pp. 956-961 ◽  
Author(s):  
Miho Ota ◽  
Junko Matsuo ◽  
Noriko Sato ◽  
Toshiya Teraishi ◽  
Hiroaki Hori ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Healthy Male ◽  
Regional Cerebral Blood ◽  
Autistic Spectrum ◽  
Male Subjects

scholarly journals Sirkadiese fluktuasies in serumserotonienkonsentrasies van normale gesonde mans

1993 ◽  
Vol 12 (2) ◽  
pp. 44-46
Author(s):  
Editorial Office
Keyword(s):  
Amino Acid ◽  
Pineal Gland ◽  
Biogenic Amine ◽  
Essential Amino Acid ◽  
Healthy Male ◽  
Blood Samples ◽  
Peripheral Plasma ◽  
Indole Compounds ◽  
Male Subjects ◽  
Serum Serotonin

The biogenic amine, serotonin (5-HT), is synthesized from tryptophan (an essential amino acid) and acts multipotent as neurotransmitter/neuromodulator/hormone/precursor for methoxy-indole compounds such as N-acetyl-5-methoxytryptamine (melatonin). The circadian secretion pattern of melatonin is well known. Circadian fluctuations in pineal gland (“central”) concentrations of 5-HT have already been reported in literature. Since information with regard to possible circadian fluctuations in “peripheral" (plasma/serum) serotonin concentrations is scanty, the main objective of this study was to ascertain whether such fluctuations do in fact occur. Serum serotonin concentrations were determined in blood samples obtained hourly from twelve healthy male subjects during a period of 24 hours. The results clearly suggest a triphasic secretion pattern for serum serotonin. (The said circadian secretion tendency does not correspond with that of any determinable 5-HT metabolite).

Cerebral blood flow velocity in humans exposed to 24 h of head-down tilt

1993 ◽  
Vol 74 (6) ◽  
pp. 3046-3051 ◽  
Author(s):  
Y. Kawai ◽  
G. Murthy ◽  
D. E. Watenpaugh ◽  
G. A. Breit ◽  
C. W. Deroshia ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Linear Regression ◽  
Cerebral Blood Flow Velocity ◽  
Bed Rest ◽  
Healthy Male ◽  
Increased Risk ◽  
The Right ◽  
Male Subjects ◽  
Peak Value

This study investigates cerebral blood flow (CBF) velocity in humans before, during, and after 24 h of 6 degree head-down tilt (HDT), which is a currently accepted experimental model to simulate microgravity. CBF velocity was measured by use of the transcranial Doppler technique in the right middle cerebral artery of eight healthy male subjects. Mean CBF velocity increased from the pre-HDT upright seated baseline value of 55.5 +/- 3.7 (SE) cm/s to 61.5 +/- 3.3 cm/s at 0.5 h of HDT (P < 0.05), reached a peak value of 63.2 +/- 4.1 cm/s at 3 h of HDT, and remained significantly above the pre-HDT baseline for > or = 6 h of HDT. During upright seated recovery (1–5 h post-HDT), mean CBF velocity decreased to 87% of the pre-HDT baseline value (P < 0.05). Mean CBF velocity correlated well with calculated intracranial arterial pressure (IAP) (r = 0.54, P < 0.001). As analyzed by linear regression, mean CBF velocity = 29.6 + 0.32IAP. These results suggest that HDT increases CBF velocity by increasing IAP during several hours after the onset of microgravity. Importantly, the decrease in CBF velocity after HDT may be responsible, in part, for the increased risk of syncope observed in subjects after prolonged bed rest and also in astronauts returning to Earth.

scholarly journals Hemodynamic and Lactate Response to Exhaustive Exercise with L-Arginine Supplementation

2022 ◽  
Vol 5 (1) ◽  
Author(s):  
Matthew Feeback ◽  
Bailey Reitsma
Keyword(s):  
Blood Flow ◽  
Area Under Curve ◽  
Lactate Clearance ◽  
Anaerobic Exercise ◽  
Healthy Male ◽  
Post Exercise ◽  
Volitional Fatigue ◽  
Male Subjects ◽  
Arginine Supplementation ◽  
Push Up

Introduction: To further understand the effects of L-arginine on both its ability to enhance lactate clearance and increase overall blood flow before, during, and after exhaustive anaerobic exercise. Methods:  Twelve healthy male subjects between the ages of 18-25 first completed an initial visit where baseline data was recorded. Subjects completed three additional visits, in which they ingested either a placebo, two-gram or four-gram dose of L-arginine. Blood flow (BF) and lactate were recorded before ingestion of the treatment, 5 and 15-minutes post-ingestion prior to performing a push-up test to volitional fatigue.  Immediately following the push-up test, BF and lactate were assessed and again 15-minutes post exercise. Results: Blood lactate did not differ across condition (p=0.569).  Lactate clearance was not influenced by L-arginine when analyzing the Area Under Curve.  Blood flow increased with ingestion of the four-gram dose while at rest (the 15-minute mark).  Blood flow was also enhanced in the four-gram dose immediately after exercise at the 25-minute mark.  Conclusions: The data suggests that a four-gram dose of L-arginine plays a more significant role in blood flow than the clearance of lactate after exercise compared to a two-gram dose or placebo.

The Effect of Noradrenalin Infusion on Plasma and Platelet Lipids and Platelet Function in Man

1975 ◽  
Vol 33 (02) ◽  
pp. 328-334 ◽  
Author(s):  
A Nordøy ◽  
K Gjesdal ◽  
S Jaeger ◽  
H Berntsen
Keyword(s):  
Platelet Function ◽  
Lipid Fraction ◽  
Moderate Increase ◽  
Healthy Male ◽  
Platelet Function Tests ◽  
Platelet Factor ◽  
Blood Samples ◽  
Plasma Ffa ◽  
Main Components ◽  
Male Subjects

SummaryNoradrenalin was given as an intravenous infusion in a dosage of 0.1 μg/kg/h over a period of 30 minutes to 5 healthy male subjects. Blood samples were collected before, at the end of and 24 hours after the infusion. A significant increase in the number of circulating platelets and a marked increase of plasma FFA, reflecting an increase of all the main components of the FFA fraction were observed. No significant changes were observed in the similar lipid fraction in platelets and except for a moderate increase in platelet factor 3 activity, no significant changes in other platelet function tests were present.

884: Phase I, Double-Blind, Placebo-Controlled Study in Healthy Male Subjects to Investigate the Safety, Tolerability, and Pharmacokinetics of DA-8159

2004 ◽  
Vol 171 (4S) ◽  
pp. 234-234 ◽  
Author(s):  
Harin Padma-Nathan ◽  
Jae Seung Pacik ◽  
Byoung Ok Ahn ◽  
Kyung Koo Kang ◽  
Mi Young Bahng ◽  
...  
Keyword(s):  
Phase I ◽  
Controlled Study ◽  
Healthy Male ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Male Subjects

Arterio-Venous Differences in the Components of the Fibrinolytic Enzyme System

1966 ◽  
Vol 16 (01/02) ◽  
pp. 032-037 ◽  
Author(s):  
D Ogston ◽  
C. M Ogston ◽  
N. B Bennett
Keyword(s):  
Plasminogen Activator ◽  
Enzyme System ◽  
Venous Blood ◽  
Fibrinolytic Enzyme ◽  
Blood Levels ◽  
Activator Concentration ◽  
Blood Samples ◽  
Arterial Blood ◽  
Male Subjects

Summary1. The concentration of the major components of the fibrinolytic enzyme system was compared in venous and arterial blood samples from male subjects.2. The plasminogen activator concentration was higher in venous blood and the arterio-venous difference increased as its concentration rose, but the ratio of the arterial to venous level remained constant.3. No arterio-venous difference was found for anti-urokinase activity, antiplasmin, plasminogen and fibrinogen.4. It is concluded that venous blood determinations of the components of the fibrinolytic enzyme system reflect satisfactorily arterial blood levels.

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