scholarly journals A VIRUS RECOVERED FROM THE FECES OF "POLIOMYELITIS" PATIENTS PATHOGENIC FOR SUCKLING MICE

1949 ◽  
Vol 89 (6) ◽  
pp. 567-582 ◽  
Author(s):  
Gilbert Dalldorf ◽  
Grace M. Sickles ◽  
Hildegard Plager ◽  
Rebecca Gifford
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Experimental Animal ◽  
Rhesus Monkeys ◽  
Skeletal Muscles ◽  
Suckling Mice ◽  
The Central Nervous System

A virus has been recovered from the feces of two children having symptoms similar to those of poliomyelitis. The virus is pathogenic for suckling mice and hamsters but not for rhesus monkeys. It induces striking lesions in the skeletal muscles of the experimental animal but not in the central nervous system. Other viruses inducing similar signs and lesions in suckling mice have been isolated from several other outbreaks of a poliomyelitis-like disease, including one large urban epidemic.

SARS-CoV-2 Invades the Central Nervous System via the Olfactory Route in Rhesus Monkeys

2020 ◽  
Author(s):  
Li Jiao ◽  
Yun Yang ◽  
Wenhai Yu ◽  
Yuan Zhao ◽  
Haiting Long ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rhesus Monkeys ◽  
The Central Nervous System

Lack of effect of morphine, reserpine, and halothane on oscillation of plasma insulin in M. mulatta

1981 ◽  
Vol 240 (1) ◽  
pp. E1-E4 ◽  
Author(s):  
F. G. Hom ◽  
D. J. Koerker ◽  
C. J. Goodner
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rhesus Monkeys ◽  
Plasma Insulin ◽  
Insulin Levels ◽  
Plasma Insulin Levels ◽  
The Central Nervous System ◽  
Male Rhesus

Oscillating plasma insulin levels, with periods averaging 9 min, in fasting rhesus monkeys have been previously reported by us. To test whether an oscillator in the central nervous system might be driving these oscillations, we subjected five male rhesus monkeys to morphine, reserpine, and halothane, agents known to affect the central nervous system, in an attempt to either disrupt or change the frequency of the oscillations. We could demonstrate no significant effect of any of the three drugs on the oscillations. We conclude, therefore, that the oscillations in plasma insulin are not driven by an oscillator in the central nervous system. Coupled with the results of others, these data suggest that these oscillations are probably due to an intrinsic pancreatic pacemaker.

scholarly journals Zika Virus Persistence in the Central Nervous System and Lymph Nodes of Rhesus Monkeys

Cell ◽  
2017 ◽  
Vol 169 (4) ◽  
pp. 610-620.e14 ◽  
Author(s):  
Malika Aid ◽  
Peter Abbink ◽  
Rafael A. Larocca ◽  
Michael Boyd ◽  
Ramya Nityanandam ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Lymph Nodes ◽  
Zika Virus ◽  
Rhesus Monkeys ◽  
Virus Persistence ◽  
The Central Nervous System

scholarly journals The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Li Jiao ◽  
Yun Yang ◽  
Wenhai Yu ◽  
Yuan Zhao ◽  
Haiting Long ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rhesus Monkeys ◽  
Microvascular Endothelial Cells ◽  
Brain Microvascular Endothelial Cells ◽  
Primate Model ◽  
The Central Nervous System ◽  
Functional Areas ◽  
Human Primate

AbstractNeurological manifestations are frequently reported in the COVID-19 patients. Neuromechanism of SARS-CoV-2 remains to be elucidated. In this study, we explored the mechanisms of SARS-CoV-2 neurotropism via our established non-human primate model of COVID-19. In rhesus monkey, SARS-CoV-2 invades the CNS primarily via the olfactory bulb. Thereafter, viruses rapidly spread to functional areas of the central nervous system, such as hippocampus, thalamus, and medulla oblongata. The infection of SARS-CoV-2 induces the inflammation possibly by targeting neurons, microglia, and astrocytes in the CNS. Consistently, SARS-CoV-2 infects neuro-derived SK-N-SH, glial-derived U251, and brain microvascular endothelial cells in vitro. To our knowledge, this is the first experimental evidence of SARS-CoV-2 neuroinvasion in the NHP model, which provides important insights into the CNS-related pathogenesis of SARS-CoV-2.

scholarly journals EXPERIMENTAL STUDY OF THE VOLATILE PETROLEUM PRODUCTS EFFECT ON THE CENTRAL NERVOUS SYSTEM

2018 ◽  
Vol 11 (3) ◽  
pp. 350
Author(s):  
Ragim Almamed Orujov ◽  
Rana Anver Jafarova
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Skeletal Muscles ◽  
Muscle Tone ◽  
Motor Reaction ◽  
Animal Hypnosis ◽  
Static Work ◽  
Functional Changes ◽  
Electric Pulses ◽  
The Central Nervous System

 Objective: The goal of the research is studying the functional changes in the central nervous system against the background of intoxication with the minimum dosages of gasoline, benzene and acetone.Methods: The research was performed on 45 white mice divided into 3 groups; each group received corresponding hydrocarbon in the exposure chamber by inhaling. The functional state of the CNS was assessed with a complex of integral tests: By summation of subliminal pulses, the ability of animals to restore rectilinear movement after centrifugation, by the tone of skeletal muscles, and by the activity of muscle static work.Results: The durations of the narcosis phases in case of acute inhalation poisoning are different for all studied substances. The study of the functional changes in the CNS on the background of intoxication with low dosages has revealed that at the first exposure to benzene for activating the motor reaction the required number of electric pulses from the outside increases, the muscle tone increases, the ability to static work reduces, and the time for rectilinear movement and “animal hypnosis” increases. At the same time, on the background of intoxication during the fifth exposure, a decrease is observed in the number of electric pulses from the outside for activating the motor reaction, the muscle tone remains increased, the ability to static work is reduced, and the time of “animal hypnosis” is shorter than that during the first exposure.Conclusion: Against the background of the repeated use of small doses of benzene, the CNS adapts to the action of the toxic factor. With that, the ability of the CNS to sum the subliminal pulses, the cholinergic innervation of the skeletal muscles tone and other integral tests during the fifth exposure change less than during the first exposure.

scholarly journals THE RAPID PRODUCTION OF ACUTE DISSEMINATED ENCEPHALOMYELITIS IN RHESUS MONKEYS BY INJECTION OF HETEROLOGOUS AND HOMOLOGOUS BRAIN TISSUE WITH ADJUVANTS

1947 ◽  
Vol 85 (1) ◽  
pp. 117-130 ◽  
Author(s):  
Elvin A. Kabat ◽  
Abner Wolf ◽  
Ada E. Bezer
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rhesus Monkeys ◽  
Demyelinating Disease ◽  
Acute Disseminated Encephalomyelitis ◽  
Rabbit Brain ◽  
Adult Rabbit ◽  
Rabbit Lung ◽  
The Central Nervous System ◽  
Experimental Findings

1. A picture resembling acute disseminated encephalomyelitis in the human being has been regularly and rapidly produced in rhesus monkeys by injection of emulsions of adult rabbit and monkey brain administered with adjuvants. 2. No lesions of the central nervous system resulted from injection of similar emulsions of fetal rabbit brain or adult rabbit lung. 3. A description of the gross and histological findings in the central nervous system is given and compared with features of human demyelinating disease. 4. The experimental findings are in accord with the hypothesis that antibody to the injected brain emulsion reacts with the tissues of the nervous system of the animal to produce the pathological changes.

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