Vital microscopy of islet blood flow: catecholamine effects in normal and ob/ob mice

1987 ◽  
Vol 252 (1) ◽  
pp. E130-E135 ◽  
Author(s):  
P. Rooth ◽  
I. B. Taljedal
Keyword(s):  
Blood Flow ◽  
Capillary Flow ◽  
Inhibitory Influence ◽  
Video Recordings ◽  
Islet Blood Flow ◽  
Visible Effect ◽  
Flow Through ◽  
Vital Microscopy ◽  
Semiquantitative Method ◽  
Normal Controls

The pancreatic microcirculation in noninbred ob/ob mice and normal controls was visualized in a fluorescence microscope and examined for responses to intravenous infusions of epinephrine or norepinephrine. Evaluations of coded video recordings revealed a smooth dose-response relationship and validated a semiquantitative method of analysis. In ob/ob mice the islet microcirculation was markedly and reversibly inhibited by 0.14–4 micrograms of epinephrine X min-1 X kg body wt-1; the flow was almost totally stopped at the highest infusion rates. Capillary flow in the exocrine pancreas appeared unaffected, except for some inhibition at 4.0 micrograms X min-1 X kg-1. Norepinephrine was less potent an inhibitor of islet blood flow. Normal lean mice exhibited minor responses to 1–11.3 micrograms of epinephrine X min-1 X kg-1; in most cases there was no visible effect. It is concluded that there is a selective regulation of blood flow through the endocrine portion of the pancreas and that the islet microcirculation is hypersensitive to catecholamines in noninbred ob/ob mice. A defective inhibitory influence from the brain may play a role in the development of excessive hyperinsulinemia in ob/ob mice.

Effects of invariant sympathetic activity on cutaneous circulatory responses to heat stress

1991 ◽  
Vol 71 (2) ◽  
pp. 521-529 ◽  
Author(s):  
D. Richardson ◽  
Q. F. Hu ◽  
S. Shepherd
Keyword(s):  
Blood Flow ◽  
Heat Stress ◽  
Sympathetic Activity ◽  
Capillary Flow ◽  
Local Heating ◽  
Doppler Flowmetry ◽  
Cell Velocity ◽  
Flow Through ◽  
Unanesthetized Animals ◽  
Indirect Heating

This study investigated the role of sympathetic withdrawal on blood flow responses in cutaneous arteriovenous anastomoses (AVAs) and capillaries to direct and indirect heat stress. This was achieved by clamping sympathetic activity (SC) to the tail of anesthetized rats so that constrictor tone remained invariant during exposure of either the animal's tail (direct heating) or body (indirect heating) to a 35 degrees C environment. Flow through the AVAs in the tail was evaluated by laser-Doppler flowmetry (LDF), while capillary flow was investigated by videodensitometry measurements of blood cell velocity (CBV) in single capillaries within the subepidermal vascular plexus. Both direct and indirect heating significantly increased LDF and CBV. In comparison to blood flow responses in sham-operated control rats, the SC procedure resulted in significantly lower LDF responses to both direct and indirect heat stress. By contrast, the response of CBV was not significantly affected by SC during either mode of heating. These results indicate that the withdrawal of sympathetic constrictor tone plays a role in the response of cutaneous AVAs, but not precapillary arterioles, to direct as well as indirect heat stress. Additional studies on unanesthetized animals showed that superimposing body heating on a base of local heating elicited a further increase in LDF, suggesting that local heating does not deplete neural mediated dilatory reserve.

Activity of pulmonary surfactant after blocking the associated proteins SP-A and SP-B

1991 ◽  
Vol 71 (2) ◽  
pp. 530-536 ◽  
Author(s):  
T. Kobayashi ◽  
K. Nitta ◽  
R. Takahashi ◽  
K. Kurashima ◽  
B. Robertson ◽  
...  
Keyword(s):  
Blood Flow ◽  
Heat Stress ◽  
Capillary Flow ◽  
Local Heating ◽  
Doppler Flowmetry ◽  
Cell Velocity ◽  
Associated Proteins ◽  
Flow Through ◽  
Unanesthetized Animals ◽  
Indirect Heating

This study investigated the role of sympathetic withdrawal on blood flow responses in cutaneous arteriovenous anastomoses (AVAs) and capillaries to direct and indirect heat stress. This was achieved by clamping sympathetic activity (SC) to the tail of anesthetized rats so that constrictor tone remained invariant during exposure of either the animal's tail (direct heating) or body (indirect heating) to a 35 degrees C environment. Flow through the AVAs in the tail was evaluated by laser-Doppler flowmetry (LDF), while capillary flow was investigated by videodensitometry measurements of blood cell velocity (CBV) in single capillaries within the subepidermal vascular plexus. Both direct and indirect heating significantly increased LDF and CBV. In comparison to blood flow responses in sham-operated control rats, the SC procedure resulted in significantly lower LDF responses to both direct and indirect heat stress. By contrast, the response of CBV was not significantly affected by SC during either mode of heating. These results indicate that the withdrawal of sympathetic constrictor tone plays a role in the response of cutaneous AVAs, but not precapillary arterioles, to direct as well as indirect heat stress. Additional studies on unanesthetized animals showed that superimposing body heating on a base of local heating elicited a further increase in LDF, suggesting that local heating does not deplete neural mediated dilatory reserve.

A Non-Newtonian Fluid Flow Model for the Slip Condition on Blood Flow through a Stenosed Artery using Power-law Fluid

2018 ◽  
Vol 9 (7) ◽  
pp. 871-879
Author(s):  
Rajesh Shrivastava ◽  
R. S. Chandel ◽  
Ajay Kumar ◽  
Keerty Shrivastava and Sanjeet Kumar
Keyword(s):  
Blood Flow ◽  
Fluid Flow ◽  
Newtonian Fluid ◽  
Power Law ◽  
Flow Model ◽  
Slip Condition ◽  
Power Law Fluid ◽  
Stenosed Artery ◽  
Flow Through

scholarly journals Numerical Study of Blood Flow Through Artificial Heart Valves

2021 ◽  
Vol 1094 (1) ◽  
pp. 012120
Author(s):  
Hussein Togun ◽  
Ali Abdul Hussain ◽  
Saja Ahmed ◽  
Iman Abdul hussain ◽  
Huda Shaker
Keyword(s):  
Blood Flow ◽  
Artificial Heart ◽  
Heart Valves ◽  
Numerical Study ◽  
Artificial Heart Valves ◽  
Flow Through

scholarly journals A Simple Transient Poiseuille-Based Approach to Mimic the Womersley Function and to Model Pulsatile Blood Flow

Dynamics ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 9-17
Author(s):  
Andrea Natale Impiombato ◽  
Giorgio La Civita ◽  
Francesco Orlandi ◽  
Flavia Schwarz Franceschini Zinani ◽  
Luiz Alberto Oliveira Rocha ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Blood Flow ◽  
Boundary Conditions ◽  
Quadratic Function ◽  
Pulsatile Blood Flow ◽  
Flow Through ◽  
Simplified Analysis ◽  
Function Models ◽  
Flow Reversals

As it is known, the Womersley function models velocity as a function of radius and time. It has been widely used to simulate the pulsatile blood flow through circular ducts. In this context, the present study is focused on the introduction of a simple function as an approximation of the Womersley function in order to evaluate its accuracy. This approximation consists of a simple quadratic function, suitable to be implemented in most commercial and non-commercial computational fluid dynamics codes, without the aid of external mathematical libraries. The Womersley function and the new function have been implemented here as boundary conditions in OpenFOAM ESI software (v.1906). The discrepancy between the obtained results proved to be within 0.7%, which fully validates the calculation approach implemented here. This approach is valid when a simplified analysis of the system is pointed out, in which flow reversals are not contemplated.

scholarly journals Mechanics of non-Newtonian blood flow in an artery having multiple stenosis and electroosmotic effects

2021 ◽  
Vol 104 (3) ◽  
pp. 003685042110316
Author(s):  
Salman Akhtar ◽  
Luthais B McCash ◽  
Sohail Nadeem ◽  
Salman Saleem ◽  
Alibek Issakhov
Keyword(s):  
Blood Flow ◽  
Flow Problem ◽  
Fluid Model ◽  
Casson Fluid ◽  
Viscous Effects ◽  
Heating Effects ◽  
Casson Fluid Model ◽  
Flow Through ◽  
Mathematical Equations ◽  
Mathematica Software

The electro-osmotically modulated hemodynamic across an artery with multiple stenosis is mathematically evaluated. The non-Newtonian behaviour of blood flow is tackled by utilizing Casson fluid model for this flow problem. The blood flow is confined in such arteries due to the presence of stenosis and this theoretical analysis provides the electro-osmotic effects for blood flow through such arteries. The mathematical equations that govern this flow problem are converted into their dimensionless form by using appropriate transformations and then exact mathematical computations are performed by utilizing Mathematica software. The range of the considered parameters is given as [Formula: see text]. The graphical results involve combine study of symmetric and non-symmetric structure for multiple stenosis. Joule heating effects are also incorporated in energy equation together with viscous effects. Streamlines are plotted for electro-kinetic parameter [Formula: see text] and flow rate [Formula: see text]. The trapping declines in size with incrementing [Formula: see text], for symmetric shape of stenosis. But the size of trapping increases for the non-symmetric case.

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