Immunofluorescence localization of the receptor Mas in cardiovascular-related areas of the rat brain

2007 ◽  
Vol 293 (3) ◽  
pp. H1416-H1424 ◽  
Author(s):  
Lenice K. Becker ◽  
Gisele M. Etelvino ◽  
Thomas Walther ◽  
Robson A. S. Santos ◽  
Maria J. Campagnole-Santos
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Physiological Role ◽  
Ventrolateral Medulla ◽  
Hypothalamic Nucleus ◽  
Hypoglossal Nucleus ◽  
Anatomical Basis ◽  
Male Wistar Rats ◽  
The Central Nervous System

The G protein-coupled receptor Mas was recently described as an angiotensin-(1–7) [ANG-(1–7)] receptor. In the present study we evaluated the anatomical localization of Mas using immunofluorescence in the central nervous system of adult male Wistar rats. An abundant labeling was found in the hippocampus, amigdala, anterodorsal thalamic nucleus, cortex, and hypoglossal nucleus. More importantly, a dense ANG-(1–7) receptor Mas immunoreactivity was observed in cardiovascular-related areas of the medulla and forebrain, shown in several previous studies as sites for the action of ANG-(1–7) in the brain. A strong staining was found in the nucleus of the solitary tract, caudal and rostral ventrolateral medulla, inferior olive, parvo and magnocellular portions of the paraventricular hypothalamic nucleus, supraoptic nucleus, and lateral preoptic area. Furthermore, Mas staining was predominantly present in neurons. At the medullary sites, a specific and high-intensity binding for rhodamine-ANG-(1–7) was also shown. The specific ANG-(1–7) binding was completely displaced by the anti-Mas antibody or by the ANG-(1–7) antagonist, A-779. The data presented provide the first anatomical basis for the physiological role of ANG-(1–7)/Mas axis in the modulation of different cardiovascular functions and give new insights for clarifying the role of ANG-(1–7) in the central nervous system.

scholarly journals Disrupted Leptin Signaling in the Lateral Hypothalamus and Ventral Premammillary Nucleus Alters Insulin and Glucagon Secretion and Protects Against Diet-Induced Obesity

Endocrinology ◽  
2016 ◽  
Vol 157 (7) ◽  
pp. 2671-2685 ◽  
Author(s):  
Heather C. Denroche ◽  
Maria M. Glavas ◽  
Eva Tudurí ◽  
Subashini Karunakaran ◽  
Whitney L. Quong ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Weight Gain ◽  
Blood Glucose ◽  
Glucagon Secretion ◽  
Hypothalamic Nucleus ◽  
Leptin Signaling ◽  
Glucose Levels ◽  
The Central Nervous System

Leptin signaling in the central nervous system, and particularly the arcuate hypothalamic nucleus, is important for regulating energy and glucose homeostasis. However, the roles of extra-arcuate leptin responsive neurons are less defined. In the current study, we generated mice with widespread inactivation of the long leptin receptor isoform in the central nervous system via Synapsin promoter-driven Cre (Leprflox/flox Syn-cre mice). Within the hypothalamus, leptin signaling was disrupted in the lateral hypothalamic area (LHA) and ventral premammillary nucleus (PMV) but remained intact in the arcuate hypothalamic nucleus and ventromedial hypothalamic nucleus, dorsomedial hypothalamic nucleus, and nucleus of the tractus solitarius. To investigate the role of LHA/PMV neuronal leptin signaling, we examined glucose and energy homeostasis in Leprflox/flox Syn-cre mice and Leprflox/flox littermates under basal and diet-induced obese conditions and tested the role of LHA/PMV neurons in leptin-mediated glucose lowering in streptozotocin-induced diabetes. Leprflox/flox Syn-cre mice did not have altered body weight or blood glucose levels but were hyperinsulinemic and had enhanced glucagon secretion in response to experimental hypoglycemia. Surprisingly, when placed on a high-fat diet, Leprflox/flox Syn-cre mice were protected from weight gain, glucose intolerance, and diet-induced hyperinsulinemia. Peripheral leptin administration lowered blood glucose in streptozotocin-induced diabetic Leprflox/flox Syn-cre mice as effectively as in Leprflox/flox littermate controls. Collectively these findings suggest that leptin signaling in LHA/PMV neurons is not critical for regulating glucose levels but has an indispensable role in the regulation of insulin and glucagon levels and, may promote the development of diet-induced hyperinsulinemia and weight gain.

scholarly journals NEUROMODULATOR LIGAND-RECEPTOR SYSTEM TIP39 - PTH2R

2020 ◽  
Vol 10 (2) ◽  
pp. 78-85
Author(s):  
A. N. Kurzanov ◽  
I. M. Bykov
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Signal Transmission ◽  
Physiological Role ◽  
Receptor System ◽  
Axon Terminals ◽  
Nociceptive Information ◽  
The Central Nervous System ◽  
Anxiety Depression

Widely spread axon terminals of TIP39 neurons have a distribution similar to PTH2R containing neurons and their fibers which provides an anatomic base of neuromodulation action of TIP39. This functional and anatomic link- ing lets state that TIP39 and PTH2R form a neuromodulator ligand-receptor system. Basing on mechanisms of signal transmission used by TIP39 and PTH2R, they can form a neuromodulator system in many brain parts. TIP39-PTH2R system is a unique neuropeptide-receptor system, which localization and functions in the central nervous system differ from any other neuropeptides. Neuromodulator system TIP39-PTH2R predominantly participates in neuroendocrinal modulation by affecting the endocrinal system by means of its presence in several areas of hypothalamus. TIP39 influences neurons that contain somatostatin and corticotropin-releasing hormone. TIP39 can affect the release of adrenocorticotropin, luteinizing hormone, growth hormone and arginine-vasopressin from hypophysis. Experimental data prove that TIP39 modulates regulatory network of anxiety and depression, several aspects of stress reaction and also controls body temperature, participates in processing of auditory and nociceptive information. Physiological role of TIP39-PTH2R system is still to some extent unknown. However, distribution of PTH2R and TIP39 in tissues outside central nervous system assumes other potential physiological effects for this signal way. It is assumed that TIP39- PTH2R system should be probably considered as a potential therapeutic target for treatment of anxiety, depression and chronic pain, control and correction of neuroendocrine disruptions.

Evidence for a physiological role of nerve growth factor in the central nervous system of neonatal rats

Neuron ◽  
1989 ◽  
Vol 3 (3) ◽  
pp. 267-273 ◽  
Author(s):  
G. Vantini ◽  
N. Schiavo ◽  
A. Di Martino ◽  
P. Polato ◽  
C. Triban ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Physiological Role ◽  
Neonatal Rats ◽  
Nerve Growth ◽  
The Central Nervous System

scholarly journals The physiological role of vitamin D and the significance of its deficiency in the pathogenesis of climacteric syndrome

2018 ◽  
Vol 67 (3) ◽  
pp. 74-82 ◽  
Author(s):  
Yulia E. Morozova ◽  
Marina A. Tarasova
Keyword(s):  
Central Nervous System ◽  
Vitamin D ◽  
Nervous System ◽  
Literature Review ◽  
Affective Disorders ◽  
Physiological Role ◽  
Climacteric Syndrome ◽  
The Central Nervous System ◽  
The Impact

This literature review summarizes data on the physiological role of vitamin D in women during menopause. We discuss the peculiarities of climacteric syndrome affected by vitamin D deficiency, including the impact of the vitamin on the central nervous system and its role in cognitive and affective disorders. The necessity of vitamin D therapy to prevent pathologies associated with menopause is highlighted.

scholarly journals An Overview of the Physiological and Pathological Role of Mast Cells in the Central Nervous System

2020 ◽  
Vol 3 (1) ◽  
pp. 56-64
Author(s):  
Serghei Covantev ◽  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mast Cells ◽  
Cerebrovascular Disorders ◽  
Physiological Role ◽  
Pharmaceutical Treatment ◽  
Central Nervous System Trauma ◽  
The Central Nervous System ◽  
Lateral Sclerosis

Neurological disorders present a major group of diseases with the global prevalence of 6.3%. They are responsible for 12% global mortality. Mast cells are one of the most abundantly present cell of the immune system in the connective tissue and the central nervous system is not an exception. In this article is presented a review of studies on mast cells regarding their physiological role in cental nervous system. We also disscuss their role in several conditions like: multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer’s disease, neuropsychiatric disorders, cerebrovascular disorders and central nervous system trauma, epilepsy, seizures and tumors. Finally, we evaluate whether they can be used as a targed for pharmaceutical treatment.

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