Airway epithelial cells suppress T cell proliferation by an IFNγ/STAT1/TGFβ-dependent mechanism
2012 ◽
Vol 302
(1)
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pp. L167-L173
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Keyword(s):
T Cell
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Organ-specific regulation of immune responses relies on the exchange of information between nonimmune and immune cells. In a primary culture model of the lung airway, we demonstrate that T cell proliferation is potently inhibited by airway epithelial cells (ECs). This is mediated by activation of the IFNγ/STAT1 pathway in the EC and transforming growth factor-β (TGFβ)-dependent suppression of T cell proliferation. In this way, the EC can restrict the expansion of T cells. Given the constant exposure of the airway to inhaled antigen, this may be important in setting a threshold for the initiation of T cell-dependent immune responses and preventing unwanted, chronic inflammation.
2000 ◽
Vol 68
(11)
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pp. 6505-6508
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2004 ◽
Vol 30
(6)
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pp. 816-822
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1992 ◽
Vol 267
(24)
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pp. 17409-17414
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2015 ◽
Vol 95
(1)
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pp. 13-20
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