Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage

2007 ◽  
Vol 292 (6) ◽  
pp. R2168-R2173 ◽  
Author(s):  
J. Mark Davis ◽  
E. Angela Murphy ◽  
Martin D. Carmichael ◽  
Mark R. Zielinski ◽  
Claire M. Groschwitz ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Muscle Damage ◽  
Inflammatory Cytokines ◽  
Eccentric Exercise ◽  
Activity Wheel ◽  
Voluntary Activity ◽  
Running Performance ◽  
Functional Deficits ◽  
Downhill Running ◽  
Exercise Induced

Downhill running is associated with fiber damage, inflammation, delayed-onset muscle soreness, and various functional deficits. Curcumin, a constituent of the Indian spice turmeric has been investigated for its anti-inflammatory activity and may offset some of the damage and functional deficits associated with downhill running. This study examined the effects of curcumin on inflammation and recovery of running performance following downhill running in mice. Male mice were assigned to downhill placebo (Down-Plac), downhill curcumin (Down-Cur), uphill placebo (Up-Plac), or uphill curcumin (Up-Cur) groups and run on a treadmill at 22 m/min at −14% or +14% grade, for 150 min. At 48 h or 72 h after the up/downhill run, mice ( experiment 1) underwent a treadmill performance run to fatigue. Another subset of mice was placed in voluntary activity wheel cages following the up/downhill run ( experiment 2) and their voluntary activity (distance, time and peak speed) was recorded. Additional mice ( experiment 3) were killed at 24 h and 48 h following the up/downhill run, and the soleus muscle was harvested for analysis of inflammatory cytokines (IL-1β, IL-6, and TNF-α), and plasma was collected for creatine kinase analysis. Downhill running decreased both treadmill run time to fatigue (48 h and 72 h) and voluntary activity (24 h) ( P < 0.05), and curcumin feedings offset these effects on running performance. Downhill running was also associated with an increase in inflammatory cytokines (24 h and 48 h) and creatine kinase (24 h) ( P < 0.05) that were blunted by curcumin feedings. These results support the hypothesis that curcumin can reduce inflammation and offset some of the performance deficits associated with eccentric exercise-induced muscle damage.

North American ginseng protects against muscle damage and reduces neutrophil infiltration after an acute bout of downhill running in rats

2015 ◽  
Vol 40 (2) ◽  
pp. 116-121 ◽  
Author(s):  
Mehrbod Estaki ◽  
Earl G. Noble
Keyword(s):  
Muscle Damage ◽  
Eccentric Exercise ◽  
North American ◽  
Neutrophil Infiltration ◽  
American Ginseng ◽  
Functional Deficits ◽  
Downhill Running ◽  
Single Bout ◽  
Male Wistar Rats ◽  
Exercise Induced

Eccentric muscle contractions such as those experienced during downhill running are associated with inflammation, delayed-onset of muscle soreness, myofiber damage, and various functional deficits. North American ginseng (Panax quinquefolius L.) has been reported to possess anti-inflammatory properties and thus may offset some of this exercise-induced damage. Hence, we tested the hypothesis that intervention with North American ginseng would reduce eccentric exercise-induced muscle damage and inflammation. Male Wistar rats were fed (300 mg/(kg·day)–1) of either an alcohol (AL) or aqueous (AQ) extract of North American ginseng for 14 days before a single bout of downhill running and were compared with matching nonexercised (C) groups. Plasma creatine kinase levels were significantly reduced in both ginseng treated groups compared with the C group that received a water placebo (p < 0.002). Further, the AQ but not AL group also showed attenuated morphological signs of damage (hemotoxylin and eosin) as well as reduced levels of infiltrating neutrophils (HIS48) in the soleus muscle (p < 0.001). In summary, supplementation with an AQ but not AL extract of North American ginseng was able to reduce eccentric exercise-induced muscle damage and inflammation.

scholarly journals Exercise-Induced Muscle Damage and Running Economy in Humans

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Cláudio de Oliveira Assumpção ◽  
Leonardo Coelho Rabello Lima ◽  
Felipe Bruno Dias Oliveira ◽  
Camila Coelho Greco ◽  
Benedito Sérgio Denadai
Keyword(s):  
Muscle Damage ◽  
High Intensity ◽  
Energy Demand ◽  
Negative Impact ◽  
High Intensity Exercise ◽  
Running Economy ◽  
Running Performance ◽  
Downhill Running ◽  
Short Period ◽  
Exercise Induced

Running economy (RE), defined as the energy demand for a given velocity of submaximal running, has been identified as a critical factor of overall distance running performance. Plyometric and resistance trainings, performed during a relatively short period of time (~15–30 days), have been successfully used to improve RE in trained athletes. However, these exercise types, particularly when they are unaccustomed activities for the individuals, may cause delayed onset muscle soreness, swelling, and reduced muscle strength. Some studies have demonstrated that exercise-induced muscle damage has a negative impact on endurance running performance. Specifically, the muscular damage induced by an acute bout of downhill running has been shown to reduce RE during subsequent moderate and high-intensity exercise (>65% VO2max). However, strength exercise (i.e., jumps, isoinertial and isokinetic eccentric exercises) seems to impair RE only for subsequent high-intensity exercise (~90% VO2max). Finally, a single session of resistance exercise or downhill running (i.e., repeated bout effect) attenuates changes in indirect markers of muscle damage and blunts changes in RE.

Increase Expression of Brain and Muscle Inflammatory Cytokines Following Eccentric Exercise-Induced Muscle Damage

2011 ◽  
Vol 43 (Suppl 1) ◽  
pp. 47-48
Author(s):  
Benjamin T. Gordon ◽  
Angela E. Murphy ◽  
Jamie L. McClellan ◽  
Martin D. Carmichael ◽  
Mark J. Davis
Keyword(s):  
Muscle Damage ◽  
Inflammatory Cytokines ◽  
Eccentric Exercise ◽  
Exercise Induced

Age-Related Variations of Serum CK and CK MB Response in Females

2000 ◽  
Vol 25 (6) ◽  
pp. 419-429 ◽  
Author(s):  
Mark G. Arnett ◽  
Richard Hyslop ◽  
Carolyn A. Dennehy ◽  
Carole M. Schneider
Keyword(s):  
Creatine Kinase ◽  
Key Words ◽  
Muscle Damage ◽  
Eccentric Exercise ◽  
Inverse Relationship ◽  
Serum Creatine Kinase ◽  
Serum Estradiol ◽  
Post Exercise ◽  
Age Related ◽  
Exercise Induced

The objective was to determine whether serum creatine kinase (CK) and serum CK MB activity following exercise-induced muscle damage activity differs among females of varying menarchial status and to determine whether there is a relationship between serum estradiol (E2) concentration, CK, and CK MB activity. Fifteen menarchial (M), 15 premenarchial (P), and 10 postmenopausal (PM) females participated in the study. Exercise consisted of eccentric hamstring contractions. Estradiol concentrations were significantly higher in M women (p = .0001; M, 125.0 ± 20.8 pg/mL, P, 54.6 ± 38.6 pg/mL, PM, 46.2 ± 34.6 pg/mL). Menarchial women had lower resting CK and CK MB activity and responded with a higher efflux of CK and CK MB post exercise (p = .0001). An inverse relationship was found between E2 concentration and baseline CK (p = .02) and CK MB activity (p = .006). No relationship existed between post exercise efflux of CK and CK MB and E2 concentration. At rest, E2 influenced CK and CK MB activity across menarchial levels. However, E2 did not significantly reduce the level of CK and CK MB activity following this intense bout of eccentric exercise. Key words: exercise-induced muscle damage, estradiol, menarhial, premenarchial, postmenopausal

Investigation of serum creatine kinase variability after muscle-damaging exercise

1988 ◽  
Vol 75 (3) ◽  
pp. 257-261 ◽  
Author(s):  
Priscilla M. Clarkson ◽  
Cara Ebbeling
Keyword(s):  
Creatine Kinase ◽  
Muscle Damage ◽  
Eccentric Exercise ◽  
Muscle Injury ◽  
Serum Creatine Kinase ◽  
Blood Levels ◽  
Large Variability ◽  
Exercise Induced

1. The present study examined if the presence of creatine kinase (CK) inhibitors might explain the large variability in blood levels of CK among subjects after exercise-induced muscle damage. 2. Twenty-four women performed an eccentric exercise with the forearm flexors and were then classified as no CK responders, low CK responders and high CK responders. High CK responders repeated the exercise two weeks later (bout two). 3. Sera from high CK responders were mixed with sera from no CK responders or low CK responders. Also, serum from high CK responders obtained after bout one was mixed with the same subject's serum from after bout two. 4. In all cases, the differences between the expected and observed CK activity for the mixes were within the expected variability for the assay. 5. Although CK inhibitors have been previously observed in sera from patients with muscle injury or disease, we were unable to demonstrate the presence of CK inhibitors in the sera from subjects who showed evidence of exercise-induced muscle damage.

Role of brain IL-1β on fatigue after exercise-induced muscle damage

2006 ◽  
Vol 291 (5) ◽  
pp. R1344-R1348 ◽  
Author(s):  
Martin D. Carmichael ◽  
J. Mark Davis ◽  
E. Angela Murphy ◽  
Adrienne S. Brown ◽  
James A. Carson ◽  
...  
Keyword(s):  
Muscle Damage ◽  
Wheel Running ◽  
Systematic Evaluation ◽  
Running Performance ◽  
Downhill Running ◽  
Running Activity ◽  
Wheel Running Activity ◽  
Sickness Behaviors ◽  
Exercise Induced

Brain cytokines, induced by various inflammatory challenges, have been linked to sickness behaviors, including fatigue. However, the relationship between brain cytokines and fatigue after exercise is not well understood. Delayed recovery of running performance after muscle-damaging downhill running is associated with increased brain IL-1β concentration compared with uphill running. However, there has been no systematic evaluation of the direct effect of brain IL-1β on running performance after exercise-induced muscle damage. This study examined the specific role of brain IL-1β on running performance (either treadmill or wheel running) after uphill and downhill running by manipulating brain IL-1β activity via intracerebroventricular injection of either IL-1 receptor antagonist (ra; downhill runners) or IL-1β (uphill runners). Male C57BL/6 mice were assigned to the following groups: uphill-saline, uphill-IL-1β, downhill-saline, or downhill-IL-1ra. Mice initially ran on a motor-driven treadmill at 22 m/min and −14% or +14% grade for 150 min. After the run, at 8 h (wheel cage) or 22 h (treadmill), uphill mice received intracerebroventricular injections of IL-1β (900 pg in 2 μl saline) or saline (2 μl), whereas downhill runners received IL-1ra (1.8 μg in 2 μl saline) or saline (2 μl). Later (2 h), running performance was measured (wheel running activity and treadmill run to fatigue). Injection of IL-1β significantly decreased wheel running activity in uphill runners ( P < 0.01), whereas IL-1ra improved wheel running in downhill runners ( P < 0.05). Similarly, IL-1β decreased and Il-1ra increased run time to fatigue in the uphill and downhill runners, respectively ( P < 0.01). These results support the hypothesis that increased brain IL-1β plays an important role in fatigue after muscle-damaging exercise.

Polymethoxyflavones in orange peel extract prevent skeletal muscle damage induced by eccentric exercise in rats

2020 ◽  
Vol 85 (2) ◽  
pp. 440-446
Author(s):  
Toshihide Suzuki ◽  
Makoto Shimizu ◽  
Yoshio Yamauchi ◽  
Ryuichiro Sato
Keyword(s):  
Skeletal Muscle ◽  
Muscle Damage ◽  
Eccentric Exercise ◽  
Vastus Lateralis ◽  
Orange Peel ◽  
Skeletal Muscle Damage ◽  
Downhill Running ◽  
Exercise Induced ◽  
Orange Peel Extract ◽  
Peel Extract

ABSTRACT Polymethoxyflavones (PMFs) contained in the peel of citrus fruits have anti-inflammatory, anticancer, and antidepressant effects. However, their effects on skeletal muscle are unknown. We investigated whether PMFs could prevent skeletal muscle damage induced by eccentric exercise in rats. Downhill running for 90 min increased the levels of the inflammatory cytokines, monocyte chemotactic protein-1 (MCP-1), and interleukin-1β (IL-1β) in skeletal muscles, especially in vastus lateralis, and the plasma creatine kinase levels. These increases were attenuated by a single oral administration of orange peel extract (OPE) 30 min before downhill running. A mixture of nobiletin, sinensetin, 3,5,6,7,8,3′,4′-heptamethoxyflavone, and tangeretin, which are the major PMFs of OPE, also showed similar effects on muscle damage. These results suggest that OPE has a protective effect against eccentric exercise-induced skeletal muscle damage, and that the effects may be attributed to the 4 major PMFs.

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