Age-Related Variations of Serum CK and CK MB Response in Females

2000 ◽  
Vol 25 (6) ◽  
pp. 419-429 ◽  
Author(s):  
Mark G. Arnett ◽  
Richard Hyslop ◽  
Carolyn A. Dennehy ◽  
Carole M. Schneider
Keyword(s):  
Creatine Kinase ◽  
Key Words ◽  
Muscle Damage ◽  
Eccentric Exercise ◽  
Inverse Relationship ◽  
Serum Creatine Kinase ◽  
Serum Estradiol ◽  
Post Exercise ◽  
Age Related ◽  
Exercise Induced

The objective was to determine whether serum creatine kinase (CK) and serum CK MB activity following exercise-induced muscle damage activity differs among females of varying menarchial status and to determine whether there is a relationship between serum estradiol (E2) concentration, CK, and CK MB activity. Fifteen menarchial (M), 15 premenarchial (P), and 10 postmenopausal (PM) females participated in the study. Exercise consisted of eccentric hamstring contractions. Estradiol concentrations were significantly higher in M women (p = .0001; M, 125.0 ± 20.8 pg/mL, P, 54.6 ± 38.6 pg/mL, PM, 46.2 ± 34.6 pg/mL). Menarchial women had lower resting CK and CK MB activity and responded with a higher efflux of CK and CK MB post exercise (p = .0001). An inverse relationship was found between E2 concentration and baseline CK (p = .02) and CK MB activity (p = .006). No relationship existed between post exercise efflux of CK and CK MB and E2 concentration. At rest, E2 influenced CK and CK MB activity across menarchial levels. However, E2 did not significantly reduce the level of CK and CK MB activity following this intense bout of eccentric exercise. Key words: exercise-induced muscle damage, estradiol, menarhial, premenarchial, postmenopausal

Investigation of serum creatine kinase variability after muscle-damaging exercise

1988 ◽  
Vol 75 (3) ◽  
pp. 257-261 ◽  
Author(s):  
Priscilla M. Clarkson ◽  
Cara Ebbeling
Keyword(s):  
Creatine Kinase ◽  
Muscle Damage ◽  
Eccentric Exercise ◽  
Muscle Injury ◽  
Serum Creatine Kinase ◽  
Blood Levels ◽  
Large Variability ◽  
Exercise Induced

1. The present study examined if the presence of creatine kinase (CK) inhibitors might explain the large variability in blood levels of CK among subjects after exercise-induced muscle damage. 2. Twenty-four women performed an eccentric exercise with the forearm flexors and were then classified as no CK responders, low CK responders and high CK responders. High CK responders repeated the exercise two weeks later (bout two). 3. Sera from high CK responders were mixed with sera from no CK responders or low CK responders. Also, serum from high CK responders obtained after bout one was mixed with the same subject's serum from after bout two. 4. In all cases, the differences between the expected and observed CK activity for the mixes were within the expected variability for the assay. 5. Although CK inhibitors have been previously observed in sera from patients with muscle injury or disease, we were unable to demonstrate the presence of CK inhibitors in the sera from subjects who showed evidence of exercise-induced muscle damage.

scholarly journals Comparison of Pro-Regenerative Effects of Carbohydrates and Protein Administrated by Shake and Non-Macro-Nutrient Matched Food Items on the Skeletal Muscle after Acute Endurance Exercise

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 744 ◽  
Author(s):  
Eduard Isenmann ◽  
Franziska Blume ◽  
Daniel Bizjak ◽  
Vera Hundsdörfer ◽  
Sarah Pagano ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Muscle Damage ◽  
Serum Insulin ◽  
Serum Markers ◽  
Serum Creatine Kinase ◽  
Skeletal Muscle Regeneration ◽  
Skeletal Muscle Damage ◽  
Leg Strength ◽  
Exercise Induced

Physical performance and regeneration after exercise is enhanced by the ingestion of proteins and carbohydrates. These nutrients are generally consumed by athletes via whey protein and glucose-based shakes. In this study, effects of protein and carbohydrate on skeletal muscle regeneration, given either by shake or by a meal, were compared. 35 subjects performed a 10 km run. After exercise, they ingested nothing (control), a protein/glucose shake (shake) or a combination of white bread and sour milk cheese (food) in a randomized cross over design. Serum glucose (n = 35), serum insulin (n = 35), serum creatine kinase (n = 15) and myoglobin (n = 15), hematologic parameters, cortisol (n = 35), inflammation markers (n = 27) and leg strength (n = 15) as a functional marker were measured. Insulin secretion was significantly stimulated by shake and food. In contrast, only shake resulted in an increase of blood glucose. Food resulted in a decrease of pro, and stimulation of anti-inflammatory serum markers. The exercise induced skeletal muscle damage, indicated by serum creatine kinase and myoglobin, and exercise induced loss of leg strength was decreased by shake and food. Our data indicate that uptake of protein and carbohydrate by shake or food reduces exercise induced skeletal muscle damage and has pro-regenerative effects.

Children Are Less Susceptible to Exercise-Induced Muscle Damage than Adults: A Preliminary Investigation

1996 ◽  
Vol 8 (4) ◽  
pp. 361-367 ◽  
Author(s):  
José M.C. Soares ◽  
Paulo Mota ◽  
José A. Duarte ◽  
Hans J. Appell
Keyword(s):  
Creatine Kinase ◽  
Muscle Damage ◽  
Muscle Pain ◽  
Bench Press ◽  
Preliminary Investigation ◽  
Serum Creatine Kinase ◽  
Subjective Perception ◽  
Adult Group ◽  
Intense Exercise ◽  
Exercise Induced

The aim of the present study was to investigate whether children showed similar signs of muscle overuse like adults after intense exercise. One child group (n = 10) and one adult group (n = 10) of males both had to perform five series of bench press exercises at an intensity of 80% of maximum strength until exhaustion. Maximum isometric strength, subjective perception of muscle pain, was measured before, immediately after, 48 hr, 72 hr, and 1 week after the exercise. Serum creatine kinase (CK) activity was measured before, 48 hr, 72 hr, and 1 week after the exercise. The adults showed all symptoms of muscle overuse: reduced strength, muscle pain, and elevated CK activities until 3 days after the exercise. In contrast, the children experienced only some light muscle pain, but neither showed reduced strength nor elevated CK activities. It is concluded that children’s muscles can easier withstand physical stress than adult muscles.

scholarly journals Do Antioxidant Vitamins Prevent Exercise-Induced Muscle Damage? A Systematic Review

Antioxidants ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 372 ◽  
Author(s):  
María Martinez-Ferran ◽  
Fabian Sanchis-Gomar ◽  
Carl J. Lavie ◽  
Giuseppe Lippi ◽  
Helios Pareja-Galeano
Keyword(s):  
Systematic Review ◽  
Creatine Kinase ◽  
Muscle Damage ◽  
Web Of Science ◽  
Exercise Session ◽  
Post Exercise ◽  
High Doses ◽  
Exercise Induced ◽  
Cell Signaling Pathways

Free radicals produced during exercise play a role in modulating cell signaling pathways. High doses of antioxidants may hamper adaptations to exercise training. However, their benefits are unclear. This review aims to examine whether vitamin C (VitC) and/or vitamin E (VitE) supplementation (SUP) prevents exercise-induced muscle damage. The PubMed, Web of Science, Medline, CINAHL, and SPORTDiscus databases were searched, and 21 articles were included. Four studies examined the effects of acute VitC SUP given pre-exercise: in one study, lower CK levels post-exercise was observed; in three, no difference was recorded. In one study, acute VitE SUP reduced CK activity 1 h post-exercise in conditions of hypoxia. In three studies, chronic VitE SUP did not reduce CK activity after an exercise session. Chronic VitE SUP did not reduce creatine kinase (CK) concentrations after three strength training sessions, but it was effective after 6 days of endurance training in another study. Chronic SUP with VitC + E reduced CK activity post-exercise in two studies, but there was no such effect in four studies. Finally, three studies described the effects of chronic VitC + E SUP and long-term exercise, reporting dissimilar results. To conclude, although there is some evidence of a protective effect of VitC and/or VitE against exercise-induced muscle damage, the available data are not conclusive.

Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage

2007 ◽  
Vol 292 (6) ◽  
pp. R2168-R2173 ◽  
Author(s):  
J. Mark Davis ◽  
E. Angela Murphy ◽  
Martin D. Carmichael ◽  
Mark R. Zielinski ◽  
Claire M. Groschwitz ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Muscle Damage ◽  
Inflammatory Cytokines ◽  
Eccentric Exercise ◽  
Activity Wheel ◽  
Voluntary Activity ◽  
Running Performance ◽  
Functional Deficits ◽  
Downhill Running ◽  
Exercise Induced

Downhill running is associated with fiber damage, inflammation, delayed-onset muscle soreness, and various functional deficits. Curcumin, a constituent of the Indian spice turmeric has been investigated for its anti-inflammatory activity and may offset some of the damage and functional deficits associated with downhill running. This study examined the effects of curcumin on inflammation and recovery of running performance following downhill running in mice. Male mice were assigned to downhill placebo (Down-Plac), downhill curcumin (Down-Cur), uphill placebo (Up-Plac), or uphill curcumin (Up-Cur) groups and run on a treadmill at 22 m/min at −14% or +14% grade, for 150 min. At 48 h or 72 h after the up/downhill run, mice ( experiment 1) underwent a treadmill performance run to fatigue. Another subset of mice was placed in voluntary activity wheel cages following the up/downhill run ( experiment 2) and their voluntary activity (distance, time and peak speed) was recorded. Additional mice ( experiment 3) were killed at 24 h and 48 h following the up/downhill run, and the soleus muscle was harvested for analysis of inflammatory cytokines (IL-1β, IL-6, and TNF-α), and plasma was collected for creatine kinase analysis. Downhill running decreased both treadmill run time to fatigue (48 h and 72 h) and voluntary activity (24 h) ( P < 0.05), and curcumin feedings offset these effects on running performance. Downhill running was also associated with an increase in inflammatory cytokines (24 h and 48 h) and creatine kinase (24 h) ( P < 0.05) that were blunted by curcumin feedings. These results support the hypothesis that curcumin can reduce inflammation and offset some of the performance deficits associated with eccentric exercise-induced muscle damage.

scholarly journals An acute eccentric exercise increases circulating myomesin 3 fragments

2021 ◽  
Vol 71 (1) ◽  
Author(s):  
Minjung Lee ◽  
Jaehoon Shin ◽  
Tatsuya Kato ◽  
Kazue Kanda ◽  
Satoshi Oikawa ◽  
...  
Keyword(s):  
Body Weight ◽  
Muscle Damage ◽  
Eccentric Exercise ◽  
Blood Biomarkers ◽  
Analog Scale ◽  
Post Exercise ◽  
Blood Samples ◽  
Exercise Induced ◽  
Potential Biomarkers ◽  
Healthy Males

AbstractDiscovery of blood biomarkers to evaluate exercise-induced muscle damage have attracted many researchers and coaches. This study aimed to determine changes in circulating myomesin 3 fragments as a novel biomarker for exercise-induced muscle damage. Nine healthy males performed 10 sets of 40 repetitions of one-leg calf-raise exercise by the load corresponding to the half of their body weight. Muscle symptoms were evaluated by a visual analog scale (VAS). Blood samples were collected before and 2, 4, 24, 48, 72, and 96 h post-exercise. Plasma myomesin 3 fragments levels were significantly increased at 96 h after the eccentric exercise. The myomesin 3 fragments levels were correlated with other biomarkers of muscle damage and the muscle symptoms. These results suggest that the circulating myomesin 3 fragments levels are potential biomarkers reflecting eccentric exercise-induced muscle damage.

scholarly journals Effects of Muscle Architecture on Eccentric Exercise Induced Muscle Damage Responses

2021 ◽  
pp. 655-664
Author(s):  
Seher Çağdaş Şenışık ◽  
Bedrettin Akova ◽  
Ufuk Şekir ◽  
Hakan Gür
Keyword(s):  
Range Of Motion ◽  
Muscle Damage ◽  
Eccentric Exercise ◽  
Peak Torque ◽  
Pennation Angle ◽  
Muscle Architecture ◽  
Muscle Volume ◽  
Post Exercise ◽  
Muscle Groups ◽  
Exercise Induced

There is a need to investigate the role of muscle architecture on muscle damage responses induced by exercise. The aim of this study was to determine the effect of muscle architecture and muscle length on eccentric exercise-induced muscle damage responses. Eccentric exercise-induced muscle damage was performed randomly to the elbow flexor (EF), knee extensor (KE), and knee flexor (KF) muscle groups with two week intervals in 12 sedentary male subjects. Before and after each eccentric exercise (immediately after, on the 1st, 2nd, 3rd, and 7th days) range of motion, delayed onset muscle soreness, creatine kinase activity, myoglobin concentration and isometric peak torque in short and long muscle positions were evaluated. Furthermore, muscle volume and pennation angle of each muscle group was evaluated before initiating the eccentric exercise protocol. Pennation angle and muscle volume was significantly higher and the workload per unit muscle volume was significantly lower in the KE muscles compared with the KF and EF muscles (p < 0.01). EF muscles showed significantly higher pain levels at post-exercise days 1 and 3 compared with the KE (p < 0.01-0.001) and KF (p < 0.01) muscles. The deficits in range of motion were higher in the EF muscles compared to the KE and KF muscles immediately after (day 0, p < 0.01), day 1 (p < 0.05-0.01), and day 3 (p < 0.05) evaluations. The EF muscles represented significantly greater increases in CK and Mb levels at day 1, 3, and 7 than the KE muscles (p < 0.05-0.01). The CK and Mb levels were also significantly higher in the KF muscles compared with the KE muscles (p < 0.05, p < 0.01 respectively). The KF and EF muscles represented higher isometric peak torque deficits in all the post-exercise evaluations at muscle short position (p < 0.05-0.001) compared with the KE muscle after eccentric exercise. Isometric peak torque deficits in muscle lengthened position was significantly higher in EF in all the post-exercise evaluations compared with the KE muscle (p < 0.05-0.01). According to the results of this study it can be concluded that muscle structural differences may be one of the responsible factors for the different muscle damage responses following eccentric exercise in various muscle groups.

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