Central AT1 receptor signaling by circulating angiotensin II is permissive to acute intermittent hypoxia-induced sympathetic neuroplasticity
2020 ◽
Vol 128
(5)
◽
pp. 1329-1337
Keyword(s):
Ang Ii
◽
Acute intermittent hypoxia (AIH) triggers sympathetic long-term facilitation (sLTF) that relies on peripheral renin-angiotensin system (RAS) activation. Here, increasing AIH cycles from 5 to 10 proportionally increased RAS activity, but not the magnitude of post-AIH sLTF. Brain angiotensin II (ANG II) receptor blockade and nephrectomy each largely prevented sLTF, whereas central ANG II rescued it following nephrectomy. Peripheral RAS activation by AIH induces time-dependent neuroplasticity at an apparent central ANG II signaling threshold, triggering a stereotyped sLTF response.
2003 ◽
Vol 95
(6)
◽
pp. 2614-2623
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Keyword(s):
1985 ◽
Vol 248
(3)
◽
pp. R371-R377
◽
1985 ◽
Vol 248
(5)
◽
pp. R541-R548
1994 ◽
Vol 266
(1)
◽
pp. F117-F119
◽
2017 ◽
Vol 312
(2)
◽
pp. H223-H231
◽