Bimodal distribution of vasodilator responsiveness to adenosine due to difference in nitric oxide contribution: implications for exercise hyperemia

2006 ◽  
Vol 101 (2) ◽  
pp. 492-499 ◽  
Author(s):  
Elizabeth A. Martin ◽  
Wayne T. Nicholson ◽  
John H. Eisenach ◽  
Nisha Charkoudian ◽  
Michael J. Joyner
Keyword(s):  
Nitric Oxide ◽  
Human Subjects ◽  
Bimodal Distribution ◽  
The Other ◽  
Arterial Infusion ◽  
Exercise Hyperemia ◽  
Forearm Vascular Conductance ◽  
High Doses ◽  
Insight Into

To gain insight into the role of adenosine (Ado) in exercise hyperemia, we compared forearm vasodilation induced by intra-arterial infusion of three doses of Ado with vasodilation during three workloads of forearm handgrip exercise in 27 human subjects. We measured forearm blood flow (FBF) using Doppler ultrasound and mean arterial pressure (MAP) via brachial artery catheters and calculated forearm vascular conductance (FVC = FBF/MAP) during each infusion dose or workload. We found that about half of the subjects demonstrated robust vasodilator responsiveness to both Ado infusion and exercise, and the other half demonstrated blunted vasodilator responsiveness to Ado infusion compared with exercise. In 15 subjects (identified as “Ado responders”), the change in FVC above baseline was 209 ± 33, 419 ± 57, and 603 ± 75 ml·min−1·100 mmHg−1 for the low, medium, and high doses of Ado, respectively, and 221 ± 35, 413 ± 54, and 582 ± 70 ml·min−1·100 mmHg−1 for the low, medium, and high exercise workloads, respectively. In the other 12 subjects (identified as “Ado nonresponders”), the change in FVC above baseline was 102 ± 36, 113 ± 42, and 151 ± 54 ml·min−1·100 mmHg−1 for the low, medium, and high doses of Ado, respectively ( P < 0.05 vs. Ado responders), whereas exercise hyperemia was not different from Ado responders ( P > 0.05). Furthermore, infusion of NG-monomethyl-l-arginine (l-NMMA) blunted vasodilator responses to Ado infusion only in Ado responders ( P < 0.01 vs. post-l-NMMA) and had no effect on exercise in either group. We also found differences in vasodilator responses to isoproterenol at all doses, but acetylcholine only at one dose, between Ado responders and nonresponders. We conclude that vasodilator responsiveness to Ado exhibits a bimodal distribution among human subjects involving differences in the contribution of nitric oxide to Ado-mediated vasodilation. Finally, our data support the concept that neither Ado nor nitric oxide is obligatory for exercise hyperemia.

scholarly journals New Insight into the Role of Nitric Oxide Pathways in Pancreas

2018 ◽  
Vol 51 (6) ◽  
pp. 167-172 ◽  
Author(s):  
Igor Buchwalow ◽  
Jürgen Schnekenburger ◽  
Vera Samoilova ◽  
Werner Boecker ◽  
Joachim Neumann ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Insight Into

scholarly journals Japanese Concepts of Angels: Analyzing Depictions of Celestial Beings in the shōjo Manga Kamikaze Kaitō Jeanne

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Dunja Sharbat Dar
Keyword(s):  
Popular Culture ◽  
The Other ◽  
Religious Traditions ◽  
Cultural Perspectives ◽  
Christian Religion ◽  
Hermeneutic Approach ◽  
Shojo Manga ◽  
Insight Into

White wings, long hair, 'pure' faces: the appearance of angels frequently follows similar aesthetics connected to Christian imagery. Angels and Christian religion also are popular themes in manga, Japanese comics, often intermingled with Buddhist or Shinto notions. Since imagery in popular culture resonates and shapes vernacular and cultural perspectives, manga like Kamikaze Kaitō Jeanne (KKJ) provide an important insight into the conceptualization of angels in Japan. This article therefore analyzes the contrary role of angels in KKJ as the Other, the mysterious, serene one, while simultaneously angels are depicted as part of the circle of life every creature undergoes in Buddhist cosmology. Based on a visual hermeneutic approach, this article demonstrates how the intermix of both visual and religious traditions in Japan shape the depiction of angels in Japanese popcultural media.

Part I General Aspects, 2 The IPO Process, IPO Disclosure, and the Prospectus Regulation

2020 ◽  
Author(s):  
Teerink Han
Keyword(s):  
Initial Public Offering ◽  
The Other ◽  
Business Information ◽  
Other Hand ◽  
The One ◽  
General Aspects ◽  
Public Offering ◽  
The Right ◽  
Insight Into

This chapter offers insight into a typical initial public offering (IPO) process, highlighting key practical and legal considerations around disclosure, through the IPO prospectus and otherwise. The prospectus plays a key role in the preparations for, and execution of, an IPO. As an IPO prospectus typically constitutes a company's first public dissemination of financial and business information, the company and other parties involved in the IPO process must carefully consider the right balance between, on the one hand, drafting the IPO prospectus as a marketing document introducing the company and its business to potential investors, whilst, on the other hand, being able to use the prospectus as a disclosure document that protects the company against liability arising from claims from investors or others after the IPO. Here, the chapter summarizes the different phases in an IPO process and the most important documents and parties involved, focusing on the central role of the IPO prospectus. In addition, a number of changes resulting from the enactment of the Prospectus Regulation are likely to be of particular relevance to IPO processes. The expected impact of these changes is therefore also discussed.

scholarly journals Intercultural Training: Learn to avoid treading on other people’s toes or experience walking in the other person’s shoes

2014 ◽  
Vol 1 (1) ◽  
Author(s):  
Kristin Rygg
Keyword(s):  
Intercultural Communication ◽  
Traditional Approach ◽  
The Other ◽  
Intercultural Training ◽  
Theoretical Discussion ◽  
Culture Clash ◽  
Interactive Tools ◽  
Case Work ◽  
Insight Into

This article raises the question of whether the traditional approach in intercultural training focusing on knowledge about cultural differences and skills to avoid culture clash is sufficient in order to prepare intercultural communication trainees for dynamic and psychologically demanding multicultural environments. Inspired by the concept of mentalizing in the psycho-therapeutic method called Mentalization-based treatment, training that encourages imaginatively “seeing the other from the inside and oneself from the outside” is suggested as better able to prepare for complex intercultural realities. Tolerance is seen as tolerance for being in the intercultural process as much as tolerance for others’ differences. A theoretical discussion between the notion of mentalizing in mentalization-based treatment and perceptions of empathy, imagination and mindfulness further provides insight into the role of interactive tools such as case work and role plays in intercultural training. These, in turn, are seen as best suited to fulfil the goals and ambitions of the theories. However, experiences gained from them must be verbalized in order to cause increased awareness.

scholarly journals Bestuursetiek in bestuursopleiding: Retoriek of realiteit

1993 ◽  
Vol 19 (3) ◽  
Author(s):  
S. Kruger
Keyword(s):  
Business Ethics ◽  
The Other ◽  
Literature Study ◽  
Business Training ◽  
Other Hand ◽  
The Future ◽  
The Subject ◽  
The One ◽  
Insight Into

Business ethics in business training: Oratory or the actuality. This article is the culmination of an in-depth literature study. On the one hand an attempt is made to incorporate the views of different authors, while on the other hand an attempt is made to take part in the debate which is initiated by the current renewal of interest in the subject Business Ethics. Within this framework attention is paid to the question of whether business ethics can be taught and if so, to what extent it's influence will be felt. Secondly, an insight into the teaching of business ethics in the future is provided. Within this context the approach to the teaching, the content, the role of the student and the responsibility of the educator in particular are addressed. Opsomming Hierdie artikel is die resultaat van 'n indringende literatuurstudie. Daar word gepoog om enersyds verskillende skrywers se standpunte saam te vat, maar andersyds ook kritiese kommentaar te lower en deel te neem aan die debat wat deur die huidige opiewing in die belangstelling in Bestuursetiek bestaan. Binne die raamwerk sal aandag aan die volgende geskenk word: Die beantwoording van die vraag of Bestuursetiek onderrig kan word en indien wel die trefwydte daarvan. Tweedens 'n toekomsblik op die onderrig van Bestuursetiek. Binne die konteks word die benadering tot die onderrig/ die inhoud en die rol van die student en die verantwoordelikheid van die dosent bekvk.

scholarly journals The role of the endothelium in the hyperemic response to passive leg movement: looking beyond nitric oxide

2020 ◽  
Author(s):  
Joel D. Trinity ◽  
Oh Sung Kwon ◽  
Ryan M. Broxterman ◽  
Jayson R. Gifford ◽  
Andrew C. Kithas ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Vascular Function ◽  
No Synthase ◽  
Ketorolac Tromethamine ◽  
Arterial Infusion ◽  
Healthy Men ◽  
Leg Movement ◽  
Hyperemic Response

Passive leg movement (PLM) evokes a robust and predominantly nitric oxide (NO)-mediated increase in blood flow that declines with age and disease. Consequently, PLM is becoming increasingly accepted as a sensitive assessment of endothelium-mediated vascular function. However, a substantial PLM-induced hyperemic response is still evoked despite NO synthase (NOS) inhibition. Therefore, in 9 young healthy men (25±4 yrs), this investigation aimed to determine if the combination of two potent endothelium-dependent vasodilators, specifically prostaglandin (PG) and endothelium-derived hyperpolarizing factor (EDHF), account for the remaining hyperemic response to the two variants of PLM, PLM (60 movements) and single PLM (sPLM, 1 movement) when NOS is inhibited. The leg blood flow (LBF, Doppler ultrasound) response to PLM and sPLM following the intra-arterial infusion of NG-monomethyl L-arginine (L-NMMA), to inhibit NOS, was compared to the combined inhibition of NOS, cyclooxygenase (COX), and cytochrome P450 (CYP450) by L-NMMA, ketorolac tromethamine (KET), and fluconazole (FLUC), respectively. NOS inhibition attenuated the overall LBF (LBFAUC) response to both PLM (control: 456±194, L-NMMA: 168±127 ml, p<0.01) and sPLM (control: 185±171, L-NMMA: 62±31 ml, p=0.03). The combined inhibition of NOS, COX, and CYP450 (i.e. L-NMMA+KET+FLUC) did not further attenuate the hyperemic responses to PLM (LBFAUC: 271±97 ml, p>0.05) or sPLM (LBFAUC: 72±45 ml, p>0.05). Therefore, PG and EDHF do not collectively contribute to the non-NOS-derived NO-mediated, endothelium-dependent, hyperemic response to either PLM or sPLM in healthy young men. These findings add to the mounting evidence and understanding of the vasodilatory pathways assessed by the PLM and sPLM vascular function tests.

scholarly journals Leg exercise hyperemia: role of nitric oxide synthase and cyclooxygenase

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Jacqueline K Limberg ◽  
William G Schrage ◽  
Brad W Wilkins ◽  
Christopher P Johnson ◽  
Eisenach John ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Exercise Hyperemia ◽  
Leg Exercise ◽  
Oxide Synthase

Black Pentecostal Hermeneutics?

Pneuma ◽  
2019 ◽  
Vol 41 (2) ◽  
pp. 193-217
Author(s):  
Antipas L. Harris
Keyword(s):  
Social Justice ◽  
Black Theology ◽  
The Other ◽  
Critical Dialogue ◽  
Social Advocacy ◽  
Other Hand ◽  
Black Pentecostal ◽  
The One ◽  
Insight Into

Abstract This essay advances hermeneutical insights for emerging black pentecostal scholars to consider. The salient question is, “What distinguishes black Pentecostalism?” This study revisits James H. Cone’s sources for black theology for insight into the role of blackness in shaping black Pentecostalism. On the one hand, the study dispels the myth that black Pentecostalism is inherently a spiritual alternative to the fight for social justice. On the other hand, it calls for critical dialogue between Cone’s sources for black theology and black Pentecostalism to advance scholarship on the formation of black pentecostal hermeneutics. This essay explains that blackness is more than a cultural and experiential reality. Blackness is a theological source that correlates with other sources in shaping black Pentecostalism. Blackness, moreover, legitimates black pentecostal proclivities for the integration of the faith, spirituality, and social advocacy. Theological blackness in Pentecostalism has historically distinguished black Pentecostalism from subsequent white Pentecostalism.

scholarly journals Elevated extracellular potassium prior to muscle contraction reduces onset and steady-state exercise hyperemia in humans

2018 ◽  
Vol 125 (2) ◽  
pp. 615-623 ◽  
Author(s):  
Janée D. Terwoord ◽  
Christopher M. Hearon ◽  
Gary J. Luckasen ◽  
Jennifer C. Richards ◽  
Michael J. Joyner ◽  
...  
Keyword(s):  
Steady State ◽  
Voluntary Contraction ◽  
Extracellular Potassium ◽  
Handgrip Exercise ◽  
Exercise Hyperemia ◽  
Forearm Vascular Conductance ◽  
Response To Exercise ◽  
Exercise In Humans ◽  
Hyperemic Response

The increase in interstitial potassium (K+) during muscle contractions is thought to be a vasodilatory signal that contributes to exercise hyperemia. To determine the role of extracellular K+ in exercise hyperemia, we perfused skeletal muscle with K+ before contractions, such that the effect of any endogenously-released K+ would be minimized. We tested the hypothesis that local, intra-arterial infusion of potassium chloride (KCl) at rest would impair vasodilation in response to subsequent rhythmic handgrip exercise in humans. In 11 young adults, we determined forearm blood flow (FBF) (Doppler ultrasound) and forearm vascular conductance (FVC) (FBF/mean arterial pressure) during 4 min of rhythmic handgrip exercise at 10% of maximal voluntary contraction during 1) control conditions, 2) infusion of KCl before the initiation of exercise, and 3) infusion of sodium nitroprusside (SNP) as a control vasodilator. Infusion of KCl or SNP elevated resting FVC similarly before the onset of exercise (control: 39 ± 6 vs. KCl: 81 ± 12 and SNP: 82 ± 13 ml·min−1·100 mmHg−1; both P < 0.05 vs. control). Infusion of KCl at rest diminished the hyperemic (ΔFBF) and vasodilatory (ΔFVC) response to subsequent exercise by 22 ± 5% and 30 ± 5%, respectively (both P < 0.05 vs. control), whereas SNP did not affect the change in FBF ( P = 0.74 vs. control) or FVC ( P = 0.61 vs. control) from rest to steady-state exercise. These findings implicate the K+ ion as an essential vasodilator substance contributing to exercise hyperemia in humans. NEW & NOTEWORTHY Our findings support a significant and obligatory role for potassium signaling in the local vasodilatory and hyperemic response to exercise in humans.

scholarly journals The Role of Income Uncertainty in the Corruption–Growth Nexus

2016 ◽  
Vol 16 (2) ◽  
pp. 1169-1201 ◽  
Author(s):  
Ratbek Dzhumashev
Keyword(s):  
Economic Growth ◽  
The Other ◽  
Growth Effect ◽  
Income Uncertainty ◽  
Other Hand ◽  
The Relationship ◽  
Insight Into

Abstract This paper analyses how corruption-induced income uncertainty affects the relationship between corruption and economic growth. The analysis reveals both the growth-enhancing and deteriorating effects of corruption that transmit through the income and productivity channels, and shows how income uncertainty caused by corruption interacts with both of these effects. In particular, it is found that an increase in bribe rates and the probability of corruption that reduces the burden of regulations generate counteracting effects on income and productivity, where both effects are further aggravated by corruption-induced income uncertainty. On the other hand, a higher burden of bribes imposed by extortive bureaucrats hampers growth unambiguously. However, in a highly corrupt environment, an increase in the incidence of extortive behaviour can be growth enhancing as it reduces income uncertainty, while if corruption levels are relatively low, then a further increase in the incidence of such behaviour deteriorates growth. These findings give us a new insight into why the overall growth effect of corruption is ambiguous.

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