Differential Effect of Ethanol on NMDA EPSCs in Pyramidal Cells in the Posterior Cingulate Cortex of Juvenile and Adult Rats

2002 ◽  
Vol 87 (2) ◽  
pp. 705-711 ◽  
Author(s):  
Qiang Li ◽  
Wilkie A. Wilson ◽  
H. Scott Swartzwelder
Keyword(s):  
Nmda Receptor ◽  
Pyramidal Cells ◽  
Cingulate Cortex ◽  
Mean Amplitude ◽  
Inhibitory Effect ◽  
Posterior Cingulate Cortex ◽  
Adult Rats ◽  
Posterior Cingulate ◽  
Cellular Analysis ◽  
The Mean

Ethanol (EtOH) is a potent inhibitor of N-methyl-d-aspartate (NMDA) receptor–mediated activity in a number of brain areas, and recent studies have indicated that this inhibitory effect of ethanol is more powerful in the juvenile brain compared with the adult brain. However, previous direct developmental comparisons have been limited to studies of extracellular responses in the hippocampus. To begin an assessment of the mechanisms underlying this developmental sensitivity, we assessed the inhibitory effect of EtOH on NMDA receptor–mediated synaptic transmission in neocortical slices from adult (95–135 days old) and juvenile (28–32 days old) rats using the whole cell patch-clamp recording technique. In the presence of 6,7-dinitroquinoxaline-2,3-dione (20 μM) and bicuculline methiodine (20 μM), NMDA receptor–mediated excitatory postsynaptic currents were isolated from pyramidal cells of the posterior cingulate cortex (PCC). In slices from juvenile rats 5, 10, 30, and 60 mM EtOH reduced the mean amplitude of NMDA receptor–mediated EPSCs by 11, 22, 35, and 46%, respectively. However, the same concentrations of EtOH inhibited the mean amplitude of EPSCs by only 4, 8, 15, and 31% in slices from adult rats. This developmental difference in the potency of EtOH against NMDA receptor–mediated EPSCs was also observed when the holding potential of the neurons was increased to +30 mV, although the inhibitory effect of ethanol on adult neurons was diminished at that voltage. These results provide a cellular analysis of the enhanced potency of ethanol against NMDA receptor–mediated EPSCs in neocortical cells from juvenile animals compared with adults.

Effects of inhibitory avoidance training and/or isolated foot-shock on ectonucleotidase activities in synaptosomes of the anterior and posterior cingulate cortex and the medial precentral area of adult rats

2002 ◽  
Vol 128 (2) ◽  
pp. 121-127 ◽  
Author(s):  
Grace Schenatto Pereira ◽  
Tadeu Mello e Souza ◽  
Ana Maria Oliveira Battastini ◽  
Iván Izquierdo ◽  
João José Freitas Sarkis ◽  
...  
Keyword(s):  
Avoidance Training ◽  
Cingulate Cortex ◽  
Inhibitory Avoidance ◽  
Posterior Cingulate Cortex ◽  
Adult Rats ◽  
Posterior Cingulate

Serum Vitamin D and Cingulate Cortex Thickness in Older Adults: Quantitative MRI of the Brain

2019 ◽  
Vol 16 (11) ◽  
pp. 1063-1071 ◽  
Author(s):  
Gonzague Foucault ◽  
Guillaume T Duval ◽  
Romain Simon ◽  
Olivier Beauchet ◽  
Mickael Dinomais ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Brain Mri ◽  
Serum Vitamin ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Vitamin D Insufficiency ◽  
Anterior Cingulate ◽  
Posterior Cingulate ◽  
Significant Difference

Background: Vitamin D insufficiency is associated with brain changes, and cognitive and mobility declines in older adults. Method: Two hundred and fifteen Caucasian older community-dwellers (mean±SD, 72.1±5.5years; 40% female) received a blood test and brain MRI. The thickness of perigenual anterior cingulate cortex, midcingulate cortex and posterior cingulate cortex was measured using FreeSurfer from T1-weighted MR images. Age, gender, education, BMI, mean arterial pressure, comorbidities, use of vitamin D supplements or anti-vascular drugs, MMSE, GDS, IADL, serum calcium and vitamin B9 concentrations, creatinine clearance were used as covariables. Results: Participants with vitamin D insufficiency (n=80) had thinner total cingulate thickness than the others (24.6±1.9mm versus 25.3±1.4mm, P=0.001); a significant difference found for all 3 regions. Vitamin D insufficiency was cross-sectionally associated with a decreased total cingulate thickness (β=- 0.49, P=0.028). Serum 25OHD concentration correlated positively with the thickness of perigenual anterior (P=0.011), midcingulate (P=0.013) and posterior cingulate cortex (P=0.021). Conclusion: Vitamin D insufficiency was associated with thinner cingulate cortex in the studied sample of older adults. These findings provide insight into the pathophysiology of cognitive and mobility declines in older adults with vitamin D insufficiency.

scholarly journals Long-term Chinese calligraphic handwriting reshapes the posterior cingulate cortex: A VBM study

PLoS ONE ◽  
2019 ◽  
Vol 14 (4) ◽  
pp. e0214917
Author(s):  
Wen Chen ◽  
Chuansheng Chen ◽  
Pin Yang ◽  
Suyu Bi ◽  
Jin Liu ◽  
...  
Keyword(s):  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Posterior Cingulate

scholarly journals HIV Distal Neuropathic Pain Is Associated with Smaller Ventral Posterior Cingulate Cortex

Pain Medicine ◽  
2016 ◽  
pp. pnw180 ◽  
Author(s):  
John R. Keltner ◽  
Colm G. Connolly ◽  
Florin Vaida ◽  
Mark Jenkinson ◽  
Christine Fennema-Notestine ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Posterior Cingulate

scholarly journals Correlation between Traits of Emotion-Based Impulsivity and Intrinsic Default-Mode Network Activity

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Jizheng Zhao ◽  
Dardo Tomasi ◽  
Corinde E. Wiers ◽  
Ehsan Shokri-Kojori ◽  
Şükrü B. Demiral ◽  
...  
Keyword(s):  
Brain Activity ◽  
Low Frequency ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Anterior Cingulate ◽  
Network Activity ◽  
High Risk Behaviors ◽  
Posterior Cingulate ◽  
Healthy Humans ◽  
Dorsolateral Prefrontal

Negative urgency (NU) and positive urgency (PU) are implicated in several high-risk behaviors, such as eating disorders, substance use disorders, and nonsuicidal self-injury behavior. The current study aimed to explore the possible link between trait of urgency and brain activity at rest. We assessed the amplitude of low-frequency fluctuations (ALFF) of the resting-state functional magnetic resonance imaging (fMRI) signal in 85 healthy volunteers. Trait urgency measures were related to ALFF in the lateral orbitofrontal cortex, dorsolateral prefrontal cortex, ventral and dorsal medial frontal cortex, anterior cingulate, and posterior cingulate cortex/precuneus. In addition, trait urgency measures showed significant correlations with the functional connectivity of the posterior cingulate cortex/precuneus seed with the thalamus and midbrain region. These findings suggest an association between intrinsic brain activity and impulsive behaviors in healthy humans.

Quantitative cytoarchitectonics of the posterior cingulate cortex in primates

1986 ◽  
Vol 253 (4) ◽  
pp. 514-524 ◽  
Author(s):  
Karl Zilles ◽  
Este Armstrong ◽  
Gottfried Schlaug ◽  
Axel Schleicher
Keyword(s):  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Posterior Cingulate ◽  
Quantitative Cytoarchitectonics
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