Synaptic Enhancement Induced Through Callosal Pathways in Cat Association Cortex

2004 ◽  
Vol 92 (6) ◽  
pp. 3221-3232 ◽  
Author(s):  
Youssouf Cissé ◽  
Sylvain Crochet ◽  
Igor Timofeev ◽  
Mircea Steriade

The corpus callosum plays a major role in synchronizing neocortical activities in the two hemispheres. We investigated the changes in callosally elicited excitatory postsynaptic potentials (EPSPs) of neurons from cortical association areas 5 and 7 of cats under barbiturate or ketamine-xylazine anesthesia. Single pulses to callosal pathway evoked control EPSPs; pulse-trains were subsequently applied at different frequencies to homotopic sites in the contralateral cortex, as conditioning stimulation; thereafter, the single pulses were applied again to test changes in synaptic responsiveness by comparing the amplitudes of control and conditioned EPSPs. In 41 of 42 neurons recorded under barbiturate anesthesia, all frequencies of conditioning callosal stimuli induced short-term (5–30 min) enhancement of test EPSPs elicited by single stimuli. Neurons tested with successive conditioning pulse-trains at different frequencies displayed stronger enhancement with high-frequency (40–100 Hz) than with low-frequency (10–20 Hz) rhythmic pulse-trains; >100 Hz, the potentiation saturated. In a neuronal sample, microdialysis of an N-methyl-d-aspartate (NMDA) receptor blocker in barbiturate-treated cats suppressed this potentiation, and potentiation of callosally evoked EPSPs was not detected in neurons recorded under ketamine-xylazine anesthesia, thus indicating that EPSPs' potentiation implicates, at least partially, NMDA receptors. These data suggest that callosal activities occurring within low-frequency and fast-frequency oscillations play a role in cortical synaptic plasticity.

2021 ◽  
Vol 9 (6) ◽  
pp. 651
Author(s):  
Yan Yan ◽  
Hongyan Xing

In order for the detection ability of floating small targets in sea clutter to be improved, on the basis of the complete ensemble empirical mode decomposition (CEEMD) algorithm, the high-frequency parts and low-frequency parts are determined by the energy proportion of the intrinsic mode function (IMF); the high-frequency part is denoised by wavelet packet transform (WPT), whereas the denoised high-frequency IMFs and low-frequency IMFs reconstruct the pure sea clutter signal together. According to the chaotic characteristics of sea clutter, we proposed an adaptive training timesteps strategy. The training timesteps of network were determined by the width of embedded window, and the chaotic long short-term memory network detection was designed. The sea clutter signals after denoising were predicted by chaotic long short-term memory (LSTM) network, and small target signals were detected from the prediction errors. The experimental results showed that the CEEMD-WPT algorithm was consistent with the target distribution characteristics of sea clutter, and the denoising performance was improved by 33.6% on average. The proposed chaotic long- and short-term memory network, which determines the training step length according to the width of embedded window, is a new detection method that can accurately detect small targets submerged in the background of sea clutter.


Author(s):  
Yunxuan Li ◽  
Jian Lu ◽  
Lin Zhang ◽  
Yi Zhao

The Didi Dache app is China’s biggest taxi booking mobile app and is popular in cities. Unsurprisingly, short-term traffic demand forecasting is critical to enabling Didi Dache to maximize use by drivers and ensure that riders can always find a car whenever and wherever they may need a ride. In this paper, a short-term traffic demand forecasting model, Wave SVM, is proposed. It combines the complementary advantages of Daubechies5 wavelets analysis and least squares support vector machine (LS-SVM) models while it overcomes their respective shortcomings. This method includes four stages: in the first stage, original data are preprocessed; in the second stage, these data are decomposed into high-frequency and low-frequency series by wavelet; in the third stage, the prediction stage, the LS-SVM method is applied to train and predict the corresponding high-frequency and low-frequency series; in the last stage, the diverse predicted sequences are reconstructed by wavelet. The real taxi-hailing orders data are applied to evaluate the model’s performance and practicality, and the results are encouraging. The Wave SVM model, compared with the prediction error of state-of-the-art models, not only has the best prediction performance but also appears to be the most capable of capturing the nonstationary characteristics of the short-term traffic dynamic systems.


Author(s):  
Nick Perham ◽  
Toni Howell ◽  
Andy Watt

AbstractFunding to support students with dyslexia in post-compulsory education is under pressure and more efficient assessments may offset some of this shortfall. We tested potential tasks for screening dyslexia: recall of adjective-noun, compared to noun-adjective, pairings (syntax) and recall of high versus low frequency letter pairings (bigrams). Students who reported themselves as dyslexic failed to show a normal syntax effect (greater recall of adjective-noun compared to noun-adjective pairings) and no significant difference in recall between the two types of bigrams whereas students who were not dyslexic showed the syntax effect and a bias towards recalling high frequency bigrams. Findings are consistent with recent explanations of dyslexia suggesting that those affected find it difficult to learn and utilise sequential long-term order information (Szmalec et al. Journal of Experimental Psychology: Learning, Memory & Cognition, 37(5) ,1270-1279, 2011). Further, ROC curve analyses revealed both tasks showed acceptable diagnostic properties as they were able to discriminate between the two groups of participants.


2017 ◽  
Vol 63 (No. 3) ◽  
pp. 136-148 ◽  
Author(s):  
Xiong Tao ◽  
Li Chongguang ◽  
Bao Yukun

Short-term forecasting of hog price, which forms the basis for the decision making, is challenging and of great interest for hog producers and market participants. This study develops improved ensemble empirical mode decomposition (EEMD)-based hybrid approach for the short-term hog price forecasting. Specifically, the EEMD is first used to decompose the original hog price series into several intrinsic-mode functions (IMF) and one residue. The fine-to-coarse reconstruction algorithm is then applied to compose the obtained IMFs and residue into the high-frequency fluctuation, the low-frequency fluctuation, and the trend terms which can highlight new features of the hog price fluctuations. Afterwards, the extreme learning machine (ELM) is employed to model the low-frequency fluctuation, while the autoregressive integrated moving average (ARIMA) and the polynomial function are used to fit the high-frequency fluctuation and trend term, respectively, in a multistep-ahead fashion. The commonly used iterated prediction strategy is adopted for the implementation of the multistep-ahead forecasting. The monthly hog price series from January 2000 to May 2015 in China is employed to evaluate the forecasting performance of the proposed approach with the selected counterparts. The numerical results indicate that the improved EEMD-based hybrid approach is a promising alternative for the short-term hog price forecasting.  


2003 ◽  
Vol 15 (01) ◽  
pp. 8-16
Author(s):  
CHANG-WEI HSIEH ◽  
CHI-WU MAO ◽  
MING-SHING YOUNG ◽  
TZUNG-LIEH YEH

A new pulse spectrum method of assessing autonomic function was examined in a pharmacological experiment on eight healthy volunteers. The pulse pressure data is obtained under control condition and in parasympathetic blocked by atropine. Compared with the spectral method of heart rate variability (HRV), which is wide-spreading in laboratory studies and clinical diagnosis nowadays, the method of pulsation spectrum provides a new and direct view to assess parasympathetic control. As can be seen from the results, the high frequency of pulsation harmonics are reduced by the parasympathetic blocked, and on the contrary, low frequency component increased. By the analysis of linear regression, the pulsation spectrum method indicates more correlations with atropine doses. We anticipate that the non-invasive assessment of short-term autonomic function will come to be performed more reliably and conveniently by using this method.


2017 ◽  
Vol 122 (1) ◽  
pp. 48-59 ◽  
Author(s):  
Casper Skovgaard ◽  
Nicki Winfield Almquist ◽  
Jens Bangsbo

The aim of the study was, in runners accustomed to speed endurance training (SET), to examine the effect of increased and maintained frequency of SET on performance and muscular adaptations. After familiarization (FAM) to SET, 18 male ( n = 14) and female ( n = 4) runners (V̇o2max: 57.3 ± 3.4 ml/min; means ± SD) completed 20 sessions of maintained low-frequency (LF; every fourth day; n = 7) or high-frequency (HF; every second day; n = 11) SET. Before FAM as well as before and after an intervention period (INT), subjects completed a series of running tests and a biopsy from m. vastus lateralis was collected. Ten-kilometer performance improved ( P < 0.05) ~3.5% during FAM with no further change during INT. Time to exhaustion at 90% vV̇o2max was 15 and 22% longer ( P < 0.05) during FAM and a further 12 and 16% longer ( P < 0.05) during INT in HF and LF, respectively. During FAM, muscle expression of NHE1 and maximal activity of citrate synthase (CS) and phosphofructokinase (PFK) increased ( P < 0.05), running economy (RE) improved ( P < 0.05), and V̇o2max was unchanged. During INT, both HF and LF increased ( P < 0.05) muscle expression of NKAβ1, whereas maximal activity of CS and PFK, RE, and V̇o2max were unchanged. Furthermore, during INT, muscle expression of FXYD1 and SERCA1, and FXYD1 activity increased ( P < 0.05) in HF, while muscle expression of SERCA2 decreased ( P < 0.05) in LF. Thus increased or maintained frequency of SET leads to further improvements in short-term exercise capacity, but not in 10-km running performance. The better short-term exercise capacity may be associated with elevated expression of muscle proteins related to Na+/K+ transportation and Ca2+ reuptake. NEW & NOTEWORTHY Ten speed endurance training (SET) sessions improved short-term exercise capacity and 10-km performance, which was followed by further improved short-term exercise capacity, but unchanged 10-km performance after 20 SET sessions performed with either high frequency (4 per 8 days) or continued low frequency (2 per 8 days) in trained runners. The further gain in short-term exercise capacity was associated with changes in muscle expression of proteins of importance for the development of fatigue.


1966 ◽  
Vol 18 (1) ◽  
pp. 31-38 ◽  
Author(s):  
W. A. Matthews

Two experiments on the short-term free recall of 12-word associated and non-associated lists are reported. Degree of association (derived from norms obtained by continuous controlled association) and word frequency were varied. Significant facilitation as a result of the associative manipulations was obtained and clustering of the responses was positively related to this. Clustering was also affected by the method of presentation of the associated words; this occurred more often when they were grouped in presentation than when they were presented randomly arranged among other words in the list. Low frequency associated word lists were generally found to be more efficiently recalled than those of comparable association values but consisting of high frequency words.


2004 ◽  
Vol 92 (6) ◽  
pp. 3332-3337 ◽  
Author(s):  
Jens Ellrich

Long-term depression (LTD) of somatosensory processing has been demonstrated in slice preparations of the spinal dorsal horn. Although LTD could be reliably induced in vitro, inconsistent results were encountered when the same types of experiments were conducted in adult animals in vivo. We addressed the hypothesis that LTD of orofacial sensorimotor processing can be induced in mice under general anesthesia. The effects of electric low- and high-frequency conditioning stimulation of the tongue on the sensorimotor jaw-opening reflex (JOR) elicited by electric tongue stimulation were investigated. Low-frequency stimulation induced a sustained decrease of the reflex integral for ≥1 h after the end of conditioning stimulation. After additional high-frequency stimulation, the reflex partly recovered from LTD. High-frequency stimulation alone induced a transient increase of the JOR integral for <10 min. The LTD of the sensorimotor jaw-opening reflex in anesthetized mice may be an appropriate model to investigate the central mechanisms and the pharmacology of synaptic plasticity in the orofacial region. The application of electrophysiological techniques in mice provides the opportunity to include adequate knock-out models to elucidate the neurobiology of LTD.


Author(s):  
Dinghui Wu ◽  
Haibo Huang ◽  
Ren Xiao ◽  
Cong Gao

Short-term wind power forecasting plays an important role in power generation, because it prevents the power system operation from its uncertain and intermittent nature. This article proposes a novel method for short-term wind power forecasting, which combines the wavelet transform, particle swarm optimization dynamic gray model and Lyapunov exponent prediction method. First, the approach decomposes the wind power curve into the high-frequency and low-frequency curves by wavelet transform, which represent the detail and tendency signals, respectively. Then, we use the proposed particle swarm optimization dynamic gray model to forecast the low-frequency curve with its smooth and periodic outline. Moreover, Lyapunov exponent prediction method is used to predict high-frequency curves, which possess the chaos characteristics. Finally, we obtain the wind power forecasting result from the combination of the predicted low and high frequencies. The experiment of four seasons in an US wind farm validates that the proposed method is effective in solving the short-term wind power forecasting problem. The obtained results, discussed comprehensively, show that the hybrid method has better prediction accuracy than the other methods, such as artificial neural network, persistence, and autoregressive integrated moving average model, with the lowest average mean absolute percentage error is 8.07% and the average root mean square error is 0.8164 over four seasons.


2003 ◽  
Vol 284 (6) ◽  
pp. G956-G962 ◽  
Author(s):  
Jinhong Xing ◽  
Frederick Brody ◽  
Michael Rosen ◽  
J. D. Z. Chen ◽  
Edy Soffer

This study determined the most efficient parameters of low-frequency/long-pulse gastric electrical stimulation (GES) required to entrain gastric slow waves and also evaluated the effect of entrainment and high-frequency, short-pulse GES on gastric electrical activity (GEA). Nine dogs were fitted with stimulation wires along the greater curvature. Entrainment was observed in six or seven animals, with long-pulse GES at six cycles per minute (cpm), at various combinations of current and pulse width and was directly related to the energy delivered. Entrainment was observed in four to seven animals, with GES at 12 cpm, and the maximal driven frequency was 6 cpm. Entrainment did not significantly increase the dominant power of GEA. High-frequency, short-pulse GES, using pulse trains of 14 Hz, 5 mA, and 330 μs, with 0.1 s on and 5 s off, and pulse trains of 40 Hz, 10 mA, and 330 μs, with 2 s on 3 s off, did not affect variables of GEA. We conclude that acute low-frequency GES but not high-frequency, short-pulse GES can entrain slow waves; the power of slow waves is not affected by either type of stimulation.


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