scholarly journals Variations in the TNF-α Gene (TNF-α -308G→A) Affect Attention and Action Selection Mechanisms in a Dissociated Fashion

2010 ◽  
Vol 104 (5) ◽  
pp. 2523-2531 ◽  
Author(s):  
Christian Beste ◽  
Bernhard T. Baune ◽  
Michael Falkenstein ◽  
Carsten Konrad
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Cognitive Functions ◽  
Action Selection ◽  
Event Related Potential ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Genotype Group ◽  
Brain Functions ◽  
Specific Effects ◽  
Tnf Α

There is growing interest to understand the molecular basis of complex cognitive processes. While neurotransmitter systems have frequently been examined, other, for example neuroimmunological factors have attracted much less interest. Recent evidence suggests that the A allele of the tumor necrosis factor alpha (TNF-α) 308G→A single nucleotide polymorphism (SNP; rs1800629) enhances cognitive functions. However, it is also known that TNF-α exerts divergent, region-specific effects on neuronal functioning. Thus the finding that the A allele is associated with enhanced cognitive performance may be due to regionally specific effects of TNF-α. In this study, associations between the TNF-α −308G→A single nucleotide polymorphism (rs1800629) and cognitive function in an event-related potential (ERP) study in healthy participants ( n = 96) are investigated. We focus on subprocesses of stimulus-response compatibility that are known to be mediated by different brain systems. The results show a dissociative effect of the TNF- 308G→A SNP on ERPs reflecting attentional (N1) versus conflict and action selection processes [N2 and early-lateralized readiness potential (e-LRP)] between the AA/AG and the GG genotypes. Compared with the GG genotype group, attentional processes (N1) were enhanced in the combined AA/AG genotype group, while conflict processing functions (N2) and the selection of actions (LRP) were reduced. The results refine the picture of the effects of the TNF-α −308G→A SNP on cognitive functions and emphasize the known divergent effects of TNF-α on brain functions.

The TNF-α-238G > A single-nucleotide polymorphism protects against memory decline in older adults with Type 2 diabetes.

2007 ◽  
Vol 121 (3) ◽  
pp. 619-624 ◽  
Author(s):  
Michael H. Chui ◽  
Yanni Papanikolaou ◽  
Bénédicte Fontaine-Bisson ◽  
Josée Turcotte ◽  
Thomas M. S. Wolever ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Older Adults ◽  
Single Nucleotide Polymorphism ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Memory Decline ◽  
Tnf Α

scholarly journals Single Nucleotide Polymorphism of Spp2 Confers Sex-Specific Effects on Blood Pressure and Bone Health

Hypertension ◽  
2020 ◽  
Vol 76 (4) ◽  
Author(s):  
Saroj Chakraborty ◽  
Blair Mell ◽  
Ying Nie ◽  
Xi Cheng ◽  
Sarah Galla ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Single Nucleotide Polymorphism ◽  
Bone Health ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Specific Effects

scholarly journals IDENTIFICATION OF -308 TNF-α PROMOTER SINGLE NUCLEOTIDE POLYMORPHISM IN ACTIVE AND PASSIVE SMOKERS

2019 ◽  
Vol 19 (1) ◽  
pp. 28
Author(s):  
Gracia A.V. Pollo ◽  
Rooije R.H. Rumende ◽  
Trina E. Tallei
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Promoter Region ◽  
Chronic Obstructive ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Obstructive Pulmonary Disease ◽  
Tnf Α ◽  
Factor Α ◽  
Clustal Omega ◽  
Necrosis Factor

IDENTIFICATION OF -308 TNF-α PROMOTER SINGLE NUCLEOTIDE POLYMORPHISM IN ACTIVE AND PASSIVE SMOKERS ABSTRACTTumour necrosis factor-α (TNF-α) is one of the pro-inflammatory cytokines that play a role in the inflammatory process, immune system development, and apoptosis. This protein is encoded by the TNF-α gene. Several studies had linked the presence of polymorphisms in the TNF-α promoter region with susceptibility to the onset of chronic obstructive pulmonary disease (COPD) in active and passive smokers. This study aimed to identify and analyze the nucleotide polymorphism in TNF-α gene promoter regions in active and passive smokers in Manado. The method used in this study included blood sampling, DNA extraction, amplification of -308 TNF-α promoter region, sequencing and data analysis. The softwares used for data analysis were Geneious, Multalin, Clustal Omega and DnaSP. DnaSP was used to compute the level of polymorphism based on haplotype statistics. The results did not show single nucleotide polymorphism at position -308 in TNF-α gene promoters in active and passive smokers. This was because at that position, the nucleotides were both in the form of guanosine monophosphate and there were no mutation caused by cigarette smoke exposure.Keywords: active smoker, passive smoker, single nucleotide polymorphism, TNF-α promoter DETEKSI POLIMORFISME NUKLEOTIDA TUNGGAL-308 PROMOTERTNF-α PADA PEROKOK AKTIF DAN PASIF ABSTRAKTumor necrosis factor-α (TNF-α) merupakan salah satu sitokin pro-inflamasi yang berperan dalam proses inflamasi, perkembangan sistem imun, dan apoptosis. Protein ini dikode oleh gen TNF-α. Beberapa penelitian telah mengkaitkan adanya polimorfisme pada daerah promoter TNF-α dengan kerentanan terhadap timbulnya chronic obstructive pulmonary disease (COPD) pada perokok aktif maupun pasif. Penelitian ini bertujuan untuk mengidentifikasi dan menganalisis polimorfisme nukleotida tunggal pada posisi -308 dari promoter gen TNF-α perokok aktif dan pasif. Metode yang digunakan dalam penelitian ini meliputi pengambilan sampel darah, ekstraksi DNA, amplifikasi daerah -308 promoter gen TNF-α, sekuensing serta analisis data. Analisis data menggunakan perangkat lunak Geneious, BLAST, Multalin, Clustal Omega dan DnaSP. Perangkat DnaSP akan mengkomputasi tingkat polimorfisme berdasarkan statistik haplotype-based. Hasil yang didapatkan menunjukkan bahwa polimorfisme nukleotida tunggal pada posisi -308 dari promoter gen TNF-α antara perokok aktif dan pasif tidak ditemukan. Hal ini dikarenakan oleh pada posisi tersebut, nukleotidanya sama-sama berbentuk guanosin monofosfat dan tidak terjadi mutasi akibat pengaruh paparan asap rokok.Kata kunci: perokok aktif, perokok pasif, single nucleotide polymorphism, TNF-α promoter

Genetic susceptibility to postherniotomy pain. The influence of polymorphisms in the Mu opioid receptor, TNF-α, GRIK3, GCH1, BDNF and CACNA2D2 genes

2016 ◽  
Vol 12 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Maija-Liisa Kalliomäki ◽  
Gabriel Sandblom ◽  
Mathias Hallberg ◽  
Alfhild Grönbladh ◽  
Ulf Gunnarsson ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Opioid Receptor ◽  
Groin Hernia ◽  
Genetic Variance ◽  
Mu Opioid Receptor ◽  
Specific Gene ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Mu Opioid ◽  
Tnf Α

AbstractBackground and aimsDespite improvements in surgical technique, 5%-8% of patients undergoing herniorrhaphy still suffer from clinically relevant persistent postherniotomy pain. This is a problem at both individual and society levels. The aim of this study was to determine whether or not a single nucleotide polymorphism in a specific gene contributes to the development of persistent pain after surgery.MethodsOne hundred individuals with persistent postherniotomy pain, along with 100 without pain matched for age, gender and type of surgery were identified in a previous cohort study on patients operated for groin hernia. All patients underwent a thorough sensory examination and blood samples were collected. DNA was extracted and analysed for single nucleotide polymorphism in the Mu opioid receptor, TNF-α, GRIK3, GCH1, BDNF and CACNA2D2 genes.ResultsPatients with neuropathic pain were found to have a homozygous single nucleotide polymorph in the TNF-α gene significantly more often than pain-free patients (P =0.036, one-tailed test). ConclusionsSNP in the TNF-α gene has a significant impact on the risk for developing PPSP.ImplicationsThe result suggests the involvement of genetic variance in the development of pain and this requires further investigation.

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