scholarly journals Single Nucleotide Polymorphism of Spp2 Confers Sex-Specific Effects on Blood Pressure and Bone Health

Hypertension ◽  
2020 ◽  
Vol 76 (4) ◽  
Author(s):  
Saroj Chakraborty ◽  
Blair Mell ◽  
Ying Nie ◽  
Xi Cheng ◽  
Sarah Galla ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Single Nucleotide Polymorphism ◽  
Bone Health ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Specific Effects

scholarly journals Variations in the TNF-α Gene (TNF-α -308G→A) Affect Attention and Action Selection Mechanisms in a Dissociated Fashion

2010 ◽  
Vol 104 (5) ◽  
pp. 2523-2531 ◽  
Author(s):  
Christian Beste ◽  
Bernhard T. Baune ◽  
Michael Falkenstein ◽  
Carsten Konrad
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Cognitive Functions ◽  
Action Selection ◽  
Event Related Potential ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Genotype Group ◽  
Brain Functions ◽  
Specific Effects ◽  
Tnf Α

There is growing interest to understand the molecular basis of complex cognitive processes. While neurotransmitter systems have frequently been examined, other, for example neuroimmunological factors have attracted much less interest. Recent evidence suggests that the A allele of the tumor necrosis factor alpha (TNF-α) 308G→A single nucleotide polymorphism (SNP; rs1800629) enhances cognitive functions. However, it is also known that TNF-α exerts divergent, region-specific effects on neuronal functioning. Thus the finding that the A allele is associated with enhanced cognitive performance may be due to regionally specific effects of TNF-α. In this study, associations between the TNF-α −308G→A single nucleotide polymorphism (rs1800629) and cognitive function in an event-related potential (ERP) study in healthy participants ( n = 96) are investigated. We focus on subprocesses of stimulus-response compatibility that are known to be mediated by different brain systems. The results show a dissociative effect of the TNF- 308G→A SNP on ERPs reflecting attentional (N1) versus conflict and action selection processes [N2 and early-lateralized readiness potential (e-LRP)] between the AA/AG and the GG genotypes. Compared with the GG genotype group, attentional processes (N1) were enhanced in the combined AA/AG genotype group, while conflict processing functions (N2) and the selection of actions (LRP) were reduced. The results refine the picture of the effects of the TNF-α −308G→A SNP on cognitive functions and emphasize the known divergent effects of TNF-α on brain functions.

scholarly journals A Single Nucleotide Polymorphism in the CYP4F2 but not CYP4A11 Gene Is Associated With Increased 20-HETE Excretion and Blood Pressure

Hypertension ◽  
2008 ◽  
Vol 51 (5) ◽  
pp. 1393-1398 ◽  
Author(s):  
Natalie C. Ward ◽  
I-Jung Tsai ◽  
Anne Barden ◽  
Frank M. van Bockxmeer ◽  
Ian B. Puddey ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Single Nucleotide Polymorphism ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

scholarly journals Association of a single nucleotide polymorphism of RANK gene with blood pressure in Spanish women

Medicine ◽  
2020 ◽  
Vol 99 (40) ◽  
pp. e22436
Author(s):  
Clara Pertusa ◽  
Juan J. Tarín ◽  
Antonio Cano ◽  
Miguel Angel García-Pérez
Keyword(s):  
Blood Pressure ◽  
Single Nucleotide Polymorphism ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Spanish Women ◽  
Rank Gene

scholarly journals Frequencies of CYP1A2 Single Nucleotide Polymorphism in Indonesian and Its Effect on Blood Pressure

2018 ◽  
Vol 10 (3) ◽  
pp. 297-302
Author(s):  
Erizal Sugiono ◽  
Andi Wijaya ◽  
Anwar Santoso ◽  
Ferry Sandra ◽  
Ilham Jaya Patellongi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Single Nucleotide Polymorphism ◽  
High Performance ◽  
Enzyme Polymorphism ◽  
Interindividual Variation ◽  
Nucleotide Polymorphisms ◽  
Nucleotide Polymorphism ◽  
Cross Sectional ◽  
Single Nucleotide ◽  
Coffee Drinking

BACKGROUND:  The association between caffeine with blood pressure (BP) still remains controversial. Caffeine is mainly metabolized by cytochrome-P450 (CYP)1A2 enzyme. Polymorphism of CYP1A2 is known to cause interindividual variation on enzymatic activity, thus affects caffeine metabolism and its effect on cardiovascular (CV) system.METHODS: We conducted a cross-sectional study and recruited 121 Indonesian subjects aged 25-60 years with varying coffee-drinking habits. DNA was extracted from peripheral blood and genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCRRFLP) technique. Blood pressures were measured in the morning prior to the daily activity. Caffeine concentration in blood plasma was measured using high-performance liquid chromatography (HPLC). The differences between variables were analyzed using MannWhitney analysis and the correlations among variables were determined using multivariate logistic regression analysis.RESULTS: This study showed that the frequencies of single nucleotide polymorphisms (SNPs) among Indonesian were 31.8%, 18.2%, 25.2% and 24.8% respectively for CYP1A2*1A, CYP1A2*1B, CYP1A2*1C and CYP1A2*1F alleles. The genotype analysis showed that the subject number of the wild type (*1A/*1A) and the variants were 9.92% and 90.08%. There were no significant differences in term of BP levels among CYP1A2 genotypes and coffee drinking habit groups.CONCLUSIONS: The frequencies of CYP1A2 SNPs in Indonesian are different with frequencies in other populations. Since the association were not statistically significant, CYP1A2 polymorphisms as the predictor of elevated blood pressuare should be investigated further.KEYWORDS: coffee, caffeine, blood pressure, single nucleotide polymorphism, CYP1A2

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