Subthreshold Resonance Explains the Frequency-Dependent Integration of Periodic as Well as Random Stimuli in the Entorhinal Cortex

2004 ◽  
Vol 92 (1) ◽  
pp. 408-415 ◽  
Author(s):  
Susanne Schreiber ◽  
Irina Erchova ◽  
Uwe Heinemann ◽  
Andreas V. M. Herz

Neurons integrate subthreshold inputs in a frequency-dependent manner. For sinusoidal stimuli, response amplitudes thus vary with stimulus frequency. Neurons in entorhinal cortex show two types of such resonance behavior: stellate cells in layer II exhibit a prominent peak in the resonance profile at stimulus frequencies of 5–16 Hz. Pyramidal cells in layer III show only a small impedance peak at low frequencies (1–5 Hz) or a maximum at 0 Hz followed by a monotonic decrease of the impedance. Whether the specific frequency selectivity for periodic stimuli also governs the integration of non-periodic stimuli has been questioned recently. Using frozen-noise stimuli with different distributions of power over frequencies, we provide experimental evidence that the integration of non-periodic subthreshold stimuli is determined by the same subthreshold frequency selectivity as that of periodic stimuli. Differences between the integration of noise stimuli in stellate and pyramidal cells can be fully explained by the resonance properties of each cell type. Response power thus reflects stimulus power in a frequency-selective way. Theoretical predictions based on linear system's theory as well as on conductance-based model neurons support this finding. We also show that the frequency selectivity in the subthreshold range extends to suprathreshold responses in terms of firing rate. Cells in entorhinal cortex are representative examples of cells with resonant or low-pass filter impedance profiles. It is therefore likely that neurons with similar frequency selectivity will process input signals according to the same simple principles.

2015 ◽  
Vol 137 (3) ◽  
Author(s):  
Zamir A. Zulkefli ◽  
Maurice L. Adams

A proposed solution to reducing gear mesh-frequency vibrations in a gear-set involves the utilization of hydrostatic bearings placed in series, load wise, with the main support bearing. The hydrostatic bearings are expected to utilize its low pass filtering effect of the vibrational energies to prevent its transmission from the shaft to the gear housing where it would be emitted as noise. The present investigation examines the frequency response of a single-recess circular hydrostatic bearing under applied sinusoidal loads. The results show that as the driving frequency increases, the filtering effect of the hydrostatic bearing increases. The exhibited behavior is similar to the behavior of a low pass filter: negligible filtering effect at low frequencies, the filtering effect increasing from 0% to 90% over the midfrequencies range and the filtering effect remaining at the maximum value as the frequencies of the applied signals continue to increase. This observed behavior is expected to play a central role in the proposed gear mesh-frequency vibration mitigation system.


Perception ◽  
1997 ◽  
Vol 26 (1_suppl) ◽  
pp. 327-327 ◽  
Author(s):  
A N Raninen ◽  
J Rovamo

We determined DeLange curves with and without external temporal noise at eccentricities of 0 – 70 deg by measuring flicker sensitivity at 1 – 45 Hz for sharp-edged M-scaled spots with an equiluminous surround. Without noise, flicker sensitivity at high frequencies increased with eccentricity but remained unchanged at low frequencies. In strong noise, flicker sensitivity was independent of eccentricity. The only exception was 70 deg where sensitivity was reduced at 1 – 3 Hz with and without noise. The data at each eccentricity are well described by our flicker-sensitivity model (Rovamo et al, 1996 Vision Research36 3767 – 3774) comprising (i) low-pass filtering by the modulation transfer function (MTF) of the retina, (ii) filtering in direct proportion to temporal frequency by the high-pass MTF of the retina and subsequent neural visual pathways, (iii) addition of white internal neural noise, and (iv) detection by a temporal matched filter. When interpreted in the context of the model, our results mean that while the high-pass filter and the magnitude of internal noise remained unchanged across eccentricities, the bandwith of the low-pass filter increased with eccentricity and at 70 deg eccentricity the efficiency of the detecting mechanism in the brain was reduced at 1 – 3 Hz. The increase in the bandwidth of the low-pass filter is in agreement with the eccentricity-dependent changes in the retinal function as revealed by the electroretinogram (ERG).


2019 ◽  
Author(s):  
Marion S. Mercier ◽  
Vincent Magloire ◽  
Jonathan Cornford ◽  
Dimitri M. Kullmann

AbstractHippocampal interneurons located within stratum lacunosum-moleculare (SLM), which include neurogliaform (NGF) cells, mediate powerful feed-forward inhibition that can modulate spiking and plasticity in CA1 pyramidal cells. Despite evidence of long-term plasticity at excitatory inputs onto almost all other hippocampal interneuron subtypes, including stratum radiatum feed-forward interneurons, it is not known whether long-term potentiation (LTP) occurs in CA1 SLM interneurons. Here, we show that these interneurons exhibit Hebbian NMDA receptor-dependent LTP, and that Ca2+ influx through voltage-gated Ca2+ channels can also be sufficient for induction of plasticity. Furthermore, using an optogenetic dissection strategy, we find that selective stimulation of excitatory fibers from entorhinal cortex can induce LTP in SLM interneurons, whilst stimulation of thalamic afferents from the nucleus reuniens, also known to project to SLM, does not. Finally, we show that a mouse line selective for cortical NGF cells, where Cre recombinase is under the control of the neuron-derived neurotrophic factor (NDNF) promoter, can also be used to target these interneurons within the hippocampus, and that hippocampal NGF cells exhibit LTP. Recruitment of NGF cells can thus be persistently enhanced in an activity-dependent manner, implying that their role in gating dendritic signaling in pyramidal neurons is modifiable.Significance statementLong-term potentiation (LTP) of synaptic transmission within the hippocampus is involved in memory formation and spatial navigation. While LTP has been extensively studied in excitatory principal cells, less is known about plasticity mechanisms in inhibitory interneurons, which represent a diverse population of cells. Here we characterize LTP in interneurons that mediate powerful feed-forward inhibition of pyramidal neuron distal dendrites, and show that this plasticity can be induced by afferents originating in the entorhinal cortex. Importantly, we identify at least a subset of these LTP-expressing interneurons as neurogliaform cells. The results shed light on this relatively understudied sub-type of hippocampal interneurons and show that their recruitment by extrinsic afferents can be modified in a use-dependent manner.


1982 ◽  
Vol 17 (6) ◽  
pp. 1024-1029 ◽  
Author(s):  
D.C. von Grungen ◽  
R. Sigg ◽  
M. Ludwig ◽  
U.W. Brugger ◽  
G.S. Moschytz ◽  
...  

1983 ◽  
Vol 105 (1) ◽  
pp. 297-303 ◽  
Author(s):  
J. C. Montgomery

A method is described of obtaining the relationship between electrical stimulation of the abducens nerve and horizontal eye movement in the dogfish. The stump of the VIth nerve was stimulated intracranially in a fish in which the brain had been removed, but in which the circulation remained intact, and the gills were perfused with sea water. Horizontal rotation of the eye was monitored with an opto-electronic movement detector. Eye rotation was linearly related to stimulus frequency in the 0–20 Hz range, and was maximal at frequencies above 40 Hz. Stimulation of the VIth nerve, with a pulse train whose frequency was modulated sinusoidally between 0 and 20 Hz, produced sinusoidal eye movements. The frequency response of the system approximates a first order low pass filter with a characteristic frequency of 0.23 Hz, and an additional phase lag equivalent to a time delay of approximately 50 ms.


2021 ◽  
Author(s):  
Victoria R. Bourne ◽  
C. Dario Cantu Bendeck ◽  
Mark W. Hildyard ◽  
Roger A. Clark ◽  
William Wills

<div> <div> <div> <p>We integrate two topics – seismic characterisation of fractures, and seismic attenuation quantified as the frequency-dependent Seismic Quality Factor Q, Q(f). The former is vital for predicting and monitoring fluid movement and containment in energy-related settings (hydrocarbons; geothermal; CO<sub>2</sub>, hydrogen or compressed air storage; radwaste). Fractures control the fluid flow and structural behaviour of a rock mass, yet their expression in Q is poorly studied and not well understood despite it typically being more sensitive than wavespeeds as a rock physics parameter. The latter is long-recognised, little-studied, and a paradigm shift from frequency-independent Q (‘constant-Q’, a routine signal-processing and image enhancement tool in hydrocarbon exploration), despite theory, laboratory, and field data showing that Q must be frequency dependent due to varying scale-lengths of the physical-mechanical phenomena causing attenuation.</p> <p>We therefore measure Q(f) from the downgoing direct P-wave arrival in a near-offset vertical seismic profile in granite at a former geothermal test site in Cornwall, SW England, where vertical and horizontal fracturing is seen at surface: horizontal fractures are confirmed at depth by well-log data. Sensors were 3-component 15Hz geophones at 15m depth spacing: the source was a single vibrator, linear 8-100Hz up-sweep, 30m offset from the wellhead in the azimuth of well deviation: record length was 1000ms at 1ms sample interval. We analyse only the deeper cased interval, from 700m to 1735m. Pre-processing was geometric spreading correction, hodogram-based component rotation toward the source, and wavefield separation using a 7-point median filter to suppress interference from upgoing energy. Measured attenuation Q<sub>eff</sub> is the harmonic sum of intrinsic Q, Q<sub>int</sub>, and apparent attenuation, Q<sub>app</sub>. Q<sub>int</sub> in massive granite is typically 500-1000, yet we find Q<sub>eff</sub>(f) is 50-70 at >60Hz and only ≈30 at <30-35Hz, features masked in the constant-Q result of 55±11 over our working bandwidth of 25-90Hz.</p> <p>One contribution to Q<sub>app</sub> is ‘stratigraphic attenuation’, forward-scattering interference of short-path internal multiple reflections superimposed on direct arrivals, and quantifiable from sonic and density well-logs using O’Doherty-Anstey-Shapiro methodology. We find it is indeed frequency-dependent (peaking at ≈50-60Hz, 10-40% lower at our bandwidth limits) but its absolute magnitude is insignificant (Q≈20,000-30,000) and unable to explain the measured Q<sub>eff</sub>(f). We therefore investigate the effect of fracturing directly using finite difference models in which fractures are defined explicitly as displacement discontinuities with opposing surfaces connected by a normal and shear stiffness. An individual fracture acts somewhat like a low pass filter: more complex frequency behaviour emerges from multiple fractures, particularly when fracture stiffness, spacing and size can vary. We concentrate first on large horizontal fractures perpendicular to the borehole receiver array, and find that these can indeed influence effective attenuation within the 25-90Hz bandwidth. We then discuss the range of fracture spacings and stiffnesses capable of explaining the data and whether they are sufficiently physically credible as an explanation of the observed Q(f).</p> </div> </div> </div>


2000 ◽  
Vol 41 (4) ◽  
pp. 481-492
Author(s):  
Naohiko Takahashi ◽  
Morio Ito ◽  
Shuji Ishida ◽  
Takao Fujino ◽  
Mikiko Nakagawa ◽  
...  

2017 ◽  
Vol E100.C (10) ◽  
pp. 858-865 ◽  
Author(s):  
Yohei MORISHITA ◽  
Koichi MIZUNO ◽  
Junji SATO ◽  
Koji TAKINAMI ◽  
Kazuaki TAKAHASHI

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