Hindlimb Locomotor and Postural Training Modulates Glycinergic Inhibition in the Spinal Cord of the Adult Spinal Cat

1999 ◽  
Vol 82 (1) ◽  
pp. 359-369 ◽  
Author(s):  
R. D. de Leon ◽  
H. Tamaki ◽  
J. A. Hodgson ◽  
R. R. Roy ◽  
V. R. Edgerton
Keyword(s):  
Spinal Cord ◽  
Weight Bearing ◽  
Activity Patterns ◽  
Motor Task ◽  
Full Weight Bearing ◽  
Electromyographic Activity ◽  
Hindlimb Muscle ◽  
Before And After ◽  
Glycinergic Inhibition ◽  
Locomotor Ability

Adult spinal cats were trained initially to perform either bipedal hindlimb locomotion on a treadmill or full-weight-bearing hindlimb standing. After 12 wk of training, stepping ability was tested before and after the administration (intraperitoneal) of the glycinergic receptor antagonist, strychnine. Spinal cats that were trained to stand after spinalization had poor locomotor ability as reported previously, but strychnine administration induced full-weight-bearing stepping in their hindlimbs within 30–45 min. In the cats that were trained to step after spinalization, full-weight-bearing stepping occurred and was unaffected by strychnine. Each cat then was retrained to perform the other task for 12 wk and locomotor ability was retested. The spinal cats that were trained initially to stand recovered the ability to step after they received 12 wk of treadmill training and strychnine was no longer effective in facilitating their locomotion. Locomotor ability declined in the spinal cats that were retrained to stand and strychnine restored the ability to step to the levels that were acquired after the step-training period. Based on analyses of hindlimb muscle electromyographic activity patterns and kinematic characteristics, strychnine improved the consistency of the stepping and enhanced the execution of hindlimb flexion during full-weight-bearing step cycles in the spinal cats when they were trained to stand but not when they were trained to step. The present findings provide evidence that 1) the neural circuits that generate full-weight-bearing hindlimb stepping are present in the spinal cord of chronic spinal cats that can and cannot step; however, the ability of these circuits to interpret sensory input to drive stepping is mediated at least in part by glycinergic inhibition; and 2) these spinal circuits adapt to the specific motor task imposed, and that these adaptations may include modifications in the glycinergic pathways that provide inhibition.

Retention of Hindlimb Stepping Ability in Adult Spinal Cats After the Cessation of Step Training

1999 ◽  
Vol 81 (1) ◽  
pp. 85-94 ◽  
Author(s):  
R. D. De Leon ◽  
J. A. Hodgson ◽  
R. R. Roy ◽  
V. R. Edgerton
Keyword(s):  
Weight Bearing ◽  
Activity Patterns ◽  
Motor Task ◽  
Full Weight Bearing ◽  
Electromyographic Activity ◽  
Locomotor Training ◽  
Neural Pathways ◽  
Step Cycle ◽  
Rapid Learning ◽  
Hindlimb Muscle

de Leon, R. D., J. A. Hodgson, R. R. Roy, and V. R. Edgerton. Retention of hindlimb stepping ability in adult spinal cats after the cessation of step training. J. Neurophysiol. 81: 85–94, 1999. Adult spinal cats were trained to perform bipedal hindlimb locomotion on a treadmill for 6–12 wk. After each animal acquired the ability to step, locomotor training was withheld, and stepping was reexamined 6 and 12 wk after training ended. The performance characteristics, hindlimb muscle electromyographic activity patterns, and kinematic characteristics of the step cycle that were acquired with training were largely maintained when training was withheld for 6 wk. However, after 12 wk without training, locomotor performance declined, i.e., stumbling was more frequent, and the ability to consistently execute full weight-bearing steps at any treadmill speed decreased. In addition, the height that the paw was lifted during the swing phase decreased, and a smaller range of extension in the hindlimbs occurred during the E3 phase of stance. When three of the spinal cats underwent 1 wk of retraining, stepping ability was regained more rapidly than when trained initially. The finding that stepping ability in trained adult spinal cats can persist for 6 wk without training provides further evidence that training-induced enhancement of stepping is learned in the spinal cats and that a memory of the enhanced stepping is stored in the spinal networks. However, it appears that the spinal cord can forget how to consistently execute stepping if that task is not practiced for 12 wk. The more rapid learning that occurred with retraining is also consistent with a learning phenomenon. These results in conjunction with our earlier findings suggest that the efficacy of the neural pathways that execute a motor task is highly dependent on the periodic activation of those pathways in a sequence compatible with that motor task.

scholarly journals Sports activity participation after curved periacetabular osteotomy for acetabular dysplasia

2020 ◽  
Author(s):  
Yoshiki Takahashi ◽  
Naonobu Takahira ◽  
Katsufumi Uchiyama ◽  
Kensuke Fukushima ◽  
Mitsutoshi Moriya ◽  
...  
Keyword(s):  
Physical Function ◽  
Acetabular Dysplasia ◽  
Periacetabular Osteotomy ◽  
Weight Bearing ◽  
Activity Participation ◽  
Full Weight Bearing ◽  
Sports Activity ◽  
Before And After ◽  
Curved Periacetabular Osteotomy ◽  
Sports Activities

Abstract Background: Curved periacetabular osteotomy (CPO) was developed to treat acetabular dysplasia. Given that CPO can improve physical function in the early post-operative period, patients might be able to participate in sports activities post-operatively. Therefore, this study examined the post-operative sports activity participation and characteristics of acetabular dysplasia patients who have undergone CPO.Methods: A total of 52 patients who underwent CPO for acetabular dysplasia were given a questionnaire on pre- and post-operative sports activities; 43 patients responded. We surveyed patients’ sports activities, satisfaction, and physical function. Patients were divided according to whether they participated in sports activities after CPO. Physical function was compared before and after CPO.Results: The pre- and post-operative sports activity participation rates were 55.8% and 72.1%, respectively. Patients mostly performed low-impact sports activities. Moreover, patients who participated in sports activities post-operatively had smaller pre-operative range of motion of hip flexion and returned to full weight bearing earlier.Conclusions: Among acetabular dysplasia patients who underwent CPO, 72.1% participated in sports activities post-operatively. Post-operatively, patients participated not only in low-impact sports activities, but also in high-impact ones. These findings might be useful for advising patients who are concerned about participating in sports activities after CPO.

scholarly journals Sports activity participation after curved periacetabular osteotomy for acetabular dysplasia

2020 ◽  
Author(s):  
Yoshiki Takahashi ◽  
Naonobu Takahira ◽  
Katsufumi Uchiyama ◽  
Kensuke Fukushima ◽  
Mitsutoshi Moriya ◽  
...  
Keyword(s):  
Physical Function ◽  
Acetabular Dysplasia ◽  
Periacetabular Osteotomy ◽  
Weight Bearing ◽  
Activity Participation ◽  
Full Weight Bearing ◽  
Sports Activity ◽  
Before And After ◽  
Curved Periacetabular Osteotomy ◽  
Sports Activities

Abstract Background: Curved periacetabular osteotomy (CPO) was developed to treat acetabular dysplasia. Given that CPO can improve physical function in the early post-operative period, patients might be able to participate in sports activities post-operatively. Therefore, this study examined the post-operative sports activity participation and characteristics of acetabular dysplasia patients who have undergone CPO.Methods: A total of 52 patients who underwent CPO for acetabular dysplasia were given a questionnaire on pre- and post-operative sports activities; 43 patients responded. We surveyed patients’ sports activities, satisfaction, and physical function. Patients were divided according to whether they participated in sports activities after CPO. Physical function was compared before and after CPO.Results: The pre- and post-operative sports activity participation rates were 55.8% and 72.1%, respectively. Patients mostly performed low-impact sports activities. Moreover, patients who participated in sports activities post-operatively had smaller pre-operative range of motion of hip flexion and returned to full weight bearing earlier.Conclusions: Among acetabular dysplasia patients who underwent CPO, 72.1% participated in sports activities post-operatively. Post-operatively, patients participated not only in low-impact sports activities, but also in high-impact ones. These findings might be useful for advising patients who are concerned about participating in sports activities after CPO.

scholarly journals The recovery of standing and locomotion after spinal cord injury does not require task-specific training

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Jonathan Harnie ◽  
Adam Doelman ◽  
Emmanuelle de Vette ◽  
Johannie Audet ◽  
Etienne Desrochers ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Specific Activity ◽  
Weight Bearing ◽  
Triceps Surae ◽  
Full Weight Bearing ◽  
Specific Training ◽  
Spinal Transection ◽  
Cord Injury ◽  
Complete Spinal Cord Injury

After complete spinal cord injury, mammals, including mice, rats and cats, recover hindlimb locomotion with treadmill training. The premise is that sensory cues consistent with locomotion reorganize spinal sensorimotor circuits. Here, we show that hindlimb standing and locomotion recover after spinal transection in cats without task-specific training. Spinal-transected cats recovered full weight bearing standing and locomotion after five weeks of rhythmic manual stimulation of triceps surae muscles (non-specific training) and without any intervention. Moreover, cats modulated locomotor speed and performed split-belt locomotion six weeks after spinal transection, functions that were not trained or tested in the weeks prior. This indicates that spinal networks controlling standing and locomotion and their interactions with sensory feedback from the limbs remain largely intact after complete spinal cord injury. We conclude that standing and locomotor recovery is due to the return of neuronal excitability within spinal sensorimotor circuits that do not require task-specific activity-dependent plasticity.

Locomotor Capacity Attributable to Step Training Versus Spontaneous Recovery After Spinalization in Adult Cats

1998 ◽  
Vol 79 (3) ◽  
pp. 1329-1340 ◽  
Author(s):  
R. D. de Leon ◽  
J. A. Hodgson ◽  
R. R. Roy ◽  
V. R. Edgerton
Keyword(s):  
Spinal Cord ◽  
Spontaneous Recovery ◽  
Weight Bearing ◽  
Full Weight Bearing ◽  
Lumbar Spinal Cord ◽  
Maximum Speed ◽  
Step Cycle ◽  
Locomotor Recovery ◽  
Adult Cats ◽  
Locomotor Capacity

de Leon, R. D., J. A. Hodgson, R. R. Roy, and V. R. Edgerton. Locomotor capacity attributable to step training versus spontaneous recovery after spinalization in adult cats. J. Neurophysiol. 79: 1329–1340, 1998. Locomotor performance, hindlimb muscle activity and gait patterns during stepping were studied in step-trained and non-trained female, adult spinal cats. Changes in locomotor characteristics relative to prespinalization bipedal and quadrupedal stepping patterns were used to evaluate the effects of step training on the capacity to execute full weight-bearing stepping after spinalization. Step training consisted of full weight-bearing stepping of the hindlimbs at the greatest range of treadmill speeds possible at any given stage of locomotor recovery. In the initial stages of training the limbs were assisted as needed to execute successful steps. On the basis of two behavioral criteria, the maximum speed of treadmill stepping and the number of successful steps per unit time, the ability to step was at least 3 times greater in animals trained to step versus those allowed to recover spontaneously, i.e., the non-trained. The greater success in stepping was reflected in several physiological and kinematic properties. For example, the amplitude of electromyograph (EMG) bursts in the tibialis anterior (an ankle dorsiflexor), the amount of extension at the end of both the stance (E3) and swing (E1) phases of the step cycle, and the amount of lift of the hindlimb during swing were greater in step-trained than in non-trained spinal cats. The changes that occurred in response to training reflected functional adaptations at specific phases of the step cycle, e.g., enhanced flexor and extensor function. The improved stepping capacity attributable to step training is interpreted as a change in the probability of the appropriate neurons being activated in a temporally appropriate manner. This interpretation, in turn, suggests that step training facilitated or reinforced the function of extant sensorimotor pathways rather than promoting the generation of additional pathways. These results show that the capacity of the adult lumbar spinal cord to generate full weight-bearing stepping over a range of speeds is defined, in large part, by the functional experience of the spinal cord after supraspinal connectivity has been eliminated. These results have obvious implications with regards to 1) the possibility of motor learning occurring in the spinal cord; 2) the importance of considering “motor experience” in assessing the effect of any postspinalization intervention; and 3) the utilization of use-dependent interventions in facilitating and enhancing motor recovery.

scholarly journals Full Weight-Bearing Hindlimb Standing Following Stand Training in the Adult Spinal Cat

1998 ◽  
Vol 80 (1) ◽  
pp. 83-91 ◽  
Author(s):  
R. D. De Leon ◽  
J. A. Hodgson ◽  
R. R. Roy ◽  
V. R. Edgerton
Keyword(s):  
Spinal Cord ◽  
Weight Bearing ◽  
Extensor Muscle ◽  
Full Weight Bearing ◽  
Lumbar Spinal Cord ◽  
Emg Activity ◽  
Activity Levels ◽  
Neural Pathways ◽  
Weight Support ◽  
Lumbar Spinal

De Leon, R. D., J. A. Hodgson, R. R. Roy, and V. R. Edgerton. Full weight-bearing hindlimb standing following stand training in the adult spinal cat. J. Neurophysiol. 80: 83–91, 1998. Behavioral and physiological characteristics of standing were studied in nontrained spinal cats and in spinal cats that received daily stand training of the hindlimbs for 12 wk. Training consisted of assisting the cats to stand with full weight support either on both hindlimbs or on one hindlimb (30 min/day, 5 days/wk). Extensor muscle electromyographic (EMG) amplitude and extension at the knee and ankle joints during full weight bearing recovered to prespinal levels in both stand-trained and nontrained spinal cats. However, full weight bearing of the hindquarters was sustained for up to ∼20 min in the spinal cats that received bilateral stand training compared with ∼4 min in cats that were not trained to stand. Unilateral stand training selectively improved weight bearing on the trained limb based on ground reaction forces and extensor muscle EMG activity levels measured during bilateral standing. These results suggest that the capacity of the adult lumbar spinal cord to generate full weight-bearing standing can be improved by as much as fivefold by the repetitive activation of selected neural pathways in the spinal cord after supraspinal connectivity has been eliminated. Given that stepping is improved in response to step training, it appears that the recovery of standing provides another example of training-specific motor learning in the spinal cord, i.e., the spinal cord learns to perform hindlimb standing by practicing that specific task.

scholarly journals ELECTROGMYOGRAPHIC FEATURES OF MUSCLES SOLEUS IN PEOPLE WITH THE INCREASED SENSITIVITY OF THE VESTIBULAR ANALYZER

2020 ◽  
Vol 2 ◽  
pp. 24-28
Author(s):  
Stepan Vadzyuk ◽  
Roman Shmata ◽  
Nataliia Ulianytska
Keyword(s):  
Spinal Cord ◽  
Semicircular Canals ◽  
Lower Extremities ◽  
Upright Position ◽  
Electromyographic Activity ◽  
Human Spinal Cord ◽  
Before And After ◽  
Increased Sensitivity ◽  
Written Test ◽  
Romberg Test

The article deals with the features of electromyographic indicators of the soleus muscles while maintaining a upright position in people with increased vestibular sensitivity. From the literature, it is concluded that the study of electromyographic features of indicators in the conditions of irritation of the vestibular analyzer in people with different vestibular sensitivity is an important area in physiology. Vestibular sensitivity was determined by the questionnaire, Voyachek's sample and Fukuda's written test. To assess the electromyographic activity of the soleus muscles, a computer DX complex was used for registration of interference electromyography. Registration was carried out during performing Romberg test, before and after vestibular loading. According to the results of the vestibular irritation, there was a greater decrease in the amplitude of the flap muscles of the lower extremities in persons with the increased vestibular sensitivity than in people with the adequate sensitivity. Based on the results achieved, it can be assumed, that in people with the increased sensitivity of the vestibular analyzer, the irritation of the receptors of the semicircular canals alters the activity of extensor motoneurons of the human spinal cord more significantly than in persons with the adequate sensitivity.

scholarly journals Sports activity participation after curved periacetabular osteotomy for acetabular dysplasia

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Yoshiki Takahashi ◽  
Naonobu Takahira ◽  
Katsufumi Uchiyama ◽  
Kensuke Fukushima ◽  
Mitsutoshi Moriya ◽  
...  
Keyword(s):  
Physical Function ◽  
Acetabular Dysplasia ◽  
Periacetabular Osteotomy ◽  
Weight Bearing ◽  
Activity Participation ◽  
Full Weight Bearing ◽  
Sports Activity ◽  
Before And After ◽  
Curved Periacetabular Osteotomy ◽  
Sports Activities

Abstract Background Curved periacetabular osteotomy (CPO) was developed to treat acetabular dysplasia. Given that CPO can improve physical function in the early post-operative period, patients might be able to participate in sports activities post-operatively. Therefore, this study examined the post-operative sports activity participation and characteristics of acetabular dysplasia patients who have undergone CPO. Methods A total of 52 patients who underwent CPO for acetabular dysplasia were given a questionnaire on pre- and post-operative sports activities; 43 patients responded. We surveyed patients’ sports activities, satisfaction, and physical function. Patients were divided according to whether they participated in sports activities after CPO. Physical function was compared before and after CPO. Results The pre- and post-operative sports activity participation rates were 55.8 and 72.1%, respectively. Patients mostly performed low-impact sports activities. Moreover, patients who participated in sports activities post-operatively had smaller pre-operative range of motion of hip flexion and returned to full weight bearing earlier. Conclusions Among acetabular dysplasia patients who underwent CPO, 72.1% participated in sports activities post-operatively. Post-operatively, patients participated not only in low-impact sports activities, but also in high-impact ones. These findings might be useful for advising patients who are concerned about participating in sports activities after CPO.

scholarly journals Sports activity participation after curved periacetabular osteotomy for acetabular dysplasia

2020 ◽  
Author(s):  
Yoshiki Takahashi ◽  
Naonobu Takahira ◽  
Katsufumi Uchiyama ◽  
Kensuke Fukushima ◽  
Mitsutoshi Moriya ◽  
...  
Keyword(s):  
Physical Function ◽  
Acetabular Dysplasia ◽  
Periacetabular Osteotomy ◽  
Weight Bearing ◽  
Activity Participation ◽  
Full Weight Bearing ◽  
Sports Activity ◽  
Before And After ◽  
Curved Periacetabular Osteotomy ◽  
Sports Activities

Abstract Background: Curved periacetabular osteotomy (CPO) was developed to treat acetabular dysplasia. Given that CPO can improve physical function in the early post-operative period, patients might be able to participate in sports activities post-operatively. Therefore, this study examined the post-operative sports activity participation and characteristics of acetabular dysplasia patients who have undergone CPO.Methods: A total of 52 patients who underwent CPO for acetabular dysplasia were given a questionnaire on pre- and post-operative sports activities; 43 patients responded. We surveyed patients’ sports activities, satisfaction, and physical function. Patients were divided according to whether they participated in sports activities after CPO. Physical function was compared before and after CPO.Results: The pre- and post-operative sports activity participation rates were 55.8% and 72.1%, respectively. Patients mostly performed low-impact sports activities. Moreover, patients who participated in sports activities post-operatively had smaller pre-operative range of motion of hip flexion and returned to full weight bearing earlier.Conclusions: Among acetabular dysplasia patients who underwent CPO, 72.1% participated in sports activities post-operatively. Post-operatively, patients participated not only in low-impact sports activities, but also in high-impact ones. These findings might be useful for advising patients who are concerned about participating in sports activities after CPO.

FULL WEIGHT BEARING KINEMATIC MRI STUDY OF TT-TG DISTANCE: COMPARING PATIENTS WITH PATELLOFEMORAL PAIN TO HEALTHY INDIVIDUALS

2015 ◽  
Vol 21 (4.1) ◽  
pp. 638-642
Author(s):  
Andrius Brazaitis ◽  
Algirdas Tamosiunas ◽  
Janina Tutkuviene
Keyword(s):  
Patellar Instability ◽  
Weight Bearing ◽  
Patellofemoral Pain ◽  
Full Weight Bearing ◽  
Trochlear Groove ◽  
Patellar Tilt ◽  
Full Extension ◽  
Low Degrees ◽  
Mri Study ◽  
Kinematic Magnetic Resonance Imaging

Purpose. The aim of the present study was to investigate tibial tuberosity-trochlear groove (TT-TG) distance dynamics in patients with patellofemoral pain (PFP) and pain free individuals by using full weight bearing kinematic magnetic resonance imaging (MRI) And correlation with patellar instability. Materials and methods. 51 female individuals with PFP and 26 pain free female individuals participated in the study. The kinematic MRI was performed with 1,5 T MRI unit and full-weight bearing. TT-TG distance, bissect offset (BSO) and patellar tilt angle (PTA) were measured in steps of 10° between 50° of flexion to full extension. Results. The TT–TG was higher in PFP patients compared to volunteers’ from 40° to full extension. This difference was statistically significant (p<0.01). PFP patients demonstrated statistically significantly greater TT-TG distance increase from 30° to full extension. BSO and PTA were moderately correlated to TT-TG from 20° of flexion to full extension. Conclusion. TT-TG distance is dynamic and increases significantly during extension in patients with PFP and pain free individuals, depending on knee flexion angle. It shows different pattern of dynamics in PFP group. TT-TG distance is associated with patellar instability (BSO and PTA) at low degrees of flexion.

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