scholarly journals Modeling Obesity and Its Associated Disorders in Drosophila

Physiology ◽  
2013 ◽  
Vol 28 (2) ◽  
pp. 117-124 ◽  
Author(s):  
Irene Trinh ◽  
Gabrielle L. Boulianne

In recent years, obesity has been recognized as a major public health problem due to its increased prevalence in both children and adults and its association with numerous life-threatening complications including diabetes, heart disease, hypertension, and cancer. Obesity is a complex disorder that is the result of the interaction between predisposing genetic and environmental factors. However, the precise nature of these gene-gene and gene-environment interactions remains unclear. Here, we will describe recent studies demonstrating how fruit flies can be used to identify and characterize the mechanisms underlying obesity and to establish models of obesity-associated disorders.

2021 ◽  
Vol 9 (3) ◽  
pp. 511
Author(s):  
Gabriela Certad ◽  
Eric Viscogliosi

The apicomplexan parasite Cryptosporidium represents a major public health problem in humans and animals by causing self-limited diarrhea in immunocompetent individuals and life-threatening disease in immunocompromised hosts [...]


2020 ◽  
Author(s):  
Pintu Paul

Abstract Background Globally, diarrhoea is a second leading cause of deaths among under-five children and is a major public health problem. Despite several health care initiatives, a large proportion of under-five children are still experienced diarrhoeal diseases causes high mortality in India. This study aims to examine the socio-demographic and environmental factors of diarrhoea among children under-five in India.Methods A cross-sectional study was designed using the recent round of the National Family Health Survey (NFHS), conducted in 2015-16. A total of living children below 5 years of age were utilized for the analysis of this study. Bi-variate and multivariate logistic regression were carried out to investigate the factors of childhood diarrhoea.Results In India, about 9% under-five children experience diarrhoeal disease in the past 2 weeks. Children from rural areas (AOR: 1.05; 95% CI: 1.01, 1.09), Scheduled Tribe (AOR: 0.83; 95% CI: 0.79, 0.89) and others caste (AOR: 0.92; 95% CI: 0.88, 0.97), Muslim (AOR: 1.18; 95% CI: 1.13, 1.24), and from central (AOR: 1.61; 95% CI: 1.52, 1.70) and west region (AOR: 1.08; 95% CI: 1.01, 1.15) were significantly associated with higher likelihood of diarrhoea in past 2 weeks. Furthermore, this study also revealed that child’s stool disposal (AOR: 1.06; 95% CI: 0.98, 1.09), floor materials (AOR: 1.08; 95% CI: 1.03, 1.12) and roof materials (AOR: 1.08; 95% CI: 1.04, 1.13) of the household were found to be significant factors of childhood diarrhoea occurrence.Conclusions Diarrhoeal disease remains a serious public health problem in India. The findings of this study suggest strengthening of existing health care programs. Policy intervention should also address socio-economic vulnerabilities of mothers and children to combat the incidence of diarrhoea. In addition, provisioning of sanitation and housing facilities may help positively to control diarrhoeal disease that could eventually reduce the incidence of child mortality.


1996 ◽  
Vol 13 (2) ◽  
pp. 3-39 ◽  
Author(s):  
Pierre Baume

AbstractIn 1995, 2367 Australians lost their lives through suicide, and up to 100 times this number may attempt each year: Suicide has now become a major public health problem in Australia, which has seen the suicide rates in young males quadruple over the last 35 years or so. An analysis of current research on suicide and suicidal behaviour exploring possible causes and crosscultural issues, is discussed. As well, an extended definition of suicide as an intentional death and its antecedents provides the foundation for a discourse on the views now held by our corntemporary society. The paper argues that suicide not only is one of the most extreme consequences of personal psychosocial distress but also is often also an indicator of previous life events and environmental factors that potentiates for personal vulnerabilities.


2017 ◽  
Vol 22 (2) ◽  
pp. 106-112
Author(s):  
A. M Bronshteyn ◽  
N. G Kochergin ◽  
N. A Malyshev ◽  
V. Ya Lashin ◽  
S. V Burova ◽  
...  

Two cases of New World cutaneous leishmaniasis acquired by Russian tourists in Peru and possibly in Bolivia are presented. L. viannia ( L.braziliensis complex) was identified in Liverpool School of Tropical medicine in the patient travelled to Bolivia. The present study aimed to investigate Balsamum peruvianum one of the product of folk medicine of Indians of Amazon region against local species of Leishmania resulted in healing the ulcers. Leishmaniasis is a major public health problem, and the alarming spread of parasite resistance has increased the importance of discovering new therapeutic products.


2021 ◽  
Author(s):  
Felipe Figuerôa Moreira ◽  
Juliana de Araujo Portes ◽  
Nathalia Florencia Barros Azeredo ◽  
Christiane Fernandes ◽  
Adolfo Horn ◽  
...  

Chagas disease is a neglected tropical disease caused by the protozoan pathogen Trypanosoma cruzi. The disease is the major public health problem affecting about 6 to 7 million people worldwide,...


1998 ◽  
Vol 14 (suppl 3) ◽  
pp. S109-S115 ◽  
Author(s):  
Vera Luiza da Costa e Silva ◽  
Sergio Koifman

Smoking has become a major public health problem in Latin America, and its scope varies from country to country. Despite difficulties in obtaining methodologically consistent data for the region, we analyzed the results from prevalence surveys in 14 Latin American countries. Smoking prevalence among men varied from 24.1% (Paraguay) to 66.3% (Dominican Republic) and among women from 5.5% (Paraguay) to 26,6% (Uruguay). By applying point prevalence data to the stage model of the tobacco epidemic in developed countries, we concluded that the Latin American countries are in stage 2, i.e., with a clearly rising prevalence among men, a prevalence for women that is beginning to increase, and mortality attributable to smoking among men still not reflecting peak prevalence. None of the countries analyzed appeared to have reached stage 3, in which one observes a downward trend in prevalence of smoking among men and peak prevalence among women, with broad impact on tobacco-related mortality. The only exception appears to be Paraguay, which is still emerging from stage 1, i.e., with low prevalence rates among men, too. Nevertheless, high lung cancer mortality rates in Uruguay and Argentina are comparable to those of the developed countries.


2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Abolghasem Siyadatpanah ◽  
Enrico Brunetti ◽  
Amir Emami Zeydi ◽  
Yousef Dadi Moghadam ◽  
Nelson Iván Agudelo Higuita

Cystic echinococcosis (CE) is a neglected helminthic disease and major public health problem in several regions of the world. The zoonosis is caused by the larval stage of different cestode species belonging to the genus Echinococcus. CE can affect any organ with the liver and lungs being most commonly involved. The brain is involved in less than 2% of the cases. We report a case of a CE1 echinococcal cyst of the brain in an Iranian patient.


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