scholarly journals ASICs Mediate Pain and Inflammation in Musculoskeletal Diseases

Physiology ◽  
2015 ◽  
Vol 30 (6) ◽  
pp. 449-459 ◽  
Author(s):  
Ramy E. Abdelhamid ◽  
Kathleen A. Sluka
Keyword(s):  
Rheumatoid Arthritis ◽  
Skeletal Muscle ◽  
Musculoskeletal Pain ◽  
Musculoskeletal Diseases ◽  
Ph Sensitivity ◽  
Chronic Musculoskeletal Pain ◽  
Factors Affecting ◽  
Different Types ◽  
Tissue Acidosis

Chronic musculoskeletal pain is debilitating and affects ∼20% of adults. Tissue acidosis is present in painful musculoskeletal diseases like rheumatoid arthritis. ASICs are located on skeletal muscle and joint nociceptors as well as on nonneuronal cells in the muscles and joints, where they mediate nociception. This review discusses the properties of different types of ASICs, factors affecting their pH sensitivity, and their role in musculoskeletal hyperalgesia and inflammation.

scholarly journals “On their own”: social isolation, loneliness and chronic musculoskeletal pain in older adults

2017 ◽  
Vol 18 (2) ◽  
pp. 87-92 ◽  
Author(s):  
Toby Smith
Keyword(s):  
Social Isolation ◽  
Musculoskeletal Pain ◽  
Negative Impact ◽  
Musculoskeletal Diseases ◽  
Well Being ◽  
Chronic Musculoskeletal Pain ◽  
Content Type ◽  
Raising Awareness ◽  
Conceptual Paper ◽  
Health And Well Being

Purpose The purpose of this paper is to explore the concepts of social isolation and loneliness in relation to people with chronic musculoskeletal pain. Through these concepts, biological, psychological and social factors will be examined to consider how we can identify people at risk of social isolation and loneliness who have chronic musculoskeletal pain and then how health professionals may intervene to reduce their effects. Design/methodology/approach Conceptual paper. Findings Social isolation and loneliness are often evident in the situation of people with chronic musculoskeletal diseases. This may be bi-directional where pains may lead to social isolation and loneliness, but equally, social isolation and loneliness may exacerbate pain. Interventions to improve the symptoms of chronic musculoskeletal pain, and also approaches around social participation and engagement should be adopted in combination to ameliorate this potentially disabling scenario. Originality/value There remains limited evidence around the prevalence and management of social isolation and loneliness for people with chronic musculoskeletal pain. By raising awareness of social isolation and loneliness in this population, people with chronic musculoskeletal pain may be better supported to reduce the negative impact that social isolation and loneliness can have on their health and well-being.

scholarly journals Exploratory study of the factors affecting quality of life in patients with chronic musculoskeletal pain

2021 ◽  
Author(s):  
Naoto Takahashi ◽  
Kozue Takatsuki ◽  
Satoshi Kasahara ◽  
Shoji Yabuki
Keyword(s):  
Pain Management ◽  
Musculoskeletal Pain ◽  
Pain Catastrophizing ◽  
Depression Scale ◽  
Chronic Musculoskeletal Pain ◽  
Anxiety And Depression ◽  
Hospital Anxiety ◽  
Five Dimensions ◽  
Factors Affecting

Abstract Background A therapeutic target for patients with chronic musculoskeletal pain is the improvement of quality of life (QOL). A multidisciplinary approach to pain management is implemented at the Pain Management Center, Hoshi General Hospital, Japan. We consistently evaluate not only biological pain factors but also pain levels, psychosocial factors associated with pain, and QOL using questionnaires. The study aim was to explore the factors affecting QOL in patients with chronic musculoskeletal pain. Methods Subjects were 166 patients attending checkups at our pain management center from April 2015 to March 2020 who had valid questionnaire responses. We evaluated age, scores on the Brief Pain Inventory (BPI), Pain Catastrophizing Scale, Pain Disability Assessment Scale (PDAS), Hospital Anxiety and Depression Scale, Pain Self-Efficacy Questionnaire (PSEQ), EuroQol Five Dimensions Questionnaire, and Athens Insomnia Scale (AIS). Descriptive statistics were calculated for the 166 patients’ scores. Pearson’s product-moment coefficient correlations were calculated to examine associations among the variables. Subsequent multiple regression analysis, in which QOL was the dependent variable, resulted in a coefficient of determination (R2) of 0.58, indicating strong relationships among the variables (p < 0.01). Results The standardized regression (beta) coefficients showed significant associations (p < 0.05) among BPI, PDAS, PSEQ, and AIS scores and QOL (EuroQol Five Dimensions Questionnaire scores). However, Hospital Anxiety and Depression Scale and Pain Catastrophizing Scale scores were not strongly associated with QOL. Conclusions QOL in patients with chronic musculoskeletal pain was strongly related to BPI, PDAS, PSEQ, and AIS scores. We should focus on these factors to improve QOL.

Mecanismos neurobiológicos del dolor de origen no maligno asociado a estructuras óseas

2020 ◽  
Vol 2 (2) ◽  
pp. 106-112
Author(s):  
Enriqueta Muñoz-Islas ◽  
Martha Beatriz Ramírez-Rosas ◽  
Héctor Fabián Torres-Rodríguez ◽  
Rosa Issel Acosta-González ◽  
Juan Miguel Jiménez-Andrade
Keyword(s):  
Musculoskeletal Pain ◽  
Musculoskeletal Diseases ◽  
Imaging Techniques ◽  
Sympathetic Innervation ◽  
Nerve Fibers ◽  
Chronic Musculoskeletal Pain ◽  
Preclinical Models ◽  
Keywords Pain ◽  
High Prevalence ◽  
Bone Structures

Introduction. Despite the high prevalence of musculoskeletal diseases, the neurobiological mechanisms underlying bone-related pain are not fully known. Objective. To summarize the information on neurobiological mechanisms of bone structures-related pain that has been reported in the last two decades. Material and Methods. A scientific search was performed on the PubMed platform in the last 20 years using the keywords pain, bone, skeletal, non-malignant, aging, periosteum, and nerve fibers. Results and Discussion. Significant advances in biochemical, immunohistochemical and imaging techniques have helped to characterize sensory and sympathetic innervation of different natural compartments in healthy tissue. Likewise, several preclinical models of acute and chronic musculoskeletal pain —providing a clearer understanding of the mechanisms underlying bone-related pain— have been established.

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