Mecanismos neurobiológicos del dolor de origen no maligno asociado a estructuras óseas

Introduction. Despite the high prevalence of musculoskeletal diseases, the neurobiological mechanisms underlying bone-related pain are not fully known. Objective. To summarize the information on neurobiological mechanisms of bone structures-related pain that has been reported in the last two decades. Material and Methods. A scientific search was performed on the PubMed platform in the last 20 years using the keywords pain, bone, skeletal, non-malignant, aging, periosteum, and nerve fibers. Results and Discussion. Significant advances in biochemical, immunohistochemical and imaging techniques have helped to characterize sensory and sympathetic innervation of different natural compartments in healthy tissue. Likewise, several preclinical models of acute and chronic musculoskeletal pain —providing a clearer understanding of the mechanisms underlying bone-related pain— have been established.

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ASICs Mediate Pain and Inflammation in Musculoskeletal Diseases

Physiology ◽

10.1152/physiol.00030.2015 ◽

2015 ◽

Vol 30 (6) ◽

pp. 449-459 ◽

Cited By ~ 12

Author(s):

Ramy E. Abdelhamid ◽

Kathleen A. Sluka

Keyword(s):

Rheumatoid Arthritis ◽

Skeletal Muscle ◽

Musculoskeletal Pain ◽

Musculoskeletal Diseases ◽

Ph Sensitivity ◽

Chronic Musculoskeletal Pain ◽

Factors Affecting ◽

Different Types ◽

Tissue Acidosis

Chronic musculoskeletal pain is debilitating and affects ∼20% of adults. Tissue acidosis is present in painful musculoskeletal diseases like rheumatoid arthritis. ASICs are located on skeletal muscle and joint nociceptors as well as on nonneuronal cells in the muscles and joints, where they mediate nociception. This review discusses the properties of different types of ASICs, factors affecting their pH sensitivity, and their role in musculoskeletal hyperalgesia and inflammation.

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“On their own”: social isolation, loneliness and chronic musculoskeletal pain in older adults

Quality in Ageing and Older Adults ◽

10.1108/qaoa-03-2017-0010 ◽

2017 ◽

Vol 18 (2) ◽

pp. 87-92 ◽

Cited By ~ 14

Author(s):

Toby Smith

Keyword(s):

Social Isolation ◽

Musculoskeletal Pain ◽

Negative Impact ◽

Musculoskeletal Diseases ◽

Well Being ◽

Chronic Musculoskeletal Pain ◽

Content Type ◽

Raising Awareness ◽

Conceptual Paper ◽

Health And Well Being

Purpose The purpose of this paper is to explore the concepts of social isolation and loneliness in relation to people with chronic musculoskeletal pain. Through these concepts, biological, psychological and social factors will be examined to consider how we can identify people at risk of social isolation and loneliness who have chronic musculoskeletal pain and then how health professionals may intervene to reduce their effects. Design/methodology/approach Conceptual paper. Findings Social isolation and loneliness are often evident in the situation of people with chronic musculoskeletal diseases. This may be bi-directional where pains may lead to social isolation and loneliness, but equally, social isolation and loneliness may exacerbate pain. Interventions to improve the symptoms of chronic musculoskeletal pain, and also approaches around social participation and engagement should be adopted in combination to ameliorate this potentially disabling scenario. Originality/value There remains limited evidence around the prevalence and management of social isolation and loneliness for people with chronic musculoskeletal pain. By raising awareness of social isolation and loneliness in this population, people with chronic musculoskeletal pain may be better supported to reduce the negative impact that social isolation and loneliness can have on their health and well-being.

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