scholarly journals Role of Astrocytic Mitochondria in Limiting Ischemic Brain Injury?

Physiology ◽  
2018 ◽  
Vol 33 (2) ◽  
pp. 99-112 ◽  
Author(s):  
Evelyn K. Shih ◽  
Michael B. Robinson
Keyword(s):  
Brain Injury ◽  
Neuronal Activity ◽  
Brain Function ◽  
Functional Significance ◽  
Normal Brain ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Normal Brain Function

Until recently, astrocyte processes were thought to be too small to contain mitochondria. However, it is now clear that mitochondria are found throughout fine astrocyte processes and are mobile with neuronal activity resulting in positioning near synapses. In this review, we discuss evidence that astrocytic mitochondria confer selective resiliency to astrocytes during ischemic insults and the functional significance of these mitochondria for normal brain function.

scholarly journals Role of Exosomes in Brain Diseases

2021 ◽  
Vol 15 ◽  
Author(s):  
Nan Zhang ◽  
Fengling He ◽  
Ting Li ◽  
Jinzhi Chen ◽  
Liping Jiang ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Function ◽  
Host Cells ◽  
Brain Diseases ◽  
Normal Brain ◽  
Normal Brain Function ◽  
Target Molecules ◽  
Non Coding Rnas

Exosomes are a subset of extracellular vesicles that act as messengers to facilitate communication between cells. Non-coding RNAs, proteins, lipids, and microRNAs are delivered by the exosomes to target molecules (such as proteins, mRNAs, or DNA) of host cells, thereby playing a key role in the maintenance of normal brain function. However, exosomes are also involved in the occurrence, prognosis, and clinical treatment of brain diseases, such as Alzheimer's disease, Parkinson's disease, stroke, and traumatic brain injury. In this review, we have summarized novel findings that elucidate the role of exosomes in the occurrence, prognosis, and treatment of brain diseases.

scholarly journals Effects of sevoflurane on rats with ischemic brain injury and the role of the TREK-1 channel

2017 ◽  
Vol 14 (4) ◽  
pp. 2937-2942 ◽  
Author(s):  
Lixiao Pan ◽  
Fengyun Yang ◽  
Caixia Lu ◽  
Changxin Jia ◽  
Qing Wang ◽  
...  
Keyword(s):  
Brain Injury ◽  
Ischemic Brain Injury ◽  
Ischemic Brain

scholarly journals Pathophysiological role of zinc in ischemic brain injury

Oncotarget ◽  
2016 ◽  
Vol 8 (4) ◽  
pp. 5670-5671
Author(s):  
Zhifeng Qi ◽  
Ke Jian Liu
Keyword(s):  
Brain Injury ◽  
Ischemic Brain Injury ◽  
Ischemic Brain ◽  
Pathophysiological Role
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