Differential response to dietary fat in large (LG/J) and small (SM/J) inbred mouse strains

1999 ◽  
Vol 1 (1) ◽  
pp. 33-39 ◽  
Author(s):  
JAMES M. CHEVERUD ◽  
L. SUSAN PLETSCHER ◽  
TY T. VAUGHN ◽  
BESS MARSHALL
Keyword(s):  
Dietary Fat ◽  
Fasting Glucose ◽  
Inbred Mouse ◽  
Strain Differences ◽  
Liver Weight ◽  
Differential Response ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Fat Pad ◽  
Glucose Levels

Cheverud, James M., L. Susan Pletscher, Ty T. Vaughn, and Bess Marshall. Differential response to dietary fat in large (LG/J) and small (SM/J) inbred mouse strains. Physiol. Genomics 1: 33–39, 1999.—The “large” (LG/J) and “small” (SM/J) inbred mouse strains differ for a wide variety of traits related to body size and obesity. Ninety-three LG/J and SM/J mice were divided into two treatment categories and fed a moderately high-fat diet (21% kcal fat) or a low-fat diet (12% kcal fat) from weaning to necropsy. Strain differences in obesity-related traits and differential response to dietary fat increases were analyzed using ANOVA. LG/J animals grow faster from 3 to 10 wk, have longer tails, and have heavier body weight, liver weight, and fat pad weight than SM/J animals. SM/J animals grow faster after 10 wk of age and have higher fasting glucose levels than LG/J animals. SM/J mice were more responsive to increased dietary fat than LG/J mice for growth after 10 wk, necropsy weight, liver weight, fat pad weights, and fasting glucose levels (in males). The growth from 3 to 10 wk had a much greater response in the LG/J strain, whereas tail length had no response. This pattern of dietary response is similar to that expected under the “thrifty” phenotype hypothesis. Genes affecting strain differences and the differential response of the strains to dietary fat can be successfully mapped in the intercross of the LG/J and SM/J strains. This intercross provides an excellent multigenic model for the genetic basis of complex traits and diseases related to body size and obesity.

scholarly journals Strain Differences in the Morphology of the Gametes of the Mouse

1959 ◽  
Vol 12 (1) ◽  
pp. 65 ◽  
Author(s):  
AWH Braden
Keyword(s):  
Inbred Mouse ◽  
Strain Differences ◽  
Sperm Head ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Posterior Portion ◽  
Interstrain Differences

Characteristic differences in the morphology of the spenTI head have been noted between. the inbred mouse strains C57BL, CBA, A, and RIlL There were interstrain differences in the shape of the posterior portion of the sperm head and in the length and width of the .head. The spenTI of mice derived from certain interstrain crosses were also studied.

scholarly journals Genetic Relationships Between Ethanol-Induced Conditioned Place Aversion and Other Ethanol Phenotypes in 15 Inbred Mouse Strains

2019 ◽  
Vol 9 (8) ◽  
pp. 209 ◽  
Author(s):  
Christopher L. Cunningham
Keyword(s):  
Genetic Relationships ◽  
Inbred Mouse ◽  
Genetic Correlations ◽  
Strain Differences ◽  
Mouse Strains ◽  
Place Conditioning ◽  
Conditioned Place Aversion ◽  
Inbred Mouse Strains ◽  
Place Aversion ◽  
Tactile Cues

The genetic relationships between different behaviors used to index the aversive effects of ethanol are unknown. To address this issue, ethanol-induced conditioned place aversion (CPA) was tested in a genetically diverse panel of 15 inbred mouse strains. Mice were exposed to an unbiased place conditioning procedure using ethanol doses of 0, 2, or 4 g/kg; all injections were given immediately after 5-min exposure to distinctive tactile cues. There were dose-dependent effects of ethanol on CPA and on the change in pre-injection activity rates between the first and last conditioning trials. Most strains (80%) developed CPA, demonstrating the generalizability of this behavior. Moreover, genotype had significant effects on CPA magnitude and locomotor activity rates. Strain means from this study and previously published studies were then used to examine genetic correlations. These analyses showed significant genetic correlations between CPA and ethanol intake/preference, conditioned taste aversion, and drug withdrawal (but not blood ethanol concentration or conditioned place preference), supporting the idea of commonality in the genes underlying CPA and each of these behaviors. The overall pattern of findings is consistent with previous data suggesting that genetic differences in sensitivity to ethanol’s aversive effects play a role in determining strain differences in ethanol drinking. The broader implication is that individuals who are more sensitive to the aversive effects of ethanol may be protected from developing the excessive drinking behaviors characteristic of alcohol use disorders.

scholarly journals Genetic variation in body weight gain and composition in the intercross of Large (LG/J) and Small (SM/J) inbred strains of mice

1998 ◽  
Vol 21 (2) ◽  
pp. 211-218 ◽  
Author(s):  
Melissa G. Kramer ◽  
Ty T. Vaughn ◽  
L. Susan Pletscher ◽  
Kelly King-Ellison ◽  
Emily Adams ◽  
...  
Keyword(s):  
Body Weight ◽  
Maternal Effects ◽  
Body Weight Gain ◽  
Inbred Mouse ◽  
Genetic Correlations ◽  
Tail Length ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Fat Pad ◽  
Correlation Pattern

Strain intercross experiments provide a powerful means for mapping genes affecting complex quantitative traits. We report on the genetic variability of the intercross of the Large (LG/J) and Small (SM/J) inbred mouse strains as a guide to gene mapping studies. Ten SM/J males were crossed to 10 LG/J females, after which animals were randomly mated to produce F1, F2, and F3 intercross generations. The 1632 F3 animals from 200 full-sib families were used to estimate heritabilities and genetic correlations of the traits measured. A subset of families was cross-fostered at birth to allow measurement of the importance of post-natal maternal effects. Data was collected on weekly body weight from one to 10 weeks and on organ weights, body weight, reproductive fat pad weight, and tail length at necropsy in the intercross generations. There was no heterosis for age-specific weights or necropsy traits, except that one-week weight was the highest in the F2 generation, indicating heterosis for maternal effect in the F1 mothers. We found moderate to high heritability for most age-specific weights and necropsy traits. Maternal effects were significant for age-specific weights from one to four weeks but disappeared completely at ten-week weight. Maternal effects for necropsy traits were low and not statistically significant. Age-specific weights showed a typical correlation pattern, with correlation declining as the difference in ages increased. Among necropsy traits, reproductive fat pad and body weights were very highly genetically correlated. Most other genetic correlations were low to moderate. The intercross between SM/J and LG/J inbred mouse strains provides a valuable resource for mapping quantitative trait loci for body size, composition, and morphology

scholarly journals THE Ah PHENOTYPE. SURVEY OF FORTY-EIGHT RAT STRAINS AND TWENTY INBRED MOUSE STRAINS

Genetics ◽  
1982 ◽  
Vol 100 (1) ◽  
pp. 79-87
Author(s):  
Daniel W Nebert ◽  
Nancy M Jensen ◽  
Hisashi Shinozuka ◽  
Heinz W Kunz ◽  
Thomas J Gill
Keyword(s):  
Specific Activity ◽  
Inbred Mouse ◽  
Inbred Mouse Strain ◽  
Mouse Strains ◽  
Ah Receptor ◽  
Inbred Mouse Strains ◽  
Sprague Dawley ◽  
Rat Strains ◽  
Specific Activities ◽  
Inbred Rat

ABSTRACT Forty-four inbred and four randombred rat strains and 20 inbred mouse strains were examined for their Ah phenotype by determining the induction of liver microsomal aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity (EC 1.14.14.1) by intraperitoneal treatment with either β-naphthoflavone or 3-methylcholanthrene. All 48 rat strains were found to be Ah-responsive. The maximally induced hydroxylase specific activities of the ALB/Pit, MNR/Pit, MR/Pit, SHR/Pit, and Sprague-Dawley strains were of the same order of magnitude as the basal hydroxylase specific activities of the ACI/Pit, F344/Pit, OKA/Pit, and MNR/N strains. Six of the 20 mouse strains were Ah-nonresponsive (i.e. lacking the normal induction response and presumably lacking detectable amounts of the Ah receptor). The basal hydroxylase specific activities of the BDL/N, NFS/N, STAR/N, and ST/JN mouse strains were more than twice as high as the maximally induced hydroxylase specific activity of the CBA/HT strain.——To date, 24 Ah-nonresponsive mouse strains have been identified, out of a total of 68 known to have been characterized. The reasons for not finding a single Ah-nonresponsive inbred rat strain—as compared with about one Ah-nonresponsive inbred mouse strain found for every three examined—remain unknown.

scholarly journals Relationship between phospholipid transfer protein activity and HDL level and size among inbred mouse strains

1999 ◽  
Vol 40 (2) ◽  
pp. 295-301 ◽  
Author(s):  
John J. Albers ◽  
Wendy Pitman ◽  
Gertrud Wolfbauer ◽  
Marian C. Cheung ◽  
Hal Kennedy ◽  
...  
Keyword(s):  
Inbred Mouse ◽  
Mouse Strains ◽  
Phospholipid Transfer Protein ◽  
Inbred Mouse Strains ◽  
Protein Activity ◽  
Transfer Protein ◽  
Phospholipid Transfer

scholarly journals Heterogeneity of respiratory dendritic cell subsets and lymphocyte populations in inbred mouse strains

2012 ◽  
Vol 13 (1) ◽  
pp. 94 ◽  
Author(s):  
Holger Hackstein ◽  
Andreas Wachtendorf ◽  
Sabine Kranz ◽  
Jürgen Lohmeyer ◽  
Gregor Bein ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Inbred Mouse ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Dendritic Cell Subsets ◽  
Lymphocyte Populations
Sign in / Sign up

Export Citation Format

Share Document