scholarly journals Multiple Sclerosis Cerebrospinal Fluid Biomarkers

2006 ◽  
Vol 22 (4) ◽  
pp. 187-196 ◽  
Author(s):  
Gavin Giovannoni
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Formal Method ◽  
The Body ◽  
End Point ◽  
Neurodegenerative Process ◽  
Sufficient Detail ◽  
Cerebrospinal Fluid Biomarkers ◽  
Biomarker Research ◽  
Relationship Of

Cerebrospinal fluid (CSF) is the body fluid closest to the pathology of multiple sclerosis (MS). For many candidate biomarkers CSF is the only fluid that can be investigated. Several factors need to be standardized when sampling CSF for biomarker research: time/volume of CSF collection, sample processing/storage, and the temporal relationship of sampling to clinical or MRI markers of disease activity. Assays used for biomarker detection must be validated so as to optimize the power of the studies. A formal method for establishing whether or not a particular biomarker can be used as a surrogate end-point needs to be adopted. This process is similar to that used in clinical trials, where the reporting of studies has to be done in a standardized way with sufficient detail to permit a critical review of the study and to enable others to reproduce the study design. A commitment must be made to report negative studies so as to prevent publication bias. Pre-defined consensus criteria need to be developed for MS-related prognostic biomarkers. Currently no candidate biomarker is suitable as a surrogate end-point. Bulk biomarkers of the neurodegenerative process such as glial fibrillary acidic protein (GFAP) and neurofilaments (NF) have advantages over intermittent inflammatory markers.

Multiplex assessment of cerebrospinal fluid biomarkers in multiple sclerosis

2020 ◽  
Vol 45 ◽  
pp. 102391 ◽  
Author(s):  
Mie Reith Mahler ◽  
Helle Bach Søndergaard ◽  
Sophie Buhelt ◽  
Marina Rode von Essen ◽  
Jeppe Romme Christensen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Cerebrospinal Fluid Biomarkers

scholarly journals Evaluation of laboratory research data in patients with multiple sclerosis in the aspect of comboridity

2019 ◽  
pp. 75-82
Author(s):  
G. Chupryna
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Blood Test ◽  
Laboratory Data ◽  
Well Being ◽  
The Body ◽  
Blood Cholesterol ◽  
Laboratory Research ◽  
Blood Tests ◽  
Study Laboratory

The objective of the work – to study laboratory data in patients with multiple sclerosis in order to clarify the nature of the influence of comorbid pathology on the level of dysfunction of biochemical processes of the body. We examined 216 patients with multiple sclerosis with various forms of course. Patients of the general sample were divided into two groups: І (n = 109) – without concomitant diseases and ІІ (n = 107) – with the presence of concomitant diseases. The results of general clinical tests of blood and urine, a biochemical blood test, a study of cerebrospinal fluid, the immune status of the blood, and the level of autoantibodies to brain antigens were evaluated. General clinical blood and urine tests, a biochemical blood test were performed on all 216 patients with multiple sclerosis from the study group. The study of cerebrospinal fluid (macroscopic, microscopic, polymerase chain reaction) and immunological blood tests (study of indicators of cellular and humoral immunity, the level of autoantibodies to brain antigens) were performed in 42 patients with multiple sclerosis of both groups. As a result, it was found that significant differences between groups І and ІІ exist due to an increase in platelet counts in patients of group ІІ (P < 0.05) and AsAT concentration (P < 0.05), an increase in creatinine concentration (P < 0.05), an increase in blood cholesterol (P < 0.05). Such differences in the indicators of general clinical and biochemical blood tests are, in our opinion, due to the presence of cardiovascular and gastroenterological comorbidity in patients with multiple sclerosis and correlate with a decrease in their overall well-being. As a result of studying the general analysis of urine in 84.7 % of patients of the general sample, there were general inflammatory signs, which were more pronounced in several indicators in the ІІ group of patients, clinically correlated with the severity of pelvic disorders. Systemic and deeper changes in the level of NK cells, the main protein of myelin, the total human brain antigen, as well as the immunoregulatory cycle in patients with multiple sclerosis with comorbid pathology were also established.

scholarly journals Cerebrospinal Fluid Biomarkers of Japanese Encephalitis

F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 334
Author(s):  
Nabonita Sengupta ◽  
Sriparna Mukherjee ◽  
Piyush Tripathi ◽  
Rashmi Kumar ◽  
Amol Ratnakar Suryawanshi ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Japanese Encephalitis ◽  
Clinical Manifestations ◽  
Complement C3 ◽  
Gamma Chain ◽  
Acute Encephalitis ◽  
Cerebrospinal Fluid Biomarkers ◽  
Wide Range ◽  
2D Gel ◽  
Biomarker Research

Japanese encephalitis (JE) is the leading cause of viral encephalitis in Asia. Acute encephalitis syndrome (AES) is a group of central nervous system (CNS) disorders caused by a wide range of viruses, bacteria, fungi, chemicals and toxins. It is important to distinguish between various forms of infectious encephalitis with similar clinical manifestations in order to ensure specific and accurate diagnosis and development of subsequent therapeutic strategies. Cerebrospinal fluid (CSF) is in direct contact with the CNS and hence it is considered to be an excellent source for identifying biomarkers for various neurological disorders. With the recent advancement in proteomic methodologies, the field of biomarker research has received a remarkable boost.  The present study identifies potential biomarkers for JE using a proteomics based approach. The CSF proteomes from ten patients each with JE and Non-JE acute encephalitis were analyzed by 2D gel electrophoresis followed by mass spectrometry. Vitamin D-binding protein (DBP), fibrinogen gamma chain, fibrinogen beta chain, complement C4-B, complement C3 and cytoplasmic actin were found to be significantly elevated in case of JE indicating severe disruption of the blood brain barrier and DBP can be suggested to be an important diagnostic marker.

Relationship of TNF-alpha, sTNFRI levels in cerebrospinal fluid and blood serum with TNFRSF2, TNFR1 polymorphisms and the course of multiple sclerosis

2019 ◽  
Vol 17 (7) ◽  
pp. 74-78
Author(s):  
I. V. Smagina ◽  
◽  
A. S. Palashenko ◽  
S. A. Elchaninova ◽  
E. A. Nazarchuk ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Blood Serum ◽  
Tnf Alpha ◽  
Relationship Of
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