scholarly journals Effects of Repeated Intrathecal Triamcinolone-Acetonide Application on Cerebrospinal Fluid Biomarkers of Axonal Damage and Glial Activity in Multiple Sclerosis Patients

2014 ◽  
Vol 18 (6) ◽  
pp. 631-637 ◽  
Author(s):  
P. S. Rommer ◽  
F. Kamin ◽  
A. Petzold ◽  
H. Tumani ◽  
M. Abu-Mugheisib ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Triamcinolone Acetonide ◽  
Axonal Damage ◽  
Cerebrospinal Fluid Biomarkers ◽  
Multiple Sclerosis Patients

scholarly journals Are Cerebrospinal Fluid Biomarkers Useful in Predicting the Prognosis of Multiple Sclerosis Patients?

2011 ◽  
Vol 12 (11) ◽  
pp. 7960-7970 ◽  
Author(s):  
Alberto Gajofatto ◽  
Matilde Bongianni ◽  
Gianluigi Zanusso ◽  
Maria Donata Benedetti ◽  
Salvatore Monaco
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Cerebrospinal Fluid Biomarkers ◽  
Multiple Sclerosis Patients

scholarly journals Decreased Neurofilament L Chain Levels in Cerebrospinal Fluid and Tolerogenic Plasmacytoid Dendritic Cells in Natalizumab-Treated Multiple Sclerosis Patients – Brief Research Report

2021 ◽  
Vol 15 ◽  
Author(s):  
Adriel S. Moraes ◽  
Vinicius O. Boldrini ◽  
Alliny C. Dionete ◽  
Marilia D. Andrade ◽  
Ana Leda F. Longhini ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Dendritic Cells ◽  
Serum Levels ◽  
Plasmacytoid Dendritic Cells ◽  
Axonal Damage ◽  
Research Report ◽  
Neurofilament Light ◽  
Soluble Hla ◽  
Multiple Sclerosis Patients

BackgroundNeurofilament Light (NfL) chain levels in both cerebrospinal fluid (CSF) and serum have been correlated with the reduction of axonal damage in multiple sclerosis (MS) patients treated with Natalizumab (NTZ). However, little is known about the function of plasmacytoid cells in NTZ-treated MS patients.ObjectiveTo evaluate CSF NfL, serum levels of soluble-HLA-G (sHLA-G), and eventual tolerogenic behavior of plasmacytoid dendritic cells (pDCs) in MS patients during NTZ treatment.MethodsCSF NfL and serum sHLA-G levels were measured using an ELISA assay, while pDCs (BDCA-2+) were accessed through flow cytometry analyses.ResultsCSF levels of NfL were significantly reduced during NTZ treatment, while the serum levels of sHLA-G were increased. Moreover, NTZ treatment enhanced tolerogenic (HLA-G+, CD274+, and HLA-DR+) molecules and migratory (CCR7+) functions of pDCs in the peripheral blood.ConclusionThese findings suggest that NTZ stimulates the production of molecules with immunoregulatory function such as HLA-G and CD274 programmed death-ligand 1 (PD-L1) which may contribute to the reduction of axonal damage represented by the decrease of NfL levels in patients with MS.

scholarly journals No prognostic value of routine cerebrospinal fluid biomarkers in a population-based cohort of 407 multiple sclerosis patients

BMC Neurology ◽  
2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Madlyne Becker ◽  
Clotilde Latarche ◽  
Emilie Roman ◽  
Marc Debouverie ◽  
Catherine Malaplate-Armand ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Prognostic Value ◽  
Population Based ◽  
Cerebrospinal Fluid Biomarkers ◽  
Multiple Sclerosis Patients

scholarly journals Complement Receptor 2 is increased in cerebrospinal fluid of multiple sclerosis patients and regulates C3 function

2016 ◽  
Vol 166-167 ◽  
pp. 89-95 ◽  
Author(s):  
Rickard P.F. Lindblom ◽  
Shahin Aeinehband ◽  
Mikael Ström ◽  
Faiez Al Nimer ◽  
Kerstin Sandholm ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Complement Receptor ◽  
Complement Receptor 2 ◽  
Multiple Sclerosis Patients

scholarly journals Genetic and Infectious Profiles Influence Cerebrospinal Fluid IgG Abnormality in Japanese Multiple Sclerosis Patients

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e95367 ◽  
Author(s):  
Satoshi Yoshimura ◽  
Noriko Isobe ◽  
Takuya Matsushita ◽  
Katsuhisa Masaki ◽  
Shinya Sato ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Multiple Sclerosis Patients

scholarly journals Cerebrospinal-fluid-derived Immunoglobulin G of Different Multiple Sclerosis Patients Shares Mutated Sequences in Complementarity Determining Regions

2013 ◽  
Vol 12 (12) ◽  
pp. 3924-3934 ◽  
Author(s):  
Vaibhav Singh ◽  
Marcel P. Stoop ◽  
Christoph Stingl ◽  
Ronald L. Luitwieler ◽  
Lennard J. Dekker ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Immunoglobulin G ◽  
Complementarity Determining Regions ◽  
Multiple Sclerosis Patients
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