scholarly journals Recurrent Respiratory Papillomatosis Causing Chronic Stridor and Delayed Speech in an 18-Month-Old Boy

2006 ◽  
Vol 13 (7) ◽  
pp. 381-383
Author(s):  
Adel Alharbi ◽  
Derek Drummond ◽  
Alfredo Pinto ◽  
Valerie Kirk
Keyword(s):  
Present Report ◽  
Spontaneous Remission ◽  
Recurrent Respiratory Papillomatosis ◽  
Laser Evaporation ◽  
Laryngeal Papillomatosis ◽  
Papilloma Virus ◽  
Uncommon Disease ◽  
Adjuvant Drug Therapy ◽  
Mother To Child ◽  
Lymphoblastoid Interferon

Recurrent respiratory papillomatosis is a relatively uncommon disease that presents clinically with symptoms ranging from hoarseness to severe dyspnea. Human papilloma virus types 6 and 11 are important in the etiology of papillomas and are most probably transmitted from mother to child during birth. Although spontaneous remission is frequent, pulmonary spread and/or malignant transformation resulting in death has been reported. CO2laser evaporation of papillomas and adjuvant drug therapy using lymphoblastoid interferon-alpha are the most common treatments. However, several other treatments have been tried, with varying success. In the present report, a case of laryngeal papillomatosis presenting with chronic stridor and delayed speech is described.

E6 and E7 oncogene expression by human papilloma virus (HPV) and the aggressive behavior of recurrent laryngeal papillomatosis (RLP)

2006 ◽  
Vol preprint (2007) ◽  
pp. 1
Author(s):  
Bahig Shehata ◽  
Kristen Otto ◽  
Steven Sobol ◽  
Christina Stockwell ◽  
Cora Foulks ◽  
...  
Keyword(s):  
Human Papilloma Virus ◽  
Aggressive Behavior ◽  
Laryngeal Papillomatosis ◽  
Papilloma Virus ◽  
Oncogene Expression ◽  
E6 And E7 ◽  
E7 Oncogene

New technique for laryngomicrosurgery: narrow band imaging-assisted video-laryngomicrosurgery for laryngeal papillomatosis

2015 ◽  
Vol 129 (S2) ◽  
pp. S74-S76 ◽  
Author(s):  
K Adachi ◽  
T Umezaki ◽  
H Kiyohara ◽  
S Komune
Keyword(s):  
Case Report ◽  
Tumor Recurrence ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Present Report ◽  
New Technique ◽  
Laryngeal Papillomatosis

AbstractObjective:In the present report, we describe the use of narrow band imaging during video-laryngomicrosurgery for laryngeal papillomatosis.Case report:It is difficult to peri-operatively locate all the superficial papillomatous lesions when the disease is widespread, which then results in tumor recurrence. Therefore, we have constructed a narrow band imaging video-laryngomicrosurgery system, which we have used for two cases of laryngeal papillomatosis.Conclusion:Our narrow band imaging-assisted video-laryngomicrosurgery system to visualise superficial laryngeal papillomatosis more clearly.

Congenital Pure Red Cell Hypoplasia in Identical Twins

PEDIATRICS ◽  
1974 ◽  
Vol 54 (5) ◽  
pp. 646-647
Author(s):  
G. W. Waterkotte ◽  
A. E. McElfresh
Keyword(s):  
Bone Marrow ◽  
Spontaneous Remission ◽  
Identical Twins ◽  
Early Infancy ◽  
Normocytic Anemia ◽  
Red Cell ◽  
Normal Numbers ◽  
Genetic Transmission ◽  
The Past ◽  
Uncommon Disease

Congenital aregenerative anemia is a relatively uncommon disease first described by Blackfan and Diamond in the late 1930s.1 The condition usually begins in early infancy as a normochromic, normocytic anemia with decreased red cell precursors in the bone marrow and normal numbers of thrombocytes and leukocytes. With the exception of a few patients undergoing spontaneous remission, patients required repeated transfusions until steroids became available. Over the past forty years several hundred cases of this disease have been reported with speculation regarding the etiology. Occasional families have been described with two or three involved members, suggesting genetic transmission. We have recently observed a set of twins with the uncommon disease.

2′,5′-Oligoadenylate synthetase activity analysis and human papilloma virus typing as prognostic factors in patients with recurrent respiratory papillomatosis

2004 ◽  
Vol 118 (10) ◽  
pp. 750-756 ◽  
Author(s):  
V. Gerein ◽  
E. Rastorguev ◽  
J. Gerein ◽  
E. Lodemann ◽  
H. Pfister ◽  
...  
Keyword(s):  
Human Papilloma Virus ◽  
Interferon Alpha ◽  
Clinical Course ◽  
Recurrent Respiratory Papillomatosis ◽  
Synthetase Activity ◽  
Oligoadenylate Synthetase ◽  
Papilloma Virus ◽  
Interferon Alpha Therapy ◽  
Alpha Therapy

Objective: Determination of early prognostic factors in patients with recurrent respiratory papillomatosis is extremely important, so the major goal of our prospective, multicentre study was to evaluate (1) the feasibility of various factors to determine prognosis of the clinical course,as well as (2) the response to interferon-alpha therapy in recurrent respiratory papillomatosis. Methods: Forty-two patients with recurrent respiratory papillomatosis were treated with interferon-alpha (3 MU/m2 three times per week; mean therapy duration was 2.7 ± 1.8 years)in 1983–1994 and followed-up until 2003. Human papilloma virus (HPV) type, recurrent respiratory papillomatosis severity and 2′,5′-oligoadenylate synthetase activity were determined by standard methods and analysed for correlation with the results of long-term clinical outcome.Results and conclusion: Patients with HPV type 11, a severity score >4, a high number of surgical procedures prior to interferon-alpha therapy and a high basal 2′,5′-oligoadenylate synthetase activity should be considered at high risk of an aggressive clinical course, often with spread to lower airway passages, malignant transformation and death. Human papilloma virus type, score for recurrent respiratory papillomatosis severity, number of surgical procedures and 2′,5′-oligoadenylate synthetase activity showed significant association with response to interferon-alpha therapy and the long-term clinical course, so these factors have value in predicting prognosis in recurrent respiratory papillomatosis.

Concurrent oral human papilloma virus infection in patients with recurrent respiratory papillomatosis: A preliminary study

2014 ◽  
Vol 124 (12) ◽  
pp. 2785-2790 ◽  
Author(s):  
Hayley Born ◽  
Ryan Ruiz ◽  
Avanti Verma ◽  
Salvatore Taliercio ◽  
Stratos Achlatis ◽  
...  
Keyword(s):  
Virus Infection ◽  
Human Papilloma Virus ◽  
Human Papilloma Virus Infection ◽  
Recurrent Respiratory Papillomatosis ◽  
Papilloma Virus ◽  
Preliminary Study

scholarly journals Recurrent Respiratory Papillomatosis With Complete Response to Systemic Bevacizumab Therapy

2021 ◽  
pp. 014556132110405
Author(s):  
Daniel Gorelik ◽  
Amy Frantz ◽  
Jeffrey S. Dome ◽  
Brian K. Reilly
Keyword(s):  
Human Papilloma Virus ◽  
Airway Obstruction ◽  
Clinical Symptoms ◽  
Complete Response ◽  
Recurrent Respiratory Papillomatosis ◽  
Benign Neoplasms ◽  
Respiratory Compromise ◽  
Papilloma Virus

Recurrent respiratory papillomatosis is a condition caused by human papilloma virus, usually sub types 6 and 11. Papillomas are benign neoplasms that are most commonly found on the larynx and can be often associated with significant airway involvement. Frequency of episodes varies among patients as do the clinical symptoms. Patients often present with symptoms such as hoarseness but there is potential for respiratory compromise and even complete airway obstruction.

scholarly journals An estimate of the incidence and prevalence of laryngeal papillomatosis in São Paulo State (Brasil)

2020 ◽  
Vol 66 (9) ◽  
pp. 1247-1251
Author(s):  
Gustavo Mercuri ◽  
Sérgio Augusto Rodrigues ◽  
Regina Helena Garcia Martins
Keyword(s):  
Epidemiological Data ◽  
Sao Paulo ◽  
Health Centers ◽  
São Paulo ◽  
Regional Health ◽  
Laryngeal Papillomatosis ◽  
Papilloma Virus ◽  
Paulo State ◽  
São Paulo State

SUMMARY BACKGROUND: Recurrent laryngeal papillomatosis, caused by the Human Papilloma Virus, has a significant economic impact worldwide and there are no epidemiological data of this disease in Brasil. OBJECTIVE: The objective of the study was to estimate the incidence and prevalence of laryngeal papillomatosis of some otorhinolaryngology centers in São Paulo State (Brasil). METHODS: A questionnaire containing data on the number of new and follow-up cases diagnosed with laryngeal papillomatosis was sent to the Otorhinolaryngology services (n=35) of São Paulo State (Brasil). RESULTS: A total of 20 otorhinolaryngology centers answered the questionnaire. Of these, the five largest regional health centers were selected as follows: Campinas (42 cities – 4,536,657 inhabitants), Sao Jose do Rio Preto (102 cities – 1,602,845 inhabitants), Ribeirão Preto (26 cities – 1,483,715 inhabitants), Bauru (68 cities – 1,770,427 inhabitants), and Sorocaba (47 cities – 2,478,208 inhabitants). The incidence and prevalence of each regional health centers were, respectively: Campinas (5.51;7.27), Sorocaba (2.02;6.86), São José do Rio Preto (1.87;7.49), Ribeirão Preto (11.46;22.92), and Bauru (3.95;7.91). CONCLUSION: The incidence and prevalence of the laryngeal papillomatosis of the five largest regional health centers of the interior of São Paulo State (Brasil) varied between 1.87 to 11.46 and 6.86 to 22.92 per 1,000,000 inhabitants, respectively for a total population of 11,871,852 inhabitants.

Treatment of Recurrent Respiratory Papillomatosis: Case Series and Review of Technique

2021 ◽  
Author(s):  
Christopher Manley ◽  
Christoph Hutchinson ◽  
Amit Mahajan ◽  
Omar Ibrahim ◽  
Erik Folch ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Argon Plasma Coagulation ◽  
Case Series ◽  
Argon Plasma ◽  
Recurrent Respiratory Papillomatosis ◽  
Bronchial Obstruction ◽  
Effective Technique ◽  
Surgical Smoke ◽  
Papilloma Virus ◽  
Plasma Coagulation

Adult Recurrent Respiratory Papillomatosis (RRP) is a rare disease caused by the human papilloma virus in which papilloma grows from the respiratory epithelium. Patients can suffer from significant respiratory distress secondary to tracheal or bronchial obstruction by papilloma and the mainstay of treatment is bronchoscopic debridement. There are a variety of techniques to resect the endoluminal tumor, including CO2 or YAG laser, argon plasma coagulation, microdebrider and cold forceps. There have been documented cases of healthcare workers contracting HPV after exposure to surgical smoke during ablation of papilloma and measures should be taken to avoid inhalation of the smoke plume. For proximal lesions that are accessible to a microdebrider, this appears to be a safe and effective technique that does not generate heat or surgical smoke.

Long-Term Response of Recurrent Respiratory Papillomatosis to Treatment with Lymphoblastoid Interferon Alfa-N1

1991 ◽  
Vol 325 (9) ◽  
pp. 613-617 ◽  
Author(s):  
Brigid G. Leventhal ◽  
H.K. Kashima ◽  
Phoebe Mounts ◽  
Linda Thurmond ◽  
Sharon Chapman ◽  
...  
Keyword(s):  
Recurrent Respiratory Papillomatosis ◽  
Interferon Alfa ◽  
Term Response ◽  
Lymphoblastoid Interferon

scholarly journals Immunomodulatory Effects of Bcg in Patients with Recurrent Respiratory Papillomatosis / Иммуномоделирующие Эффекты Всg У Пациентов С Рецидивирующим Респираторным Папилломатозом

Folia Medica ◽  
2013 ◽  
Vol 55 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Evelina K. Vetskova ◽  
Mariya N. Muhtarova ◽  
Toma I. Avramov ◽  
Tsvetelina R. Stefanova ◽  
Ivan J. Chalakov ◽  
...  
Keyword(s):  
Combined Therapy ◽  
Hpv Infection ◽  
Recurrent Respiratory Papillomatosis ◽  
Efficient Treatment ◽  
Papilloma Virus ◽  
Cell Clones ◽  
Rare Manifestation ◽  
Th1 Cytokine ◽  
Treg Differentiation

Abstract BACKGROUND: Recurrent respiratory papillomatosis (RRP) is a rare manifestation of human papilloma virus (HPV) infection with extremely high relapse frequency, poorly understood immunopathogenesis, and lack of efficient treatment. Immunotherapy with Calgevax (BCG) in combination with CO2 surgery significantly improves the outcome of RRP. The present study investigates cellular immunity parameters in RRP patients, and the effects of 20-month Calgevax immunomodulation. MATERIALS AND METHODS: RRP patients (n = 15) subjected to combined therapy were tested before, 6, 12 and 20 months after the start of immunomodulation. Absolute counts and percentage of T, B and NK cells, effector Tc1 (CD8 + IFNγ+); Th1 (CD4+IFNγ+), Th17 (CD4+IL-17+) and regulatory (CD4+FoxP3+) T lymphocytes, as well as the in vitro stimulated secretion of IL-2, IL-4, IL-5, IL-10, IFNγ and TNFα were determined by flow cytometry (FACSCanto II, BD). RESULTS: While no significant changes were detected in the circulating T, B and NK subsets, RRP patients presented increased proportions of Tc1, Th1 and Th17 cells, and significantly reduced IFNγ/IL-4 and IFNγ/IL-10 ratios as compared to healthy controls (15% vs. 8%), (58 vs. 139 and 15 vs. 26, respectively), p < 0.05 for all comparisons. Increased Treg (9% vs. 4%), and decreased Th17 effectors share (0.7% vs. 0.4%) were observed at 12 months, while IFNγ/IL-4 and IFNγ/IL-10 ratios were restored after 20 months of Calgevax application. CONCLUSIONS: Antiviral response closely depends on cytokine background. Calgevax potentiates Treg differentiation at the expense of proinflammatory Th17, limits hyperactivation and virus-specific T cell clones depletion, and restores a Th1 cytokine background.

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