scholarly journals Frequency of Certain Established Risk Factors in Soft Tissue Sarcomas in Adults: A Prospective Descriptive Study of 658 Cases

Sarcoma ◽  
2008 ◽  
Vol 2008 ◽  
pp. 1-6 ◽  
Author(s):  
Nicolas Penel ◽  
Jessica Grosjean ◽  
Yves Marie Robin ◽  
Luc Vanseymortier ◽  
Stéphanie Clisant ◽  
...  
Keyword(s):  
Risk Factors ◽  
Radiation Therapy ◽  
Soft Tissue ◽  
Genetic Disease ◽  
Soft Tissue Sarcomas ◽  
Descriptive Study ◽  
Genetic Syndromes ◽  
Genetic Syndrome ◽  
Rare Tumours ◽  
Radiation Induced

Soft tissue sarcomas are rare tumours with infrequent identified aetiological factors. Several genetic syndromes as well as previous radiation therapy and/or chronic lymphoedema have been suspected to predispose to some soft tissue sarcomas. Between January 1997 and September 2005, we carried out a prospective descriptive study to estimate the frequency of some particular etiological factors among 658 patients with soft tissue sarcomas. Sarcomas associated with a clinically identified genetic disease represent 2.8% out of all cases (95%CI: 1.5–3.8%). Most of these cases (14/19) are related to Recklinghausen neurofibromatosis. Radiation-induced sarcomas represent 3.3% out of all cases (95%CI: 1.7–5.1%). Most of these cases (9/22) are related to prior breast cancer treatment. We had observed only 1 case of Stewart-Treves syndrome. Liposarcoma, the most frequent histological subtype observed, is not associated with any particular aetiological entity. Finally, most of the adult soft tissue sarcomas are not related to any classical clinically identified genetic disease or previous radiation therapy and/or chronic lymphoedema risk factors. Frequency of underlying genetic syndrome which may predispose to soft tissue sarcomas could be higher than previously reported.

Surgical and Adjuvant Radiation Therapy of Resectable Retroperitoneal Soft Tissue Sarcomas in Adults

1992 ◽  
Vol 78 (6) ◽  
pp. 388-391 ◽  
Author(s):  
Alessandro Testolin ◽  
Franco Pozza ◽  
Sandro Dal Fior ◽  
Gian Paolo Bolzicco ◽  
Gino Antonio Panizzoni ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Soft Tissue ◽  
Adjuvant Radiotherapy ◽  
Soft Tissue Sarcomas ◽  
Disease Free Survival ◽  
Distant Metastases ◽  
Adjuvant Radiation ◽  
Adjuvant Radiation Therapy ◽  
Radiation Induced ◽  
Local Regional Recurrence

Primary soft tissue sarcoma of the retroperitoneum is a rare disease. A series of 11 evaluable adult patients with retroperitoneal soft tissue sarcomas is reported. These patients were treated with complete surgery and adjuvant radiation therapy (total dose from 50 to 64 Gy) using an 18 MeV linear accelerator. After a median follow-up of 48 months (range, 6-84), 4 patients had a local-regional recurrence, 3 had distant metastases, and 4 died of progressive disease. Four-year estimated disease-free survival was 54.5% and overall survival was 70%. Treatment was well tolerated by most patients: 7 patients experienced moderate gastrointestinal toxicity, mainly nausea and diarrhea, during radiotherapy; 2 cases had weight loss > 15% at the end of the therapy; and chronic ileitis was observed in 2 cases. We conclude that adjuvant radiotherapy seems to reduce the incidence of local-regional recurrences in these patients. No radiation-induced irreversible injury was observed, but one young woman had amenorrhea after radiotherapy. Controlled clinical trials are warrented to define the role and effiectiveness of adjuvant radiotherapy and/or chemotherapy in retroperitoneal soft tissue sarcomas.

scholarly journals Head and neck sarcomas: imaging “pearls” and “mimics”

2020 ◽  
pp. 20200922
Author(s):  
Xin-Ying Kowa ◽  
Sofia Otero ◽  
Susan Jawad
Keyword(s):  
Differential Diagnosis ◽  
Soft Tissue ◽  
Head And Neck ◽  
Soft Tissue Sarcomas ◽  
Rare Tumours ◽  
Radiation Induced ◽  
Characteristic Features ◽  
Definitive Management

Sarcomas are rare tumours, which can arise in any location in the head and neck. This review highlights the characteristic features of the commoner subtypes of bone and soft tissue sarcomas (including radiation-induced sarcomas), with emphasis on diagnostic “pearls” and imaging “mimics”. This knowledge will help the radiologist formulate a differential diagnosis and expedite referral to a regional sarcoma unit for definitive management.

Functional and psychosocial effects of multimodality limb-sparing therapy in patients with soft tissue sarcomas.

1989 ◽  
Vol 7 (9) ◽  
pp. 1217-1228 ◽  
Author(s):  
A E Chang ◽  
S M Steinberg ◽  
M Culnane ◽  
M H Lampert ◽  
A J Reggia ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Soft Tissue ◽  
Sexual Activity ◽  
Standardized Test ◽  
Soft Tissue Sarcomas ◽  
High Grade ◽  
Postoperative Radiation ◽  
Limb Function ◽  
Postoperative Radiation Therapy ◽  
Global Quality Of Life

We have documented functional and psychosocial changes in patients with extremity soft tissue sarcomas who have undergone multimodality limb-sparing treatments. In 88 patients, parameters related to economic status, sexual activity, pain, limb function, and global quality of life (QOL) were recorded prior to surgery and every 6 months postoperatively. Changes from the preoperative assessment for every parameter were analyzed in each patient. Six months after surgery, there was a decrease in employment status, sexual activity, and in limb function in a significant number of patients. At 12 months, these decreases were still evident. Despite these changes, global QOL measured by a standardized test showed at least some improvement in a significant proportion of patients at 12 months. These findings highlight the difficulty in defining QOL. It could not be ascertained if radiation therapy and/or chemotherapy were causative factors in specific changes because of the small numbers of patients in each subgroup. However, among 60 patients with high-grade sarcomas, significant wound problems developed in 10 of 33 who received postoperative radiation therapy in combination with adjuvant doxorubicin and cyclophosphamide chemotherapy compared with one of 27 patients who received adjuvant chemotherapy alone (P = .016). Also, among high-grade sarcoma patients with 12-month follow-up, six of 19 patients who received radiation therapy and chemotherapy developed joint contractures compared with zero of 15 patients who received chemotherapy alone (P less than .04). The combination of postoperative radiation therapy and chemotherapy appeared to be associated with significantly more tissue-related injury in patients with high-grade sarcomas compared with chemotherapy alone.

OC-0087: Preoperative Hypofractionated Radiation Therapy for Soft Tissue Sarcomas of Extremity and Trunk

2020 ◽  
Vol 152 ◽  
pp. S40
Author(s):  
F. Navarria ◽  
A. Lauretta ◽  
E. Palazzari ◽  
R. Innocente ◽  
M. Gigante ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Hypofractionated Radiation Therapy ◽  
Hypofractionated Radiation

Flap Reconstruction of Sarcoma Defects in the Setting of Neoadjuvant and Adjuvant Radiation

2018 ◽  
Vol 35 (04) ◽  
pp. 287-293 ◽  
Author(s):  
Rohini Kadle ◽  
Catherine Motosko ◽  
George Zakhem ◽  
John Stranix ◽  
Timothy Rapp ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Soft Tissue ◽  
Radiation Treatment ◽  
Soft Tissue Sarcomas ◽  
Adjuvant Radiation ◽  
Complication Rates ◽  
Flap Reconstruction ◽  
Fasciocutaneous Flaps ◽  
Musculoskeletal Tumor Society

Background Limb-sparing treatment of extremity soft tissue sarcomas requires wide resections and radiation therapy. The resulting complex composite defects necessitate reconstructions using either muscle or fasciocutaneous flaps, often in irradiated wound beds. Methods A retrospective chart review was performed of all limb-sparing soft tissue sarcoma resections requiring immediate flap reconstruction from 2012 through 2016. Results Forty-four patients with 51 flaps were identified: 25 fasciocutaneous and 26 muscle-based flaps. Mean defect size, radiation treatment, and follow-up length were similar between groups. More often, muscle-based flaps were performed in younger patients and in the lower extremity. Seventeen flaps were exposed to neoadjuvant radiation, 12 to adjuvant radiation, 5 to both, and 17 to no radiation therapy. Regardless of radiation treatment, complication rates were comparable, with 28% in fasciocutaneous and 31% in muscle-based groups (p < 0.775). Muscle-based flaps performed within 6 weeks of undergoing radiotherapy were less likely to result in complications than those performed after greater than 6 weeks (p < 0.048). At time of follow-up, Musculoskeletal Tumor Society scores for fasciocutaneous and muscle-based reconstructions, with or without radiation, showed no significant differences between groups (mean [SD]: 91% [8%] vs. 89% [13%]). Conclusion The similar complication rates and functional outcomes in this study support the safety and efficacy of both fasciocutaneous flaps and muscle-based flaps in reconstructing limb-sparing sarcoma resection defects, with or without radiotherapy.

scholarly journals Radiation therapy and conservative surgery for soft tissue sarcomas of the extremities, torso and head and neck

1992 ◽  
Vol 3 ◽  
pp. S97-S101 ◽  
Author(s):  
A. De Paoli ◽  
G. Bertola ◽  
G. Boz ◽  
F. Gherlinzoni ◽  
S. Frustaci ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Soft Tissue ◽  
Head And Neck ◽  
Soft Tissue Sarcomas ◽  
Conservative Surgery
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