Structure-Processing-Property Relationship of Poly(Glycolic Acid) for Drug Delivery Systems 1: Synthesis and Catalysis

Till date, market is augmented with a huge number of improved drug delivery systems. The success in this area is basically due to biodegradable polymers. Although conventional systems of drug delivery utilizing the natural and semisynthetic polymers so long but synthetic polymer gains success in the controlled drug delivery area due to better degradation profile and controlled network and functionality. The polyesters are the most studied class group due the susceptible ester linkage in their backbone. The Poly(glycolic Acid) (PGA), Poly(lactic acid) (PLA), and Polylactide-co-glycolide (PLGA) are the best profiled polyesters and are most widely used in marketed products. These polymers, however, still are having drawbacks which failed them to be used in platform technologies like matrix systems, microspheres, and nanospheres in some cases. The common problems arose with these polymers are entrapment inefficiency, inability to degrade and release drugs with required profile, and drug instability in the microenvironment of the polymers. These problems are forcing us to develop new polymers with improved physicochemical properties. The present review gave us an insight in the various structural elements of Poly(glycolic acid), polyester, with in depth study. The first part of the review focuses on the result of studies related to synthetic methodologies and catalysts being utilized to synthesize the polyesters. However the author will also focus on the effect of processing methodologies but due some constraints those are not included in the preview of this part of review.

Download Full-text

Drug delivery systems based on pharmaceutically active ionic liquids and biocompatible poly(lactic acid)

Journal of Materials Chemistry B ◽

10.1039/c4tb00264d ◽

2014 ◽

Vol 2 (20) ◽

pp. 3133-3141 ◽

Cited By ~ 14

Author(s):

Claire Jouannin ◽

Corine Tourné-Péteilh ◽

Vincent Darcos ◽

Tahmer Sharkawi ◽

Jean-Marie Devoisselle ◽

...

Keyword(s):

Drug Delivery ◽

Ionic Liquids ◽

Lactic Acid ◽

Controlled Release ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Poly Lactic Acid

API-ILs were encapsulated into biocompatible PLLA. The morphology and crystallinity of the resulting membranes can be tuned by varying the IL nature and content leading to controlled release.

Download Full-text

PLGA – THE SMART POLYMER FOR DRUG DELIVERY

Pharmacy & Pharmacology ◽

10.19163/2307-9266-2021-9-5-334-345 ◽

2021 ◽

Vol 9 (5) ◽

pp. 334-345

Author(s):

N. Surya ◽

S. Bhattacharyya

Keyword(s):

Drug Delivery ◽

Biodegradable Polymers ◽

Biomedical Applications ◽

Drug Delivery Systems ◽

Glycolic Acid ◽

Delivery Systems ◽

Nano Particles ◽

Natural Polymers ◽

Smart Polymer ◽

Novel Drug

Polymers have become an integral part of novel drug delivery system. One such successful biodegradable polymer is poly lactic-co-glycolic acid (PLGA) which consists of polyesters of lactic acid and glycolic acid. It is one of the FDA-approved biodegradable polymers which is extensively used for therapeutic purposes in recent times.The aim. To illuminate researchers on the chemistry, novel properties and applications of PLGA in pharmaceutical fields.Materials and methods. Various internet sources like Science Direct, Scopus, Web of Science, PubMed and google scholar were used as the data source. The key words search was carried out for the following words and combinations: PLGA, Novel drug delivery, PLGA Nano particles, biomedical applications of PLGA.Results. Pharmaceutical and biomedical industries are flooded with the use of synthetic and natural polymers. The mechanical and viscoelastic properties of the polymers make them suitable for the temporal and spatial delivery of therapeutic agents for an extended period. Employment of copolymerization techniques lead to the modification of water solubility of the polymers and make them suitable for various applications of drug delivery systems. Biodegradable polymers due to their biocompatibility and biodegradable property have attracted their use in novel drug delivery systems. PLGA is one of them. PLGA is versatile as it can be fabricated into any size, shape, and can be used to encapsulate small molecules, tissue engineering, and bone repair, etc.Conclusion. The sensitivity and biodegradability of PLGA makes it a smart polymer for targeted and sustained delivery of drugs and in various biomedical applications.

Download Full-text

Emulgel: A Review

Asian Journal of Pharmaceutical Research ◽

10.52711/2231-5691.2021.00047 ◽

2021 ◽

pp. 263-268

Author(s):

Sahil Hasan ◽

Saloni Bhandari ◽

Anshu Sharma ◽

Poonam Garg

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Control Release ◽

Delivery Systems ◽

Antifungal Drugs ◽

Therapeutic Drug ◽

Topical Drug Delivery ◽

Drug Molecules ◽

Control Release System ◽

Conventional Systems

Emulgel systems are currently attention to the pharmaceutical sectors because of their substantial potential to act as drug delivery vehicle by incorporating a broad range of drug molecules and higher stability compared to the other dosage form like cream, lotion, gel, etc. Emulsions are either available in an oil in water or water in oil type. These are prepared by the incorporation of the emulsion into the gel with constant stirring at a moderate speed. Incorporation of emulsion into a gel makes it a dual control release system, thereby, increasing its stability. It has better drug release if we compare to other topical drug delivery system. It is non greasy because of the presence of gel phase which enhances patient compliance. Gels has a major limitation for the delivery of hydrophobic drugs, so to overcome this limitation an emulsion based approach is being used so that even a hydrophobic therapeutic drug can enjoy the unique properties of gels. In recent years, these have also been a great interest in the use of novel polymers. These emulgels are having major advantages on vesicular drug delivery systems as well as on conventional systems in various aspects. Various permeation enhancers can enhance the effect; due to this emulgels can be used as better topical drug delivery systems over current drug delivery systems. The emulsion can be use for analgesics and antifungal drugs.

Download Full-text