scholarly journals Effect of Honey and Eugenol on Ehrlich Ascites and Solid Carcinoma

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Saravana Kumar Jaganathan ◽  
Dilip Mondhe ◽  
Z. A. Wani ◽  
Harish C. Pal ◽  
Mahitosh Mandal
Keyword(s):  
Tumor Growth ◽  
Growth Inhibition ◽  
Phenolic Content ◽  
Cancer Chemoprevention ◽  
Ehrlich Ascites Carcinoma ◽  
Mammary Adenocarcinoma ◽  
Tumor Growth Inhibition ◽  
Ehrlich Ascites ◽  
Phenolic Constituents ◽  
Solid Carcinoma

Ehrlich ascites carcinoma is a spontaneous murine mammary adenocarcinoma adapted to ascites form and carried in outbred mice by serial intraperitoneal (i/p) passages. The previous work from our laboratory showed that honey having higher phenolic content was potent in inhibiting colon cancer cell proliferation. In this work, we extended our research to screen the antitumor activity of two selected honey samples and eugenol (one of the phenolic constituents of honey) against murine Ehrlich ascites and solid carcinoma models. Honey containing higher phenolic content was found to significantly inhibit the growth of Ehrlich ascites carcinoma as compared to other samples. When honey containing higher phenolic content was given at 25% (volume/volume) intraperitoneally (i/p), the maximum tumor growth inhibition was found to be 39.98%. However, honey was found to be less potent in inhibiting the growth of Ehrlich solid carcinoma. On the other hand, eugenol at a dose of 100 mg/kg i/p was able to inhibit the growth of Ehrlich ascites by 28.88%. In case of solid carcinoma, eugenol (100 mg/kg; i/p) showed 24.35% tumor growth inhibition. This work will promote the development of honey and eugenol as promising candidates in cancer chemoprevention.

EFFECT OF METFORMIN, MELATONIN AND THEIR COMBINATIONS WITH PACLITAXEL ON THE GROWTH OF TRANSPLANTABLE HER2-POSITIVE BREAST TUMOR IN FEMALE FVB/N MICE

2017 ◽  
Vol 63 (4) ◽  
pp. 650-654
Author(s):  
Mikhail Osipov ◽  
Tatyana Semiglazova ◽  
Irina Popovich ◽  
Andrey Panchenko ◽  
Margarita Tyndyk ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Growth Inhibition ◽  
Treatment Efficacy ◽  
Breast Tumor ◽  
Cytotoxic Effect ◽  
Growth Index ◽  
Mammary Adenocarcinoma ◽  
Tumor Growth Inhibition ◽  
Her2 Positive ◽  
Subcutaneous Inoculation

69 female FVB/N mice were used. After subcutaneous inoculation of tumor cells of transplantable HER2-positive mammary adenocarcinoma all animals were randomly divided into 7 groups and received metformin 100 mg /kgdaily, melatonin 10 mg/kg daily, paclitaxel 6 mg/kg once a week as a monotherapy or in combination. Treatment efficacy was assessed by tumor growth inhibition and the tumor growth index. It was shown that melatonin increased the cytotoxic effect of pacli-taxel whereas monotherapy with metformin led to statistically significant tumor growth inhibition

scholarly journals Close Interactions between Mesenchymal Stem Cells and Neuroblastoma Cell Lines Lead to Tumor Growth Inhibition

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e48654 ◽  
Author(s):  
Giovanna Bianchi ◽  
Fabio Morandi ◽  
Michele Cilli ◽  
Antonio Daga ◽  
Chiara Bocelli-Tyndall ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tumor Growth ◽  
Growth Inhibition ◽  
Cell Lines ◽  
Neuroblastoma Cell ◽  
Tumor Growth Inhibition ◽  
Neuroblastoma Cell Lines

Diverse Roles of Macrophage Matrix Metalloproteinases in Tissue Destruction and Tumor Growth

1999 ◽  
Vol 82 (08) ◽  
pp. 846-849 ◽  
Author(s):  
Steven Shapiro
Keyword(s):  
Tumor Growth ◽  
Growth Inhibition ◽  
Gene Targeting ◽  
Critical Role ◽  
Human Biology ◽  
Disease Models ◽  
Tumor Growth Inhibition ◽  
Mouse Macrophage ◽  
Tissue Destruction

SummaryIn the mouse, macrophage elastase is critical to macrophage proteolysis. The use of gene-targeting has uncovered both pathological roles, including destructive effects in aneurysm formation and emphysema, and physiological roles, such as tumor growth inhibition and regulation of inflammation. Translation of findings from mouse to human biology depends upon how well the disease models replicate the human conditions and the similarity of enzyme profile between species. We know that human MMP-12 is associated with these diseases, but as opposed to the mouse, other MMPs may also be of importance (MMP-9, and perhaps MMP-7, in particular). Our interpretation is that findings in mice reflect the critical role of macrophage proteolysis in these disease processes.

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