scholarly journals Dermatitis Herpetiformis: From the Genetics to the Development of Skin Lesions

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Diletta Bonciani ◽  
Alice Verdelli ◽  
Veronica Bonciolini ◽  
Antonietta D'Errico ◽  
Emiliano Antiga ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Autoimmune Disease ◽  
Environmental Factors ◽  
Genetic Predisposition ◽  
Dermatitis Herpetiformis ◽  
Skin Lesions ◽  
Cutaneous Manifestation ◽  
Gluten Sensitivity

Dermatitis herpetiformis (DH) is a rare autoimmune disease linked to gluten sensitivity with a chronic-relapsing course. It is currently considered to be the specific cutaneous manifestation of celiac disease (CD). Both conditions are mediated by the IgA class of autoantibodies, and the diagnosis of DH is dependent on the detection of granular deposits of IgA in the skin. There is an underlying genetic predisposition to the development of DH, but environmental factors are also important. This paper describes these different factors and discusses the known mechanism that lead to the development of skin lesions.

scholarly journals Gluten-related disorders

2021 ◽  
pp. 100-100
Author(s):  
Biljana Vuletic ◽  
Aleksandar Kocovic ◽  
Marija Mladenovic ◽  
Zoran Lekovic ◽  
Vladimir Radlovic ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Clinical Features ◽  
Dermatitis Herpetiformis ◽  
Current Knowledge ◽  
Diagnosis And Treatment ◽  
Gluten Sensitivity ◽  
Wheat Allergy ◽  
Clinical Expression ◽  
Barley Flour ◽  
Gluten Ataxia

Gluten-related disorders are a heterogeneous group of clinical entities caused by intolerance of wheat, rye, and barley flour components. They occur in 3-5% of genetically predisposed persons and based on pathogenic and clinical features are classified into celiac disease, non-celiac gluten sensitivity, and wheat allergy. There are also specific entities such as dermatitis herpetiformis or gluten ataxia, which can occur either within the celiac disease or independently. This article based on the current knowledge shows the basic details of the pathogenesis, clinical expression, diagnosis, and treatment of these disorders.

scholarly journals Recent Advances in Dermatitis Herpetiformis

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Kimiko Nakajima
Keyword(s):  
Celiac Disease ◽  
Small Bowel ◽  
Immune Responses ◽  
Dermatitis Herpetiformis ◽  
Gluten Sensitivity ◽  
Bullous Disease ◽  
Autoimmune Bullous Disease ◽  
Multifactorial Disorders ◽  
Epidermal Transglutaminase ◽  
Transglutaminase 3

Dermatitis herpetiformis is an autoimmune bullous disease that is associated with gluten sensitivity which typically presents as celiac disease. As both conditions are multifactorial disorders, it is not clear how specific pathogenetic mechanisms may lead to the dysregulation of immune responses in the skin and small bowel, respectively. Recent studies have demonstrated that IgA and antibodies against epidermal transglutaminase 3 play an important role in the pathogenesis of dermatitis herpetiformis. Here, we review recent immunopathological progress in understanding the pathogenesis of dermatitis herpetiformis.

scholarly journals The Gluten-Free Diet for Celiac Disease and Beyond

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3993
Author(s):  
Bara Aljada ◽  
Ahmed Zohni ◽  
Wael El-Matary
Keyword(s):  
Celiac Disease ◽  
Dermatitis Herpetiformis ◽  
Cognitive Disorders ◽  
Gluten Free Diet ◽  
Nutritional Deficiencies ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Immune Mediated ◽  
The Brain

The gluten-free diet (GFD) has gained popularity beyond its main medical indication as the treatment for gluten-induced immune-mediated disorders such as celiac disease (CD), dermatitis herpetiformis, gluten ataxia, wheat allergy, and non-celiac gluten sensitivity. However, the diet carries some disadvantages such as elevated costs, nutritional deficiencies, and social and psychological barriers. The present work aims to review indications, proven benefits, and adverse events of a gluten-free diet. Close follow-up with patients following the diet is recommended. More data is needed to assess the effectiveness of the diet in managing mental and cognitive disorders and to establish a connection between the brain and gluten.

scholarly journals The many faces of the problem of intolerance to gluten.

2018 ◽  
Vol 96 (2) ◽  
pp. 123-128
Author(s):  
M. A. Livsan ◽  
M. F. Osipenko ◽  
Natalya V. Zayakina ◽  
T. S. Krolevets
Keyword(s):  
Celiac Disease ◽  
Dermatitis Herpetiformis ◽  
Current Data ◽  
Gluten Sensitivity ◽  
Wheat Allergy ◽  
Serological Markers ◽  
Gluten Intolerance ◽  
Rising Incidence ◽  
The Many

Rising incidence of different variants of gluten intolerance associated with changes in eating behaviorin many countries, changes in the technology of growing and processing crops, new culinary technologies. Until recently, celiac disease, dermatitis herpetiformis and wheat allergy were the only known disease with a proven role of gluten in their pathogenesis. Non-celiac gluten sensitivity (NCGS) - a new syndrome of intolerance to gluten. This pathology can be suspected in patients with persistent intestinal and extra-intestinal symptoms clearly associated with the intake of foods containing gluten, the absence of serological markers of celiac disease or suspected allergy to wheat. The paper presents the current data on the epidemiology, etiology and pathogenesis, clinical features and diagnosis NCGS.

scholarly journals The Imbalance Between Metalloproteinases and Their Tissue Inhibitors Is Involved in the Pathogenesis of Dermatitis Herpetiformis

2005 ◽  
Vol 2005 (6) ◽  
pp. 373-379 ◽  
Author(s):  
Agnieszka Zebrowska ◽  
Joanna Narbutt ◽  
Anna Sysa-Jedrzejowska ◽  
Jozef Kobos ◽  
Elzbieta Waszczykowska
Keyword(s):  
Autoimmune Disease ◽  
Coeliac Disease ◽  
Healthy Subjects ◽  
Dermatitis Herpetiformis ◽  
Skin Lesions ◽  
Blister Fluid ◽  
Exact Role ◽  
Basal Keratinocytes ◽  
Intestinal Lesions ◽  
Skin Biopsies

Dermatitis herpetiformis (DH) is a subepidermal autoimmune disease characterized by skin and intestinal lesions consistent with coeliac disease. There are also some data that metalloproteinases (MMPs) are involved in the development of skin lesions in DH, however their exact role in this process is not fully understood. The aim of the study was to investigate whether MMPs and their inhibitors are involved in pathogenesis of DH. Skin biopsies were taken from 13 patients with active DH and from 10 healthy subjects. The localization and expression of MMPs and TIMPs were examined by immunohistochemistry. MMPs expression was detected in basal keratinocytes and in the whole epidermis in all of the DH subjects. Neutrophils in microabscesses and in blister fluid were also positive for MMPs. Expression of TIMPs was moderate or weak in all examined biopsies. Our results allow us to conclude that imbalance between these enzymes takes an important role in the pathogenesis of DH.

scholarly journals Celiac Disease and Dermatologic Manifestations: Many Skin Clue to Unfold Gluten-Sensitive Enteropathy

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Marzia Caproni ◽  
Veronica Bonciolini ◽  
Antonietta D'Errico ◽  
Emiliano Antiga ◽  
Paolo Fabbri
Keyword(s):  
Celiac Disease ◽  
Skin Diseases ◽  
Dermatitis Herpetiformis ◽  
Inflammatory Diseases ◽  
Cutaneous Manifestation ◽  
Cutaneous Manifestations ◽  
Intestinal Diseases ◽  
Diagnostic Aspects ◽  
Gluten Sensitive Enteropathy ◽  
Dermatologic Manifestations

Cutaneous manifestations of intestinal diseases are increasingly reported both in the adult and in the children, and this association cannot longer be considered a simple random. Besides the well-known association between celiac disease (CD) and dermatitis herpetiformis (DH), considered as the cutaneous manifestation of gluten-dependent enteropathy, is more frequently reported also the association with other mucocutaneous diseases. Among these there are both autoimmune, allergic, and inflammatory diseases, but also a more heterogeneous group called miscellaneous. The knowledge about pathogenic, epidemiological, clinical, and diagnostic aspects of CD is increasing in recent years as well as those about DH, but some aspects still remain to be defined, in particular the possible pathogenetic mechanisms involved in the association between both CD and DH and CD and other immunological skin diseases. The aim of this paper is to describe the skin diseases frequently associated with CD, distinguishing them from those which have a relationship probably just coincidental.

Neurological syndromes of celiac disease

2021 ◽  
pp. 39-48
Author(s):  
S. V. Kopishinskaia ◽  
S. S. Nikitin
Keyword(s):  
Small Intestine ◽  
Celiac Disease ◽  
Autoimmune Disease ◽  
Cerebellar Ataxia ◽  
Genetic Predisposition ◽  
Nerve Fibers ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Gluten Proteins ◽  
Small Nerve

Celiac disease is an autoimmune disease in people with a genetic predisposition resulting from the consumption of gluten proteins from wheat, rye, barley and characterized by inflammation of the mucous membrane of the small intestine and atrophy of the villi. Neuropathy, migraine, chronic cerebellar ataxia and fibromyalgia are the most common extraintestinal celiac disease syndromes. The study of small nerve fibers is necessary for painful celiac disease syndromes such as gluten neuropathy and fibromyalgia, as well as for gluten autonomic neuropathy. The study of antineuronal antiganglioside antibodies is necessary for such lesions of both the central and peripheral nervous systems as gluten neuropathy and gluten cerebellar ataxia. A gluten-free diet directly affects the disappearance of headache attacks or a decrease in their frequency and intensity. There is little research on the effect of a gluten-free diet on headache risk.

scholarly journals Autoimmune Diseases: An Introduction

2015 ◽  
Vol 3 (1) ◽  
pp. 63-70
Author(s):  
Shubha Ratna Shakya
Keyword(s):  
Immune System ◽  
Autoimmune Disease ◽  
Environmental Factors ◽  
Autoimmune Diseases ◽  
Genetic Predisposition ◽  
Natural Phenomenon

The immune system recognizes and eliminates foreign agents, and protects the host against infection. Autoimmunity is a natural phenomenon where self-reactive antibodies and autoimmune cells are present in all individuals. A combination of genetic predisposition and environmental factors contribute to the development of autoimmune diseases. Autoantibodies attack structures within individuals that produce them. Autoimmunity is a major cause for a number of serious and fatal diseases. Presence of one autoimmune disease increases the chance for simultaneously developing other autoimmune diseases in the same person.

scholarly journals A Rare Case of Dermatitis Herpetiformis Presenting as Fingertip Petechiae

2020 ◽  
Vol 4 (1) ◽  
pp. 68-71
Author(s):  
Amy Weiss ◽  
Shiri Nawrocki ◽  
Ana Cristina Laureano ◽  
Sharon Scherl ◽  
Kenneth Shulman ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Celiac Disease ◽  
Autoimmune Disease ◽  
Young Children ◽  
Children And Adolescents ◽  
Rare Case ◽  
Dermatitis Herpetiformis ◽  
Initial Manifestation ◽  
Gluten Sensitive Enteropathy ◽  
Inflammatory Autoimmune Disease

Dermatitis herpetiformis (DH) is an uncommon inflammatory autoimmune disease that most commonly presents as a pruritic, papulovesicular eruption in young children and adolescents. It follows a chronic and relapsing course and usually involves extensor surfaces of the elbows, forearms, buttocks, and knees and can also involve the scalp. DH is usually accompanied by gluten-sensitive enteropathy (celiac disease). In most patients with DH, the enteropathy is asymptomatic. DH is usually a life-long condition that requires continued treatment, including dapsoneand elimination of gluten from the diet. We describe a rare case of a patient who presented with fingertip petechiae as the only initial manifestation of DH. DH should be considered in the differential diagnosis of petechiae of the fingertips, even if it is the only presenting sign.

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