scholarly journals Recent Advances in Dermatitis Herpetiformis

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Kimiko Nakajima
Keyword(s):  
Celiac Disease ◽  
Small Bowel ◽  
Immune Responses ◽  
Dermatitis Herpetiformis ◽  
Gluten Sensitivity ◽  
Bullous Disease ◽  
Autoimmune Bullous Disease ◽  
Multifactorial Disorders ◽  
Epidermal Transglutaminase ◽  
Transglutaminase 3

Dermatitis herpetiformis is an autoimmune bullous disease that is associated with gluten sensitivity which typically presents as celiac disease. As both conditions are multifactorial disorders, it is not clear how specific pathogenetic mechanisms may lead to the dysregulation of immune responses in the skin and small bowel, respectively. Recent studies have demonstrated that IgA and antibodies against epidermal transglutaminase 3 play an important role in the pathogenesis of dermatitis herpetiformis. Here, we review recent immunopathological progress in understanding the pathogenesis of dermatitis herpetiformis.

W1288 Anti-Epidermal Transglutaminase (Tge) IgA in Dermatitis Herpetiformis and Pediatric Celiac Disease

2008 ◽  
Vol 134 (4) ◽  
pp. A-672-A-673
Author(s):  
Troy D. Jaskowski ◽  
Tracy Hamblin ◽  
Harry R. Hill ◽  
John J. Zone ◽  
Linda Book ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Dermatitis Herpetiformis ◽  
Epidermal Transglutaminase

scholarly journals Gluten-related disorders

2021 ◽  
pp. 100-100
Author(s):  
Biljana Vuletic ◽  
Aleksandar Kocovic ◽  
Marija Mladenovic ◽  
Zoran Lekovic ◽  
Vladimir Radlovic ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Clinical Features ◽  
Dermatitis Herpetiformis ◽  
Current Knowledge ◽  
Diagnosis And Treatment ◽  
Gluten Sensitivity ◽  
Wheat Allergy ◽  
Clinical Expression ◽  
Barley Flour ◽  
Gluten Ataxia

Gluten-related disorders are a heterogeneous group of clinical entities caused by intolerance of wheat, rye, and barley flour components. They occur in 3-5% of genetically predisposed persons and based on pathogenic and clinical features are classified into celiac disease, non-celiac gluten sensitivity, and wheat allergy. There are also specific entities such as dermatitis herpetiformis or gluten ataxia, which can occur either within the celiac disease or independently. This article based on the current knowledge shows the basic details of the pathogenesis, clinical expression, diagnosis, and treatment of these disorders.

scholarly journals The Gluten-Free Diet for Celiac Disease and Beyond

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3993
Author(s):  
Bara Aljada ◽  
Ahmed Zohni ◽  
Wael El-Matary
Keyword(s):  
Celiac Disease ◽  
Dermatitis Herpetiformis ◽  
Cognitive Disorders ◽  
Gluten Free Diet ◽  
Nutritional Deficiencies ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Immune Mediated ◽  
The Brain

The gluten-free diet (GFD) has gained popularity beyond its main medical indication as the treatment for gluten-induced immune-mediated disorders such as celiac disease (CD), dermatitis herpetiformis, gluten ataxia, wheat allergy, and non-celiac gluten sensitivity. However, the diet carries some disadvantages such as elevated costs, nutritional deficiencies, and social and psychological barriers. The present work aims to review indications, proven benefits, and adverse events of a gluten-free diet. Close follow-up with patients following the diet is recommended. More data is needed to assess the effectiveness of the diet in managing mental and cognitive disorders and to establish a connection between the brain and gluten.

scholarly journals The many faces of the problem of intolerance to gluten.

2018 ◽  
Vol 96 (2) ◽  
pp. 123-128
Author(s):  
M. A. Livsan ◽  
M. F. Osipenko ◽  
Natalya V. Zayakina ◽  
T. S. Krolevets
Keyword(s):  
Celiac Disease ◽  
Dermatitis Herpetiformis ◽  
Current Data ◽  
Gluten Sensitivity ◽  
Wheat Allergy ◽  
Serological Markers ◽  
Gluten Intolerance ◽  
Rising Incidence ◽  
The Many

Rising incidence of different variants of gluten intolerance associated with changes in eating behaviorin many countries, changes in the technology of growing and processing crops, new culinary technologies. Until recently, celiac disease, dermatitis herpetiformis and wheat allergy were the only known disease with a proven role of gluten in their pathogenesis. Non-celiac gluten sensitivity (NCGS) - a new syndrome of intolerance to gluten. This pathology can be suspected in patients with persistent intestinal and extra-intestinal symptoms clearly associated with the intake of foods containing gluten, the absence of serological markers of celiac disease or suspected allergy to wheat. The paper presents the current data on the epidemiology, etiology and pathogenesis, clinical features and diagnosis NCGS.

scholarly journals Missing Insight Into T and B Cell Responses in Dermatitis Herpetiformis

2021 ◽  
Vol 12 ◽  
Author(s):  
Esko Kemppainen ◽  
Teea Salmi ◽  
Katri Lindfors
Keyword(s):  
T Cells ◽  
Celiac Disease ◽  
Small Bowel ◽  
B Cell ◽  
Plasma Cells ◽  
Dermatitis Herpetiformis ◽  
Gluten Free Diet ◽  
Cell Populations ◽  
Gluten Free ◽  
Cell Responses

Dermatitis herpetiformis is a cutaneous form of celiac disease manifesting as an itching rash typically on the elbows, knees and buttocks. It is driven by the ingestion of gluten-containing cereals and characterized by granular deposits of immunoglobulin A in the papillary dermis. These antibodies target transglutaminase (TG) 3 and in the majority of patients they are also found in circulation. The circulating antibodies disappear and skin symptoms resolve as a result of gluten-free diet but the cutaneous anti-TG3 IgA deposits may persist for several years. In dermatitis herpetiformis, plasma cells secreting antibodies against TG3 are located in the intestinal mucosa similarly to those producing TG2 antibodies characteristic for celiac disease. In fact, both TG2- and TG3-specific plasma cells and gluten responsive T cells are found in dermatitis herpetiformis patients but the interplay between these cell populations is unknown. The small bowel mucosal damage in celiac disease is believed to be mediated by co-operation of cytotoxic intraepithelial T cells and the inflammatory milieu contributed by gluten-reactive CD4+ T cells, whereas the skin lesions in dermatitis herpetiformis appear to be devoid of gluten reactive T cells. Thus, how celiac disease-type intestinal T and B cell responses develop into an autoimmune condition affecting the skin is still incompletely understood. Finally, the skin and small bowel lesions may reappear upon reintroduction of gluten in patients treated with gluten-free diet but virtually nothing is known about the long-lived B cell and memory T cell populations activating in response to dietary gluten in dermatitis herpetiformis.

scholarly journals Epidermal Transglutaminase (TGase 3) Is the Autoantigen of Dermatitis Herpetiformis

2002 ◽  
Vol 195 (6) ◽  
pp. 747-757 ◽  
Author(s):  
Miklós Sárdy ◽  
Sarolta Kárpáti ◽  
Barbara Merkl ◽  
Mats Paulsson ◽  
Neil Smyth
Keyword(s):  
Dermatitis Herpetiformis ◽  
Tissue Transglutaminase ◽  
Papillary Dermis ◽  
Gluten Sensitivity ◽  
Skin Symptoms ◽  
Related Enzyme ◽  
Small Intestinal ◽  
Type 3 ◽  
Epidermal Transglutaminase ◽  
Antibody Population

Gluten sensitivity typically presents as celiac disease, a common chronic small intestinal disorder. However, in certain individuals it is associated with dermatitis herpetiformis, a blistering skin disease characterized by granular IgA deposits in the papillary dermis. While tissue transglutaminase has been implicated as the major autoantigen of gluten sensitive disease, there has been no explanation as to why this condition appears in two distinct forms. Here we show that while sera from patients with either form of gluten sensitive disease react both with tissue transglutaminase and the related enzyme epidermal (type 3) transglutaminase, antibodies in patients having dermatitis herpetiformis show a markedly higher avidity for epidermal transglutaminase. Further, these patients have an antibody population specific for this enzyme. We also show that the IgA precipitates in the papillary dermis of patients with dermatitis herpetiformis, the defining signs of the disease, contain epidermal transglutaminase, but not tissue transglutaminase or keratinocyte transglutaminase. These findings demonstrate that epidermal transglutaminase, rather than tissue transglutaminase, is the dominant autoantigen in dermatitis herpetiformis and explain why skin symptoms appear in a proportion of patients having gluten sensitive disease.

scholarly journals Dermatitis Herpetiformis: From the Genetics to the Development of Skin Lesions

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Diletta Bonciani ◽  
Alice Verdelli ◽  
Veronica Bonciolini ◽  
Antonietta D'Errico ◽  
Emiliano Antiga ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Autoimmune Disease ◽  
Environmental Factors ◽  
Genetic Predisposition ◽  
Dermatitis Herpetiformis ◽  
Skin Lesions ◽  
Cutaneous Manifestation ◽  
Gluten Sensitivity

Dermatitis herpetiformis (DH) is a rare autoimmune disease linked to gluten sensitivity with a chronic-relapsing course. It is currently considered to be the specific cutaneous manifestation of celiac disease (CD). Both conditions are mediated by the IgA class of autoantibodies, and the diagnosis of DH is dependent on the detection of granular deposits of IgA in the skin. There is an underlying genetic predisposition to the development of DH, but environmental factors are also important. This paper describes these different factors and discusses the known mechanism that lead to the development of skin lesions.

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