scholarly journals Myelopoiesis and Myeloid Leukaemogenesis in the Zebrafish

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
A. Michael Forrester ◽  
Jason N. Berman ◽  
Elspeth M. Payne
Keyword(s):  
Zebrafish Embryo ◽  
Zebrafish Model ◽  
Future Directions ◽  
Myeloid Malignancies ◽  
The Past ◽  
Haematopoietic Cells ◽  
Recent Advances ◽  
Disease Biology ◽  
Key Questions

Over the past ten years, studies using the zebrafish model have contributed to our understanding of vertebrate haematopoiesis, myelopoiesis, and myeloid leukaemogenesis. Novel insights into the conservation of haematopoietic lineages and improvements in our capacity to identify, isolate, and culture such haematopoietic cells continue to enhance our ability to use this simple organism to address disease biology. Coupled with the strengths of the zebrafish embryo to dissect developmental myelopoiesis and the continually expanding repertoire of models of myeloid malignancies, this versatile organism has established its niche as a valuable tool to address key questions in the field of myelopoiesis and myeloid leukaemogenesis. In this paper, we address the recent advances and future directions in the field of myelopoiesis and leukaemogenesis using the zebrafish system.

Oxford Textbook of Rheumatoid Arthritis

2020 ◽  
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Presentation ◽  
Disease Assessment ◽  
Future Research ◽  
Clinical Aspects ◽  
Comprehensive Overview ◽  
Future Directions ◽  
The Past ◽  
Recent Advances ◽  
Drug Treatments

This new textbook provides a comprehensive overview of the scientific and clinical aspects of rheumatoid arthritis (RA). Split into eight sections—history, diagnosis, and epidemiology; pathogenesis; clinical presentation; disease assessment; impact on life; non-drug treatments; drug treatments; and management and outcomes—it collects the contemporary ideas about RA and explains the revolutionary changes that have taken place over the past two decades, and indicates areas of future research. Witten by leading clinicians and scientists in the field, each chapter gives a detailed background, key recent advances, areas of doubt, and future directions of research.

scholarly journals Organo-f-Complexes for Efficient and Selective Hydroborations

Synthesis ◽  
2020 ◽  
Vol 52 (05) ◽  
pp. 629-644 ◽  
Author(s):  
Heng Liu ◽  
Moris S. Eisen
Keyword(s):  
Organic Synthesis ◽  
Small Molecule ◽  
Kinetic Studies ◽  
Catalytic Performance ◽  
Future Directions ◽  
The Past ◽  
Recent Advances

Organo-f-complexes catalyzing small molecule transformations have been a hot topic in the past few years. Compared to other transformations, the hydroboration of C=X (X = C, N, O) unsaturated bonds serves as an important strategy to prepare organoborane derivatives, which are important intermediates in organic synthesis. This review outlines recent advances in organolanthanide and organoactinide complexes promoting the hydroboration of C=X containing substrates. After a brief introduction, three types of hydroboration will be presented: alkene hydroboration, carbonyl hydroboration, and imine and nitrile hydroborations. The catalytic performance, mechanism, and kinetic studies are discussed in detail, aiming to emphasize the catalytic differences between the diverse organo-f-catalysts. Additionally, challenges and future directions of this field are also presented.1 Introduction2 Alkene Hydroboration3 Carbonyl Hydroboration4 Imine and Nitrile Hydroboration5 Conclusions and Outlook

scholarly journals LOOKING FORWARD BY STUDYING THE PAST IN EAST AND SOUTHEAST ASIAN ARCHAEOLOGY: THE NEXT 50 YEARS

2016 ◽  
Vol 35 ◽  
Author(s):  
Miriam Stark
Keyword(s):  
Southeast Asia ◽  
Southeast Asian ◽  
Future Directions ◽  
The Past ◽  
University Of Wisconsin ◽  
Recent Advances ◽  
East And Southeast Asia ◽  
The University ◽  
Conference Papers

<p>A discussion on the collection of articles resulting from the 2013 conference at the University of Wisconsin-Madison entitled, “Recent Advances in the Archaeology of East and Southeast Asia.” These papers are contextualized by considering the fifty years before the published JIPA papers appeared in 2015. I then review major themes in the conference papers, and discuss future directions. </p>

scholarly journals Recent Advances in Vertically Aligned Nanowires for Photonics Applications

Micromachines ◽  
2020 ◽  
Vol 11 (8) ◽  
pp. 726
Author(s):  
Sehui Chang ◽  
Gil Lee ◽  
Young Song
Keyword(s):  
Packing Fraction ◽  
Future Directions ◽  
Structural Coloration ◽  
Light Emitting ◽  
Spectral Filters ◽  
Fabrication Cost ◽  
The Core ◽  
The Past ◽  
Recent Advances ◽  
Vertically Aligned

Over the past few decades, nanowires have arisen as a centerpiece in various fields of application from electronics to photonics, and, recently, even in bio-devices. Vertically aligned nanowires are a particularly decent example of commercially manufacturable nanostructures with regard to its packing fraction and matured fabrication techniques, which is promising for mass-production and low fabrication cost. Here, we track recent advances in vertically aligned nanowires focused in the area of photonics applications. Begin with the core optical properties in nanowires, this review mainly highlights the photonics applications such as light-emitting diodes, lasers, spectral filters, structural coloration and artificial retina using vertically aligned nanowires with the essential fabrication methods based on top-down and bottom-up approaches. Finally, the remaining challenges will be briefly discussed to provide future directions.

Tissue Proteomic Approaches to Understand the Pathogenesis of Inflammatory Bowel Disease

2021 ◽  
Author(s):  
Montserrat Baldan-Martin ◽  
María Chaparro ◽  
Javier P Gisbert
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Molecular Mechanisms ◽  
Biomarker Discovery ◽  
The Past ◽  
Recent Advances ◽  
Disease Biology ◽  
Tissue Proteomics ◽  
Inflammatory Bowel

Abstract Inflammatory bowel disease (IBD) has become a global disease encompassing a group of progressive disorders characterized by recurrent chronic inflammation of the gut with variable disease courses and complications. Despite recent advances in the knowledge of IBD pathophysiology, the elucidation of its etiopathology and progression is far from fully understood, requiring complex and multiple approaches. Therefore, limited clinical progress in diagnosis, assessment of disease activity, and optimal therapeutic regimens have been made over the past few decades. This review explores recent advances and challenges in tissue proteomics with an emphasis on biomarker discovery and better understanding of the molecular mechanisms underlying IBD pathogenesis. Future multi-omic studies are required for the comprehensive molecular characterization of disease biology in real time with a future impact on early detection, disease monitoring, and prediction of the clinical outcome.

On Future Directions in Pathology

1982 ◽  
Vol 40 ◽  
pp. 274-277
Author(s):  
Benjamin F. Trump ◽  
Irene K. Berezesky ◽  
Raymond T. Jones
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Clinical Pathology ◽  
Future Directions ◽  
Diagnostic Pathology ◽  
The Past ◽  
Transmission Electron ◽  
Organ Systems ◽  
The Many

The role of electron microscopy and associated techniques is assured in diagnostic pathology. At the present time, most of the progress has been made on tissues examined by transmission electron microscopy (TEM) and correlated with light microscopy (LM) and by cytochemistry using both plastic and paraffin-embedded materials. As mentioned elsewhere in this symposium, this has revolutionized many fields of pathology including diagnostic, anatomic and clinical pathology. It began with the kidney; however, it has now been extended to most other organ systems and to tumor diagnosis in general. The results of the past few years tend to indicate the future directions and needs of this expanding field. Now, in addition to routine EM, pathologists have access to the many newly developed methods and instruments mentioned below which should aid considerably not only in diagnostic pathology but in investigative pathology as well.

Immunotherapy for regional, recurrent and metastatic head and neck cancer: recent advances and future directions

2020 ◽  
pp. 60-69
Author(s):  
Z. A.-G. Radzhabova ◽  
M. Д. Kotov ◽  
A. S. Mitrofanov ◽  
Z. S. Bekyasheva ◽  
E. V. Levchenko
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Future Directions ◽  
Recent Advances

Comparison and Analysis of Computational Methods for Identifying N6 - methyladenosine Sites in Saccharomyces Cerevisiae

2020 ◽  
Vol 26 ◽  
Author(s):  
Pengmian Feng ◽  
Lijing Feng ◽  
Chaohui Tang
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Computational Methods ◽  
Computational Analysis ◽  
Computational Prediction ◽  
Experimental Methods ◽  
Biological Processes ◽  
Biological Functions ◽  
Precise Location ◽  
Future Directions ◽  
The Past

Background and Purpose: N 6 -methyladenosine (m6A) plays critical roles in a broad set of biological processes. Knowledge about the precise location of m6A site in the transcriptome is vital for deciphering its biological functions. Although experimental techniques have made substantial contributions to identify m6A, they are still labor intensive and time consuming. As good complements to experimental methods, in the past few years, a series of computational approaches have been proposed to identify m6A sites. Methods: In order to facilitate researchers to select appropriate methods for identifying m6A sites, it is necessary to give a comprehensive review and comparison on existing methods. Results: Since researches on m6A in Saccharomyces cerevisiae are relatively clear, in this review, we summarized recent progresses on computational prediction of m6A sites in S. cerevisiae and assessed the performance of existing computational methods. Finally, future directions of computationally identifying m6A sites were presented. Conclusion: Taken together, we anticipate that this review will provide important guides for computational analysis of m 6A modifications.

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