scholarly journals Complete Response of Liver Metastasis of Gastric Cancer Treated by S-1 Chemoradiotherapy: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Tomonori Miyazawa ◽  
Kazuyu Ebe ◽  
Norihiko Koide ◽  
Nobuhiro Fujita
Keyword(s):  
Gastric Cancer ◽  
Computed Tomography ◽  
Radiation Therapy ◽  
Case Report ◽  
Liver Metastasis ◽  
Liver Metastases ◽  
Distal Gastrectomy ◽  
Complete Response ◽  
Complete Disappearance ◽  
Multiple Liver Metastases

This paper presents a case of suspected liver metastasis of gastric cancer and a virtual complete response to S-1 chemoradiotherapy. A 69-year-old man underwent distal gastrectomy for gastric cancer in 2008. Multiple liver metastases occurred in 2009. He underwent 15 courses of S-1 therapy and radiation therapy (37.5 Gy). Abdominal computed tomography showed virtual complete disappearance of liver metastasis after chemoradiotherapy. Hence, this case was interpreted as a complete response. No sign of recurrence was noted 18 months after complete response was confirmed. S-1 chemoradiotherapy is likely to be effective in treating patients with liver metastases of gastric cancer.

scholarly journals Leiomyosarcoma of the sigmoid colon with multiple liver metastases and gastric cancer: a case report

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Yoichi Hamai ◽  
Jun Hihara ◽  
Manabu Emi ◽  
Yoshiro Aoki ◽  
Kei Kushitani ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Case Report ◽  
Liver Metastases ◽  
Sigmoid Colon ◽  
Multiple Liver Metastases

scholarly journals A Case Report of Recurrent Gastric Cancer with Multiple Liver Metastases Responding to Weekly Paclitaxel Therapy.

2002 ◽  
Vol 63 (5) ◽  
pp. 1175-1178
Author(s):  
Takashi EMOTO ◽  
Kiyoshi YOSHIKAWA ◽  
Tsutomu DOUSEI ◽  
Masahiro FUJIKAWA ◽  
Makoto FUJII ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Case Report ◽  
Liver Metastases ◽  
Weekly Paclitaxel ◽  
Recurrent Gastric Cancer ◽  
Multiple Liver Metastases

Hepatectomy for Liver Metastasis of Gastric Cancer: A Meta-Analysis

2019 ◽  
Vol 26 (6) ◽  
pp. 692-697 ◽  
Author(s):  
Jun-Kai Cui ◽  
Mei Liu ◽  
Xiao-Ke Shang
Keyword(s):  
Gastric Cancer ◽  
Liver Metastasis ◽  
Liver Metastases ◽  
Hepatic Resection ◽  
Meta Analysis ◽  
Hepatic Metastases ◽  
Outcome Analysis ◽  
Significant Difference ◽  
Promising Treatment ◽  
Multiple Liver Metastases

Background. Management of gastric cancer (GC) with liver metastases is debated. It is still controversial whether surgical resection provides a survival benefit or not. This systematic review was designed to evaluate the efficacy of hepatectomy for GC liver metastasis. Methods. We searched several electronic databases to identify eligible studies updated on September 2018. Studies assessing the efficacy and safety of hepatectomy versus no hepatectomy were included. Odds ratio (OR) along with 95% confidence interval (95% CI) were utilized for main outcome analysis. Results. In all, 10 studies were included. Patients who underwent hepatectomy had lower 1-year (OR = 0.15, 95% CI = 0.10-0.22, P < .00001), 3-year (OR = 0.16, 95% CI = 0.10-0.27, P < .00001), and 5-year mortality (OR = 0.13, 95% CI = 0.07-0.24, P < .00001) than those without hepatectomy. We also reported favorable survival outcome in patients with metachronous hepatic resection versus synchronous hepatic resection (OR = 2.09, 95% CI = 1.21-3.60, P = .008). However, there was no significant difference between solitary and multiple liver metastases (OR = 0.61, 95% CI = 0.35-1.07, P = .08). Conclusion. The present study demonstrates that hepatic resection in the management of liver metastases of GC can prolong the survival of patients and should be considered a promising treatment for such patients. Furthermore, there are more favorable outcomes in patients with metachronous metastases versus those with synchronous disease. Therefore, metachronous hepatic metastases from GC are not necessarily a contraindication for hepatectomy of the metastatic site.

scholarly journals HER-2-positive gastric cancer accompanied by liver metastasis: a case report of a rare complete response and literature review

2018 ◽  
Vol 2 (1) ◽  
pp. 59-62
Author(s):  
Hongmei Yong ◽  
◽  
Yeping Du ◽  
Wei Wang ◽  
Huichang Shi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Case Report ◽  
Liver Metastasis ◽  
Literature Review ◽  
Complete Response ◽  
Her 2

scholarly journals Pseudocirrhosis in Gastric Cancer with Diffuse Liver Metastases after a Dramatic Response to Chemotherapy

2016 ◽  
Vol 9 (1) ◽  
pp. 106-111 ◽  
Author(s):  
Seiichiro Mitani ◽  
Shigenori Kadowaki ◽  
Hiroya Taniguchi ◽  
Hisanori Muto ◽  
Kei Muro
Keyword(s):  
Gastric Cancer ◽  
Liver Metastases ◽  
Group Performance ◽  
Performance Status ◽  
Eastern Cooperative Oncology Group ◽  
Oral Intake ◽  
Complete Response ◽  
Metastatic Gastric Cancer ◽  
Response To Chemotherapy ◽  
Multiple Liver Metastases

We present the first reported case of pseudocirrhosis arising after a dramatic response to chemotherapy in metastatic gastric cancer. A 74-year-old man was diagnosed with gastric adenocarcinoma having multiple liver metastases. His general condition was poor, with an Eastern Cooperative Oncology Group performance status of 3, inadequate oral intake, and jaundice (total bilirubin 2.8 mg/dl). Chemotherapy with oxaliplatin, L-leucovorin, and 5-fluorouracil (modified FOLFOX-6) was initiated. After four treatment cycles, he experienced a marked regression of liver metastases; however, he developed massive ascites with a lobular liver surface and segmental atrophy, which were consistent with pseudocirrhosis. Chemotherapy was continued along with ascites management. Thereafter, ascites disappeared, and a complete response of the metastatic lesions was achieved at 11 months after initial treatment. He had no evidence of disease progression at 30 months after initial chemotherapy. This report suggests clinicians should recognize this entity, even in gastric cancer metastatic to the liver.

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