scholarly journals FOLDNA, a Web Server for Self-Assembled DNA Nanostructure Autoscaffolds and Autostaples

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Chensheng Zhou ◽  
Heng Luo ◽  
Xiaolu Feng ◽  
Xingwang Li ◽  
Jie Zhu ◽  
...  

DNA self-assembly is a nanotechnology that folds DNA into desired shapes. Self-assembled DNA nanostructures, also known as origami, are increasingly valuable in nanomaterial and biosensing applications. Two ways to use DNA nanostructures in medicine are to form nanoarrays, and to work as vehicles in drug delivery. The DNA nanostructures perform well as a biomaterial in these areas because they have spatially addressable and size controllable properties. However, manually designing complementary DNA sequences for self-assembly is a technically demanding and time consuming task, which makes it advantageous for computers to do this job instead. We have developed a web server, FOLDNA, which can automatically design 2D self-assembled DNA nanostructures according to custom pictures and scaffold sequences provided by the users. It is the first web server to provide an entirely automatic design of self-assembled DNA nanostructure, and it takes merely a second to generate comprehensive information for molecular experiments including: scaffold DNA pathways, staple DNA directions, and staple DNA sequences. This program could save as much as several hours in the designing step for each DNA nanostructure. We randomly selected some shapes and corresponding outputs from our server and validated its performance in molecular experiments.

2013 ◽  
Vol 25 (32) ◽  
pp. 4386-4396 ◽  
Author(s):  
Jiang Li ◽  
Chunhai Fan ◽  
Hao Pei ◽  
Jiye Shi ◽  
Qing Huang

2020 ◽  
Vol 11 (2) ◽  
pp. 527-540 ◽  
Author(s):  
Meiyu Gai ◽  
Johanna Simon ◽  
Ingo Lieberwirth ◽  
Volker Mailänder ◽  
Svenja Morsbach ◽  
...  

Attaching targeting ligands on the surface of self-assembled drug delivery systems is one of the key requests for a controlled transport of the drug to a desired location.


ChemInform ◽  
2013 ◽  
Vol 44 (46) ◽  
pp. no-no
Author(s):  
Jiang Li ◽  
Chunhai Fan ◽  
Hao Pei ◽  
Jiye Shi ◽  
Qing Huang

2018 ◽  
Vol 54 (36) ◽  
pp. 4529-4532 ◽  
Author(s):  
Ilenia Manuguerra ◽  
Stefano Croce ◽  
Afaf H. El-Sagheer ◽  
Abhichart Krissanaprasit ◽  
Tom Brown ◽  
...  

A gene was obtained from 14 oligonucleotides self-assembled and chemically ligated in a DNA nanostructure.


2016 ◽  
Vol 4 (22) ◽  
pp. 3854-3858 ◽  
Author(s):  
Juan Liu ◽  
Xiaowei Ma ◽  
Chunni Lei ◽  
Xiangdong Xue ◽  
Tuo Wei ◽  
...  

The self-assembled DNA nanostructure was able to specifically target cancer cells and release the drug at pH 5.0.


ChemInform ◽  
2016 ◽  
Vol 47 (20) ◽  
Author(s):  
Ruokun Jia ◽  
Ting Wang ◽  
Qiao Jiang ◽  
Zhengang Wang ◽  
Chen Song ◽  
...  

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 278
Author(s):  
Laura Osorno ◽  
Alyssa Brandley ◽  
Daniel Maldonado ◽  
Alex Yiantsos ◽  
Robert Mosley ◽  
...  

The novel and unique design of self-assembled micro and nanostructures can be tailored and controlled through the deep understanding of the self-assembly behavior of amphiphilic molecules. The most commonly known amphiphilic molecules are surfactants, phospholipids, and block copolymers. These molecules present a dual attraction in aqueous solutions that lead to the formation of structures like micelles, hydrogels, and liposomes. These structures can respond to external stimuli and can be further modified making them ideal for specific, targeted medical needs and localized drug delivery treatments. Biodegradability, biocompatibility, drug protection, drug bioavailability, and improved patient compliance are among the most important benefits of these self-assembled structures for drug delivery purposes. Furthermore, there are numerous FDA-approved biomaterials with self-assembling properties that can help shorten the approval pathway of efficient platforms, allowing them to reach the therapeutic market faster. This review focuses on providing a thorough description of the current use of self-assembled micelles, hydrogels, and vesicles (polymersomes/liposomes) for the extended and controlled release of therapeutics, with relevant medical applications. FDA-approved polymers, as well as clinically and commercially available nanoplatforms, are described throughout the paper.


2020 ◽  
Vol 21 (4) ◽  
pp. 401-412 ◽  
Author(s):  
Sreekanth Pentlavalli ◽  
Sophie Coulter ◽  
Garry Laverty

Self-assembled peptides have been shown to form well-defined nanostructures which display outstanding characteristics for many biomedical applications and especially in controlled drug delivery. Such biomaterials are becoming increasingly popular due to routine, standardized methods of synthesis, high biocompatibility, biodegradability and ease of upscale. Moreover, one can modify the structure at the molecular level to form various nanostructures with a wide range of applications in the field of medicine. Through environmental modifications such as changes in pH and ionic strength and the introduction of enzymes or light, it is possible to trigger self-assembly and design a host of different self-assembled nanostructures. The resulting nanostructures include nanotubes, nanofibers, hydrogels and nanovesicles which all display a diverse range of physico-chemical and mechanical properties. Depending on their design, peptide self-assembling nanostructures can be manufactured with improved biocompatibility and in vivo stability and the ability to encapsulate drugs with the capacity for sustained drug delivery. These molecules can act as carriers for drug molecules to ferry cargo intracellularly and respond to stimuli changes for both hydrophilic and hydrophobic drugs. This review explores the types of self-assembling nanostructures, the effects of external stimuli on and the mechanisms behind the assembly process, and applications for such technology in drug delivery.


Author(s):  
Xiang Li ◽  
Huijun Zhang ◽  
Lingyan Liu ◽  
Chunyan Cao ◽  
Peng Wei ◽  
...  

The short peptides with self-assembled nanostructures are widely applied in the areas of drug delivery system and biomaterials. In this article, we create a new peptide-based hydrogelator (Fmoc-FFRRVR) based on...


Nanoscale ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 2501-2509 ◽  
Author(s):  
Chan-Jin Kim ◽  
Eun Hye Jeong ◽  
Hyukjin Lee ◽  
So-Jung Park

Binary self-assembly of DNA block copolymers and thermo-responsive block copolymers generated dynamic DNA nanostructures with unique capabilities to selectively block or unblock interactions with proteins and cells.


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