scholarly journals Folate Intake and Markers of Folate Status in Women of Reproductive Age, Pregnant and Lactating Women: A Meta-Analysis

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Cristiana Berti ◽  
Katalin Fekete ◽  
Carla Dullemeijer ◽  
Monica Trovato ◽  
Olga W. Souverein ◽  
...  
Keyword(s):  
Blood Cell ◽  
Dose Response ◽  
Red Blood Cell ◽  
Meta Analysis ◽  
Plasma Homocysteine ◽  
Folate Intake ◽  
Childbearing Age ◽  
Lactating Women ◽  
Folate Status ◽  
Plasma Folate

Background. Pregnant and breastfeeding women are at risk for folate deficiency. Folate supplementation has been shown to be associated with enhanced markers of folate status. However, dose-response analyses for adult women are still lacking.Objective. To assess the dose-response relationship between total folate intake (folic acidplusdietary folate) and markers of folate status (plasma/serum folate, red blood cell folate, and plasma homocysteine); to evaluate potential differences between women in childbearing age, pregnant and lactating women.Methods. Electronic literature searches were carried out on three databases until February 2010. The overall pooled regression coefficient (β) and SE(β) were calculated using meta-analysis on a double-log scale.Results. The majority of data was based on nonpregnant, nonlactating women in childbearingage. The pooled estimate of the relationship between folate intake and serum/plasma folate was 0.56 (95% CI = 0.40–0.72,P<0.00001); that is, the doubling of folate intake increases the folate level in serum/plasma by 47%. For red blood cell folate, the pooled-effect estimate was 0.30 (95% CI = 0.22–0.38,P<0.00001), that is, +23% for doubling intake. For plasma-homocysteine it was –0.10 (95% = –0.17 to –0.04,P=0.001), that is, –7% for doubling the intake. Associations tended to be weaker in pregnant and lactating women.Conclusion. Significant relationships between folate intake and serum/plasma folate, red blood cell folate, and plasma homocysteine were quantified. This dose-response methodology may be applied for setting requirements for women in childbearing age, as well as for pregnant and lactating women.

scholarly journals Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly

2018 ◽  
Vol 73 (1) ◽  
pp. 30-43 ◽  
Author(s):  
Romana Novaković ◽  
Anouk Geelen ◽  
Danijela Ristić-Medić ◽  
Marina Nikolić ◽  
Olga W. Souverein ◽  
...  
Keyword(s):  
Reference Values ◽  
Dose Response ◽  
Observational Studies ◽  
Meta Analysis ◽  
The Elderly ◽  
Plasma Homocysteine ◽  
Folate Intake ◽  
Dietary Recommendations ◽  
Plasma Folate ◽  
Dietary Reference Values

Background: Dietary reference values for folate intake vary widely across Europe. Methods: MEDLINE and Embase through November 2016 were searched for data on the association between folate intake and biomarkers (serum/plasma folate, red blood cell [RBC] folate, plasma homocysteine) from observational studies in healthy adults and elderly. The regression coefficient of biomarkers on intake (β) was extracted from each study, and the overall and stratified pooled β and SE (β) were obtained by random effects meta-analysis on a double log scale. These dose-response estimates may be used to derive folate intake reference values. Results: For every doubling in folate intake, the changes in serum/plasma folate, RBC folate and plasma homocysteine were +22, +21, and –16% respectively. The overall pooled regression coefficients were β = 0.29 (95% CI 0.21–0.37) for serum/plasma folate (26 estimates from 17 studies), β = 0.28 (95% CI 0.21–0.36) for RBC (13 estimates from 11 studies), and β = –0.21 (95% CI –0.31 to –0.11) for plasma homocysteine (10 estimates from 6 studies). Conclusion: These estimates along with those from randomized controlled trials can be used for underpinning dietary recommendations for folate in adults and elderly.

The Administration of a Multivitamin/Mineral Fortified Dairy Product Improves Folate Status and Reduces Plasma Homocysteine Concentration in Women of Reproductive Age

2004 ◽  
Vol 74 (3) ◽  
pp. 234-240 ◽  
Author(s):  
Baró ◽  
Martínez-Férez ◽  
Rodríguez ◽  
Valero ◽  
Fonollá ◽  
...  
Keyword(s):  
Folic Acid ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Dairy Product ◽  
Plasma Homocysteine ◽  
Reproductive Age ◽  
Total Plasma ◽  
Women Of Reproductive Age ◽  
Homocysteine Concentration ◽  
Folate Status

Background and objectives: Folate deficiency during the periconceptional period is related to the occurrence and recurrence of neural tube defects. The aim of the study was to assess whether the administration of folic acid and other vitamins and minerals as a fortified dairy product (400 mug per day of folic acid) improves the folate status in women of reproductive age. Design and methods: Plasma and red blood cell folate, plasma vitamin E, B12, total plasma homocysteine, plasma lipid profile, and serum ferritin and transferrin levels were investigated in 31 healthy nonpregnant women receiving 500 mL/day of the fortified dairy product for eight weeks. Results: The women showed a significant increase in plasma levels of folate and vitamin B12 concentrations after four and eight weeks of supplementation. Moreover, we observed an increase in red blood cell folate concentration during the period of the study. Simultaneously, total plasma homocysteine levels decreased significantly during the intervention period. Conclusions: The regular consumption of a folic acid and other vitamins (mainly vitamins B6 and B12) and minerals in alpha fortified dairy product improves folate status and reduces total plasma homocysteine concentration in healthy women of childbearing age.

scholarly journals An overall and dose-response meta-analysis of red blood cell distribution width and CVD outcomes

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Haifeng Hou ◽  
Tao Sun ◽  
Cheng Li ◽  
Yuanmin Li ◽  
Zheng Guo ◽  
...  
Keyword(s):  
Blood Cell ◽  
Dose Response ◽  
Red Blood Cell ◽  
Meta Analysis ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution

scholarly journals Plasma folate status and dietary folate intake among Chinese women of childbearing age

2009 ◽  
Vol 5 (2) ◽  
pp. 104-116 ◽  
Author(s):  
Yaling Zhao ◽  
Ling Hao ◽  
Le Zhang ◽  
Yihua Tian ◽  
Yiwu Cao ◽  
...  
Keyword(s):  
Chinese Women ◽  
Folate Intake ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Dietary Folate ◽  
Folate Status ◽  
Plasma Folate ◽  
Dietary Folate Intake

scholarly journals Association of folate intake and plasma folate level with the risk of breast cancer: a dose-response meta-analysis of observational studies

Aging ◽  
2020 ◽  
Vol 12 (21) ◽  
pp. 21355-21375
Author(s):  
Xueting Ren ◽  
Peng Xu ◽  
Dai Zhang ◽  
Kang Liu ◽  
Dingli Song ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dose Response ◽  
Observational Studies ◽  
Meta Analysis ◽  
Folate Intake ◽  
Folate Level ◽  
Plasma Folate

scholarly journals Effect of plateletpheresis on hematocrit, hemoglobin and erythrocyte count: Meta-analysis 1980–2018

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Alejandro Gil-Betacur ◽  
Carmen Yulieth Mantilla-Gutiérrez ◽  
Jaiberth Antonio Cardona-Arias
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Red Blood Cell ◽  
Meta Analysis ◽  
Erythrocyte Count ◽  
Blood Cell Count ◽  
Selection Processes ◽  
Negative Effect ◽  
Red Blood Cell Count ◽  
The Mean

AbstractThe effects of platelet donation by apheresis on different parameters of the erythrogram are still unclear. The objective was to meta-analyze the effect of plateletpheresis on hematocrit, hemoglobin, and erythrocyte count, with a systematic review with random effects meta-analysis of the mean difference. The PRISMA guidelines were considered, as well as 133 search strategies on four different databases. Reproducibility was guaranteed and methodological quality was evaluated. Heterogeneity was evaluated with Galbraith and DerSimonian-Laird’s, publication bias with a funnel plot and a Begg’s test, sensitivity analysis and a cumulative meta-analysis were also conducted. Eighteen (18) articles were included, 17 evaluated the effects on hematocrit in 2,564 donors; 13 on hemoglobin in 1,640 donors; and 4 on red blood cell count in 243 donors. A decrease of 2.26% (CI95% = 2.11–2.41) was observed in hematocrit, of 0.80 g/dL (CI95% = 0.75–0.86) in hemoglobin and −0.21 × 1012/L (CI95% = −0.13; −0.29) in red blood cell count. Plateletpheresis has a negative effect on the erythrogram parameters, explained by blood loss in the kits used for the procedure and cell lysis. Such evidence is relevant to secure the efficiency and safety of the procedure, improve selection processes or determine the number of donations that can be performed without affecting donors’ health.

scholarly journals Red Blood Cell Distribution Width, Disease Severity, and Mortality in Hospitalized Patients with SARS-CoV-2 Infection: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 10 (2) ◽  
pp. 286
Author(s):  
Angelo Zinellu ◽  
Arduino A. Mangoni
Keyword(s):  
Systematic Review ◽  
Blood Cell ◽  
Disease Severity ◽  
Red Blood Cell ◽  
Effect Size ◽  
Meta Analysis ◽  
Severe Illness ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution

The identification of biomarkers predicting disease severity and outcomes is the focus of intense research in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 infection). Ideally, such biomarkers should be easily derivable from routine tests. We conducted a systematic review and meta-analysis of the predictive role of the red blood cell distribution width (RDW), a routine hematological test, in patients with SARS-CoV-2 infection. We searched the electronic databases PubMed, Web of Science and Scopus, from January 2020 to November 2020, for studies reporting data on the RDW and coronavirus disease 2019 (COVID-19) severity, defined as severe illness or admission to the intensive care unit (ICU), and mortality. Eleven studies in 4901 COVID-19 patients were selected for the meta-analysis. Pooled results showed that the RDW values were significantly higher in patients with severe disease and non-survivors (standard mean difference, SMD = 0.56, 95% CI 0.31 to 0.81, p < 0.001). Heterogeneity between studies was extreme (I2 = 80.6%; p < 0.001). In sensitivity analysis, the effect size was not modified when each study was in turn removed (effect size range, between 0.47 and 0.63). The Begg’s (p = 0.53) and Egger’s tests (p = 0.52) showed no evidence of publication bias. No significant correlations were observed between SMD and age, gender, whole blood count, end point, study geographic area, or design. Our meta-analysis showed that higher RDW values are significantly associated with COVID-19 severity and mortality. This routine parameter might assist with early risk stratification in patients with SARS-CoV-2 infection.

Sign in / Sign up

Export Citation Format

Share Document