scholarly journals Clinical Aspects of IgG4-Related Orbital Inflammation in a Case Series of Ocular Adnexal Lymphoproliferative Disorders

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Masayuki Takahira ◽  
Yoshiaki Ozawa ◽  
Mitsuhiro Kawano ◽  
Yoh Zen ◽  
Shoko Hamaoka ◽  
...  
Keyword(s):  
Malt Lymphoma ◽  
Case Series ◽  
B Cell Lymphoma ◽  
Lymphoid Hyperplasia ◽  
Lymphoproliferative Disorders ◽  
Clinical Aspects ◽  
Lacrimal Glands ◽  
Malignant Lymphomas ◽  
Orbital Inflammation ◽  
Adnexal Tumors

The most frequent ocular adnexal tumors and simulating lesions are lymphoproliferative disorders (LPDs), including malignant lymphomas and orbital inflammation with lymphoid hyperplasia or infiltration. IgG4-related orbital inflammation (IgG4-ROI) often involves lacrimal glands and other orbital tissues and is an important differential diagnosis. The present study evaluated clinical aspects of IgG4-ROI in a case series of orbital LPD. Sixty-two consecutive cases of orbital LPD, pathologically diagnosed from November, 2004, through March, 2011, were investigated. Histological types were 22 cases with MALT lymphoma, 11 cases with diffuse large B-cell lymphoma (DLBCL), 3 cases with other malignant lymphomas, 16 cases with IgG4-ROI, and 10 cases with non-IgG4-ROI. Ages of the IgG4-ROI group (56±10?yrs) were significantly lower than the MALT lymphoma (71±12?yrs) and DLBCL (75±14?yrs) groups. Orbital lesions other than lacrimal glands were present in six cases including extraocular muscle swelling, mass lesions surrounding the optic nerve, and supraorbital and infraorbital nerves enlargements. Although none of the malignant lymphomas were related to IgG4, previous evidence suggested that malignant lymphomas can arise from IgG4-ROI. Based on this study (26%) and another report (33%), it is likely that nearly a quarter of orbital LPD are IgG4-ROI.

scholarly journals KSHV/HHV8-Associated Lymphoproliferative Disorders: Lessons Learnt from People Living with HIV

Hemato ◽  
2021 ◽  
Vol 2 (4) ◽  
pp. 703-712
Author(s):  
Mark Bower ◽  
Antonino Carbone
Keyword(s):  
Who Classification ◽  
Primary Effusion Lymphoma ◽  
Case Series ◽  
Kaposi Sarcoma ◽  
B Cell Lymphoma ◽  
Lymphoproliferative Disorders ◽  
People Living With Hiv ◽  
Living With Hiv ◽  
Hiv Negative

In 1992, Kaposi sarcoma herpesvirus (KSHV/HHV8) was discovered and identified as the causative agent for Kaposi sarcoma. Subsequently, the presence of this virus has been detected in a number of lymphoproliferative disorders in people living with HIV (PLWH), including: KSHV-associated multicentric Castleman disease, primary effusion lymphoma, KSHV-positive diffuse large B-cell lymphoma, and germinotropic lymphoproliferative disorder. Each of these rare entities has subsequently been diagnosed in HIV-negative individuals. The recognition of some of these KSHV/HHV8-associated lymphoproliferative disorders has led to their inclusion in the WHO classification of lymphomas in 2008 and the revision of 2016; however, further revision is under way to update the classification. The relatively recent recognition of these lymphoproliferative disorders and their low incidence, particularly in the HIV-negative population, means that there is little published evidence and consensus on their clinical features and management. The publication of a new WHO classification of lymphomas should yield diagnostic clarity, providing an impetus for retrospective case series and prospective clinical trials in these KSHV/HHV8-associated lymphoproliferative disorders.

PD-1, S-100 and CD1a expression in pseudolymphomatous folliculitis, primary cutaneous marginal zone B-cell lymphoma (MALT lymphoma) and cutaneous lymphoid hyperplasia

2014 ◽  
Vol 42 (1) ◽  
pp. 6-15 ◽  
Author(s):  
Amrita Goyal ◽  
Johanna B. Moore ◽  
Devon Gimbel ◽  
Joi B. Carter ◽  
Daniela Kroshinsky ◽  
...  
Keyword(s):  
B Cell ◽  
Malt Lymphoma ◽  
Marginal Zone ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Lymphoid Hyperplasia ◽  
S 100

scholarly journals Tumor-associated macrophages as major source of APRIL in gastric MALT lymphoma

Blood ◽  
2011 ◽  
Vol 117 (24) ◽  
pp. 6612-6616 ◽  
Author(s):  
Fabio Munari ◽  
Silvia Lonardi ◽  
Marco A. Cassatella ◽  
Claudio Doglioni ◽  
Maria Giulia Cangi ◽  
...  
Keyword(s):  
T Cells ◽  
B Cells ◽  
B Cell ◽  
Malt Lymphoma ◽  
Cell Activation ◽  
Gastric Lymphoma ◽  
B Cell Lymphoma ◽  
Lymphoid Hyperplasia ◽  
Gastric Malt Lymphoma ◽  
Direct Stimulation

Abstract Lymphoid hyperplasia of gastric mucosa associated with Helicobacter pylori (HP) infection represents a preneoplastic condition of the mucosa associated lymphoid tissue (MALT), which may evolve to a B-cell lymphoma. While it is well established that the initial neoplastic proliferation of B cells is antigen-driven and dependent on the helper activity of HP-specific T cells, it needs to be elucidated which cytokine or soluble factor(s) promote B-cell activation and lymphomagenesis. Herein, we originally report that gastric MALT lymphoma express high levels of a proliferation inducing ligand (APRIL), a novel cytokine crucial in sustaining B-cell proliferation. By immunohistochemistry, we demonstrate that APRIL is produced almost exclusively by gastric lymphoma-infiltrating macrophages located in close proximity to neoplastic B cells. We also show that macrophages produce APRIL on direct stimulation with both HP and HP-specific T cells. Collectively, our results represent the first evidence for an involvement of APRIL in gastric MALT lymphoma development in HP-infected patients.

scholarly journals Neoplastic lesions in domestic pigs detected at slaughter: literature review and a 20-year review (1998–2018) of carcass inspection in Catalonia

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Antonia Morey-Matamalas ◽  
Enric Vidal ◽  
Jorge Martínez ◽  
Jaume Alomar ◽  
Antonio Ramis ◽  
...  
Keyword(s):  
B Cell ◽  
Case Series ◽  
B Cell Lymphoma ◽  
Support Network ◽  
Published Data ◽  
Nerve Sheath Tumor ◽  
Lymphoid Leukemia ◽  
Lymphoid Neoplasms ◽  
Neoplastic Lesions ◽  
Slaughtered Pigs

Abstract Background The present paper reviews the occurrence of neoplasms in swine and presents a case series of 56 tumors submitted to the Slaughterhouse Support Network (Servei de Suport a Escorxadors [SESC] IRTA-CReSA]) from slaughtered pigs from 1998 to 2018 (April) in Catalonia (Spain). The aim of the study was to describe the spectrum of spontaneous neoplastic lesions found in slaughtered pigs and to compare the reported tumor cases with previous published data. Lymphoid neoplasms were characterized and classified using the WHO classification adapted for animals. Results The most reported neoplasm during this period was lymphoma (28). Within lymphomas, the B-cell type was the most common, being the diffuse large B-cell lymphoma (15/28) the most represented subtype. Other submitted non-lymphoid neoplasms included melanoma (7), nephroblastoma (3), mast cell tumor (2), liposarcoma (2), osteochondromatosis (2), papillary cystadenocarcinoma (1), peripheral nerve sheath tumor (1), lymphoid leukemia (1), fibropapilloma (1), hemangiosarcoma (1), hepatoma (1), histiocytic sarcoma (1), pheochromocytoma (1) and osteosarcoma (1). Conclusions The existence of a well-established Slaughterhouse Support Network allowed the compilation of comprehensive data for further epidemiological and pathological studies, particularly about less commonly reported lesions in livestock such as neoplasms in pigs.

scholarly journals Computerized Tomography-Guided Core-Needle Biopsy of Orbital Space-Occupying Lesions: A Case Series

2020 ◽  
pp. 1-8
Author(s):  
Bashar M. Bata ◽  
Andrew Martin ◽  
Daniel Connolly ◽  
Hardeep Singh Mudhar ◽  
Naomi Hersey ◽  
...  
Keyword(s):  
Computerized Tomography ◽  
Neuroendocrine Tumour ◽  
Case Series ◽  
B Cell Lymphoma ◽  
Major Surgery ◽  
Open Biopsy ◽  
Core Needle ◽  
Peribulbar Block ◽  
Orbital Space ◽  
Mass Lesions

<b><i>Purpose:</i></b> To describe our experience in performing biopsy of post-septal orbital masses with core needle under computerized tomography guidance (CT-CNB). <b><i>Methods:</i></b> The medical records of all patients who underwent this procedure were reviewed. The procedure was performed under local anesthesia on a day case basis under a peribulbar block. A planning non-contrast computerized tomography (CT) scan of the orbits was performed to localise the mass. A 6-cm 18-G Temno Evolution® semi-automated biopsy needle was inserted through the skin into the orbit. Prior to further advancement of the needle, a low-dose CT limited to the previously determined plane was performed to confirm its position. The needle was then advanced, and the cutting needle was deployed to obtain the biopsy. <b><i>Results:</i></b> Five patients who underwent CT-CNB were identified. The CNB was successful in 4 patients and revealed a metastatic prostate adenocarcinoma, diffuse large B-cell lymphoma, a metastatic neuroendocrine tumour, and orbital inflammatory disease. The biopsy failed in the fifth patient when the needle failed to penetrate the tumour despite good localisation on CT. He was eventually diagnosed with fibrous meningioma of the greater wing of sphenoid on open biopsy. None of the patients had any complications other than peri-ocular bruising which was present in all of them. <b><i>Conclusion:</i></b> CT-CNB of mass lesions located in the lateral aspect of the orbit can be an alternative to open biopsy in selected cases. It avoids major surgery and allows the use of radiotherapy, if required, without any delay.

Cartilage Regeneration with Cell-free Type 1 Collagen Matrix – Past, Present and Future (Part 1 – Clinical Aspects)

2020 ◽  
Author(s):  
Philip Peter Roessler ◽  
Turgay Efe ◽  
Dieter Christian Wirtz ◽  
Frank Alexander Schildberg
Keyword(s):  
Type I Collagen ◽  
Case Series ◽  
Cartilage Regeneration ◽  
Collagen Matrix ◽  
Treatment Method ◽  
Collagen Type I ◽  
Legal Framework ◽  
Clinical Aspects ◽  
Type I ◽  
Collagen Hydrogel

AbstractCartilage regeneration with cell-free matrices has developed from matrix-associated autologous cartilage cell transplantation (MACT) over ten years ago. Adjustments to the legal framework and higher hurdles for cell therapy have led to the procedures being established as an independent alternative to MACT. These procedures, which can be classified as matrix-induced autologous cartilage regeneration (MACR), all rely on the chemotactic stimulus of a cross-linked matrix, which mostly consists of collagens. Given the example of a commercially available type I collagen hydrogel, the state of clinical experience with MACR shall be summarized and an outlook on the development of the method shall be provided. It has been demonstrated in the clinical case series summarized here over the past few years that the use of the matrix is not only safe but also yields good clinical-functional and MR-tomographic results for both small (~ 10 mm) and large (> 10 mm) focal cartilage lesions. Depending on the size of the defect, MACR with a collagen type I matrix plays an important role as an alternative treatment method, in direct competition with both: microfracture and MACT.

scholarly journals Oral Squamous Cell Carcinoma on Gingiva, Edentulous Ridge, and Retromolar Pad: A Case Series

Oral ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 159-167
Author(s):  
Lucio Lo Russo ◽  
Eleonora Lo Muzio ◽  
Giuseppe Colella ◽  
Maria Eleonora Bizzoca ◽  
Vera Panzarella ◽  
...  
Keyword(s):  
Case Series ◽  
Medical Consultation ◽  
Clinical Aspects ◽  
University Hospitals ◽  
Clinical Appearance ◽  
Oral Cancers ◽  
Presenting Symptoms ◽  
Medical Evaluation ◽  
Significant Incidence ◽  
Advanced Stages

(1) Background: Gingival cancer has a significant incidence and is often diagnosed at advanced stages. The aim of this paper is to highlight its clinical aspects on the basis of a case series analysis in order to promote awareness and improve the diagnosis process. (2) Methods: Oral cancers diagnosed and treated at three Italian University Hospitals over ten years were retrospectively investigated. Cancer location on the gingiva, edentulous ridge, and retromolar pad was addressed. Data regarding clinical features, stage at the diagnosis, and time from presenting symptoms to first medical consultation were retrieved. (3) Results: Thirty-three cancers located on the gingiva, edentulous ridge, and retromolar pad were retrieved from 276 total oral cancer cases (11.9%). A median of 50 days (range 2–300) passed for the patient to seek for a medical evaluation. At the time of diagnosis, 63.3% were advanced stage cancers, mainly located at the mandible (91%), especially in the retromolar pad (48.5%) and the edentulous alveolar ridge (24.2%). Lesions were red (45.5%), red and white (45.4%), or white (9.1%), appearing as an ulcer (69.7%), exophytic mass (12.1%) or flat lesion (12.1%). Sixty-six percent of cancers were completely asymptomatic, regardless their clinical appearance. A statistically significant association between the time from the presentation of symptoms to the first medical consultation and the cancers stage was found. (4) Conclusions: The clinical appearance of gingival cancer is very polymorphous; its understanding may be significant to improve patient education and early medical consultation.

A Multi-Centre Case Series Investigating the Aetiology of Hypertrophic Pachymeningitis with Orbital Inflammation

Orbit ◽  
2011 ◽  
Vol 30 (2) ◽  
pp. 64-69 ◽  
Author(s):  
Paul S. Cannon ◽  
Antonio A. V. Cruz ◽  
Carolina T. Pinto ◽  
Dante A. Mastropietro ◽  
Fernando Chahud ◽  
...  
Keyword(s):  
Case Series ◽  
Hypertrophic Pachymeningitis ◽  
Orbital Inflammation
Sign in / Sign up

Export Citation Format

Share Document