scholarly journals Association of theHindIIIand S447X Polymorphisms inLPLGene with Hypertension and Type 2 Diabetes in Mexican Families

2012 ◽  
Vol 33 (6) ◽  
pp. 313-320 ◽  
Author(s):  
Salvador Muñoz-Barrios ◽  
Iris Paola Guzmán-Guzmán ◽  
José Francisco Muñoz-Valle ◽  
Aralia Berenice Salgado-Bernabé ◽  
Lorenzo Salgado-Goytia ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Diastolic Blood Pressure ◽  
Gene Polymorphisms ◽  
The Body ◽  
Mexican Families

Lipoprotein lipase (LPL) is a key enzyme in lipid metabolismand is associatedwith obesity, dyslipidemias, hypertension (HTN) and type 2 diabetes mellitus (T2DM).LPLgene polymorphisms can be related with the development of cardiovascular risk factors. The present study was conducted to analyze the relationship of theHindIIIand S447X polymorphisms inLPLgene with cardiovascular risk factors in Mexican families. The study population comprised ninety members of 30 Mexican families, in which an index case had obesity, were included in the study. We evaluated the body composition by bioelectrical impedance. Peripheral blood samples were collected to determine biochemical parameters. Screening for both polymorphisms was made by PCR-RFLPs. In the parents, both polymorphisms were in Hardy-Weinberg’s equilibrium. We found that the genotype T/T ofHindIIIwas associated with diastolic blood pressure ≧ 85 mmHg (OR = 1.1;p= 0.011), whereas the genotype C/C of S447X was associated with systolic blood pressure ≧ 130 mmHg (OR = 1.2;p< 0.001), diastolic blood pressure ≧ 85 mmHg (OR = 1.3;p< 0.001), T2DM (OR = 1.3;p< 0.001) and with increase of total cholesterol (β = 23.6 mg/mL;p= 0.03). These data suggest that theHindIIIand S447XLPLgene polymorphisms can confer susceptibility for the development of hypertension and T2DM in Mexican families.

The effects of alcohol on ambulatory blood pressure and other cardiovascular risk factors in type 2 diabetes

2016 ◽  
Vol 34 (3) ◽  
pp. 421-428 ◽  
Author(s):  
Trevor A. Mori ◽  
Valerie Burke ◽  
Renate R. Zilkens ◽  
Jonathan M. Hodgson ◽  
Lawrence J. Beilin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Ambulatory Blood Pressure

Effects of telephone call intervention on cardiovascular risk factors in T2DM: A meta-analysis

2017 ◽  
Vol 25 (2) ◽  
pp. 93-105 ◽  
Author(s):  
Junping Wei ◽  
Huijuan Zheng ◽  
Liansheng Wang ◽  
Qiuhong Wang ◽  
Fan Wei ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Meta Analysis ◽  
Glycosylated Haemoglobin ◽  
Haemoglobin A1c ◽  
Telephone Calls

Background Mobile health interventions utilising telephone calls are promising tools for diabetes management. However, there is still a lack of convincing evidence demonstrating their beneficial effects on cardiovascular risk factors. The aim of this meta-analysis of randomised controlled trials was to assess the effect of telephone calls on glycaemic control and other cardiovascular risk factors in type 2 diabetes mellitus patients. Methods Two independent reviewers searched three online databases (PubMed, the Cochrane Library and EMBASE) to identify relevant English-language randomised controlled trials up to September 2017. Randomised controlled trials that assessed the effects of telephone calls on glycaemic control and other cardiovascular risk factors in type 2 diabetes mellitus patients were included. Effect size was calculated for changes in glycosylated haemoglobin A1c, weight, blood pressure and lipid levels using fixed- or random-effects models. Results Eighteen studies involving 3954 patients were included in the meta-analysis. Compared with usual care, telephone calls significantly decreased glycosylated haemoglobin A1c, by 0.12% (95% confidence interval: −0.22% to −0.02%). Univariate regression analysis showed that none of the covariates (number of participants, baseline age, baseline glycosylated haemoglobin A1c, duration of diabetes, call maker, number of calls and duration of study) had an impact on glycosylated haemoglobin A1c. For other cardiovascular risk factors, telephone calls significantly reduced systolic blood pressure by 0.19 mm Hg (95% confidence interval: −0.34% to −0.03%) but non-significantly changed diastolic blood pressure, body mass index, low-density lipoprotein cholesterol, total cholesterol, triglyceride or high-density cholesterol levels. Conclusions This meta-analysis supports the hypothesis that telephone calls offer moderate benefits for glycosylated haemoglobin A1c and systolic blood pressure reduction among type 2 diabetes mellitus patients. However, the data remain insufficient regarding the association of telephone calls with lowered diastolic blood pressure, body mass index or improved lipoprotein profiles.

scholarly journals Interleukin-6 Gene Promoter Polymorphisms and Cardiovascular Risk Factors. A family study

2010 ◽  
Vol 28 (1) ◽  
pp. 29-36 ◽  
Author(s):  
Iris Paola Guzmán-Guzmán ◽  
José Francisco Muñoz-Valle ◽  
Eugenia Flores-Alfaro ◽  
Lorenzo Salgado-Goytia ◽  
Aralia Berenice Salgado-Bernabé ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Interleukin 6 ◽  
Gene Polymorphisms ◽  
Hematological Parameters ◽  
High Sensitivity ◽  
The Body ◽  
Promoter Polymorphisms ◽  
Mexican Families

Interleukin-6 (IL-6) is a cytokine involved in inflammatory process, as well as in glucose and lipid metabolism. Several studies of the biological relevance of IL-6 gene polymorphisms have indicated a relationship with cardiovascular disease. The aim of this study was to assess whether the –174 G/C and –572 G/C of IL-6 gene polymorphisms are associated with cardiovascular risk factors in Mexican families. Ninety members of 30 Mexican families, in which an index case (proband) had obesity, were included in the study. We evaluated the body composition by bioelectrical impedance. Peripheral blood samples were collected to determine biochemical and hematological parameters. High sensitivity C- reactive protein levels were measurement for nephelometric analysis. Screening for both polymorphisms studied was performed by PCR-RFLP. In the parents, both polymorphisms were in Hardy-Weinberg's equilibrium. The genotypes –174 GC/CC were associated with T2D (OR = 1.23, IC95%1.01–1.5) and highest levels of hsCRP (p= 0.02), whereas genotype –572 GG was associated with T2D (OR = 1.24, IC95%1.04–1.47) with an inflammatory state determined by the increase in the leukocyte count (OR = 1.24, IC95%1.02–1.51). The genotypes –174 GC/CC and –572 GG may confer susceptibility for the development of subclinical inflammation and type 2 diabetes in Mexican families.

scholarly journals CONTROL OF GLYCEMIA AND CARDIOVASCULAR RISK FACTORS IN PATIENTS WITH TYPE 2 DIABETES IN PRIMARY CARE IN MONTENEGRO

2018 ◽  
pp. 016
Author(s):  
Milena M. Cojić ◽  
Ljiljana Cvejanov-Kezunović ◽  
Jelena Stanković ◽  
Nebojša Kavarić ◽  
Maja Koraćević ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Diabetic Patients ◽  
The Mean

Some observational studies have shown that only a small number of diabetic patients achieve optimum control of glycaemia and cardiovascular risk factors. The aim of this study was to analyze whether patients with type 2 diabetes mellitus treated in primary care achieve adequate control of glycemic levels and cardiovascular risk factors. This was a retrospective, record-based, cross-sectional study that included eligible patients from 35 to 90 years old with type 2 diabetes mellitus treated in Primary Health Care Center in Podgorica. We investigated electronic records of 531 diabetic patients. The observed prevalence of type 2 diabetes mellitus among individuals between ages 35 and 90 years, was 11,84 %. Half of the patients were female. The mean age was 65,88±9,86 years. The mean value of HbA1c was 7,56±1,71. Fifty-nine percents of patients achieved optimal levels of HbA1c ≤ 7 %. Also, more than half of patients achieved target levels of blood pressure while 27.9% achieved LDL ≤ 2.6 mmol/L. Fifty percent of patients were non-smokers and 45.1 % were obese. Among patients on primary prevention only 5.7 % had met all target levels while on secondary prevention that number was even smaller 3.7 %. Our study showed that control of HbA1c and blood pressure was similar to other studies but reaching target levels of LDL was challenging for our patients. Further analysis are needed in order to discover the reasons for poor control of certain CVRF and to develop strategies for its optimal management.

scholarly journals Practical aspects of cardiovascular risk factors identify in patients with diabetes type 1 and 2

2011 ◽  
Vol 3 (1) ◽  
pp. 4-9
Author(s):  
Mehman N. Mamedov ◽  
Marina N. Kovrigina ◽  
Marina B. Buzurtanov
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Capillary Blood ◽  
The Difference

The aim of this study was to investigate the characteristics of the risk factors and comparative analysis of different methods of identify of cardiovascular risk factors in outpatient with diabetes mellitus (DM) type 1 and 2. Methods. In cross-sectional clinical study included 244 persons with type 1 and type 2 mean age 46,4 yrs. All patients were interviewed using a questionnaire of WHO, they were measured blood pressure, heart rate, anthropometric data, including total fat mass with fat analyzer OMRON BF508. All patients were also measured venous and capillary blood glucose level, glycated hemoglobin (%), total cholesterol and triglycerides. Results. The difference between the two measurement glucose methods (in venous and capillary blood) was 6,7 0,6%. In patients with type 1 diabetes hypertension occurs 2.5 times in less compared with patients with type 2 diabetes. The difference between blood pressure measured by mechanical and automatic devices was less than 1%. The percentage of body fat, including visceral fat, both women and men with type 2 diabetes by age corresponds to the high deviation from the norm. Most men and women with type 1 and type 2 had hypercholesterolemia. Conclusion. Traditional cardiovascular risk factors are identified, not only among individuals with type 2 diabetes, but among patients with type 1 diabetes.

scholarly journals Impact of a Mediterranean Dietary Pattern and Its Components on Cardiovascular Risk Factors, Glucose Control, and Body Weight in People with Type 2 Diabetes: A Real-Life Study

Nutrients ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 1067 ◽  
Author(s):  
Marilena Vitale ◽  
Maria Masulli ◽  
Ilaria Calabrese ◽  
Angela Rivellese ◽  
Enzo Bonora ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Mediterranean Diet ◽  
Dietary Pattern ◽  
Plasma Lipids ◽  
The Mediterranean

This study evaluates the relation of a Mediterranean dietary pattern and its individual components with the cardiovascular risk factors profile, plasma glucose and body mass index (BMI) in people with type 2 diabetes. We studied 2568 participants at 57 diabetes clinics. Diet was assessed with the EPIC (European Prospective Investigation into Cancer and Nutrition) questionnaire, adherence to the Mediterranean diet was evaluated with the relative Mediterranean diet score (rMED). A high compared to a low score was associated with a better quality of diet and a greater adherence to the nutritional recommendations for diabetes. However, even in the group achieving a high score, only a small proportion of participants met the recommendations for fiber and saturated fat (respectively 17% and 30%). Nonetheless, a high score was associated with lower values of plasma lipids, blood pressure, glycated hemoglobin, and BMI. The relationship of the single food items components of the rMED score with the achievement of treatment targets for plasma lipids, blood pressure, glucose, and BMI were also explored. The study findings support the Mediterranean dietary model as a suitable model for type 2 diabetes and the concept that the beneficial health effects of the Mediterranean diet lie primarily in its synergy among various nutrients and foods rather than on any individual component.

scholarly journals Benefits of adding food education sessions to an exercise programme on cardiovascular risk factors in patients with type 2 diabetes

2021 ◽  
Vol 10 ◽  
Author(s):  
Carlos Eduardo Gonçalves da Costa Vasconcelos ◽  
Maria Manuela Lobato Guimarães Ferreira Cabral ◽  
Elisabete Conceição Pereira Ramos ◽  
Romeu Duarte Carneiro Mendes
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Older Patients ◽  
Exercise Programme ◽  
Middle Aged ◽  
Food Education

Abstract To evaluate the impact of adding food education sessions to an exercise programme on cardiovascular risk factors in middle-aged and older patients with type 2 diabetes (T2D), a randomised parallel-group study was performed. Glycated haemoglobin, body mass index (BMI), waist circumference, fat mass (FM) and blood pressure were assessed at baseline and after 9 months. The recruitment was made in three primary healthcare centres from Vila Real, Portugal. Thirty-three patients (65⋅4 ± 5⋅9 years old) were engaged in a 9-month community-based lifestyle intervention programme: a supervised exercise programme (EX; n = 15; combined aerobic, resistance, agility/balance and flexibility exercise; three sessions per week; 75 min per session); or the same exercise programme plus concomitant food education sessions (EXFE; n = 18; 15-min lectures and dual-task strategies during exercise (answer nutrition questions while walking); 16 weeks). Significant differences between groups were identified in the evolution of BMI (P < 0.001, $\eta _{\rm p}^2 = 0{\cdot} 150$ ) and FM (P < 0.001, $\eta _{\rm p}^2 = 0{\cdot}130$ ), with best improvements observed in the EXFE group. The addition of a simple food education dietary intervention to an exercise programme improved body weight and composition, but not glycaemic control and blood pressure in middle-aged and older patients with T2D.

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