scholarly journals Interleukin-6 Gene Promoter Polymorphisms and Cardiovascular Risk Factors. A family study

2010 ◽  
Vol 28 (1) ◽  
pp. 29-36 ◽  
Author(s):  
Iris Paola Guzmán-Guzmán ◽  
José Francisco Muñoz-Valle ◽  
Eugenia Flores-Alfaro ◽  
Lorenzo Salgado-Goytia ◽  
Aralia Berenice Salgado-Bernabé ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Interleukin 6 ◽  
Gene Polymorphisms ◽  
Hematological Parameters ◽  
High Sensitivity ◽  
The Body ◽  
Promoter Polymorphisms ◽  
Mexican Families

Interleukin-6 (IL-6) is a cytokine involved in inflammatory process, as well as in glucose and lipid metabolism. Several studies of the biological relevance of IL-6 gene polymorphisms have indicated a relationship with cardiovascular disease. The aim of this study was to assess whether the –174 G/C and –572 G/C of IL-6 gene polymorphisms are associated with cardiovascular risk factors in Mexican families. Ninety members of 30 Mexican families, in which an index case (proband) had obesity, were included in the study. We evaluated the body composition by bioelectrical impedance. Peripheral blood samples were collected to determine biochemical and hematological parameters. High sensitivity C- reactive protein levels were measurement for nephelometric analysis. Screening for both polymorphisms studied was performed by PCR-RFLP. In the parents, both polymorphisms were in Hardy-Weinberg's equilibrium. The genotypes –174 GC/CC were associated with T2D (OR = 1.23, IC95%1.01–1.5) and highest levels of hsCRP (p= 0.02), whereas genotype –572 GG was associated with T2D (OR = 1.24, IC95%1.04–1.47) with an inflammatory state determined by the increase in the leukocyte count (OR = 1.24, IC95%1.02–1.51). The genotypes –174 GC/CC and –572 GG may confer susceptibility for the development of subclinical inflammation and type 2 diabetes in Mexican families.

scholarly journals Association of theHindIIIand S447X Polymorphisms inLPLGene with Hypertension and Type 2 Diabetes in Mexican Families

2012 ◽  
Vol 33 (6) ◽  
pp. 313-320 ◽  
Author(s):  
Salvador Muñoz-Barrios ◽  
Iris Paola Guzmán-Guzmán ◽  
José Francisco Muñoz-Valle ◽  
Aralia Berenice Salgado-Bernabé ◽  
Lorenzo Salgado-Goytia ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Diastolic Blood Pressure ◽  
Gene Polymorphisms ◽  
The Body ◽  
Mexican Families

Lipoprotein lipase (LPL) is a key enzyme in lipid metabolismand is associatedwith obesity, dyslipidemias, hypertension (HTN) and type 2 diabetes mellitus (T2DM).LPLgene polymorphisms can be related with the development of cardiovascular risk factors. The present study was conducted to analyze the relationship of theHindIIIand S447X polymorphisms inLPLgene with cardiovascular risk factors in Mexican families. The study population comprised ninety members of 30 Mexican families, in which an index case had obesity, were included in the study. We evaluated the body composition by bioelectrical impedance. Peripheral blood samples were collected to determine biochemical parameters. Screening for both polymorphisms was made by PCR-RFLPs. In the parents, both polymorphisms were in Hardy-Weinberg’s equilibrium. We found that the genotype T/T ofHindIIIwas associated with diastolic blood pressure ≧ 85 mmHg (OR = 1.1;p= 0.011), whereas the genotype C/C of S447X was associated with systolic blood pressure ≧ 130 mmHg (OR = 1.2;p< 0.001), diastolic blood pressure ≧ 85 mmHg (OR = 1.3;p< 0.001), T2DM (OR = 1.3;p< 0.001) and with increase of total cholesterol (β = 23.6 mg/mL;p= 0.03). These data suggest that theHindIIIand S447XLPLgene polymorphisms can confer susceptibility for the development of hypertension and T2DM in Mexican families.

scholarly journals The validity of the body adiposity index in predicting percentage body fat and cardiovascular risk factors among Chinese

2013 ◽  
Vol 81 (3) ◽  
pp. 356-362 ◽  
Author(s):  
Zhe-Qing Zhang ◽  
Yan-Hua Liu ◽  
Ying Xu ◽  
Xiao-Wei Dai ◽  
Wen-hua Ling ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Body Fat ◽  
The Body ◽  
Body Adiposity Index ◽  
Percentage Body Fat ◽  
Adiposity Index ◽  
Body Adiposity

scholarly journals High-sensitivity troponin I and all-cause mortality in patients with stable COPD: an analysis of the COSYCONET study

2019 ◽  
Vol 55 (2) ◽  
pp. 1901314 ◽  
Author(s):  
Benjamin Waschki ◽  
Peter Alter ◽  
Tanja Zeller ◽  
Christina Magnussen ◽  
Johannes T. Neumann ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Diseases ◽  
Cardiovascular Risk Factors ◽  
Troponin I ◽  
High Sensitivity ◽  
Airflow Limitation ◽  
Reference Limit ◽  
High Sensitivity Troponin ◽  
All Cause Mortality

Chronic obstructive pulmonary disease (COPD) is a leading cause of death with a considerable part of the population dying from cardiovascular diseases. High-sensitivity troponin I (hs-TnI) might help to better identify COPD patients at high risk of mortality. We aimed to study the predictive value of hs-TnI for all-cause mortality beyond established COPD assessments, and after consideration of relevant cardiovascular risk factors and prevalent cardiovascular diseases, in a broad population with stable COPD.Circulating hs-TnI concentrations together with a wide range of respiratory and cardiovascular markers were evaluated in 2085 patients with stable COPD across all severity stages enrolled in the multicentre COSYCONET cohort study. The primary outcome was all-cause mortality over 3 years of follow-up.Hs-TnI was detectable in 2020 (96.9%) patients. The median hs-TnI concentration was 3.8 ng·L−1 (interquartile range 2.5–6.6 ng·L−1), with levels above the 99th percentile reference limit of 27 ng·L−1 observed in 1.8% of patients. In Cox regression analyses including adjustments for airflow limitation, dyspnoea grade, exercise capacity and history of severe exacerbations, as well as traditional cardiovascular risk factors, estimated glomerular filtration rate, ankle–brachial index, N-terminal pro-brain natriuretic peptides and prevalent cardiovascular diseases, hs-TnI was a significant predictor for all-cause mortality, both as a continuous variable (hazard ratio (HR) for log hs-TnI 1.28, 95% CI 1.01–1.62) and categorised according to the cut-off of 6 ng·L−1 (HR 1.63, 95% CI 1.10–2.42).In patients with stable COPD, hs-TnI is a strong predictor of all-cause mortality beyond established COPD mortality predictors, and independent of a broad range of cardiovascular risk factors and prevalent cardiovascular diseases. Hs-TnI concentrations well below the upper reference limit provide further prognostic value for all patients with COPD when added to established risk assessments.

scholarly journals Study on Alcohol Dependence and Factors Related to Erectile Dysfunction Among Aborigines in Taiwan

2014 ◽  
Vol 9 (3) ◽  
pp. 247-256 ◽  
Author(s):  
Jian-Kang Chao ◽  
Mi-Chia Ma ◽  
Yen-Chin Lin ◽  
Han-Sun Chiang ◽  
Thomas I-Sheng Hwang
Keyword(s):  
Risk Factors ◽  
Erectile Dysfunction ◽  
Cardiovascular Risk ◽  
Alcohol Dependence ◽  
Cardiovascular Risk Factors ◽  
Demographic Data ◽  
High Sensitivity ◽  
Serum Testosterone ◽  
Baseline Survey ◽  
Cross Sectional

Relatively few studies have addressed the risk factors of erectile dysfunction (ED) in Taiwanese— most have described ED and medical problems in the general population. In this study, the cardiovascular risk factors of ED among aborigines in Taiwan were investigated. However, alcohol dependence (AD) was prevalent in Taiwan’s aborigine population. So this study also focused on the relationship among AD, the cardiovascular risk factors and ED. A cross-sectional study was conducted, and data was obtained from a baseline survey of 192 aboriginal adults (35-75 years of age). The participants’ demographic data, AD, markers of endothelial function, serum testosterone, and ED status were assessed. Ninety-four (49%) of the 192 participants had a history of alcoholism and 79 (84%) of those with alcoholism had ED. The study reported that AD and hyperlipidemia, metabolic syndrome (MetS), ED, abnormality of testosterone, and high-sensitivity C-reactive protein are highly prevalent among the aborigines. Factors that may affect ED included age, AD, central obesity, diabetes mellitus, hyperlipidemia, hypertension, MetS, and testosterone. ED is highly prevalent among aborigines with the risk factors of AD, MetS, old age, and abnormal testosterone serum level. MetS, atherosclerosis, and ED are risk factors for cardiovascular diseases. Hence, an increased focus on Taiwanese aborigines with ED is necessary.

scholarly journals High-Sensitivity Cardiac Troponin-I Is Elevated in Patients with Rheumatoid Arthritis, Independent of Cardiovascular Risk Factors and Inflammation

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e38930 ◽  
Author(s):  
William S. Bradham ◽  
Aihua Bian ◽  
Annette Oeser ◽  
Tebeb Gebretsadik ◽  
Ayumi Shintani ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Cardiac Troponin ◽  
Troponin I ◽  
High Sensitivity ◽  
Cardiac Troponin I
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