scholarly journals SOD-Mimic Cu(II) Dimeric Complexes Involving Kinetin and Its Derivative: Preparation and Characterization

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Radka Novotná ◽  
Zdeněk Trávníček ◽  
Radovan Herchel
Keyword(s):  
Mass Spectrometry ◽  
Magnetic Susceptibility ◽  
Temperature Dependence ◽  
Elemental Analysis ◽  
Antiradical Activity ◽  
Electronic Spectroscopy ◽  
Antiferromagnetic Exchange ◽  
Dimeric Complexes ◽  
Esi Mass Spectrometry

Two SOD-mimic active dimeric Cu(II) chlorido complexes of the compositions [Cu2(μ-HL1)4Cl2]Cl2(1) and [Cu2(μ-HL2)2(μ-Cl)2(HL2)2Cl2] · 4H2O (2) involving the cosmetologically relevant cytokinin kinetin (N6-furfuryladenine, HL1) and its derivative N6-(5-methylfurfuryl)adenine (HL2) have been synthesized and characterized by elemental analysis, infrared, and electronic spectroscopy, ESI+ mass spectrometry, conductivity and temperature dependence of magnetic susceptibility measurements, and thermogravimetric (TG) and differential thermal (DTA) analyses. The results of these methods, particularly the temperature dependence of magnetic susceptibility, showed the complexes to be dimeric with a strong antiferromagnetic exchange (J= −290 cm−1for complex1andJ= −160 cm−1for2). The complexes have been identified as auspicious SOD-mimics, as their antiradical activity evaluated by thein vitroSOD-mimic assay resulted in the IC50values equal to 8.13 μM (1) and 0.71 μM (2).

Long range antiferromagnetic exchange in dinuclear copper(II) complexes containing 1,4-dicyanamidobenzene dianion bridging ligands

1995 ◽  
Vol 73 (4) ◽  
pp. 573-580 ◽  
Author(s):  
Linnus L. Cheruiyot ◽  
Robert J. Crutchley ◽  
Laurence K. Thompson ◽  
J.E. Greedan ◽  
Guo Liu
Keyword(s):  
Magnetic Susceptibility ◽  
Elemental Analysis ◽  
Epr Spectroscopy ◽  
Antiferromagnetic Exchange ◽  
Temperature Dependent ◽  
Magnetic Studies ◽  
Bridging Ligands ◽  
Dimer Model ◽  
Bridging Ligand ◽  
Exchange Constants

Six Cu(II)dimers, [{Cu(dien)}2(μ-dicyd)][CF3SO3]2 (1), [{Cu(dien)}2(μ-Me2dicyd)][CF3SO3]2 (2), [{Cu(dien)}2(μ-Cl2dicyd)][CF3SO3]2 (3), [{Cu(L)}2(μ-dicyd)] (4), [{Cu(L)}2(μ-Me2dicyd)] (5), and [{Cu(L)}2(μ-Cl2dicyd)] (6), where dicyd2−, Me2dicyd2− and Cl2dicyd2− are unsubstituted, 2,5-dimethyl- and 2,5-dichloro-1,4-dicyanamidobenzene dianions, respectively, dien is diethylenetriamine, and L− = 1,3-bis(2-pyridylimino)isoindolinato, have been synthesized and characterized by elemental analysis, IR, UV–vis, and EPR spectroscopy, and magnetic studies. Temperature-dependent magnetic susceptibility measurements of the complexes 1–6 from 5 to 300 K are reported. The data for 2, 3, 5, and 6 have been fitted to a dimer model with a modified Bleaney–Bowers expression which derived antiferromagnetic exchange constants −J = 10.6, 4.5, 5.2, and 3.0 cm−1, respectively (where the Hamiltonian is of the form [Formula: see text]) For 4, an approach to a maximum in χm with decreasing temperature gave an estimated −J < 3.5 cm−1. Only complex 1 showed Curie–Weiss behavior. This is far weaker antiferromagnetic exchange compared to that observed for dinuclear Ru(III) complexes incorporating the dicyd2− bridging ligands (J. Am. Chem Soc. 114, 5130 (1992)) and is attributed to a symmetry and energy mismatch between Cu(II) σ* magnetic orbitals and the πnb molecular orbitals of the bridging ligand which are important for superexchange. Keywords: superexchange, copper dimer, dicyanamidobenzene.

scholarly journals 1,3,4-Thiadiazole Derivatives. Part 91. Synthesis and Biological Activity of Metal Complexes of 5-(2-Aminoethyl)-2-Amino-1,3,4-Thiadiazole

1996 ◽  
Vol 3 (5) ◽  
pp. 227-232 ◽  
Author(s):  
Mihai Barboiu ◽  
Marilena Cimpoesu ◽  
Cornelia Guran ◽  
Claudiu T. Supuran
Keyword(s):  
Biological Activity ◽  
Antifungal Activity ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Electronic Spectroscopy ◽  
Candida Spp ◽  
Thiadiazole Derivatives ◽  
In Vitro Antifungal Activity

Metal complexes of the title ligand (L) containing Co(II), Ni(II) and Cu(II) were prepared and characterized by elemental analysis, IR, electronic spectroscopy and conductimetry. The new derivatives, possessing the following formulae, CuL2(OH)2, NiL2Cl2, and [Co2LCl4]n showed in vitro antifungal activity against Aspergillus and Candida spp.

New bis-pyrazolylpyridine ruthenium(III) complex as a potential anticancer drug: In vitro and in vivo activity in murine colon cancer

2021 ◽  
Author(s):  
Dejan Lazić ◽  
Andreas Scheurer ◽  
Dusan Cocic ◽  
Jelena Z Milovanović ◽  
Aleksandar Arsenijević ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Colon Cancer ◽  
Anticancer Drug ◽  
Elemental Analysis ◽  
Tert Butyl ◽  
Type Complex ◽  
Vis Spectroscopy ◽  
Murine Colon

We synthesized and characterized the ruthenium(III) pincer-type complex [RuCl3(H2Lt-Bu] (H2Lt-Bu = 2,6-bis(5-tert-butyl-1H-pyrazol-3-yl)pyridine, 1) by elemental analysis, IR and UV-Vis spectroscopy, and mass spectrometry (MS) method ESI Q-TOF. For comparison reason,...

EXTRACTION, ISOLATION, CHARACTERIZATION, SEMISYNTHESIS AND BIOLOGICAL EVALUATION OF BERBERINE FROM ROOTS OF BERBERIS ARISTATA

INDIAN DRUGS ◽  
2013 ◽  
Vol 50 (09) ◽  
pp. 18-24
Author(s):  
J Mittal ◽  
◽  
K. Chaudhary ◽  
N Kumar ◽  
D Pathak
Keyword(s):  
Mass Spectrometry ◽  
Elemental Analysis ◽  
Biological Evaluation ◽  
Diffusion Method ◽  
Significant Activity ◽  
Bacterial Strains ◽  
Percolation Method ◽  
Acetophenone Derivatives ◽  
Antibacterial And Antifungal

A methanolic extract of roots of Berberis aristata was prepared by using hot percolation method. Berberine was isolated from the above extract and characterized by IR, 1HNMR, mass spectrometry and elemental analysis. A series of 8-(substituted acetophenone) berberine derivatives was synthesized by introducing various acetophenone derivatives at 8th position of berberine and analyzed by melting point and TLC. The structures of all the synthesized compounds were characterized by IR, 1HNMR, mass spectrometry and elemental analysis. The semisynthesized compounds were screened for in vitro antibacterial and antifungal activity using disc (5mm) diffusion method on nutrient agar medium against Gram-positive (Staphylococcus aureus and Bacillus subtilis), Gram-negative bacterial strains (Pseudomonas aeruginosa and Escherichia coli) and fungal strains (Aspergillus niger and Candida albicans) respectively. The zone of inhibition was compared with standard drugs berberine and kanamycin. All the above compounds showed significant activity in comparison to the standards berberine and kanamycin.

New phosphoramidates containing selenium as leishmanicidal agents

2021 ◽  
Author(s):  
Mikel Etxebeste-Mitxeltorena ◽  
Daniel Plano ◽  
Socorro Espuelas ◽  
Esther Moreno ◽  
Carlos Aydillo ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Elemental Analysis ◽  
Theoretical Calculations ◽  
Redox System ◽  
New Agents ◽  
Analysis Techniques ◽  
Physico Chemical ◽  
Pharmacokinetic Properties ◽  
New Compounds

This work reports the synthesis, characterization by FTIR, 1 H, 13 C and 79 Se NMR, mass spectrometry and elemental analysis techniques as well as the in vitro evaluation of the leishmanicidal activity of thirteen new selenophosphoramidate derivatives. Among the new compounds, four of them (compounds 1f, 1g, 2f and 2g), which exhibited the best profile, were tested against infected macrophages and were selected for further studies related their leishmanicidal mechanism. In this regard, trypanothione redox-system alteration was determined. Compound 1g, under similar conditions, was more effective than the corresponding references. In addition, theoretical calculations showed that this compound also presents most physico-chemical and pharmacokinetic properties within the ranges expected for orally available drugs. It is believed that selenophophoramidate functionalities may represent a scaffold to be explored toward the development of new agents for leishmania treatment.

scholarly journals Molecular design and synthesis of new dithiocarbazate complexes; crystal structure, bioactivities and nano studies

RSC Advances ◽  
2018 ◽  
Vol 8 (73) ◽  
pp. 41795-41809 ◽  
Author(s):  
Zahra Yekke-ghasemi ◽  
Reza Takjoo ◽  
Mohammad Ramezani ◽  
Joel T. Mague
Keyword(s):  
Crystal Structure ◽  
Mass Spectrometry ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Molecular Design ◽  
X Ray ◽  
Design And Synthesis

New metal complexes are synthesized and characterized by elemental analysis, mass spectrometry, spectroscopic, TGA and X-ray techniques. The compounds were evaluated in anin vitrocytotoxicity. Interaction of the samples with HSA was investigated.

Synthesis and Characterization of Silver(I) and Gold(I) Complexes Bearing a Pyrido-annelated N-Heterocyclic Carbene: A Rare Example of a Cocrystal Containing Two Different Gold(I) Complexes

2014 ◽  
Vol 69 (11-12) ◽  
pp. 1188-1198 ◽  
Author(s):  
Margit Kriechbaum ◽  
Daniela Otte ◽  
Manuela List ◽  
Uwe Monkowius
Keyword(s):  
Mass Spectrometry ◽  
Nmr Spectroscopy ◽  
Aromatic Compound ◽  
Elemental Analysis ◽  
Room Temperature ◽  
Electronic Spectroscopy ◽  
Crystalline Material ◽  
Synthesis And Characterization ◽  
Aurophilic Interactions

Abstract The cyclohexyl-substituted imidazo[1,5-a]pyridin-2-ium hexafluorophosphate, 2a, has been prepared as precursor for the respective pyrido-annelated N-heterocyclic carbene. [(NHC)2Ag]PF6, 3, has been synthesized by the reaction of 2a with AgCl=KOH in dichloromethane (DCM). Unexpectedly, the reaction of 3 with (tht)AuBr yielded both (NHC)AuBr and [(NHC)Au(tht)]PF6 which formed a 1 : 1 cocrystal (4a,b). The complexes are aggregated to infinite chains, which are governed by both π-π stacking and weak aurophilic interactions. Subsequent oxidation of the co-crystalline material with CsBr3 gave (NHC)AuBr3, 5. All compounds were characterized by NMR spectroscopy, mass spectrometry and elemental analysis. Additionally, compounds 2a and 5 were investigated by electronic spectroscopy: 2a behaves like a typical aromatic compound exhibiting absorption and fluorescence bands attributable to π-π* transitions. The Au(III) complex 5 exhibits ligand-centered fluorescence at room temperature and both ligand-centered fluorescence and a weak phosphorescence at 77 K.

225. Characterisation of a diverse secretome generated by the mouse preimplantation embryo

2008 ◽  
Vol 20 (9) ◽  
pp. 25
Author(s):  
C. O.'Neill ◽  
A. Beardsley
Keyword(s):  
Mass Spectrometry ◽  
Redox Regulation ◽  
Preimplantation Embryo ◽  
Early Embryo ◽  
Arginine Deiminase ◽  
Post Translational Modification ◽  
Preimplantation Embryo Development ◽  
Mouse Preimplantation Embryo ◽  
Esi Mass Spectrometry

This study investigated the suitability of surface-enhanced laser desorption and ionisation time-of-flight (SELDI-TOF) and electro-spray ionisation (ESI) mass spectrometry for the analysis of the proteins released by the mouse preimplantation embryo in vitro. SELDI-TOF analysis with CM10 or IMAC30 (but not Q10) chips detected a protein peak at m/z 8570 released by both C57BL6 and hybrid embryos. No other peaks unique to the embryo were identified with this method. ESI mass spectrometry of tryptic digests of embryo conditioned media identified a total of 20 proteins released during development from the zygote to blastocysts stage. Four proteins were expressed in at least 7 out of 8 cultures tested, one of these (lactate dehydrogenase B) was in all cultures. A further five proteins were in at least half of the cultures and 11 more putative proteins were detected in at least one culture. The pattern of protein secretion was not obviously different for C57BL6 or hyrid embryos. The expression of two of these proteins is essential for preimplantation embryo development (NLR family, pyrin domain containing 5 protein and peptidyl arginine deiminase, type VI). A further four proteins detected have roles in redox regulation of cells, and three others are capable of inducing post-translational modification of proteins. This study shows the feasibility of ESI mass spectrometry and the limitations of SELD-TOF mass spectrometry for identifying the proteins scereted by the preimplantation embryo in vitro. This analysis identifies a range of targets that now require detailed functional analysis to assess whether their release by the embryo is an important property of the early embryo, or an artefact of in vitro culture.

scholarly journals Spectroscopic, Thermal, Electrochemical, and Antimicrobial Studies of Mononuclear Manganese(II) Ditolyldithiophosphates

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Ruchi Khajuria ◽  
Atiya Syed ◽  
Sandeep Kumar ◽  
Sushil K. Pandey
Keyword(s):  
Mass Spectrometry ◽  
Cyclic Voltammetry ◽  
Magnetic Susceptibility ◽  
Molar Conductance ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
E Coli ◽  
Antimicrobial Studies ◽  
Esi Mass Spectrometry ◽  
Uv Visible

New complexes of manganese(II) corresponding to [{(ArO)2PS2}2Mn] and [{(ArO)2PS2}2Mn.nL] (Ar=o-,m-,p-CH3C6H4andp-Cl-m-CH3C6H3;n=1, L = N2C12H8, N2C10H8;n=2, L = NC5H5, P(C6H5)3) have been synthesized and characterized by microelemental analyses (C, H, and N), magnetic susceptibility, molar conductance, thermogravimetric, cyclic voltammetry, and spectral analyses including ESI mass spectrometry, IR, and UV-visible. The presence of a four-and-six coordinated Mn atoms has been established in the complexes and adducts, respectively. Antimicrobial screening of the complexes against gram negative bacteriaE. coli,K. pneumonia,andP. aeruginosaand fungusS. rolfsiihas shown potential bioactivity.

scholarly journals Antifungal and Spectral Studies of Cr(III) and Mn(II) Complexes Derived from 3,3′-Thiodipropionic Acid Derivative

2009 ◽  
Vol 2009 ◽  
pp. 1-4 ◽  
Author(s):  
Sulekh Chandra ◽  
Amit Kumar Sharma
Keyword(s):  
Magnetic Susceptibility ◽  
Acid Derivative ◽  
Elemental Analysis ◽  
Fungicidal Activity ◽  
Molar Conductance ◽  
Octahedral Geometry ◽  
Spectral Studies ◽  
Bonding Parameters ◽  
Metal Ligand

The Cr(III) and Mn(II) complexes with a ligand derived from 3,3′-thiodipropionic acid have been synthesized and characterized by elemental analysis, molar conductance measurements, magnetic susceptibility measurements, IR, UV, and EPR spectral studies. The complexes are found to have [Cr(L)X]X2 and [Mn(L)X]X, compositions, where L = quinquedentate ligand and X=NO3−, Cl− and OAc−. The complexes possess the six coordinated octahedral geometry with monomeric compositions. The evaluated bonding parameters, Aiso and β, account for the covalent type metal-ligand bonding. The fungicidal activity of the compounds was evaluated in vitro by employing Food Poison Technique.

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