scholarly journals Antimigratory Effects of the Methanol Extract fromMomordica charantiaon Human Lung Adenocarcinoma CL1 Cells

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Hsue-Yin Hsu ◽  
Jung-Hsuan Lin ◽  
Chia-Jung Li ◽  
Shih-Fang Tsang ◽  
Chun-Hao Tsai ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Leaf Extract ◽  
Methanol Extract ◽  
Human Lung ◽  
Human Cancer ◽  
Momordica Charantia ◽  
Invasive Ability ◽  
Human Cancer Cells ◽  
Human Lung Adenocarcinoma ◽  
Significant Difference

Momordica charantiahas been found to exhibit anticancer activity, in addition to its well-known therapeutic functions. We have demonstrated that the leaf extract ofMomordica charantia(MCME) induces apoptosis in several human cancer cells through caspase- and mitochondria-dependent pathways. In this study, a different susceptibility to MCME was found in human lung adenocarcinoma CL1 cells with different metastatic ability, leading to the significant difference of cell viability and invasiveness between MCME-treated CL1-0 and CL1-5 cells. MCME was found to upregulate the expression of Wnt-2 and affect the migratory and invasive ability of CL1 cells through suppressed MMP-2 and MMP-9 enzymatic activities. We proposed that MCME mediates inhibition against migration of CL1 cells by reducing the expression and activation of Src and FAK to decrease the expression of downstream Akt,β-catenin, and MMPs.

A novel polypeptide from Meretrix meretrix Linnaeus inhibits the growth of human lung adenocarcinoma

2012 ◽  
Vol 237 (4) ◽  
pp. 442-450 ◽  
Author(s):  
Cuicui Wang ◽  
Ming Liu ◽  
Linyou Cheng ◽  
Jianteng Wei ◽  
Ning Wu ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Human Lung ◽  
Therapeutic Potential ◽  
Human Cancer ◽  
Small Cell Lung Carcinoma ◽  
Reversed Phase ◽  
Meretrix Meretrix ◽  
Cell Lung Carcinoma ◽  
Human Lung Adenocarcinoma

A novel polypeptide (Mere15) was purified from Meretrix meretrix Linnaeus by ammonium sulfate fractionation, ion exchange, gel filtration and reversed phase chromatography. Mere15 exhibited selective cytotoxicity to several human cancer cells. In vivo study showed that Mere15 significantly suppressed the growth of human lung adenocarcinoma A549 xenograft in nude mice. The mechanism was associated with a G2/M phase arrest followed by apoptosis, including membrane blebbing, loss of mitochondrial membrane potential, externalization of phosphatidylserine, chromosome condensation and DNA fragmentation. Western blot analysis showed that the intrinsic pathway was involved in Mere15-induced apoptosis. These results suggest that Mere15 may have therapeutic potential for the treatment of non-small-cell lung carcinoma.

scholarly journals Induction of G1 Arrest by Methanol Extract of Lycopus lucidus in Human Lung Adenocarcinoma A549 Cells

2013 ◽  
Vol 23 (9) ◽  
pp. 1109-1117
Author(s):  
Hyun-Jin Park ◽  
Soojung Jin ◽  
You Na Oh ◽  
Seung-Geun Yun ◽  
Ji-Young Lee ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Methanol Extract ◽  
Human Lung ◽  
A549 Cells ◽  
G1 Arrest ◽  
Human Lung Adenocarcinoma ◽  
Lung Adenocarcinoma A549 ◽  
Lycopus Lucidus

scholarly journals Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Chun-Chun Cheng ◽  
Joshua Wooten ◽  
Zane A Gibbs ◽  
Kathleen McGlynn ◽  
Prashant Mishra ◽  
...  
Keyword(s):  
Oxidative Phosphorylation ◽  
Lung Adenocarcinoma ◽  
Human Lung ◽  
Human Cancer ◽  
Human Tumor ◽  
Low Oxygen ◽  
Complex Iv ◽  
Human Lung Adenocarcinoma ◽  
Cancer Testis Antigens ◽  
Necessary And Sufficient

Cancer testis antigens (CTAs) are proteins whose expression is normally restricted to the testis but anomalously activated in human cancer. In sperm, a number of CTAs support energy generation, however, whether they contribute to tumor metabolism is not understood. We describe human COX6B2, a component of cytochrome c oxidase (complex IV). COX6B2 is expressed in human lung adenocarcinoma (LUAD) and expression correlates with reduced survival time. COX6B2, but not its somatic isoform COX6B1, enhances activity of complex IV, increasing oxidative phosphorylation (OXPHOS) and NAD+ generation. Consequently, COX6B2-expressing cancer cells display a proliferative advantage, particularly in low oxygen. Conversely, depletion of COX6B2 attenuates OXPHOS and collapses mitochondrial membrane potential leading to cell death or senescence. COX6B2 is both necessary and sufficient for growth of human tumor xenografts in mice. Our findings reveal a previously unappreciated, tumor-specific metabolic pathway hijacked from one of the most ATP-intensive processes in the animal kingdom: sperm motility.

FOX-A1 Contributes to Acquisition of Chemoresistance in Human Lung Adenocarcinoma via Transactivation of SOX5

2019 ◽  
Author(s):  
Dongqin Chen ◽  
Rui Wang ◽  
Chen Yu ◽  
Fei Cao ◽  
Xuefeng Zhang ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Human Lung ◽  
Human Lung Adenocarcinoma

Determination of the collage phenotype of H441 human lung adenocarcinoma cells in culture

1996 ◽  
Vol 15 (3) ◽  
pp. 171
Author(s):  
J. Shooks ◽  
J. Freeman ◽  
S.J. DiMari ◽  
M.A. Haralson
Keyword(s):  
Lung Adenocarcinoma ◽  
Human Lung ◽  
Human Lung Adenocarcinoma ◽  
Cells In Culture ◽  
Adenocarcinoma Cells ◽  
Human Lung Adenocarcinoma Cells ◽  
Lung Adenocarcinoma Cells
Sign in / Sign up

Export Citation Format

Share Document