scholarly journals The Genetics ofPTPN1and Obesity: Insights from Mouse Models of Tissue-Specific PTP1B Deficiency

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Ryan C. Tsou ◽  
Kendra K. Bence
Keyword(s):  
Type 2 Diabetes ◽  
Mouse Models ◽  
Tyrosine Phosphatase ◽  
Negative Regulator ◽  
Human Populations ◽  
Tissue Specific ◽  
Promising Therapeutic Target ◽  
Chromosome 20Q13 ◽  
Diabetes And Obesity

The protein tyrosine phosphatase PTP1B is a negative regulator of both insulin and leptin signaling and is involved in the control of glucose homeostasis and energy expenditure. Due to its prominent role in regulating metabolism, PTP1B is a promising therapeutic target for the treatment of human obesity and type 2 diabetes. The PTP1B protein is encoded by thePTPN1gene on human chromosome 20q13, a region that shows linkage with insulin resistance, type 2 diabetes, and obesity in human populations. In this paper, we summarize the genetics of thePTPN1locus and associations with metabolic disease. In addition, we discuss the tissue-specific functions of PTP1B as gleaned from genetic mouse models.

scholarly journals Tissue‐specific expression of insulin receptor isoforms in obesity/type 2 diabetes mouse models

2021 ◽  
Author(s):  
Noah Moruzzi ◽  
Francesca Lazzeri‐Barcelo ◽  
Ismael Valladolid‐Acebes ◽  
Tilo Moede ◽  
Meike Paschen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Receptor ◽  
Mouse Models ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression ◽  
Receptor Isoforms ◽  
Insulin Receptor Isoforms ◽  
Diabetes Mouse

scholarly journals Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity

2011 ◽  
Vol 4 (2) ◽  
pp. 155-164 ◽  
Author(s):  
R. D. Cox ◽  
C. D. Church
Keyword(s):  
Type 2 Diabetes ◽  
Mouse Models ◽  
Diabetes And Obesity

scholarly journals Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes

2016 ◽  
Vol 66 (2) ◽  
pp. 297-302 ◽  
Author(s):  
Dong-Gi Lee ◽  
Ik Soon Jang ◽  
Kyeong Eun Yang ◽  
So-Jung Yoon ◽  
Sujeong Baek ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Level ◽  
Tyrosine Phosphatase ◽  
Critical Role ◽  
Serum Glucose ◽  
Negative Regulator ◽  
Serum Glucose Level ◽  
Tartary Buckwheat ◽  
Dependent Manner

Abstract This study investigates the anti-diabetic effects of rutin from tartary buckwheat sprout in type 2 diabetes mouse model. The rutin content in tartary buckwheat sprout (TBS) is five times higher than that found in common buckwheat sprout (CBS) as evident from high-performance liquid chromatography analysis. Administration of either rutin or TBS ethanolic extract to diabetes mice decreased the serum glucose level significantly. Rutin down-regulated the expression levels of protein-tyrosine phosphatase 1B; it is negative regulator of insulin pathway, both transcriptionally and translationally in myocyte C2C12 in a dose-dependent manner. In conclusion, rutin can play a critical role in down-regulation of serum glucose level in type 2 diabetes.

Investigating the genetics of type 2 diabetes and obesity using mouse models

2015 ◽  
Vol 56 ◽  
pp. 9
Author(s):  
Roger D. Cox
Keyword(s):  
Type 2 Diabetes ◽  
Mouse Models ◽  
Diabetes And Obesity

A simple and visible colorimetric method through Zr4+–phosphate coordination for the assay of protein tyrosine phosphatase 1B and screening of its inhibitors

The Analyst ◽  
2015 ◽  
Vol 140 (16) ◽  
pp. 5716-5723 ◽  
Author(s):  
Juan Zhang ◽  
Jun Lv ◽  
Xiaonan Wang ◽  
Defeng Li ◽  
Zhaoxia Wang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Colorimetric Method ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Diabetes And Obesity

Inhibitors of protein tyrosine phosphatase 1B (PTP1B) are promising agents for the treatment of type 2 diabetes and obesity, so a colorimetric method has been developed in this work for PTP1B assay and screening of its inhibitors.

1722-P: Colocalization of TOPMed Whole Genome Sequencing Analysis and Tissue-Specific eQTL Signals Detects Target Genes for Type 2 Diabetes Risk

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1722-P
Author(s):  
MINDY D. SZETO ◽  
HEATHER M. HIGHLAND ◽  
ALISA MANNING ◽  
Keyword(s):  
Type 2 Diabetes ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Target Genes ◽  
Diabetes Risk ◽  
Whole Genome ◽  
Sequencing Analysis ◽  
Tissue Specific

1975-P: Effects of Bariatric Surgery on the Incidence of Heart Failure and Atrial Fibrillation in Patients with Type 2 Diabetes and Obesity: A Nationwide, Matched, Observational Cohort Study

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1975-P
Author(s):  
GUDRUN HÖSKULDSDOTTIR ◽  
NAVEED SATTAR ◽  
MERVETE MIFTARAJ ◽  
INGMAR NASLUND ◽  
JOHAN R. OTTOSSON ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Type 2 Diabetes ◽  
Bariatric Surgery ◽  
Cohort Study ◽  
Observational Cohort Study ◽  
Observational Cohort ◽  
Diabetes And Obesity
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