scholarly journals Comparative Studies on Conventional and Ultrasound-Assisted Synthesis of Novel Homoallylic Alcohol Derivatives Linked to Sulfonyl Dibenzene Moiety in Aqueous Media

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Mohamed F. Mady ◽  
Ahmed A. El-Kateb ◽  
Ibrahim F. Zeid ◽  
Kåre B. Jørgensen
Keyword(s):  
Spectral Data ◽  
Comparative Studies ◽  
Carbonyl Compounds ◽  
Aqueous Media ◽  
Reaction Times ◽  
Ultrasound Irradiation ◽  
Reaction Conditions ◽  
Homoallylic Alcohols ◽  
Ultrasound Assisted ◽  
High Yields

Novel homoallylic alcohols incorporating sulfone moieties were synthesized by the treatment of different carbonyl compounds with allylic bromides in aqueous mediaviasonochemical Barbier-type reaction conditions. Sulfonation ofα-bromoketones with sodium benzenesulfinate in presence of CuI/2,6-lutidine rapidly gaveβ-keto-sulfones in good yields. In general, ultrasound irradiation offered the advantages of high yields, short reaction times, and simplicity compared to the conventional methods. The structures of all the compounds were confirmed by analytical and spectral data.

Potassium phthalimide-catalysed one-pot multi-component reaction for efficient synthesis of amino-benzochromenes in aqueous media

2014 ◽  
Vol 68 (8) ◽  
Author(s):  
Hamzeh Kiyani ◽  
Fatemeh Ghorbani
Keyword(s):  
Organic Solvent ◽  
Aqueous Media ◽  
Ethyl Cyanoacetate ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Environmentally Benign ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
One Pot ◽  
High Yields

Abstract2-Amino-4-aryl-4H-benzo[h]chromenes and 3-amino-1-aryl-1H-benzo[f]chromenes were prepared by treating cyano-methylene compounds (malononitrile or ethyl cyanoacetate), substituted aromatic aldehydes, and naphtholic compounds in the presence of potassium phthalimide as a green, mild, efficient, and commercially available organocatalyst in aqueous media. The procedure was readily conducted and affords remarkable advantages such as safety, short reaction times, environmentally benign milder reaction conditions, no organic solvent required, and high yields.

Fe3O4/g-C3N4 Nanocomposites as a Reusable Catalyst for the Synthesis of 5-Arylidenepyrimidine-2,4,6-(1H,3H,5H)-Trione and Pyrano-Pyrimidinone Derivatives in Aqueous Media

2020 ◽  
Vol 20 (9) ◽  
pp. 5433-5444
Author(s):  
Farhad Shirini ◽  
Fatemeh Kamali
Keyword(s):  
Carbon Nitride ◽  
Aqueous Media ◽  
Reaction Times ◽  
Significant Loss ◽  
Graphitic Carbon Nitride ◽  
Reusable Catalyst ◽  
Magnetic Nanocatalyst ◽  
Reaction Conditions ◽  
Simple Preparation ◽  
High Yields

A green magnetic nanocatalyst is developed by immobilization of Fe3O4 on Graphitic carbon nitride (g-C3N4) support for the efficacious synthesis of 5-arylidenepyrimidine-2,4,6-(1H,3H,5H)-trione and pyrano-pyrimidinone derivatives in aqueous media. The most momentous features of the present protocol are the simple preparation of the catalyst, mild reaction conditions, short reaction times and high yields of the products. Moreover, the magnetic nanocatalyst Fe3O4/g-C3N4 can be recycled effectively and reused several times, without a significant loss in reactivity.

One-pot and Three-Component Synthesis of α-Benzylamino Pyrones

2017 ◽  
Vol 41 (1) ◽  
pp. 42-44 ◽  
Author(s):  
Jilla Sanchooli ◽  
Alireza Hassanabadi
Keyword(s):  
Oxalic Acid ◽  
Aqueous Media ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Secondary Amines ◽  
Reaction Conditions ◽  
One Pot ◽  
Aerobic Conditions ◽  
Salient Features ◽  
High Yields

The synthesis of α-benzylamino pyrones is described involving the reaction of 4-hydroxy-6-methyl-2 H-pyran-2-one with aromatic aldehydes and secondary amines in the presence of oxalic acid and in aqueous media. The salient features of this protocol are aerobic conditions, short reaction times, milder reaction conditions without additives and high yields.

A Facile and Convenient Approach for the Synthesis of Novel Sesamol–Oxazine and Quinoline–Oxazine Hybrids

2017 ◽  
Vol 70 (12) ◽  
pp. 1285 ◽  
Author(s):  
Garima Khanna ◽  
Pooja Saluja ◽  
Jitender M. Khurana
Keyword(s):  
Spectral Data ◽  
Aromatic Amines ◽  
Reaction Times ◽  
The Novel ◽  
Reaction Conditions ◽  
One Pot ◽  
X Ray ◽  
Convenient Approach ◽  
High Yields ◽  
Operational Simplicity

A series of functionalized sesamol–oxazine and quinoline–oxazine hybrids have been synthesized via one-pot reaction of sesamol/6-hydroxyquinoline, aromatic amines, and methanal. The structures of all the novel compounds were confirmed by spectral data. The structures of the synthesized hybrids were also confirmed by X-ray crystallographic studies. Mild reaction conditions, operational simplicity, short reaction times, simple workup, and high yields of products are salient features of this methodology.

Efficient synthesis of pyrido[2,3-d]pyrimidine-7-carboxylic acids catalyzed by a TiO2/SiO2 nanocomposite in aqueous media at room temperature

2018 ◽  
Vol 73 (9) ◽  
pp. 641-645 ◽  
Author(s):  
Sepehr Sadegh-Samiei ◽  
Shahrzad Abdolmohammadi
Keyword(s):  
Heterogeneous Catalyst ◽  
Carboxylic Acids ◽  
Room Temperature ◽  
Aqueous Media ◽  
Reaction Times ◽  
Molar Ratio ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
Moderate Reaction ◽  
Recyclable Heterogeneous Catalyst

AbstractA novel and efficient synthesis of eight 5-aryl-1,3-dimethyl-2,4-dioxo-1,2,3,4,5,8-hexahydropyrido[2,3-d]pyrimidine-7-carboxylic acids using a TiO2/SiO2 nanocomposite with a molar ratio of 1:1 as a recyclable heterogeneous catalyst is described. The desired products, five of which are new, are formed in short reaction times (2–3 h) with high to excellent yields (94%–98%) under very moderate reaction conditions (room temperature, aqueous media).

scholarly journals Ultrasound-promoted organocatalytic enamine–azide [3 + 2] cycloaddition reactions for the synthesis of ((arylselanyl)phenyl-1H-1,2,3-triazol-4-yl)ketones

2017 ◽  
Vol 13 ◽  
pp. 694-702 ◽  
Author(s):  
Gabriel P Costa ◽  
Natália Seus ◽  
Juliano A Roehrs ◽  
Raquel G Jacob ◽  
Ricardo F Schumacher ◽  
...  
Keyword(s):  
Reaction Times ◽  
Cycloaddition Reactions ◽  
Reaction Conditions ◽  
Keto Esters ◽  
Efficient Access ◽  
High Yields ◽  
Short Times

The use of sonochemistry is described in the organocatalytic enamine–azide [3 + 2] cycloaddition between 1,3-diketones and aryl azidophenyl selenides. These sonochemically promoted reactions were found to be amenable to a range of 1,3-diketones or aryl azidophenyl selenides, providing an efficient access to new ((arylselanyl)phenyl-1H-1,2,3-triazol-4-yl)ketones in good to excellent yields and short reaction times. In addition, this protocol was extended to β-keto esters, β-keto amides and α-cyano ketones. Selanyltriazoyl carboxylates, carboxamides and carbonitriles were synthesized in high yields at short times of reaction under very mild reaction conditions.

scholarly journals Synthesis of biscoumarin derivatives by the reaction of aldehydes and 4-hydroxycoumarin using ruthenium (III) chloride hydrate as a versatile homogeneous catalyst

2012 ◽  
Vol 77 (4) ◽  
pp. 407-413 ◽  
Author(s):  
Khalil Tabatabaeian ◽  
Hannaneh Heidari ◽  
Alireza Khorshidi ◽  
Manouchehr Mamaghani ◽  
Nosrat Mahmoodi
Keyword(s):  
Michael Reaction ◽  
Aqueous Media ◽  
Environmentally Benign ◽  
Homogeneous Catalyst ◽  
Reaction Conditions ◽  
One Pot ◽  
The One ◽  
High Yields ◽  
Chloride Hydrate ◽  
Short Times

The one-pot domino Knoevenagel-type condensation/Michael reaction of aromatic, heteroaromatic and aliphatic aldehydes with 4-hydroxycoumarin in aqueous media in the presence of ruthenium salt as homogeneous catalyst was investigated. It was found that 5 mol% of RuCl3.nH2O catalyzes biscoumarin synthesis in high yields (70-95%) under optimised, mild, green and environmentally benign reaction conditions in short times (25-35min).

scholarly journals Infrared Irradiation-Assisted Multicomponent Synthesis of 2-Amino-3-cyano-4H-pyran Derivatives

2017 ◽  
Vol 56 (2) ◽  
Author(s):  
Arturo Sánchez ◽  
Fernando Hernández ◽  
Paulo César Cruz ◽  
Yolanda Alcaraz ◽  
Joaquín Tamariz ◽  
...  
Keyword(s):  
Ethyl Acetoacetate ◽  
Present Method ◽  
Reaction Times ◽  
Ammonium Hydroxide ◽  
Infrared Irradiation ◽  
Efficient Synthesis ◽  
Multicomponent Synthesis ◽  
Reaction Conditions ◽  
High Yields ◽  
Pyran Derivative

A simple, versatile, and efficient synthesis of 4<em>H</em>-pyran derivative compounds is achieved via a three-component cyclocondensation of aldehydes, malononitrile, and ethyl acetoacetate, using ammonium hydroxide as the catalyst, promoted by infrared irradiation. The present method offers several advantages, such as high yields, non hazardous reaction conditions as well as short reaction times.

scholarly journals Polystyrene-supported aluminum chloride as an efficient and reusable catalyst for condensation of indole with various carbonyl compounds

2010 ◽  
Vol 75 (4) ◽  
pp. 423-431 ◽  
Author(s):  
Bahman Tamami ◽  
Nasrolahi Shirazi ◽  
Parvanak Borujeni
Keyword(s):  
Aluminum Chloride ◽  
Carbonyl Compounds ◽  
Low Cost ◽  
Reaction Times ◽  
Reusable Catalyst ◽  
Reaction Conditions ◽  
Crosslinked Polystyrene ◽  
Aldehydes And Ketones ◽  
Polymeric Catalyst ◽  
Work Up

Crosslinked polystyrene-supported aluminum chloride (Ps-AlCl3) is a stable, recyclable and environmental friendly heterogeneous catalyst for the condensation of indole with aldehydes and ketones to afford bis-indolylmethanes. In addition, (Ps-AlCl3) shows satisfactory selectivity in the reaction of mixtures of an aldehyde and a ketone with indole. Although AlCl3 is a water sensitive, corrosive and environmentally harmful compound, Ps-AlCl3 is a stable and water-tolerant species. The mild reaction conditions, short reaction times, easy work-up, high to excellent yields, chemoselectivity, reuse of the catalyst for at least ten times without significant change in its catalytic activity, low cost, and easy preparation and handling of the polymeric catalyst are obvious advantages of the present method.

scholarly journals One-pot, three-component synthesis of pyrrolo[2,3-d]pyrimidine derivatives

2018 ◽  
Vol 62 (1) ◽  
Author(s):  
Jabbar Khalafy ◽  
Ramin Javahershenas
Keyword(s):  
Simple Procedure ◽  
Reaction Times ◽  
Pyrimidine Derivatives ◽  
Reaction Conditions ◽  
One Pot ◽  
General Applicability ◽  
Green Approach ◽  
Three Component Reaction ◽  
High Yields ◽  
Work Up

<p>A green approach for the synthesis of polyfunctionalized pyrrolo[2,3-<em>d</em>]pyrimidine derivatives was successfully achieved by a one-pot, three-component reaction of arylglyoxals, 6-amino-1,3-dimethyluracil and barbituric acid derivatives in the presence of tetra-<em>n</em>-butylammonium bromide (TBAB) (5 mol%) as the catalyst in ethanol at 50 °C. This protocol has many advantages such as high yields (73-95%), green and simple procedure, short reaction times, easy work-up, mild reaction conditions and general applicability.</p>

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