scholarly journals Full-Length Genomic Sequence of Subgenotype IIIA Hepatitis A Virus Isolate in Republic of Korea

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Ah-Ra Lee ◽  
Sung-Geun Lee ◽  
Lae-Hyung Kang ◽  
Weon-Hwa Jheong ◽  
Soon-Young Paik
Keyword(s):  
Amino Acid ◽  
Hepatitis A ◽  
Genomic Sequence ◽  
Hepatitis A Virus ◽  
Full Length ◽  
Republic Of Korea ◽  
Nucleotide Sequencing ◽  
Number Of Patients ◽  
The Republic ◽  
Alignment Analysis

Hepatitis A virus is known to cause acute hepatitis and has significant implications for public health throughout the world. In the Republic of Korea, the number of patients with hepatitis A virus infection has been increasing rapidly since 2006. In this study, the Kor-HAV-F strain was identified as subgenotype IIIA by RT-PCR, and its identity was confirmed by nucleotide sequencing and alignment analysis. Moreover, detailed phylogenetic analysis indicated that the Kor-HAV-F strain clustered into subgenotype IIIA, including strains isolated in Japan, Norway, and India. The entire amino acid sequence of the VP1 and 2A regions was compared with that of the reference strains isolated in various countries. We found 2 amino acid changes (T168A and L96P, resp.) in the VP1 and 2A regions, which had not been found in any other hepatitis A virus strain. To our knowledge, this study is the first to report the full-length sequence of a hepatitis A virus isolated in the Republic of Korea.

First full-length genomic sequence of a hepatitis A virus isolated in Argentina shows recombination between subgenotypes IA and IB

2011 ◽  
Vol 155 (1) ◽  
pp. 316-324 ◽  
Author(s):  
Sebastian Aguirre ◽  
Viviana Malirat ◽  
Eduardo Scodeller ◽  
Nora Mattion
Keyword(s):  
Hepatitis A ◽  
Genomic Sequence ◽  
Hepatitis A Virus ◽  
Full Length

A waterborne outbreak involving hepatitis A virus genotype IA at a residential facility in the Republic of Korea in 2015

2017 ◽  
Vol 94 ◽  
pp. 63-66 ◽  
Author(s):  
Eunkyung Shin ◽  
Jin Seok Kim ◽  
Kyung-Hwan Oh ◽  
Sung Suck Oh ◽  
MunJu Kwon ◽  
...  
Keyword(s):  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Republic Of Korea ◽  
Residential Facility ◽  
Virus Genotype ◽  
Waterborne Outbreak ◽  
The Republic

scholarly journals Fulminant acute hepatitis in pediatrics in Latin America and the Caribbean

2019 ◽  
Vol 65 (6) ◽  
pp. 914-921 ◽  
Author(s):  
José Colleti Junior ◽  
Felipe Rezende Caino ◽  
Rafael Teixeira ◽  
Werther Brunow de Carvalho
Keyword(s):  
Latin America ◽  
Acute Hepatitis ◽  
Latin American ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Public Awareness ◽  
Number Of Patients ◽  
Basic Sanitation ◽  
The Caribbean ◽  
Support Methods

SUMMARY OBJECTIVE: The objective of this review was to investigate the epidemiology of Fulminant Acute Hepatitis in Latin America and the Caribbean and identify possible measures aimed at a better understanding and improvement of patient support. METHODS: We used 3 different researchers to investigate the topic of Fulminant Acute Hepatitis in pediatrics in papers published by Latin American and Caribbean authors in the PubMed and SciELO databases from 2000 to 2016. RESULTS: We found 2,879 articles in the databases searched. After selecting and excluding articles according to the study protocol, 68 remaining studies were obtained for analysis. A total of 1,265 cases of acute fulminant hepatitis were detected, with a predominance of females (42.9%), followed by males (39.4%), with no description of sex in 17.7% of the cases. The main cause was viral hepatitis, representing 45.1% of the cases. The hepatitis A virus was responsible for 34.7% of the total cases and 76.9% of the infectious causes. Of the total number of patients, 26.9% were described as idiopathic, and 11.5% had no cause. CONCLUSION: The preventable causes of Fulminant Acute Hepatitis include hepatitis viruses - primarily the hepatitis A virus - and poisoning. Active vaccination, basic sanitation, and public awareness can reduce the number of patients and, consequently, the costs of liver transplantation due to these causes.

Analysis of full-length hepatitis A virus genome in sera from patients with fulminant and self-limited acute type A hepatitis

2001 ◽  
Vol 35 (1) ◽  
pp. 112-119 ◽  
Author(s):  
Keiichi Fujiwara ◽  
Osamu Yokosuka ◽  
Kenichi Fukai ◽  
Fumio Imazeki ◽  
Hiromitsu Saisho ◽  
...  
Keyword(s):  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Type A ◽  
Virus Genome ◽  
Full Length ◽  
Acute Type

scholarly journals Genomic Sequence of the WHO International Standard for Hepatitis A Virus RNA

2018 ◽  
Vol 6 (19) ◽  
Author(s):  
Adrian Jenkins ◽  
Rehan Minhas ◽  
Clare Morris ◽  
Neil Berry
Keyword(s):  
Hepatitis A ◽  
Genomic Sequence ◽  
Hepatitis A Virus ◽  
World Health ◽  
Design Development ◽  
Noncoding Regions ◽  
International Standard ◽  
Virus Rna ◽  
Health Organization ◽  
Nucleic Acid Assays

ABSTRACT The World Health Organization (WHO) international standard for hepatitis A virus (HAV) RNA nucleic acid assays was characterized by complete genome sequencing. The entire coding sequence and noncoding regions were assigned HAV genotype IB. This information will aid the design, development, and evaluation of HAV RNA amplification assays.

scholarly journals Molecular Evolution of Hepatitis A Virus: a New Classification Based on the Complete VP1 Protein

2002 ◽  
Vol 76 (18) ◽  
pp. 9516-9525 ◽  
Author(s):  
Mauro Costa-Mattioli ◽  
Juan Cristina ◽  
Héctor Romero ◽  
Raoul Perez-Bercof ◽  
Didier Casane ◽  
...  
Keyword(s):  
Amino Acid ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Rna Virus ◽  
Amino Acid Level ◽  
Amino Acid Sequences ◽  
Vp1 Gene ◽  
Antigenic Variant ◽  
Genetic Lineages ◽  
Novel Variant

ABSTRACT Hepatitis A virus (HAV) is a positive-stranded RNA virus in the genus Hepatovirus in the family Picornaviridae. So far, analysis of the genetic variability of HAV has been based on two discrete regions, the VP1/2A junction and the VP1 N terminus. In this report, we determined the nucleotide and deduced amino acid sequences of the complete VP1 gene of 81 strains from France, Kosovo, Mexico, Argentina, Chile, and Uruguay and compared them with the sequences of seven strains of HAV isolated elsewhere. Overall strain variation in the complete VP1 gene was found to be as high as 23.7% at the nucleotide level and 10.5% at the amino acid level. Different phylogenetic methods revealed that HAV sequences form five distinct and well-supported genetic lineages. Within these lineages, HAV sequences clustered by geographical origin only for European strains. The analysis of the complete VP1 gene allowed insight into the mode of evolution of HAV and revealed the emergence of a novel variant with a 15-amino-acid deletion located on the VP1 region where neutralization escape mutations were found. This could be the first antigenic variant of HAV so far identified.

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