A Study on Course of Infection and Haematological Changes in falciparum-Infected in Comparison with Artemisinin(s)-Treated Mice

To find out the efficacy and effect of artemisinin derivatives on haematological indices, C57BL/6J mice were challenged with Plasmodium falciparum and treated with therapeutic doses of AS, AE, and AL. Course of infection was studied in the infected and treated groups up to day 42. Peak level of parasitaemia (38%) was observed on day 11 in infected group. Haematological indices indicated significant (P<0.05) decrease in RBC, WBC, haemoglobin, packed cell volume, mean cell volume, and platelet counts in infected mice. But all the parameters were restored to normal values, and significant (P<0.05) changes were observed in all drug-treated groups. Insignificant changes were observed for MCHC (P>0.05) in all drug-treated groups. Percent of peak parasitaemia was much reduced in AL- (3.2% on day 3) treated group in comparison with AE- (2.4% on day 4) and AS- (4% on day 2) treated groups. Parasites were completely cleared on day 6 in AS group, day 5 in AE group, and day 4 in AL group. Hence, our results strongly support that combination therapy has high efficacy rates than monotherapy. No adverse effects were observed on haematological parameters when animals were treated with therapeutic dosages.

Download Full-text

Can Haematological Indices Predict Positive Findings at Endoscopy in Anaemic Patients?

Annals of The Royal College of Surgeons of England ◽

10.1308/003588407x168415 ◽

2007 ◽

Vol 89 (3) ◽

pp. 221-225

Author(s):

AMP Schizas ◽

R Reid ◽

ML George

Keyword(s):

Cell Volume ◽

Blood Cells ◽

Blood Count ◽

Haematological Parameters ◽

Full Blood Count ◽

Mean Cell Volume ◽

Upper Gi ◽

Significant Difference ◽

Significant Pathology ◽

Haematological Indices

INTRODUCTION Patients with anaemia are commonly referred for bidirectional endoscopy. The aim of this study was to determine if any haematological parameters could predict positive findings at endoscopy. PATIENTS AND METHODS A total of 209 patients had bidirectional endoscopies performed for anaemia between September 2002 and March 2004. The endoscopy reports, histology and full blood count results (haemoglobin [Hb], red blood cells [RBCs], packed cell volume [PCV], mean cell volume [MCV] and mean cell haemoglobin [MCH]) were then reviewed. Statistical analysis was performed using non-parametric tests. RESULTS Overall, 197 patients had successful bidirectional endoscopies with 12 requiring completion barium enema. In 48 (23%) of these patients, a cause of anaemia was found with 15 (7.2%) carcinomas detected (2 upper GI and 13 lower GI). There was a significant difference in haemoglobin (9.2 g/dl versus 10.1 g/dl; P = 0.0044), RBCs (3.56 × 1012/l versus 3.83 × 1012/l; P = 0.0325) and PCV (0.279 l/l versus 0.31 l/l; P = 0.0112) between patients with positive findings at endoscopy and those with a normal investigation. Cancer patients had significantly lower haemoglobin (8.65 g/dl versus 10.1 g/dl; P = 0.0103), RBCs (3.45 × 1012/l versus 3.83 × 1012/l; P = 0.0179) and PCV (0.27 l/l versus 0.31 l/l; P = 0.0298) compared with patients with normal endoscopies. There was no significant difference in the other haematological parameters between those found to have positive findings and those that had normal endoscopies. CONCLUSIONS Based on this study, the yield of bidirectional endoscopy is low, with haemoglobin and PCV being the most useful haematological indices of significant pathology. Ferritin and MCV did not predict the likelihood of finding a gastrointestinal cause for the anaemia.

Download Full-text

Mathematical Correction of the In Vitro Storage–Related Increase in Erythrocyte Mean Cell Volume of an Automated Hematology Analyzer—the Cell-Dyn 4000

Laboratory Hematology ◽

10.1532/lh96.04017 ◽

2004 ◽

Vol 10 (2) ◽

pp. 68-73 ◽

Cited By ~ 7

Author(s):

Albert Huisman ◽

Ron Stokwielder ◽

Wouter W. van Solinge

Keyword(s):

Cell Volume ◽

Mean Cell Volume ◽

In Vitro Storage ◽

Hematology Analyzer ◽

Automated Hematology Analyzer ◽

Related Increase

Download Full-text

MEAN CELL VOLUME AND GAMMA-GLUTAMYL-TRANSPEPTIDASE AS MARKERS OF DRINKING IN WORKING MEN

The Lancet ◽

10.1016/s0140-6736(81)92413-2 ◽

1981 ◽

Vol 317 (8232) ◽

pp. 1249-1251 ◽

Cited By ~ 172

Author(s):

Jonathan Chick ◽

Norman Kreitman ◽

Martin Plant

Keyword(s):

Cell Volume ◽

Gamma Glutamyl Transpeptidase ◽

Mean Cell Volume ◽

Gamma Glutamyl ◽

Glutamyl Transpeptidase

Download Full-text

Alteration of the erythrocyte ultrastructure and blood viscosity by morphine

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y78-036 ◽

1978 ◽

Vol 56 (2) ◽

pp. 245-251 ◽

Cited By ~ 3

Author(s):

E. B. Vadas ◽

E. A. Hosein

Keyword(s):

Cell Volume ◽

Blood Viscosity ◽

Whole Blood ◽

Plasma Viscosity ◽

Cell Geometry ◽

Flow Properties ◽

Mean Cell Volume ◽

Morphine Administration ◽

The Mean ◽

Volume Cell

The effects of acute morphine administration on intact erythrocytes and on their flow properties were studied by measuring the mean cell volume, cell geometry, and whole blood and plasma viscosities. Morphine caused a small (2–7%) increase in mean cell volume. Changes in cell geometry were found to be time dependent and most pronounced in concave portions of the red cells. Whole blood viscosity was found to decrease upon morphine treatment; this may be due in part to a concurrent decrease in plasma viscosity.

Download Full-text

Alpha thalassemia and the hematology of homozygous sickle cell disease in childhood

Blood ◽

10.1182/blood.v67.2.411.bloodjournal672411 ◽

1986 ◽

Vol 67 (2) ◽

pp. 411-414 ◽

Cited By ~ 1

Author(s):

MC Stevens ◽

GH Maude ◽

M Beckford ◽

Y Grandison ◽

K Mason ◽

...

Keyword(s):

Cell Volume ◽

Sickle Cell ◽

Globin Gene ◽

Fetal Hemoglobin ◽

Mean Cell Volume ◽

Gene Group ◽

Cell Counts ◽

Total Hemoglobin ◽

Alpha Thalassemia ◽

Gene Status

alpha Thalassemia modifies the hematologic expression of homozygous sickle cell (SS) disease, resulting in increased total hemoglobin and HbA2 and decreased HbF, mean cell volume, reticulocytes, irreversibly sickled cells, and bilirubin levels. The age at which these changes develop in children with SS disease is unknown. Ascertainment of globin gene status in a large representative sample of children with SS disease has afforded an opportunity to study the hematologic indices in nine children homozygous for alpha thalassemia 2 (two-gene group), 90 children heterozygous for alpha thalassemia 2 (three-gene group), and 167 children with a normal alpha globin gene complement (four-gene group). The two-gene group had significantly lower mean cell volumes from birth, higher red cell counts from one month, lower reticulocytes from three months, and higher HbA2 levels from one year, as compared with the four-gene group. Children with three genes had intermediate indices but resembled more closely the four-gene group. Differences in total hemoglobin or in fetal hemoglobin between the groups were not apparent by eight years of age. The most characteristic differences of the two-gene group were the raised proportional HbA2 level and low mean cell volume, the latter having some predictive value for alpha thalassemia status at birth.

Download Full-text

The prevalence of leukocyte abnormalities among Sudanese patients with sickle cell disease

World Journal of Advanced Research and Reviews ◽

10.30574/wjarr.2021.9.1.0026 ◽

2021 ◽

Vol 9 (1) ◽

pp. 262-267

Author(s):

Tarig Osman Khalafallah Ahmed ◽

Ekhlas Alrasheid Abu Elfadul ◽

Ahmed A. Agab Eldour ◽

Omer Ibrahim Abdallah Mohammed

Keyword(s):

Sickle Cell Disease ◽

Cell Volume ◽

Sickle Cell ◽

Blood Cells ◽

White Blood Cells ◽

Blood Film ◽

Cell Disease ◽

Mean Cell Volume ◽

Blood Disorder ◽

Age Range

Sickle cell disease (SCD) is an inherited blood disorder that affects red blood cells. The study was conducted in Elobied town during the period May 2011 to September 2011. The aim of this study is to detect the abnormalities of leucocytes among sickle cell anemic patients. 40 sickle cell anemic patients; age range between 8 months to 23 years. Blood sample was taken for all patients and the laboratory investigation were performed using automated estimation for: hemoglobin (Hb), Packed cell volume (PCV), red cell count (RBCs), mean cell volume (MCV), mean cell hemoglobin (MCH), mean cell concentration (MCHC), and total white blood cells, comment on blood film using manual methods. The conclusion of this study there is increase in total white blood cells with shift to left in neutrophil precursor in sickle cell patients with complications ,the most immature cells are band form, myelocytes and metamyelocytes, and there also lymphocytosis and neutrophilia which has been increases in response to infections.

Download Full-text

Quantitative Characterization of Chick Thymus and Bursa Development

Blood ◽

10.1182/blood.v27.3.371.371 ◽

1966 ◽

Vol 27 (3) ◽

pp. 371-379 ◽

Cited By ~ 19

Author(s):

JACK SHERMAN ◽

ROBERT AUERBACH

Keyword(s):

Cell Volume ◽

Critical Size ◽

Lymphoid Cells ◽

Bursa Of Fabricius ◽

Size Analysis ◽

Quantitative Characterization ◽

Cell Size Distribution ◽

Mean Cell Volume ◽

Morphogenetic Change

Abstract 1. Critical size analysis of the lymphoid cell populations of the developing chick bursa of Fabricius and thymus indicates that characteristic shifts in cell size distribution, modal cell volume and mean cell volume occur during morphogenesis of these organs. 2. Comparison of bursa and thymus shows that while there are clear differences between the lymphoid cells of these two structures, the pattern of morphogenetic change is similar. 3. 19-nortestosterone injected in low doses can partially inhibit bursal development without affecting thymus morphogenesis. Depending on the age of the embryo at time of injection, however, doses sufficient to produce complete bursal inhibition may also retard thymic morphogenesis. 4. The size differences found between bursal and thymic lymphocytes in the chicken parallel the size differences found between lymph node and thymic lymphocytes in the mouse.

Download Full-text

Hidden Alcohol Abuse Among Women

The British Journal of Psychiatry ◽

10.1192/bjp.164.4.544 ◽

1994 ◽

Vol 164 (4) ◽

pp. 544-546 ◽

Cited By ~ 14

Author(s):

Kaija Seppä ◽

Kari Löf ◽

David Sinclair ◽

Pekka Sillanaukee

Keyword(s):

Early Intervention ◽

Alcohol Abuse ◽

Cell Volume ◽

Health Centre ◽

Initial Study ◽

Alcohol Problems ◽

Mean Cell Volume ◽

Alcohol Marker ◽

Carbohydrate Deficient Transferrin ◽

Clinical Records

Seven years ago the authors examined 64 consecutive female out-patients with macrocytosis (erythrocyte mean cell volume ⩾ 100 fl). The cause remained undetermined in 23 (35.9%). Their patient histories were evaluated in 1992, and the new highly specific alcohol marker, serum carbohydrate-deficient transferrin, from the frozen sera taken during the initial study was examined. It was elevated in 6 of the 23 women. Furthermore, four of these six had visited the health centre after 1985 and they all had clinical records indicative of alcohol problems. Because early intervention has proved to be effective, information about the risks of alcohol abuse (intervention) should be given to women with suspect alcohol-induced symptoms or signs.

Download Full-text