scholarly journals Can Haematological Indices Predict Positive Findings at Endoscopy in Anaemic Patients?

2007 ◽  
Vol 89 (3) ◽  
pp. 221-225
Author(s):  
AMP Schizas ◽  
R Reid ◽  
ML George
Keyword(s):  
Cell Volume ◽  
Blood Cells ◽  
Blood Count ◽  
Haematological Parameters ◽  
Full Blood Count ◽  
Mean Cell Volume ◽  
Upper Gi ◽  
Significant Difference ◽  
Significant Pathology ◽  
Haematological Indices

INTRODUCTION Patients with anaemia are commonly referred for bidirectional endoscopy. The aim of this study was to determine if any haematological parameters could predict positive findings at endoscopy. PATIENTS AND METHODS A total of 209 patients had bidirectional endoscopies performed for anaemia between September 2002 and March 2004. The endoscopy reports, histology and full blood count results (haemoglobin [Hb], red blood cells [RBCs], packed cell volume [PCV], mean cell volume [MCV] and mean cell haemoglobin [MCH]) were then reviewed. Statistical analysis was performed using non-parametric tests. RESULTS Overall, 197 patients had successful bidirectional endoscopies with 12 requiring completion barium enema. In 48 (23%) of these patients, a cause of anaemia was found with 15 (7.2%) carcinomas detected (2 upper GI and 13 lower GI). There was a significant difference in haemoglobin (9.2 g/dl versus 10.1 g/dl; P = 0.0044), RBCs (3.56 × 1012/l versus 3.83 × 1012/l; P = 0.0325) and PCV (0.279 l/l versus 0.31 l/l; P = 0.0112) between patients with positive findings at endoscopy and those with a normal investigation. Cancer patients had significantly lower haemoglobin (8.65 g/dl versus 10.1 g/dl; P = 0.0103), RBCs (3.45 × 1012/l versus 3.83 × 1012/l; P = 0.0179) and PCV (0.27 l/l versus 0.31 l/l; P = 0.0298) compared with patients with normal endoscopies. There was no significant difference in the other haematological parameters between those found to have positive findings and those that had normal endoscopies. CONCLUSIONS Based on this study, the yield of bidirectional endoscopy is low, with haemoglobin and PCV being the most useful haematological indices of significant pathology. Ferritin and MCV did not predict the likelihood of finding a gastrointestinal cause for the anaemia.

scholarly journals The use of peripheral blood cells as an assessment of inflammation in prostate cancer in patients attending in surgery department at ESUT teaching hospital, Parklane, Enugu, Nigeria

2020 ◽  
Vol 9 (1) ◽  
pp. 1
Author(s):  
Clara N. Soronnadi ◽  
Nancy C. Ibeh ◽  
Francis O. Ugwene ◽  
Grace I. Amilo ◽  
Anthony J. Ede
Keyword(s):  
Prostate Cancer ◽  
Blood Cells ◽  
Blood Count ◽  
Age Groups ◽  
Post Treatment ◽  
Full Blood Count ◽  
Treatment Results ◽  
Lymphocyte Ratio ◽  
Significant Difference ◽  
Pre Treatment

Background: Full blood count (FBC) is a prerequisite investigation requested from all prostate cancer (PCa) patients pre and post treatment, poor parameter influences the outcome of cancers.Methods: Total subjects consisted of 84 male subjects between the ages 41 to >80 years. Longitudinal study was conducted. Controls and test samples were collected at diagnosis and at different stages of the treatment. Demographic information was obtained using a questionnaire. The data was analyzed using IBM statistical package for social sciences (SPSS) PC, version 20.0; SPSS Inc., Chicago, III., USA; the receiver operating characteristic curve (ROC) curve was obtained via neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR) and platelet-to-lymphocyte ratio (PLR) ratios cut-off determinations. Cox proportional-hazards regression analyses the prognostic factors (duration, ratios) and overall survival (diagnosis to death or last follow-up). A paired sample t-test compared test of significance in pre/post treatment results. The analysis of variance (ANOVA) and Tukey HSD post-hoc, test susceptibility within age groups was done.Results: Increased NLR and LMR were significantly associated with increased hazard ratio (HR) and OS at p<0.05 while PLR, no significant difference at P>0.05 in PCa. In complete blood count (CBC) and erythrocytic sedimentation rate (ESR), control and treatment period, all red blood cell (RBC) parameters showed a significant decrease at p<0.05 in treatment results compared to the pre-treatment results while total platelet (TPLT), total white blood cells (TWBC), NC, LC, ESR showed significant increase at p<0.05 in treatment results compared to pre-treatment results. Age group 41-50 years showed more susceptibility than other age groups with significant decrease at p<0.05 in NC, LC and increased MC.Conclusions: This study supports CBC and ESR biomarkers as a prognostic tool in early detection, treatment and monitoring of disease progression in these subjects.

scholarly journals Effects of Age, Breed and Sex on Haematological Parameters of Growing Omani Goat Breeds

2016 ◽  
Vol 21 (2) ◽  
pp. 82
Author(s):  
Nur El Huda I. Osman ◽  
Rashid M. Al-Busaidi ◽  
Eugene H. Johnson
Keyword(s):  
Cell Volume ◽  
Blood Cells ◽  
White Blood Cells ◽  
Haemoglobin Concentration ◽  
Blood Parameters ◽  
Haematological Parameters ◽  
Mean Cell Volume ◽  
Sultan Qaboos University ◽  
Breed Differences ◽  
Agricultural Experiment

Sixty seven healthy growing goat kids of three Omani breeds, born and raised in Sultan Qaboos University Agricultural Experiment Station, were used to study the effects of age, breed and sex on haematological parameters. Blood samples were collected at several times from the first to 25 weeks to study the following parameters: Red Blood Cells (RBCs), White Blood Cells (WBCs), Packed Cell Volume (PCV), Haemoglobin (Hb), Mean Cell Volume (MCV), Mean Cell Haemoglobin Concentration (MCHC) and Mean Cell Haemoglobin (MCH). At birth, MCV and MCH levels were significantly higher in Batina (BAT) kids than both Jabal Akhdar (JA) and Dhofari (DOF), but there were no breed differences in the rest of the haematological values. There were significant breed differences in RBC, MCH, WBC, MCV at different ages, with Hb and PCV being highly significant at all ages. All blood parameters changed with time but showed different patterns in all breeds. There was no effect of sex on RBC, MCHC, PCV, Hb or WBC, but female kids had significantly higher MCH and MCV values at week 12. This study indicates that haematology parameters in Omani goat kids could be affected by age, breed and sex.  

scholarly journals Performance response, carcass evaluation and economic benefit or rabbits fed sorghum offal-based diets

2014 ◽  
Vol 14 (61) ◽  
pp. 8585-8601
Author(s):  
MH Ogunsipe ◽  
◽  
JO Agbede ◽  
OA Adedeji ◽  
◽  
...  
Keyword(s):  
Cell Volume ◽  
Blood Cells ◽  
White Blood Cells ◽  
Feed Conversion ◽  
Crude Fibre ◽  
Feed Composition ◽  
Mean Cell Volume ◽  
Significant Difference ◽  
Haematological Profile ◽  
Maize Grain

An eight-week feeding trial was conducted to investigate the performance, carcass quality, haematological indices and economics of production of rabbits fed dietary sorghum offal substitute for maize grain. A total of forty (40) weaned rabbits with a mean weight range of 820-850 g were randomly distributed to five treatment diets where 0, 25, 50, 75 and 100% of sorghum offal replaced maize grain in the gross feed composition to give Diets 1 (control), 2, 3, 4 and 5, respectively. Each treatment diet was replicated eight times with a rabbit taken as a replicate. The determined chemical composition of the experimental diets ranged between 17.12% and17.43% for crude protein (CP), 11.48 and 14.89% for crude fibre (CF), 5.04 and 7.74% for ether extract or fat (EE), 54.17 and 56.41% for nitrogen free extract (NFE) and 3069.35kcal/kg to 3241.17ME(kcal/kg). While the results on performance showed no significant difference (P>0.05) in feed intake by rabbits fed the five test diets, there appeared to be significant decrease (P<0.05) in the weight gain and feed conversion ratio of rabbits fed 50 to 100% sorghum offal-based diets. Carcass cuts that showed significant reduction (P<0.05) at 75 and 100% sorghum offal-based diets are the carcass weight, thigh, loin, shoulder and ribs weights. Organs such as liver, kidney, heart and pancreas weights measured were significantly higher (P<0.05) at 75 and 100% sorghum offal-based diets. Haematological profile such as Packed Cell Volume (PCV), Red Blood Cells (RBC), White Blood Cells (WBC), Mean Cell Volume (MCV) and White Blood Counts such as neutrophil and basophil showed significant difference (P<0.05) at 75% and 100% sorghum offal-based diets. The serum metabolites such as albumin, globulin, cholesterol and urea showed a similar trend of significant difference (P<0.05) at 75% and 100% sorghum offal inclusion compared to other test diets. For economic production, the study revealed an optimum inclusion of sorghum offal at 50% (24.60 g/kg in feed composition) for maize grain in rabbit concentrate feed is possible. Above this level, a loss of N23.17 and N13.16 was recorded as evidenced by the cost differential and benefit cost analysis.

scholarly journals Effects of Justicia carnea Leave on Hematological Parameters in Albino Mice Carried Out in Mbingo Annex Hospital Laboratory in Bamenda, North West Region, Cameroon

2020 ◽  
pp. 43-50
Author(s):  
Asakizi Augustine Nji ◽  
Nchang Chrysanthus ◽  
Ngombe David Monyongo
Keyword(s):  
Cell Volume ◽  
Blood Cells ◽  
Hematological Parameters ◽  
Positive Control ◽  
Negative Control ◽  
Mean Cell Volume ◽  
Significant Difference ◽  
Albino Mice ◽  
Mean Cell Hemoglobin ◽  
Test Control

This study is design to ascertain the hematological status in albino mice treated with Justicia carnea leave, which could aid in the treatment of anemia. The hematological parameters investigated include Mean Cell Volume (MCV), Mean Cell Hemoglobin (MCH), Mean Cell Hemoglobin Concentration (MCHC), Platelets (PLTS), Hemoglobin (Hb), Red Blood Cells (RBCs), Pack Cell Volume (PCV) and White Blood Cells (WBCs). Nine (9) male albino mice of approximately the same weight 300 g were grouped into 3 groups that’s Negative Control (NC) Positive Control (PC) and Test Control (TC), each made up of 3 mice. Negative control mice were given normal feed moisten with water,  Positive control received diluted iron folate with normal feed, finally Test control mice were  administered powdered leaves of Justicia carnea with normal feed for 7 days, after which blood samples were collected using EDTA tubes by exsanguination and run for hematological parameters using auto-hematological analyzer. The results of various groups were found to be; as there was a significant increase in RBCs, Hb, & PCV (P=0.05), between the groups. No significant change was observed on the MCV, MCH, and MCHC. Lymphocytosis was observed in all groups with mark difference in granulocytosis. TC had granulocytosis, NC showed normal granulocyte scores and the PC show granulocytopenia with a statistical difference of P=0.0017. A significant difference was seen in platelets between the groups P=0.02. This study shows that J. carnea leaves possess anti-anemic potential, lending credence to the use of these plant leaves in folk medicine for the management of hemolytic anemia would be helpful. Further research on the various phytochemicals of the plant should be done and also its toxicological aspects.

scholarly journals The prevalence of leukocyte abnormalities among Sudanese patients with sickle cell disease

2021 ◽  
Vol 9 (1) ◽  
pp. 262-267
Author(s):  
Tarig Osman Khalafallah Ahmed ◽  
Ekhlas Alrasheid Abu Elfadul ◽  
Ahmed A. Agab Eldour ◽  
Omer Ibrahim Abdallah Mohammed
Keyword(s):  
Sickle Cell Disease ◽  
Cell Volume ◽  
Sickle Cell ◽  
Blood Cells ◽  
White Blood Cells ◽  
Blood Film ◽  
Cell Disease ◽  
Mean Cell Volume ◽  
Blood Disorder ◽  
Age Range

Sickle cell disease (SCD) is an inherited blood disorder that affects red blood cells. The study was conducted in Elobied town during the period May 2011 to September 2011. The aim of this study is to detect the abnormalities of leucocytes among sickle cell anemic patients. 40 sickle cell anemic patients; age range between 8 months to 23 years. Blood sample was taken for all patients and the laboratory investigation were performed using automated estimation for: hemoglobin (Hb), Packed cell volume (PCV), red cell count (RBCs), mean cell volume (MCV), mean cell hemoglobin (MCH), mean cell concentration (MCHC), and total white blood cells, comment on blood film using manual methods. The conclusion of this study there is increase in total white blood cells with shift to left in neutrophil precursor in sickle cell patients with complications ,the most immature cells are band form, myelocytes and metamyelocytes, and there also lymphocytosis and neutrophilia which has been increases in response to infections.

Effects of Thyroid Function on Blood Cell Counts and Red Cell Indices – A Retrospective Study at a Tertiary Care Centre in Mandya, Karnataka

2021 ◽  
Vol 8 (27) ◽  
pp. 2434-2438
Author(s):  
Siddegowda M.S ◽  
Chaithra R ◽  
Shivakumar S ◽  
Maithri C.M
Keyword(s):  
Blood Cell ◽  
Blood Cells ◽  
Thyroid Dysfunction ◽  
Haematological Parameters ◽  
Red Cell ◽  
Corpuscular Haemoglobin ◽  
Significant Difference ◽  
Red Cell Indices ◽  
Mean Corpuscular Haemoglobin ◽  
Rbc Count

BACKGROUND Thyroid hormones play an important role in the regulation and production of red blood cells. Thyroid dysfunction induces different effects on blood cells such as anaemia, erythrocytosis, leucopenia, thrombocytopenia and alteration in red cell indices. In this study, we wanted to compare the changes in haematological parameters of thyroid dysfunction patients with those of euthyroid group. METHODS This was a retrospective study done on 310 individuals by collecting data from the medical records. Later the patients were categorized into hypothyroid (33) thyroid stimulating hormone (TSH > 5.5 μIU/mL), hyperthyroid (19) (TSH < 0.3 μIU/mL) and euthyroid (258) (TSH = 0.3 - 5.5 μIU/ml) groups. The haematological parameters of all these patients were obtained by 5-part automated cell count analyser. Finally, the obtained data was analyzed by statistical package for social sciences (SPSS) software. RESULTS The data obtained from the analysis revealed statistically significant (P < 0.05) difference between hypothyroidism, hyperthyroidism and euthyroidism in mean red blood cell (RBC) count, mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), red cell distribution width (RDW), white blood cell (WBC) count and platelet count but the difference was not significant for mean haemoglobin, mean corpuscular haemoglobin concentration (MCHC) (P > 0.05). The mean haemoglobin was lower in hypothyroid patients when compared to euthyroid and hyperthyroid patients. The RBC count (P < 0.007), MCH (P = 0.002) and RDW (P < 0.001) showed statistically significant difference between hypothyroidism and euthyroidism, MCV (P = 0.005) showed statistically significant difference between hyperthyroid and euthyroid groups. CONCLUSIONS In case of patients with abnormal haematological parameters, thyroid hormones evaluation is necessary. KEYWORDS Hypothyroidism, Hyperthyroidism, Haemoglobin, Blood Count, Red Cell Indices

scholarly journals Haematological Alterations among Cement Loaders in Port Harcourt, Nigeria

2020 ◽  
pp. 1-8
Author(s):  
Ransom Baribefii Jacob ◽  
Chinyelu Obianuju Mba ◽  
Patience Deborah Iduh
Keyword(s):  
Blood Cell ◽  
Cell Volume ◽  
Study Design ◽  
Haemoglobin Concentration ◽  
Healthy Male Subject ◽  
Cement Dust ◽  
Cross Sectional ◽  
Mean Cell Volume ◽  
Port Harcourt ◽  
Significant Difference

Background: Exposure to cement dust without necessary precautions to prevent its inhalation is found to cause respiratory, dermatological, ocular as well as hematological problems and this is a matter of great concern to the health of cement loaders. Aim of Study: This study was aimed at determining haematological alterations among cement loaders in Port Harcourt, Nigeria. Study Design: Cross sectional study design. Methodology: A total of 100 apparently healthy male subject consisting of 50 cement loaders and 50 non cement loaders aged between the ages of 20- 45years old were recruited for the study. Four millilitres (4 mls) of blood was collected aseptically from the antecubital vein of each participant using standard venepuncture technique into ethylene diamine tetra acetic acid (EDTA) anticoagulated vacutainer bottles with proper mixing to avoid blood clotting and then analysed using Sysmex haematology autoanalyser. Graphpad prism version 6.2 was used to analyse the data obtained. Results: Results obtained showed a statistically higher value (p<0.05) in platelet count (p=0.0001), lower values (p<0.05) in haemoglobin concentration (Hb), Packed cell volume (PCV), Mean cell volume (MCV) and Mean cell haemoglobin (MCH) (p=0.0001). No significant difference (p>0.05) was observed in the mean red blood cell (RBC) count value (p=0.3110), white blood cell (WBC) count (p=0.8138) and mean cell haemoglobin concentration (MCHC) (p=0.0584) respectively. Conclusion and Recommendation: This study has confirmed that there are haematological alterations among cement loaders in Port Harcourt, Nigeria and these alterations are attributed to inhalation of cement dust during work. It is recommended that cement loaders should be mandated to use appropriate personal protective equipment during work hours and around areas where cement dust are generated.

scholarly journals Effect of Smoked and Oven-dried Catfish (Clarias gariepinus) on Haematological Parameters, Liver and Antioxidant Enzymes of Wistar Rats

2021 ◽  
pp. 3-13
Author(s):  
I. K. Ndubueze ◽  
H. A. Ogbunugafor ◽  
A. A. Oladejo
Keyword(s):  
Antioxidant Enzymes ◽  
Wistar Rats ◽  
Hematological Parameters ◽  
Clarias Gariepinus ◽  
The Body ◽  
Haematological Parameters ◽  
Drying Methods ◽  
Mean Cell Volume ◽  
Cell Counts ◽  
Significant Difference

Catfish is a traditional part of the diet of a large section of the world’s population. This study compared the effect of smoked and oven-dried catfish on hematological parameters, liver and antioxidant enzymes of wistar rats. Catfish samples were processed by smoking and oven-drying and used for formulation of the experimental feeds. Twenty one wistar rats were acclimatized for seven (7) days, weighed and allotted into three dietary treatments; control (standard feed), smoked and oven-dried fed groups. The study was conducted for a period of 21 days. Haematological analysis was carried out using haematology auto-analyzer. Liver enzymes (Alanine aminotransferase (ALT), Aspartate aminotransferase(AST), alkaline phosphatase (ALP) and Gamma-glutamyltransferase (GGT)) were assayed using standard assay kits while antioxidant enzymes were assayed using spectrophotometric method. The result revealed a significant increase (P<0.05) in the body weights of rats maintained on experimental feeds; oven-dried catfish fed group (240.83±6.13g), smoked catfish fed group (246.83±4.97g). There were no significant difference (P>0.05) in the haematological parameters of the treatment groups except in their total red blood cell counts, mean cell volume and mean cell hemoglobin. A non-significant difference (p>0.05) was observed in the antioxidant enzymes (SOD and CAT) of the test groups, indicating the absence of oxidative stress. The results of this research showed that both drying methods (oven and smoke drying) did not affect the palatability of the diets as the experimental diets were accepted by the experimental animals and their weight significantly improved. However, both diets have deleterious effects on the blood; hence, individuals with severe cases of anaemia and other blood disorders are encouraged to avoid them.

scholarly journals Reticulocyte and Erythrocyte Hemoglobin Parameters for Iron Deficiency and Anemia Diagnostics in Patient Blood Management. A Narrative Review

2021 ◽  
Vol 10 (18) ◽  
pp. 4250
Author(s):  
Christian Hoenemann ◽  
Norbert Ostendorf ◽  
Alexander Zarbock ◽  
Dietrich Doll ◽  
Olaf Hagemann ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Blood Loss ◽  
Blood Cells ◽  
Blood Count ◽  
Iron Status ◽  
Full Blood Count ◽  
Patient Blood Management ◽  
Acute Blood Loss ◽  
Blood Management ◽  
Main Factors

Anemia, iron deficiency and other hematinic deficiencies are a major cause of perioperative transfusion needs and are associated with increased morbidity and mortality. Anemia can be caused either by decreased production of hemoglobin or red blood cells or by increased consumption and blood loss. Decreased production can involve anything from erythropoietin or vitamin B12 insufficiency to absolute or functional lack of iron. Thus, to achieve the goal of patient blood management, anemia must be addressed by addressing its causes. The traditional parameters to diagnose anemia, despite offering elaborate options, are not ideally suited to giving a simple overview of the causes of anemia, e.g., iron status for erythropoiesis, especially during the acute phase of inflammation, acute blood loss or iron deficiency. Reticulocyte hemoglobin can thus help to uncover the cause of the anemia and to identify the main factors inhibiting erythropoiesis. Regardless of the cause of anemia, reticulocyte hemoglobin can also quickly track the success of therapy and, together with the regular full blood count it is measured alongside, help in clearing the patient for surgery.

scholarly journals Effect of the inclusion of scent leaf (Ocimum gratissimum) in diet on growth and haematology of growing rabbits

2021 ◽  
Vol 43 (2) ◽  
pp. 324-331
Author(s):  
W. Buba ◽  
S. Duru ◽  
J. Metemilola ◽  
C. Uchendu ◽  
A.O. Iyiola-Tunji
Keyword(s):  
Weight Gain ◽  
Treatment Group ◽  
Blood Cells ◽  
Body Weight Gain ◽  
White Blood Cells ◽  
Haematological Parameters ◽  
Feed Additive ◽  
Treatment Groups ◽  
Ocimum Gratissimum ◽  
Significant Difference

The effect of scent leaf (Ocimum gratissimum) as feed additive in rabbit diet on growth and hematological parameters of rabbits was investigated using a number of 24 non-descript rabbits in an eight (8) weeks feeding trial. Four experimental diets were formulated to contain 0.0, 2.0, 4.0 and 6.0g scent leaf (SL) per kg of feed. The diets were randomly assigned to four treatment groups of 6 rabbits per treatment in a completely randomized design (CRD) experiment. Feed and water were offered ad libitum. Feed intake and weight gain was taken and used to calculate other growth performance parameters while blood sample (2 ml) was collected aseptically between 6:30 and 7:30 am from three rabbits per treatment and transferred into heparinised tubes which was used to determine the haematological parameters (PCV, Hb, red blood cells and white blood cells). The results showed that there was significant (P<0.05) differences in body weight gain and feed conversion ratio (FCR) across the four (4) treatment groups with treatment group fed scent leaf at 4.0g/kg diet having the highest weight gain and the best FCR. There was also significant difference (P<0.05) in albumin and cholesterol levels. Haematological parameters showed significant difference (P<0.05) across the treatment groups with treatment group fed 2.0g scent leaf having the lowest white blood cell (8.00 x 1012 /L). In conclusion treatment group fed 4.0g scent leaf gave the best result in terms of weight gain and FCR.  

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