Laryngeal Synovial Sarcoma: A Rare Clinical Entity

Introduction. Synovial sarcomas (SS) are aggressive malignant soft tissue tumours that are thought to arise from pluripotent mesenchymal cells.Clinical Report. A 20-year-old male presented with an acute onset of respiratory stridor. Computer tomography scanning confirmed a mass arising from the left supraglottic larynx and an emergency tracheostomy was performed. A diagnosis of biphasic synovial sarcoma was formed. A total laryngectomy and left hemithyroidectomy was performed in conjunction with a left modified radical neck dissection. The patient received adjuvant chemotherapy followed by a course of radiotherapy and remains alive and disease free at 18 months after treatment.Discussion. Prognosis for patients with SS is related to primary tumour extent, grade, and size. The presence of the diagnostic translocation, t(X;18), is being targeted and hopefully will lead to the development of new therapeutics (Guadagnolo et al., 2007).Conclusion. Laryngeal SS remains a rare and poorly understood entity. A multidisciplinary approach to treatment is essential and long-term followup is imperative.

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Rare case of synovial sarcoma of anterior abdominal wall in a young Indian male

International Surgery Journal ◽

10.18203/2349-2902.isj20172798 ◽

2017 ◽

Vol 4 (7) ◽

pp. 2358

Author(s):

Abhishek Katyal ◽

Yash Patel

Keyword(s):

Abdominal Wall ◽

Synovial Sarcoma ◽

Rare Case ◽

Anterior Abdominal Wall ◽

Close Association ◽

Abdominal Cavity ◽

Typically Develop ◽

Synovial Sarcomas ◽

Upper Abdominal ◽

Malignant Soft Tissue

Synovial Sarcomas (synoviomas) are the fourth most common malignant soft-tissue tumours, and typically develop in para-articular locations of the extremities in close association with joint capsules, tendon sheaths, bursae and fascial structures. Other less common sites include the head and neck, abdominal wall, intra-abdominal cavity, and mediastinum. In this article, an interesting and rare case of a 25-year-old man with left upper abdominal lump is reported which was subsequently diagnosed as biphasic synovial sarcoma (spindle cell variety) of anterior abdominal wall.

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Intraneural synovial sarcoma of the tibial nerve

Rare Tumors ◽

10.1177/2036361318776495 ◽

2018 ◽

Vol 10 ◽

pp. 203636131877649 ◽

Cited By ~ 1

Author(s):

Kazuhiko Hashimoto ◽

Shunji Nishimura ◽

Kousuke Fujii ◽

Ryosuke Kakinoki ◽

Masao Akagi

Keyword(s):

Soft Tissue ◽

Synovial Sarcoma ◽

Tibial Nerve ◽

Metastatic Potential ◽

Soft Tissue Tumors ◽

Extensive Resection ◽

Malignant Soft Tissue Tumors ◽

Limb Preservation ◽

Synovial Sarcomas ◽

Malignant Soft Tissue

Synovial sarcomas are malignant soft tissue tumors that carry a metastatic potential and portend poor prognoses. We report a very rare synovial sarcoma arising from the tibial nerve and describe its successful treatment including limb preservation. To the best of our knowledge, this is the 40th reported incident of intraneural synovial sarcoma, and only the fourth arising from the tibial nerve. Extensive resection of synovial sarcoma arising in the popliteal region is difficult, particularly when limb preservation is desired. Ours is the first reported patient treated for tibial nerve-derived synovial sarcoma whose limbs were preserved.

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Radioimmunotherapy for treatment of acute myeloid leukaemia and myelodysplastic syndrome

Nuklearmedizin ◽

10.1055/s-0038-1625714 ◽

2005 ◽

Vol 44 (03) ◽

pp. 107-117

Author(s):

R. G. Meyer ◽

W. Herr ◽

A. Helisch ◽

P. Bartenstein ◽

I. Buchmann

Keyword(s):

Acute Myeloid Leukaemia ◽

Myeloid Leukaemia ◽

Primary Tumour ◽

The Other ◽

Haematopoietic Stem Cell ◽

Other Hand ◽

Primary Reduction ◽

The One ◽

Acute Myeloid

SummaryThe prognosis of patients with acute myeloid leukaemia (AML) has improved considerably by introduction of aggressive consolidation chemotherapy and haematopoietic stem cell transplantation (SCT). Nevertheless, only 20-30% of patients with AML achieve long-term diseasefree survival after SCT. The most common cause of treatment failure is relapse. Additionally, mortality rates are significantly increased by therapy-related causes such as toxicity of chemotherapy and complications of SCT. Including radioimmunotherapies in the treatment of AML and myelodyplastic syndrome (MDS) allows for the achievement of a pronounced antileukaemic effect for the reduction of relapse rates on the one hand. On the other hand, no increase of acute toxicity and later complications should be induced. These effects are important for the primary reduction of tumour cells as well as for the myeloablative conditioning before SCT.This paper provides a systematic and critical review of the currently used radionuclides and immunoconjugates for the treatment of AML and MDS and summarizes the literature on primary tumour cell reductive radioimmunotherapies on the one hand and conditioning radioimmunotherapies before SCT on the other hand.

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A combined lateral-crestal approach of sinus floor elevation: A report on three cases

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-20-00061 ◽

2020 ◽

Author(s):

Xin Zhang ◽

Yuting Zhang ◽

Jian Wang ◽

Qianbing Wan ◽

Lei Li

Keyword(s):

Clinical Study ◽

Conservative Treatment ◽

Lateral Approach ◽

Clinical Report ◽

Sinus Lift ◽

Sinus Floor Elevation ◽

Long Term Follow Up ◽

Sinus Floor

This clinical report describes a combined lateral-crestal approach to elevate the sinus floor when placing implants on a wide maxillary posterior ridge. The buccally enlarged osteotomy broadens vision of practitioners and facilitates access of instruments in the sinus. Compared to the traditional lateral approach of sinus lift, the proposed technique may offer a more conservative treatment modality. And a clinical study with sufficient subjects and long term follow up is needed to validate the potential and limitations of the proposed technique.

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Primary renal synovial sarcoma presenting with a retroperitoneal bleed

BMJ Case Reports ◽

10.1136/bcr-2020-237099 ◽

2021 ◽

Vol 14 (3) ◽

pp. e237099

Author(s):

Daanesh Huned ◽

Juinn Huar Kam ◽

Lui Shiong Lee ◽

Raj Vikesh Tiwari

Keyword(s):

Differential Diagnosis ◽

Case Report ◽

Synovial Sarcoma ◽

Soft Tissue Mass ◽

Renal Angiomyolipoma ◽

Right Hepatectomy ◽

Tissue Mass ◽

Biopsy Confirmation ◽

Synovial Sarcomas ◽

Neo Adjuvant Chemotherapy

Synovial sarcomas are most commonly localised in extremities, especially in the lower thigh and knee areas. Comprising less than 1% of all malignancies, retroperitoneal synovial sarcoma is very rare with primary synovial sarcoma of the kidney being even more infrequent and difficult to diagnose. We describe a case report of a renal synovial sarcoma in a young adult who was initially managed as a case of Wunderlich’s syndrome secondary to what was believed to be a ruptured renal angiomyolipoma. After biopsy confirmation, the patient was eventually managed with neo-adjuvant chemotherapy followed by a right radical nephrectomy and right hepatectomy. Despite its rarity, synovial sarcoma should be considered as differential diagnosis of a bleeding retroperitoneal soft tissue mass detected in young adults.

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Laparoscopic sleeve gastrectomy for morbid obesity and Klinefelter syndrome: clinical report on two patients, with long-term follow-up

Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity ◽

10.1007/s40519-020-00951-2 ◽

2020 ◽

Cited By ~ 2

Author(s):

Emanuela Bianciardi ◽

Paolo Orsaria ◽

Cinzia Niolu ◽

Alberto Siracusano ◽

Paolo Gentileschi

Keyword(s):

Morbid Obesity ◽

Sleeve Gastrectomy ◽

Laparoscopic Sleeve Gastrectomy ◽

Klinefelter Syndrome ◽

Clinical Report ◽

Long Term Follow Up

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Clinical report on long-term bone density after short-term EMF application

Bioelectromagnetics ◽

10.1002/(sici)1521-186x(1998)19:2<75::aid-bem3>3.0.co;2-0 ◽

1998 ◽

Vol 19 (2) ◽

pp. 75-78 ◽

Cited By ~ 44

Author(s):

Frank L. Tabrah ◽

Philip Ross ◽

Mary Hoffmeier ◽

Fred Gilbert

Keyword(s):

Bone Density ◽

Clinical Report ◽

Short Term

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Title: Weighted Gene Co-Expression Network Analysis Identifies Five Hub Genes Associated with Metastasis in Synovial Sarcoma

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207324666210628112429 ◽

2021 ◽

Vol 24 ◽

Author(s):

Hongzeng Wu ◽

Benzheng Zhang ◽

Jiazheng Zhao ◽

Yi Zhao ◽

Xiaowei Ma ◽

...

Keyword(s):

Synovial Sarcoma ◽

Tumor Metastasis ◽

Gene Expression Omnibus ◽

Survival Ratio ◽

Hub Genes ◽

Protein Protein Interaction ◽

Metastatic Lesions ◽

Ppi Networks ◽

Malignant Soft Tissue ◽

Geo Database

Background: Synovial sarcoma (SS) refers to a malignant soft tissue sarcoma (STS) which often occurs in children and adults and has a poor prognosis in elderly patients. Patients with local lesions can be treated with extensive surgical resection combined with adjuvant or radiotherapy, whereas about half of the cases have recurrent diseases and metastatic lesions, and five-year survival ratio is assessed within the range of 27% - 55% only. Method: We downloaded a set of expression profile data (GSE40021) related to SS metastasis based on the Gene Expression Omnibus (GEO) database, and selected distinctly represented genes (DEGs) related to tumor metastasis. WGCNA was used to emphasize the DEGs related to tumor metastasis and obtain co-expression modules. Then, the module most related to SS metastasis was screened out. The genes enriched in this module were analyzed by Gene Ontology (GO) functional and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway improvement analysis. Cytoscape software was used for constructing protein-protein interaction (PPI) networks, and hub genes were screened in Oncomine analysis. Result: We selected 514 DEGs, consisting of 210 up-regulated genes and 304 down-regulated genes. Through WGCAN, we got seven co-expression modules and the module most related to SS metastasis was the turquoise module, which contained 66 genes. Finally, we screened out five hub genes (HJURP, NCAPG, TPX2, CENPA, NDC80) through CytoHubba and Oncomine analysis. Conclusion: In this study, we screened five hub genes that may help in clinical diagnosis and serve as the latent purpose of SS treatment.

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Synovial sarcoma: case report

RGO - Revista Gaúcha de Odontologia ◽

10.1590/1981-863720170002000123194 ◽

2017 ◽

Vol 65 (3) ◽

pp. 260-264

Author(s):

Isabella Lima Arrais RIBEIRO ◽

Larissa Cavalcanti MONTEIRO ◽

Ana Carolina Rodrigues de MELO ◽

Tácio Candeia LYRA ◽

Julio Cesar Campos FERREIRA FILHO ◽

...

Keyword(s):

Tumor Growth ◽

Synovial Sarcoma ◽

Fibrous Tissue ◽

Treatment Protocol ◽

Neck Region ◽

Cervical Region ◽

Histopathological Analysis ◽

Parotid Region ◽

Synovial Sarcomas

ABSTRACT Introduction: Synovial sarcomas are rare and aggressive neoplasms located in the head and neck region and usually occurs in young adults. Presentation of case: This report presents a case of synovial sarcoma in a 15-year-old male patient who sought medical treatment for painful symptoms and associated dysphagia. The lesion was nodular, extensive, localized in the parotid region, and extended to the left cervical region. The patient was treated in a referral hospital with a treatment protocol that initially included chemotherapy for six months and surgery to attempt to excise the lesion, but the surgery was ineffective because removal could have damaged important vital structures. The Computed Tomography scan showed a hypodense area with diffuse growth and no involvement of the facial bones and the histopathological analysis revealed pleomorphic and oval spindle cells with rounded epithelial cells that formed nests surrounded by fibrous tissue. The Immunohistochemistry analysis was conclusive for the diagnosis of a high-grade SS in the parotid and left cervical regions. The medical team opted for palliative treatment with cervical radiotherapy. The patient remained hospitalized for four months after the surgery and died after 15 months since the diagnosis for compromise of airway by fast tumor growth. Conclusion: The synovial sarcoma, when diagnosed late may reduce the survival of patients because of the complications that tumor growth can bring to the prognosis and quality of life.

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