scholarly journals Effects of Metoprolol and Nebivolol on Exercise Blood Pressure in Patients with Mild Hypertension

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Huseyin Ugur Yazici ◽  
Hande Ozduman ◽  
Yuksel Aydar ◽  
Alparslan Birdane
Keyword(s):  
Blood Pressure ◽  
Mild Hypertension ◽  
Beta Blockers ◽  
Stress Test ◽  
Exercise Stress Test ◽  
Exercise Stress ◽  
Arterial Blood ◽  
Blood Pressures ◽  
The Difference ◽  
The Impact

Objectives. We planned to compare the impact of two beta blockers, metoprolol and nebivolol, on arterial blood pressure during exercise in patients with mild hypertension.Methods. A total of 60 patients (13 males, 47 females; mean age: years) were enrolled in the present study. The patients were randomly selected to receive either nebivolol 5 mg/day () or metoprolol 50 mg/day () for 8 weeks. At the end of the 8th week, each of the patients received exercise stress test according to Bruce protocol and their blood pressures were remeasured after rest, exercise, and recovery.Results. Blood pressures were determined to be similar between metoprolol and nebivolol groups during rest, exercise, and recovery periods. Metoprolol and nebivolol achieved similar reductions in blood pressures during rest and exercise. However, five patients in nebivolol group and four patients in metoprolol group developed exaggerated BP response to exercise but the difference between metoprolol and nebivolol was not meaningful ().Conclusion. The results of the present study showed that metoprolol and nebivolol established comparable effects on the control of blood pressures during exercise in the patients with mild hypertensions.

scholarly journals Systolic Blood Pressure Response to Exercise Stress Test and Risk of Stroke

Stroke ◽  
2001 ◽  
Vol 32 (9) ◽  
pp. 2036-2041 ◽  
Author(s):  
S. Kurl ◽  
J.A. Laukkanen ◽  
R. Rauramaa ◽  
T.A. Lakka ◽  
J. Sivenius ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Blood Pressure Response ◽  
Stress Test ◽  
Exercise Stress Test ◽  
Pressure Response ◽  
Exercise Stress ◽  
Response To Exercise

scholarly journals Effects of Atorvastatin on Resting and Peak Exercise Blood Pressure among Normotensive Men and Women

Cholesterol ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Amanda L. Zaleski ◽  
Marianne L. Mentch ◽  
Linda S. Pescatello ◽  
Beth A. Taylor ◽  
Jeffrey A. Capizzi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Stress Test ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Exercise Stress Test ◽  
Total Sample ◽  
Exercise Stress ◽  
Peak Exercise ◽  
Exercise Blood Pressure ◽  
Double Blinded

Statins are the most widely prescribed and effective medication for reducing low density lipoprotein cholesterol. Statins may also lower resting blood pressure (BP); however, results are inconsistent. We sought to determine if the maximum dose of atorvastatin reduces resting BP and the peak systolic BP (SBP) achieved on a graded exercise stress test (GEST) among a large sample of 419 healthy men (48%) and women (52%). Subjects (419, 44.1±0.8 yr) were double-blinded and randomized to 80 mg·d−1 of atorvastatin (n=202) or placebo (n=217) for 6 mo. Among the total sample, there were no differences in resting BP (SBP, P=0.30; diastolic BP [DBP], P=0.69; mean arterial pressure (P=0.76); or peak SBP on a GEST (P=0.99)) over 6 mo, regardless of drug treatment group. However, among women on atorvastatin, resting SBP/DBP (3.7±1.5 mmHg, P=0.01/3.2±0.9 mmHg, P=0.02) and peak SBP on a GEST (6.5±1.5 mmHg, P=0.04) were lower versus men. Atorvastatin lowered resting BP 3-4 mmHg and peak SBP on a GEST ~7 mmHg more among women than men over 6 mo of treatment. The inconsistent findings regarding the antihypertensive effects of statins may be partially explained by not accounting for sex effects.

scholarly journals HEPATIC STEATOSIS IS INDEPENDENTLY ASSOCIATED WITH HYPERREACTIVE BLOOD PRESSURE RESPONSE ON THE EXERCISE STRESS TEST

2012 ◽  
Vol 59 (13) ◽  
pp. E1793
Author(s):  
Antonio Laurinavicius ◽  
Fernando Nary ◽  
Michael Blaha ◽  
Khurram Nasir ◽  
Raquel Conceicao ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Hepatic Steatosis ◽  
Blood Pressure Response ◽  
Stress Test ◽  
Exercise Stress Test ◽  
Pressure Response ◽  
Exercise Stress

Monogenic and oligogenic cardiovascular diseases: genetics of arrhythmias—catecholaminergic polymorphic ventricular tachycardia

ESC CardioMed ◽  
2018 ◽  
pp. 683-685
Author(s):  
Peter J. Schwartz ◽  
Lia Crotti
Keyword(s):  
Ventricular Tachycardia ◽  
Beta Blockers ◽  
Stress Test ◽  
Exercise Stress Test ◽  
Catecholaminergic Polymorphic Ventricular Tachycardia ◽  
Exercise Stress ◽  
Polymorphic Ventricular Tachycardia ◽  
Cascade Screening ◽  
Icd Implantation ◽  
Symptomatic Diagnosis

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inherited disorder associated with syncope and sudden death manifesting in the young during sympathetic activation. The electrocardiogram is normal and the heart is structurally normal. The diagnosis is usually made with an exercise stress test that shows a typical pattern of onset and offset of adrenergically induced ventricular arrhythmias. Molecular screening of RyR2, the major CPVT gene, is recommended whenever the suspicion of CPVT is high. If a disease-causing mutation is identified, cascade screening allows pre-symptomatic diagnosis among family members. All affected subjects should be treated with beta blockers (nadolol or propranolol). Preliminary data support the association of beta blockers with flecainide. After a cardiac arrest, an implantable cardioverter defibrillator (ICD) should be implanted, but it is accompanied by a disquietingly high incidence of adverse effects. After syncope on beta blocker therapy, left cardiac sympathetic denervation is most effective, preserves quality of life, and does not preclude a subsequent ICD implantation.

Elevated Blood Pressure in a High School Football Player: Case Presentation and Discussion

1990 ◽  
Vol 2 (4) ◽  
pp. 384-394
Author(s):  
Ted A Kaplan
Keyword(s):  
High School ◽  
Blood Pressure ◽  
Cardiovascular Response ◽  
Stress Test ◽  
Exercise Stress Test ◽  
Football Player ◽  
Exercise Stress ◽  
Peak Exercise ◽  
Elevated Systolic Blood Pressure ◽  
Graded Exercise

A case is presented of an adolescent high school athlete found to have mildly elevated systolic blood pressure (BP) at the preseason group physical examination. As part of the evaluation to clear him for participation, a graded exercise stress test was performed. The test revealed a systolic BP at peak exercise of 260 mm Hg. The rationale for hygienic and pharmacologic management of this situation is discussed, and the results of this process are detailed. This patient was finally treated with nifedipine after unacceptable results with lisinopril, pindolol, and nonpharmacological approaches. The graded exercise test can be a valuable part of the evaluation of a hypertensive athlete. Besides revealing the occasional dangerous superelevation of BP, the test results can reveal the individual’s cardiovascular response to stress. This can provide insight into the etiology of and prognosis for the patient’s problem. Follow-up testing should be done after any treatment is provided.

scholarly journals Coagulation and inhibitory and fibrinolytic proteins in essential hypertension.

1993 ◽  
Vol 4 (2) ◽  
pp. 222-228
Author(s):  
N D Vaziri ◽  
D H Smith ◽  
R L Winer ◽  
M A Weber ◽  
E C Gonzales ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Blood Coagulation ◽  
Plasminogen Activator ◽  
Stress Test ◽  
Exercise Stress Test ◽  
Left Ventricular ◽  
Exercise Stress ◽  
Tissue Plasminogen ◽  
D Dimer

Arterial hypertension (HTN) increases the risk of cerebral coronary, and other vascular complications that frequently involve platelet activation and blood coagulation. Several key proteins in the blood coagulation, fibrinolytic and inhibitory systems were studied in 29 men with HTN (aged 45 +/- 3 yr) and 15 normal men of the same age. Plasma levels of high-molecular-weight kininogen and factors XII, IX, VII, X, II, and XIII, as well as von Willebrand factor (vWF), fibrinogen, fibronectin, alpha 2-antiplasmin, tissue-plasminogen activator, D-dimer, platelet factor-4, and protein C were measured by the use of appropriate functional and immunologic assays before and after a cardiopulmonary exercise stress test. The concentrations of vWF, alpha 2-antiplasmin, and D-dimer were significantly (P < 0.02) higher in the HTN group as compared with the control group. The exercise stress test resulted in significant rises in the plasma vWF, alpha 2-antiplasmin, and tissue-plasminogen activator levels in the two groups. The concentrations of vWF and D-dimer were related to diastolic blood pressure (r = 0.44 and 0.40, respectively; P < 0.02). Levels of vWF also were related to left ventricular mass index and left ventricular posterior wall and septal thickness (r = 0.34, 0.43, and 0.34, respectively; P < 0.05). The constellation of these findings suggests a low-grade fibrin formation and degradation, the magnitude of which is related to the diastolic blood pressure. The observed abnormalities can potentially contribute to the cardiovascular complications of untreated HTN.

Monogenic and oligogenic cardiovascular diseases: genetics of arrhythmias—catecholaminergic polymorphic ventricular tachycardia

2018 ◽  
Author(s):  
Peter J. Schwartz ◽  
Lia Crotti
Keyword(s):  
Ventricular Tachycardia ◽  
Beta Blockers ◽  
Stress Test ◽  
Exercise Stress Test ◽  
Catecholaminergic Polymorphic Ventricular Tachycardia ◽  
Exercise Stress ◽  
Polymorphic Ventricular Tachycardia ◽  
Cascade Screening ◽  
Icd Implantation ◽  
Symptomatic Diagnosis

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inherited disorder associated with syncope and sudden death manifesting in the young during sympathetic activation. The electrocardiogram is normal and the heart is structurally normal. The diagnosis is usually made with an exercise stress test that shows a typical pattern of onset and offset of adrenergically induced ventricular arrhythmias. Molecular screening of RyR2, the major CPVT gene, is recommended whenever the suspicion of CPVT is high. If a disease-causing mutation is identified, cascade screening allows pre-symptomatic diagnosis among family members. All affected subjects should be treated with beta blockers (nadolol or propranolol). Preliminary data support the association of beta blockers with flecainide. After a cardiac arrest, an implantable cardioverter defibrillator (ICD) should be implanted, but it is accompanied by a disquietingly high incidence of adverse effects. After syncope on beta blocker therapy, left cardiac sympathetic denervation is most effective, preserves quality of life, and does not preclude a subsequent ICD implantation.

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