scholarly journals Effects of Atorvastatin on Resting and Peak Exercise Blood Pressure among Normotensive Men and Women

Cholesterol ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Amanda L. Zaleski ◽  
Marianne L. Mentch ◽  
Linda S. Pescatello ◽  
Beth A. Taylor ◽  
Jeffrey A. Capizzi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Stress Test ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Exercise Stress Test ◽  
Total Sample ◽  
Exercise Stress ◽  
Peak Exercise ◽  
Exercise Blood Pressure ◽  
Double Blinded

Statins are the most widely prescribed and effective medication for reducing low density lipoprotein cholesterol. Statins may also lower resting blood pressure (BP); however, results are inconsistent. We sought to determine if the maximum dose of atorvastatin reduces resting BP and the peak systolic BP (SBP) achieved on a graded exercise stress test (GEST) among a large sample of 419 healthy men (48%) and women (52%). Subjects (419, 44.1±0.8 yr) were double-blinded and randomized to 80 mg·d−1 of atorvastatin (n=202) or placebo (n=217) for 6 mo. Among the total sample, there were no differences in resting BP (SBP, P=0.30; diastolic BP [DBP], P=0.69; mean arterial pressure (P=0.76); or peak SBP on a GEST (P=0.99)) over 6 mo, regardless of drug treatment group. However, among women on atorvastatin, resting SBP/DBP (3.7±1.5 mmHg, P=0.01/3.2±0.9 mmHg, P=0.02) and peak SBP on a GEST (6.5±1.5 mmHg, P=0.04) were lower versus men. Atorvastatin lowered resting BP 3-4 mmHg and peak SBP on a GEST ~7 mmHg more among women than men over 6 mo of treatment. The inconsistent findings regarding the antihypertensive effects of statins may be partially explained by not accounting for sex effects.

Elevated Blood Pressure in a High School Football Player: Case Presentation and Discussion

1990 ◽  
Vol 2 (4) ◽  
pp. 384-394
Author(s):  
Ted A Kaplan
Keyword(s):  
High School ◽  
Blood Pressure ◽  
Cardiovascular Response ◽  
Stress Test ◽  
Exercise Stress Test ◽  
Football Player ◽  
Exercise Stress ◽  
Peak Exercise ◽  
Elevated Systolic Blood Pressure ◽  
Graded Exercise

A case is presented of an adolescent high school athlete found to have mildly elevated systolic blood pressure (BP) at the preseason group physical examination. As part of the evaluation to clear him for participation, a graded exercise stress test was performed. The test revealed a systolic BP at peak exercise of 260 mm Hg. The rationale for hygienic and pharmacologic management of this situation is discussed, and the results of this process are detailed. This patient was finally treated with nifedipine after unacceptable results with lisinopril, pindolol, and nonpharmacological approaches. The graded exercise test can be a valuable part of the evaluation of a hypertensive athlete. Besides revealing the occasional dangerous superelevation of BP, the test results can reveal the individual’s cardiovascular response to stress. This can provide insight into the etiology of and prognosis for the patient’s problem. Follow-up testing should be done after any treatment is provided.

scholarly journals Exaggerated blood pressure response at mild exertional intensity is associated with lower exercise capacity and worsening of cardiac structural and functional profile

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
A.K Woznicka ◽  
M Kabaj ◽  
W Kosowski ◽  
J Zachwyc ◽  
R Pehcerczyk ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Exercise Capacity ◽  
Exercise Intensity ◽  
Stress Test ◽  
Exercise Stress Test ◽  
Exercise Stress ◽  
Peak Exercise ◽  
Study Cohort ◽  
Funding Source ◽  
Cardiac Morphology

Abstract   Even with normal blood pressure (BP) measured at rest, some individuals may experience excessive BP elevation with exercise, termed as an “exaggerated BP response to exercise” (ExBPR). The most common definition of ExBPR is SBP ≥210 mm Hg in men and ≥190 mm Hg in women at peak exercise intensity (ExBPR-PI). However, evidence exists that increase in SBP ≥150 mm Hg at an early stage of exercise stress test (i.e. at mild exercise intensity, ExBPR-MI) can effectively identify hypertension not diagnosed by conventional methods. No studies exploring the pathophysiological significance of ExBPR-MI have been undertaken to date. Aim To investigate the association of ExBPR-MI with exercise capacity and cardiac morpho-functional characteristics. Methods A group of 109 subjects (mean age 52±13 yrs) with and without a pre-established diagnosis of hypertension, having clinical indications for an exercise stress test, with seated clinic BP <140/90 mm Hg, underwent resting echocardiographic imagining and cardiopulmonary exercise testing using a ramped Bruce protocol. Results Based on the BP response at 3 minutes of exercise, the population was divided into two subsets: ExBPR-MI+ and ExBPR-MI− (SBP ≥ and <150 mmHg, respectively). The ExBPR-MI+ group was characterized by lower peak oxygen uptake, higher LV mass and left atrial size, and more impaired LV diastolic function (lower E/A and e', and higher E/e'). When the study cohort was stratified using peak BP response, significant differences indicating an adverse impact of ExBPR-PI were demonstrated only for LV diastolic parameters but not for peak VO2 and cardiac morphology indices (Table 1). Conclusions ExBPR-MI predisposes to reduced exercise capacity and detrimental alterations in cardiac morphology and function. As mild exercise intensity is more frequently present during routine daily activities than peak exercise intensity, ExBPR-MI may be a more important pathophysiological contributor to target organ damage than peak BP response, and may represent a potential new target for preventive and therapeutic measures. Table 1 Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): National Science Centre Poland

scholarly journals 4.8 Reference Values for Submaximal Exercise Blood Pressure: the EXERcise Stress Test CollaboratION (EXERTION)

2020 ◽  
Vol 25 (Supplement 1) ◽  
pp. S36
Author(s):  
Schultz Martin ◽  
Ann-Marie Kovacevic ◽  
Philip Roberts-Thomson ◽  
Tony Stanton ◽  
Christian Hamilton-Craig ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Reference Values ◽  
Stress Test ◽  
Exercise Stress Test ◽  
Submaximal Exercise ◽  
Exercise Stress ◽  
Exercise Blood Pressure

scholarly journals Systolic Blood Pressure Response to Exercise Stress Test and Risk of Stroke

Stroke ◽  
2001 ◽  
Vol 32 (9) ◽  
pp. 2036-2041 ◽  
Author(s):  
S. Kurl ◽  
J.A. Laukkanen ◽  
R. Rauramaa ◽  
T.A. Lakka ◽  
J. Sivenius ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Blood Pressure Response ◽  
Stress Test ◽  
Exercise Stress Test ◽  
Pressure Response ◽  
Exercise Stress ◽  
Response To Exercise

scholarly journals HEPATIC STEATOSIS IS INDEPENDENTLY ASSOCIATED WITH HYPERREACTIVE BLOOD PRESSURE RESPONSE ON THE EXERCISE STRESS TEST

2012 ◽  
Vol 59 (13) ◽  
pp. E1793
Author(s):  
Antonio Laurinavicius ◽  
Fernando Nary ◽  
Michael Blaha ◽  
Khurram Nasir ◽  
Raquel Conceicao ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Hepatic Steatosis ◽  
Blood Pressure Response ◽  
Stress Test ◽  
Exercise Stress Test ◽  
Pressure Response ◽  
Exercise Stress

scholarly journals Coagulation and inhibitory and fibrinolytic proteins in essential hypertension.

1993 ◽  
Vol 4 (2) ◽  
pp. 222-228
Author(s):  
N D Vaziri ◽  
D H Smith ◽  
R L Winer ◽  
M A Weber ◽  
E C Gonzales ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Blood Coagulation ◽  
Plasminogen Activator ◽  
Stress Test ◽  
Exercise Stress Test ◽  
Left Ventricular ◽  
Exercise Stress ◽  
Tissue Plasminogen ◽  
D Dimer

Arterial hypertension (HTN) increases the risk of cerebral coronary, and other vascular complications that frequently involve platelet activation and blood coagulation. Several key proteins in the blood coagulation, fibrinolytic and inhibitory systems were studied in 29 men with HTN (aged 45 +/- 3 yr) and 15 normal men of the same age. Plasma levels of high-molecular-weight kininogen and factors XII, IX, VII, X, II, and XIII, as well as von Willebrand factor (vWF), fibrinogen, fibronectin, alpha 2-antiplasmin, tissue-plasminogen activator, D-dimer, platelet factor-4, and protein C were measured by the use of appropriate functional and immunologic assays before and after a cardiopulmonary exercise stress test. The concentrations of vWF, alpha 2-antiplasmin, and D-dimer were significantly (P < 0.02) higher in the HTN group as compared with the control group. The exercise stress test resulted in significant rises in the plasma vWF, alpha 2-antiplasmin, and tissue-plasminogen activator levels in the two groups. The concentrations of vWF and D-dimer were related to diastolic blood pressure (r = 0.44 and 0.40, respectively; P < 0.02). Levels of vWF also were related to left ventricular mass index and left ventricular posterior wall and septal thickness (r = 0.34, 0.43, and 0.34, respectively; P < 0.05). The constellation of these findings suggests a low-grade fibrin formation and degradation, the magnitude of which is related to the diastolic blood pressure. The observed abnormalities can potentially contribute to the cardiovascular complications of untreated HTN.

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